Abstract P216: Prevalence of Life’s Simple Seven Cardiovascular Health Metrics in the Million Veteran Program

Background: While previous studies have reported the prevalence of Life’s Simple Seven (LSS) in the general population, no data exist in a national sample of US veterans. Objective: To assess the prevalence of ideal LSS in a cross-sectional study of 500,000 US Veterans participating in the Million Veteran Program (MVP) from 2011-2016. Methods: We assigned one of three possible values (0=poor, 1=intermediate, 2=ideal) for each of the seven LSS metrics (adiposity /BMI), smoking status, total cholesterol, blood pressure, plasma glucose, diet, physical activity) at baseline using self-reported data and electronic health records. A total score of 0 across all seven metrics indicated overall poor cardiovascular health and a score of 14 indicated ideal cardiovascular health. Results: Complete data on all LSS factors were available for 171,146 Veterans (92% men and mean age 65.5yrs ±11.5 SD). Average LSS score was 6.1 ±1.9. Ideal BMI, smoking status, total cholesterol, blood pressure and plasma glucose (fasting and non-fasting) was present in 23.8%, 30%, 22.2%, 22.5% and 42.9%, respectively, in the study population (Fig). Prevalence of ideal diet was 0.4%. Among dietary factors, recommendation for fruits and vegetables (at least 4.5cups/day) was the least likely to be achieved. Physical activity at the workplace, home or at leisure was reported among 25.6% of Veterans (21.8% intermediate and 3.8% ideal physical activity). Conclusions: Our data show a low prevalence of ideal LSS among Veterans in the MVP, especially diet (0.4%) and physical activity (3.8%). Compared to NHANES 2005-2006 unadjusted prevalence estimates for AHA 2020 goals, Veterans in MVP have a lower prevalence of all ideal LSS metrics except for diet: BMI (23.8 vs 33%), physical activity (3.8 vs 45%), smoking status (30 vs 73%), total cholesterol (22.2 vs 45%) blood pressure (22.5 vs 42%) and glucose (42.9 vs 58%). These findings underscore the need to improve adherence to modifiable lifestyle factors with subsequent reduction in CVD burden among Veterans.

Download Full-text

Abstract P114: Low Prevalence of Ideal Cardiovascular Health Metrics among African Americans: The Jackson Heart Study

Circulation ◽

10.1161/circ.129.suppl_1.p114 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

Luc Djousse ◽

Andrew Petrone ◽

Chad Blackshear ◽

Michael Griswold ◽

Jane Harman ◽

...

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Cardiovascular Disease ◽

African Americans ◽

Cardiovascular Health ◽

Smoking Status ◽

Jackson Heart Study ◽

Men And Women ◽

Ideal Cardiovascular Health ◽

Heart Study

Background: While the prevalence of cardiovascular health metrics or Life’s Simple Seven (LSS) has been shown to be far from optimal in the US, such information has been predominantly reported in Caucasians. The burden of cardiovascular disease among African Americans underscores the need to evaluate the prevalence and secular trends of LSS in other ethnic groups. Objective: To test the hypothesis that the prevalence of the LSS is far from ideal among participants of the Jackson Heart Study. Methods: We analyzed LSS with 3,500 African Americans from the Jackson Heart Study, using data from their first clinic visit (2000-2004). Standard methods were used to measure blood pressure, glucose, body mass index (BMI), and cholesterol. Information on physical activity, smoking, and diet was collected with interviewer-administered questionnaires. Each of the LSS metrics (smoking status, diet, physical activity, BMI, fasting blood glucose, total cholesterol, and blood pressure) was categorized as poor, intermediate, or ideal, as defined by the AHA guidelines. Results: The mean age at baseline was 56.9 ± 12.2 years and 2,350 participants (67%) were women. Among men, the prevalence of having 0, 1, 2, 3, 4, 5, 6, and 7 ideal cardiovascular health metrics was 6.6%, 25.8%, 32.7%, 21.6%, 10.6%, 2.3%, 0.4%, and 0%, respectively. Corresponding values for women were 3.2%, 28.1%, 32.9%, 22.3%, 10.1%, 2.9%, 0.38%, and 0%. While about two-thirds of men and women reported ideal smoking status, almost none reported ideal diet quality, and few met recommendations for BMI and blood pressure ( Figure) . Conclusions: Our data are consistent with less than optimal prevalence of cardiovascular health metrics in both men and women from the Jackson Heart Study. The lower prevalence of meeting ideal recommendations for diet, physical activity, BMI, and blood pressure underscores the need for targeted interventions to improve these modifiable lifestyle factors in order to reduce the burden of cardiovascular disease among African-Americans.

Download Full-text

Abstract P114: Association of Subjective Social Status With Cardiovascular Health in Hispanics/Latinos

Circulation ◽

10.1161/circ.137.suppl_1.p114 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Lissette Piedra ◽

Keyword(s):

Physical Activity ◽

Social Status ◽

Cardiovascular Health ◽

Smoking Status ◽

Fasting Blood Glucose ◽

Heart Association ◽

Subjective Social Status ◽

Cross Sectional ◽

Ideal Cardiovascular Health ◽

Latino Adults

Introduction: Evidence suggests that subjective social status (SSS)—perceived status in the social hierarchy—may be more strongly associated with health than objective markers of social status (OSS), income and education. Compared to persons with high SSS, those with low SSS report poorer self-rated physical health and have higher rates of medical comorbidities. Little is known about the relationship between SSS and ideal cardiovascular health (CVH) profiles defined by the American Heart Association (AHA), particularly among diverse Hispanic/Latino adults. Hypothesis: Higher SSS will be associated with more favorable CVH profiles. Methods: We analyzed baseline HCHS/SOL data † on adults ages 18-74 in 2008-11 (N=15,440). SSS was assessed using the McArthur Scale, a 10-rung “social ladder” to specify social rank (scores range from 1-10; higher scores indicate higher SSS). CVH was defined based on levels of 7 metrics: diet, body mass index (BMI), physical activity, cholesterol, blood pressure, fasting glucose, and smoking status; levels of each metric were categorized as ideal, intermediate and poor using AHA criteria. A composite CVH score was calculated by summing across metrics (scores range from 0-14; higher scores indicate better CVH). Linear and logistic regressions were used to examine cross-sectional associations of SSS with CVH (overall and single metrics), after adjusting for OSS, demographics, Hispanic/Latino group, study center, marital status, insurance, prevalent coronary heart disease, and depressive symptoms (CESD). Results: In multivariate-adjusted models, each one unit increase in SSS* was associated with a higher overall CVH score (β = 0.03, 95% CI 0.004, 0.057, p <0.05); higher SSS was also positively associated with ideal levels of BMI, physical activity, and fasting blood glucose levels (see Table 1). Conclusions: These findings suggest an association between SSS and CVH among diverse Hispanic/Latino adults. Future studies will explore the mechanisms through which SSS may influence CVH.

Download Full-text

Abstract P316: Very Low Prevalence of Ideal Cardiovascular Health in Young Adults Studying at the Université de Sherbrooke

Circulation ◽

10.1161/circ.125.suppl_10.ap316 ◽

2012 ◽

Vol 125 (suppl_10) ◽

Author(s):

Marie-France Hivert ◽

Myriam Doyon ◽

Geneviève Forget ◽

Guillaume Lacerte ◽

Melissa Labonté ◽

...

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Young Adults ◽

Total Cholesterol ◽

Fruits And Vegetables ◽

Cardiovascular Health ◽

Current Guideline ◽

Ideal Cardiovascular Health ◽

Dietary Component ◽

Low Prevalence

Introduction: In 2010, the American Heart Association (AHA) published a special report to define and set national goals for cardiovascular health promotion and disease reduction (2020 Strategic Impact Goals). Ideal cardiovascular health was defined based on seven metrics including both ideal health behaviors (nonsmoking, body mass index &lt 25 kg/m2, physical activity at goal levels, and pursuit of a diet consistent with current guideline recommendations) and ideal health factors (untreated total cholesterol &lt 200 mg/dL [5.2 mmol/L], untreated blood pressure &lt 120/ &lt 80 mm Hg, and fasting blood glucose 8h of overnight fasting, using standardized procedures. Resting blood pressure was measured in the sitting position (twice, using the average for analyses). Physical activity was assessed by a validated questionnaire. Dietary intake was assessed by 3-day food diary; the average per day or the estimations per week were used accordingly to the specific dietary component recommendation. Results: The cohort was composed of young adults (20.6 ± 2.9 years old), mainly of European origin (97.8%), and 74.6% were female. Overall, only one participant (0.4%) achieved ideal cardiovascular health (all seven ideal health metrics). Very few participants (2.2%) achieved ideal healthy diet score (4-5 components /5). Investigating individual dietary component, our results showed that 9.4% consumed ≥ 4.5 cups/day of fruits and vegetables, 25.7% had ≥ two servings/week of fish, 14.5% reported ≥ three servings/day of fiber-rich whole grains, 8.0% consumed &lt 1500g/day of sodium, and 75.4% reported drinking &lt 36oz / week of sugar-sweetened beverages. Concerning the other health metrics, 22.8% achieved the recommended level of physical activity, 93.8% were non-smokers, 75.7% had a BMI &lt 25kg/m2, 42.4% had a blood pressure in the ideal range ( &lt 120/ &lt 80 mmHg), 99.6% had a normal fasting glucose ( &lt 5.6 mmol/L), and 42.4% had a total cholesterol &lt 5.2 mmol/L. Conclusions: The prevalence of ideal cardiovascular health is very low, even in a population of young adults interested in healthy lifestyle. The low prevalence is mainly dependent on the healthy dietary score where the biggest challenges seem to be consumption of fruits and vegetables, and limiting sodium intake. Public health actions are seriously needed to improve these health metrics.

Download Full-text

Abstract 37: The Association of Cardiorespiratory Fitness and Ideal Cardiovascular Health in the Aerobics Center Longitudinal Study

Circulation ◽

10.1161/circ.135.suppl_1.37 ◽

2017 ◽

Vol 135 (suppl_1) ◽

Author(s):

Leanna M Ross ◽

Jacob L Barber ◽

Xuemei Sui ◽

Steven N Blair ◽

Mark A Sarzynski

Keyword(s):

Longitudinal Study ◽

Cardiorespiratory Fitness ◽

Cardiovascular Health ◽

Smoking Status ◽

Cross Sectional ◽

Ideal Cardiovascular Health ◽

Logistic Regression Models ◽

Using Data ◽

Middle Aged Adults ◽

Aerobics Center Longitudinal Study

Purpose: To examine the cross-sectional association between cardiorespiratory fitness (CRF) and ideal cardiovascular health (CVH) in middle-aged adults. Methods: The association between CRF and ideal CVH score was examined in 11,590 adults (8,865 men, 2,725 women) from the Aerobics Center Longitudinal Study. CRF was measured as duration in minutes from a maximal treadmill test. The AHA’s ideal CVH score was calculated on a 14 point scale using data on smoking status, BMI, physical activity (MET-min/wk), healthy diet, total cholesterol, blood pressure, and fasting plasma glucose recorded between 1987 and 1999. Participants were grouped into categories of inadequate (0-4), average (5-9), and optimum (10-14) based on their CVH score. Three CRF groups were created from age- and sex-specific quintiles based on the previously established cutpoints of treadmill time: low, moderate, and high CRF. We used general linear and logistic regression models adjusted for age, sex, and year of examination to evaluate the association of CRF with ideal CVH score. Results: The mean CVH score for men was 8.4 ± 2.2 and 9.7 ± 2.0 for women. Approximately 33% of men and 57% of women had optimum CVH, while only a small proportion of participants had inadequate CVH (5.1% M, 1.4% F). Treadmill time was moderately correlated (p<0.0001) with CVH score in both men (r=0.56) and women (r=0.50). CRF explained 16% and sex 18% of the variance in CVH score (both p<0.0001). Our adjusted model found that participants in the optimum CVH category had 20% and 43% higher CRF levels than those in the average and inadequate CVH groups (p<0.0001), respectively ( Figure 1 ). The adjusted odds (95% CI) of having optimum CVH were 14.0 (11.0-17.8) and 3.1 (2.4-4.0) times greater for high CRF and moderate CRF, respectively, compared to low CRF (p<0.0001). Discussion: Higher levels of cardiorespiratory fitness are associated with better cardiovascular health profiles in both men and women. Thus, improving fitness represents a strategy to improve cardiovascular and public health.

Download Full-text

Abstract P180: Low Prevalence of Ideal Cardiovascular Health in Patients With Severe Hypercholesterolemia in a Largely Rural Population

Circulation ◽

10.1161/circ.141.suppl_1.p180 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Nicole A Groth ◽

Catherine P Benziger

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Sex Differences ◽

Total Cholesterol ◽

Body Mass ◽

Cardiovascular Health ◽

Healthy Diet ◽

Ideal Cardiovascular Health ◽

Health Factors ◽

Low Prevalence

Introduction: The American Heart Association’s ideal cardiovascular health (ICH) score is determined by 3 ideal health factors (normal blood pressure, untreated total cholesterol, and glucose) and 4 ideal health behaviors (non-smoking, normal body mass index, high physical activity, and heart healthy diet). Achieving ICH, defined as meeting 5 of the 7 metrics, decreases risk of cardiovascular disease. Prevalence estimates of ICH in patients with severe hyperlipidemia (SH) living in rural areas are lacking. Hypothesis: We aimed to determine the prevalence of poor, intermediate, and ICH in patients with SH in a large healthcare system (Essentia Health), where over 60% of the population is rural. Methods: The electronic medical record-based SH registry is a cross-sectional cohort study at the Essentia Health of patients who have ever had a low-density lipoprotein - cholesterol value of 190 mg/dL or higher, since 01/01/2000 (n=17,925). Patients were excluded if they did not have a visit at the institution within the past 5 years (n=209) or were outside of the age 20-75 years (n=3,153). Physical activity and healthy diet were not available in the record and were excluded from the score. Patients with missing data were assumed ideal given low clinical suspicion of conditions. Methods: A total of 14,544 (81.1%) of the SH registry patients met inclusion criteria (mean age 63 +13 years; 58.9% female). Figure 1 shows the prevalence of ICH metrics in the total population. Only 3 (0.02%) people met all five of the ideal metrics (score of 10); more females had a score of 8-10 than males (12.5% vs. 9.6%). A total of 13 (0.08%) had a score of 0 (poor) and 3.0% had a score of 0-2 with no sex differences. Not smoking and ideal glucose were the most prevalent health factors. The mean score was 5.6 (+1.6) with no sex differences. Conclusions: There is low prevalence of ICH in patients with SH living in rural populations. The metrics with the lowest prevalence and therefore highest potential for improvement are the health factors: total cholesterol and body mass index.

Download Full-text

Ideal cardiovascular health at age 5–6 years and cardiometabolic outcomes in preadolescence

International Journal of Behavioral Nutrition and Physical Activity ◽

10.1186/s12966-021-01090-2 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Hester Jaspers Faijer-Westerink ◽

Mette Stavnsbo ◽

Barbara A. Hutten ◽

Mai Chinapaw ◽

Tanja G. M. Vrijkotte

Keyword(s):

Blood Pressure ◽

Total Cholesterol ◽

Weight Status ◽

Cardiovascular Health ◽

Health Behaviours ◽

Healthy Weight ◽

Ideal Cardiovascular Health ◽

Health Factors ◽

Lower Total Cholesterol ◽

Ich Score

Abstract Background The American Heart Association (AHA) developed a definition of ideal cardiovascular health (ICH) based on the presence of both ideal health behaviours (diet, physical activity, weight status and smoking) and ideal health factors (glucose, total cholesterol and blood pressure levels). However, research of ICH in the paediatric population is scarce. We aimed to study ICH at age 5–6 years by extending the original ICH score with the health behaviours: sleep duration, screen time and prenatal smoke exposure, and to evaluate its association with cardiometabolic outcomes at age 11–12. Methods A total of 1666 children aged 5–6 years were selected from the database of the ABCD-study, a prospective cohort study on the health and development of children born in Amsterdam, the Netherlands. Of these, 846 (50.8%) were boys and 1460 (87.6%) had a healthy weight. Data on self-reported health behaviours and health factors were used to calculate the ICH scores (original and extended) by adding the frequency of scoring ‘healthy’ on each indicator, based on international cut-offs. The children were followed up for 6 years and cardiometabolic outcomes (carotid intima-media thickness (CIMT), blood pressure, glucose and lipids) were measured. Associations between ICH (both original and extended) and cardiometabolic outcomes were examined using multivariable regression models. Results At age 5–6 years, 11% scored poor (score 1–5), 56% intermediate (score 6–7) and 33% good (score 8–9) on extended ICH. Healthy diet and normal total cholesterol concentrations were the least prevalent. Neither the original nor the extended ICH scores were associated with CIMT at age 11–12. A higher score on the extended ICH was associated with lower total cholesterol (p for trend < 0.001), lower systolic (p for trend = 0.012) and diastolic blood pressure (p for trend = 0.011), and lower body mass index (BMI) (p < 0.001) at age 11–12. The original ICH score was associated with lower total cholesterol (p < 0.001) and BMI (p < 0.001) only. Conclusion Our findings suggest that extending the ICH score in young children with additional health behaviours improves prediction of some cardiometabolic outcomes, but not CIMT in preadolescence, compared to the original ICH score. We would recommend other researchers to incorporate objective measures of health behaviours and longer follow-up to find out whether associations persist into adulthood.

Download Full-text

Occupational physical activity and cardiovascular disease in the United States

Occupational and Environmental Medicine ◽

10.1136/oemed-2020-106948 ◽

2021 ◽

pp. oemed-2020-106948

Author(s):

Tyler D. Quinn ◽

Patrick L. Yorio ◽

Peter M. Smith ◽

Yongsuk Seo ◽

Geoffrey P. Whitfield ◽

...

Keyword(s):

Physical Activity ◽

Cardiovascular Disease ◽

Cardiovascular Health ◽

Leisure Time Physical Activity ◽

Smoking Status ◽

The United States ◽

Occupational Activity ◽

Occupational Physical Activity ◽

Cross Sectional ◽

Never Smokers

BackgroundEmerging evidence, predominately from European and Asian countries, describes opposing effects of occupational physical activity (OPA) and leisure-time physical activity (LTPA) on cardiovascular health. This analysis examined cardiovascular disease (CVD) prevalence associated with OPA and LTPA.MethodsThis cross-sectional analysis of 2015 National Health Interview Survey data (n=16 974) employed logistic regression to estimate odds (OR) of self-reported CVD (coronary heart disease, heart attack, stroke or angina) with self-reported total occupational activity (TOA), occupational exertion (OE), occupational standing and walking (OSW) and LTPA. OPA was measured using two questions: ‘How often does your job involve…’ (1) ‘repeated lifting, pushing, pulling or bending?’ (OE) and (2) ‘standing or walking around?’ (OSW) with responses on a 5-item Likert scale (0=never, 4=always). TOA was categorised similarly after summing OE and OSW scores. LTPA was defined as 0, 1–149 or ≥150 min/week of moderate-to-vigorous activity. All models adjusted for common socioeconomic variables and additional analyses were stratified by sex, smoking status and LTPA.ResultsOdds for CVD were higher when ‘always’ performing TOA (OR 1.99 95% CI 1.12 to 3.53), OE (OR 2.15, 95% CI 1.45 to 3.19) or OSW (OR 1.84, 95% CI 1.07 to 3.17) compared with ‘never’. When restricting to never-smokers, odds for CVD were higher when ‘always’ performing TOA (OR 3.00, 95% CI 1.38 to 6.51) and OE (OR 3.00, 95% CI 1.80 to 5.02) versus ‘never’.ConclusionAssociations of high OPA with CVD were equally apparent across sexes, stronger in lower LTPA levels and stronger in never-smokers. While uncontrolled confounding is still possible, even after extensive adjustment, the seemingly paradoxical adverse associations with OPA and CVD should be investigated further.

Download Full-text

Lipidomic Profiling Identifies Signatures of Poor Cardiovascular Health

Metabolites ◽

10.3390/metabo11110747 ◽

2021 ◽

Vol 11 (11) ◽

pp. 747

Author(s):

Irma Magaly Rivas Serna ◽

Michal Sitina ◽

Gorazd B. Stokin ◽

Jose R. Medina-Inojosa ◽

Francisco Lopez-Jimenez ◽

...

Keyword(s):

Blood Pressure ◽

Total Cholesterol ◽

Cardiovascular Health ◽

Fasting Blood Glucose ◽

Heart Association ◽

Population Based ◽

Individual Species ◽

Lipid Profiling ◽

Ideal Cardiovascular Health ◽

Potential Biomarker

Ideal cardiovascular health (CVH) is defined for the presence of ideal behavioral and health metrics known to prevent cardiovascular disease (CVD). The association of circulatory phospho- and sphingo-lipids to primary reduction in cardiovascular risk is unclear. Our aim was to determine the association of CVH metrics with the circulating lipid profile of a population-based cohort. Serum sphingolipid and phospholipid species were extracted from 461 patients of the randomly selected prospective Kardiovize study based on Brno, Czech Republic. Lipids species were measured by a hyphenated mass spectrometry technique, and were associated with poor CVH scores, as defined by the American Heart Association. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE) species were significantly lower in ideal and intermediate scores of health dietary metric, blood pressure, total cholesterol and blood fasting glucose compared to poor scores. Current smokers presented higher levels of PC, PE and LPE individual species compared to non-smokers. Ceramide (Cer) d18:1/14:0 was altered in poor blood pressure, total cholesterol and fasting blood glucose metrics. Poor cardiovascular health metric is associated with a specific phospho- and sphingolipid pattern. Circulatory lipid profiling is a potential biomarker to refine cardiovascular health status in primary prevention strategies.

Download Full-text

Excess Cardiovascular Disease and Mortality in Diabetes: Can It Be Offset With Ideal Cardiovascular Health Trajectories?

10.21203/rs.3.rs-714724/v1 ◽

2021 ◽

Author(s):

Bamba Gaye ◽

Donald Lloyd-Jones ◽

Eugenie Valentin ◽

Joshua J Joseph ◽

Xavier Jouven ◽

...

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Cardiovascular Disease ◽

Mortality Risk ◽

Cardiovascular Health ◽

Proportional Hazards ◽

Cohort Analysis ◽

Cox Proportional Hazards ◽

Ideal Cardiovascular Health ◽

Incidence And Mortality

Abstract Objective: To describe patterns of change in cardiovascular health (CVH) measured by the Life’s Simple 7 (LS7) over 6 years in participants with diabetes, and assess the association of these patterns of change with subsequent cardiovascular disease (CVD) and all-cause mortality.Methods: We conducted a long-term prospective cohort analysis (median follow-up 19 years) using the ARIC study, a community-based, biracial cohort with participants aged 45-64 years at baseline in 1987–1989. The LS7 metrics (smoking, body mass index, physical activity, diet, total cholesterol, blood glucose, and blood pressure) were collected at baseline and 6 years later. At both time points, participants were classified as low (0-2 ideal metrics), moderate (3-4), and favorable (5-7) CVH, and 6-year CVH change categories were created. Cox proportional hazards regressions were used to estimate the association between change categories and CVD and mortality. Results: The majority (62.2%) of participants with diabetes had a stable-low CVH at both visits, whereas 12.1% had stable-moderate and 0.4% stable-favorable, 14.9% improved, and 10.5% worsened. Compared to participants with stable-low CVH, CVD and mortality risk was lower for those who improved CVH 6 years later, or stable-moderate, or even high- or moderate-to-low CVH. This was driven by favorable changes in blood pressure, cholesterol, physical activity and smoking. Compared to participants free of diabetes with a stable-favorable CVH change, participants with diabetes had higher CVD and mortality risk regardless of their CVH trajectory. However, those with a favorable CVH trajectory displayed the same excess risk as participants without diabetes with stable-low CVH. Conclusions: Among individuals with diabetes, maintaining or reaching ideal levels of LS7 metrics can help reduce the excess CVD incidence and mortality. A favorable CVH trajectory in people with diabetes carried approximately the same excess CVD and mortality risk than an unfavorable CVH trajectory in people free of diabetes.

Download Full-text

Associations between concentrations of α- and γ-tocopherol and concentrations of glucose, glycosylated haemoglobin, insulin and C-peptide among US adults

British Journal Of Nutrition ◽

10.1079/bjn20041319 ◽

2005 ◽

Vol 93 (2) ◽

pp. 249-255 ◽

Cited By ~ 6

Author(s):

E. S. Ford ◽

A. H. Mokdad ◽

U. A. Ajani ◽

S. Liu

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Smoking Status ◽

Glycosylated Haemoglobin ◽

Nutrition Examination Survey ◽

Activity Time ◽

Tocopherol Concentration ◽

Cross Sectional ◽

C Peptide ◽

Health And Nutrition

Our objective was to study the cross-sectional associations between concentrations of α- and γ-tocopherol and concentrations of glucose, glycosylated haemoglobin, insulin and C-peptide among US adults. We used data for 1289 participants without self-reported diabetes who were aged ≥20 years in the National Health and Nutrition Examination Survey 1999–2000. α-Tocopherol concentration was inversely associated with glucose concentration (β per mmol/l=−0·01064, se 0·00356, P=0·004) after adjusting for age, sex, race or ethnicity, education, smoking status, concentrations of total cholesterol and triacylglycerols, systolic blood pressure, waist circumference, alcohol use, physical activity, time watching television or videos or using a computer, and use of vitamin/mineral/dietary supplements. Among 659 participants who did not report using supplements, this association was no longer significant whereas the concentration of α-tocopherol was inversely associated with concentration of C-peptide (β per mmol/l=−0·01121, se 0·00497, P=0·024). γ-Tocopherol concentration was positively associated with concentration of glucose (β per mmol/l=0·09169, se 0·02711, P=0·001) and glycosylated haemoglobin (β per mmol/l=0·04954, se 0·01284, P<0·001), but not insulin or C-peptide. The relationships between physiologic concentrations of the various forms of vitamin E and measures of glucose intolerance deserve additional investigation.

Download Full-text