Abstract 15895: Machine Learning Algorithms to Predict Major Adverse Cardiovascular Events in Patients Undergoing Orthotopic Liver Transplantation: A Retrospective Cohort Study

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
vardhmaan jain ◽  
Vikram Sharma ◽  
Agam Bansal ◽  
Cerise Kleb ◽  
Chirag Sheth ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Cardiovascular Events ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Major Adverse Cardiovascular Events ◽  
Support Vector ◽  
Post Transplant ◽  
Extreme Gradient Boosting ◽  
All Cause Mortality

Background: Post-transplant major adverse cardiovascular events (MACE) are amongst the leading cause of death amongst orthotopic liver transplant(OLT) recipients. Despite years of guideline directed therapy, there are limited data on predictors of post-OLT MACE. We assessed if machine learning algorithms (MLA) can predict MACE and all-cause mortality in patients undergoing OLT. Methods: We tested three MLA: support vector machine, extreme gradient boosting(XG-Boost) and random forest with traditional logistic regression for prediction of MACE and all-cause mortality on a cohort of consecutive patients undergoing OLT at our center between 2008-2019. The cohort was randomly split into a training (80%) and testing (20%) cohort. Model performance was assessed using c-statistic or AUC. Results: We included 1,459 consecutive patients with mean ± SD age 54.2 ± 13.8 years, 32% female who underwent OLT. There were 199 (13.6%) MACE and 289 (20%) deaths at a mean follow up of 4.56 ± 3.3 years. The random forest MLA was the best performing model for predicting MACE [AUC:0.78, 95% CI: 0.70-0.85] as well as mortality [AUC:0.69, 95% CI: 0.61-0.76], with all models performing better when predicting MACE vs mortality. See Table and Figure. Conclusion: Random forest machine learning algorithms were more predictive and discriminative than traditional regression models for predicting major adverse cardiovascular events and all-cause mortality in patients undergoing OLT. Validation and subsequent incorporation of MLA in clinical decision making for OLT candidacy could help risk stratify patients for post-transplant adverse cardiovascular events.

scholarly journals Techniques for Detecting Malware Traffic: A Comprehensive Approach to Feature Selection and Classification

2021 ◽  
Vol 9 (12) ◽  
pp. 1-10
Author(s):  
Harsha A K
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Random Forest ◽  
Learning Algorithms ◽  
Malware Detection ◽  
Machine Learning Algorithms ◽  
Gradient Boosting ◽  
Support Vector ◽  
Steady Increase ◽  
Extreme Gradient Boosting

Abstract: Since the advent of encryption, there has been a steady increase in malware being transmitted over encrypted networks. Traditional approaches to detect malware like packet content analysis are inefficient in dealing with encrypted data. In the absence of actual packet contents, we can make use of other features like packet size, arrival time, source and destination addresses and other such metadata to detect malware. Such information can be used to train machine learning classifiers in order to classify malicious and benign packets. In this paper, we offer an efficient malware detection approach using classification algorithms in machine learning such as support vector machine, random forest and extreme gradient boosting. We employ an extensive feature selection process to reduce the dimensionality of the chosen dataset. The dataset is then split into training and testing sets. Machine learning algorithms are trained using the training set. These models are then evaluated against the testing set in order to assess their respective performances. We further attempt to tune the hyper parameters of the algorithms, in order to achieve better results. Random forest and extreme gradient boosting algorithms performed exceptionally well in our experiments, resulting in area under the curve values of 0.9928 and 0.9998 respectively. Our work demonstrates that malware traffic can be effectively classified using conventional machine learning algorithms and also shows the importance of dimensionality reduction in such classification problems. Keywords: Malware Detection, Extreme Gradient Boosting, Random Forest, Feature Selection.

scholarly journals Feature Selection and Comparison of Machine Learning Algorithms in Classification of Grazing and Rumination Behaviour in Sheep

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3532 ◽  
Author(s):  
Nicola Mansbridge ◽  
Jurgen Mitsch ◽  
Nicola Bollard ◽  
Keith Ellis ◽  
Giuliana Miguel-Pacheco ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Time Budget ◽  
Learning Algorithms ◽  
Eating Behaviour ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Optimum Number ◽  
Eating Behaviours ◽  
Adaptive Boosting

Grazing and ruminating are the most important behaviours for ruminants, as they spend most of their daily time budget performing these. Continuous surveillance of eating behaviour is an important means for monitoring ruminant health, productivity and welfare. However, surveillance performed by human operators is prone to human variance, time-consuming and costly, especially on animals kept at pasture or free-ranging. The use of sensors to automatically acquire data, and software to classify and identify behaviours, offers significant potential in addressing such issues. In this work, data collected from sheep by means of an accelerometer/gyroscope sensor attached to the ear and collar, sampled at 16 Hz, were used to develop classifiers for grazing and ruminating behaviour using various machine learning algorithms: random forest (RF), support vector machine (SVM), k nearest neighbour (kNN) and adaptive boosting (Adaboost). Multiple features extracted from the signals were ranked on their importance for classification. Several performance indicators were considered when comparing classifiers as a function of algorithm used, sensor localisation and number of used features. Random forest yielded the highest overall accuracies: 92% for collar and 91% for ear. Gyroscope-based features were shown to have the greatest relative importance for eating behaviours. The optimum number of feature characteristics to be incorporated into the model was 39, from both ear and collar data. The findings suggest that one can successfully classify eating behaviours in sheep with very high accuracy; this could be used to develop a device for automatic monitoring of feed intake in the sheep sector to monitor health and welfare.

scholarly journals Evaluating Variable Selection and Machine Learning Algorithms for Estimating Forest Heights by Combining Lidar and Hyperspectral Data

2020 ◽  
Vol 9 (9) ◽  
pp. 507
Author(s):  
Sanjiwana Arjasakusuma ◽  
Sandiaga Swahyu Kusuma ◽  
Stuart Phinn
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Learning Algorithms ◽  
Principal Component ◽  
Hyperspectral Data ◽  
Machine Learning Algorithms ◽  
Gradient Boosting ◽  
Support Vector ◽  
Forest Height ◽  
Extreme Gradient Boosting

Machine learning has been employed for various mapping and modeling tasks using input variables from different sources of remote sensing data. For feature selection involving high- spatial and spectral dimensionality data, various methods have been developed and incorporated into the machine learning framework to ensure an efficient and optimal computational process. This research aims to assess the accuracy of various feature selection and machine learning methods for estimating forest height using AISA (airborne imaging spectrometer for applications) hyperspectral bands (479 bands) and airborne light detection and ranging (lidar) height metrics (36 metrics), alone and combined. Feature selection and dimensionality reduction using Boruta (BO), principal component analysis (PCA), simulated annealing (SA), and genetic algorithm (GA) in combination with machine learning algorithms such as multivariate adaptive regression spline (MARS), extra trees (ET), support vector regression (SVR) with radial basis function, and extreme gradient boosting (XGB) with trees (XGbtree and XGBdart) and linear (XGBlin) classifiers were evaluated. The results demonstrated that the combinations of BO-XGBdart and BO-SVR delivered the best model performance for estimating tropical forest height by combining lidar and hyperspectral data, with R2 = 0.53 and RMSE = 1.7 m (18.4% of nRMSE and 0.046 m of bias) for BO-XGBdart and R2 = 0.51 and RMSE = 1.8 m (15.8% of nRMSE and −0.244 m of bias) for BO-SVR. Our study also demonstrated the effectiveness of BO for variables selection; it could reduce 95% of the data to select the 29 most important variables from the initial 516 variables from lidar metrics and hyperspectral data.

scholarly journals Prediction of novel mouse TLR9 agonists using a random forest approach

2019 ◽  
Vol 20 (S2) ◽  
Author(s):  
Varun Khanna ◽  
Lei Li ◽  
Johnson Fung ◽  
Shoba Ranganathan ◽  
Nikolai Petrovsky
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Correlation Coefficient ◽  
Matthews Correlation Coefficient ◽  
Learning Algorithms ◽  
Ensemble Classifier ◽  
Innate Immune ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Random Forest Algorithm

Abstract Background Toll-like receptor 9 is a key innate immune receptor involved in detecting infectious diseases and cancer. TLR9 activates the innate immune system following the recognition of single-stranded DNA oligonucleotides (ODN) containing unmethylated cytosine-guanine (CpG) motifs. Due to the considerable number of rotatable bonds in ODNs, high-throughput in silico screening for potential TLR9 activity via traditional structure-based virtual screening approaches of CpG ODNs is challenging. In the current study, we present a machine learning based method for predicting novel mouse TLR9 (mTLR9) agonists based on features including count and position of motifs, the distance between the motifs and graphically derived features such as the radius of gyration and moment of Inertia. We employed an in-house experimentally validated dataset of 396 single-stranded synthetic ODNs, to compare the results of five machine learning algorithms. Since the dataset was highly imbalanced, we used an ensemble learning approach based on repeated random down-sampling. Results Using in-house experimental TLR9 activity data we found that random forest algorithm outperformed other algorithms for our dataset for TLR9 activity prediction. Therefore, we developed a cross-validated ensemble classifier of 20 random forest models. The average Matthews correlation coefficient and balanced accuracy of our ensemble classifier in test samples was 0.61 and 80.0%, respectively, with the maximum balanced accuracy and Matthews correlation coefficient of 87.0% and 0.75, respectively. We confirmed common sequence motifs including ‘CC’, ‘GG’,‘AG’, ‘CCCG’ and ‘CGGC’ were overrepresented in mTLR9 agonists. Predictions on 6000 randomly generated ODNs were ranked and the top 100 ODNs were synthesized and experimentally tested for activity in a mTLR9 reporter cell assay, with 91 of the 100 selected ODNs showing high activity, confirming the accuracy of the model in predicting mTLR9 activity. Conclusion We combined repeated random down-sampling with random forest to overcome the class imbalance problem and achieved promising results. Overall, we showed that the random forest algorithm outperformed other machine learning algorithms including support vector machines, shrinkage discriminant analysis, gradient boosting machine and neural networks. Due to its predictive performance and simplicity, the random forest technique is a useful method for prediction of mTLR9 ODN agonists.

scholarly journals Execution Assessment of Machine Learning Algorithms for Spam Profile Detection on Instagram

2021 ◽  
Vol 10 (3) ◽  
pp. 1889-1894
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Random Forest ◽  
Nearest Neighbor ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Learning Tools ◽  
Learning Models ◽  
K Nearest Neighbor

Witheverypassingsecondsocialnetworkcommunityisgrowingrapidly,becauseofthat,attackershaveshownkeeninterestinthesekindsofplatformsandwanttodistributemischievouscontentsontheseplatforms.Withthefocus on introducing new set of characteristics and features forcounteractivemeasures,agreatdealofstudieshasresearchedthe possibility of lessening the malicious activities on social medianetworks. This research was to highlight features for identifyingspammers on Instagram and additional features were presentedto improve the performance of different machine learning algorithms. Performance of different machine learning algorithmsnamely, Multilayer Perceptron (MLP), Random Forest (RF), K-Nearest Neighbor (KNN) and Support Vector Machine (SVM)were evaluated on machine learning tools named, RapidMinerand WEKA. The results from this research tells us that RandomForest (RF) outperformed all other selected machine learningalgorithmsonbothselectedmachinelearningtools.OverallRandom Forest (RF) provided best results on RapidMiner. Theseresultsareusefulfortheresearcherswhoarekeentobuildmachine learning models to find out the spamming activities onsocialnetworkcommunities.

scholarly journals PREDICTION OF POLLUTANT CONCENTRATIONS BY METEOROLOGICAL DATA USING MACHINE LEARNING ALGORITHMS

2020 ◽  
Vol XLIV-4/W3-2020 ◽  
pp. 21-27
Author(s):  
K. Alpan ◽  
B. Sekeroglu
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Smart City ◽  
Urban Areas ◽  
Meteorological Data ◽  
Learning Algorithms ◽  
Cost Effective ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Pollutant Concentrations

Abstract. Air pollution, which is one of the biggest problems created by the developing world, reaches severe levels, especially in urban areas. Weather stations established at certain points in countries regularly obtain data and inform people about air quality. In Smart City applications, it is aimed to perform this process with higher speed and accuracy by collecting data with thousands of sensors based on the Internet of Things. At this stage, artificial intelligence and machine learning plays a vital role in analyzing the data to be obtained. In this study, six pollutant concentrations; particulate matters (PM2.5 and PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), Ozone (O3), and carbon monoxide (CO), were predicted using three basic machine learning algorithms, namely, random forest, decision tree and support vector regression, by considering only meteorological data. Experiments on two different datasets showed that the random forest has a high prediction capacity (R2: 0.74–0.86), and high-accuracy predictions can be performed on pollutant concentrations using only meteorological data. This and further studies based on meteorological data would help to reduce the number of devices in Smart City applications and will make it more cost-effective.

scholarly journals Modelling hydrological responses under climate change using machine learning algorithms – semi-arid river basin of peninsular India

2020 ◽  
Vol 3 (1) ◽  
pp. 481-498
Author(s):  
G. Sireesha Naidu ◽  
M. Pratik ◽  
S. Rehana
Keyword(s):  
Climate Change ◽  
Machine Learning ◽  
Random Forest ◽  
River Basin ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Peninsular India ◽  
Hydrological Responses ◽  
Semi Arid

Abstract Catchment scale conceptual hydrological models apply calibration parameters entirely based on observed historical data in the climate change impact assessment. The study used the most advanced machine learning algorithms based on Ensemble Regression and Random Forest models to develop dynamically calibrated factors which can form as a basis for the analysis of hydrological responses under climate change. The Random Forest algorithm was identified as a robust method to model the calibration factors with limited data for training and testing with precipitation, evapotranspiration and uncalibrated runoff based on various performance measures. The developed model was further used to study the runoff response under climate change variability of precipitation and temperatures. A statistical downscaling model based on K-means clustering, Classification and Regression Trees and Support Vector Regression was used to develop the precipitation and temperature projections based on MIROC GCM outputs with the RCP 4.5 scenario. The proposed modelling framework has been demonstrated on a semi-arid river basin of peninsular India, Krishna River Basin (KRB). The basin outlet runoff was predicted to decrease (13.26%) for future scenarios under climate change due to an increase in temperature (0.6 °C), compared to a precipitation increase (13.12%), resulting in an overall reduction in water availability over KRB.

scholarly journals Systematic Evaluation of Machine Learning Algorithms for Neuroanatomically-Based Age Prediction in Youth

2021 ◽  
Author(s):  
Mandana Modabbernia ◽  
Heather C Whalley ◽  
David Glahn ◽  
Paul M. Thompson ◽  
Rene S. Kahn ◽  
...  
Keyword(s):  
Machine Learning ◽  
Computational Efficiency ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Sensitivity Analyses ◽  
Gradient Boosting ◽  
Support Vector ◽  
Age Related ◽  
Extreme Gradient Boosting ◽  
Brain Age

Application of machine learning algorithms to structural magnetic resonance imaging (sMRI) data has yielded behaviorally meaningful estimates of the biological age of the brain (brain-age). The choice of the machine learning approach in estimating brain-age in children and adolescents is important because age-related brain changes in these age-groups are dynamic. However, the comparative performance of the multiple machine learning algorithms available has not been systematically appraised. To address this gap, the present study evaluated the accuracy (Mean Absolute Error; MAE) and computational efficiency of 21 machine learning algorithms using sMRI data from 2,105 typically developing individuals aged 5 to 22 years from five cohorts. The trained models were then tested in an independent holdout datasets, comprising 4,078 pre-adolescents (aged 9-10 years). The algorithms encompassed parametric and nonparametric, Bayesian, linear and nonlinear, tree-based, and kernel-based models. Sensitivity analyses were performed for parcellation scheme, number of neuroimaging input features, number of cross-validation folds, and sample size. The best performing algorithms were Extreme Gradient Boosting (MAE of 1.25 years for females and 1.57 years for males), Random Forest Regression (MAE of 1.23 years for females and 1.65 years for males) and Support Vector Regression with Radial Basis Function Kernel (MAE of 1.47 years for females and 1.72 years for males) which had acceptable and comparable computational efficiency. Findings of the present study could be used as a guide for optimizing methodology when quantifying age-related changes during development.

scholarly journals PigLeg: prediction of swine phenotype using machine learning

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e8764 ◽  
Author(s):  
Siroj Bakoev ◽  
Lyubov Getmantseva ◽  
Maria Kolosova ◽  
Olga Kostyunina ◽  
Duane R. Chartier ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Learning Algorithms ◽  
Average Daily Gain ◽  
Nearest Neighbors ◽  
The State ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
K Nearest Neighbors ◽  
Leg Weakness

Industrial pig farming is associated with negative technological pressure on the bodies of pigs. Leg weakness and lameness are the sources of significant economic loss in raising pigs. Therefore, it is important to identify the predictors of limb condition. This work presents assessments of the state of limbs using indicators of growth and meat characteristics of pigs based on machine learning algorithms. We have evaluated and compared the accuracy of prediction for nine ML classification algorithms (Random Forest, K-Nearest Neighbors, Artificial Neural Networks, C50Tree, Support Vector Machines, Naive Bayes, Generalized Linear Models, Boost, and Linear Discriminant Analysis) and have identified the Random Forest and K-Nearest Neighbors as the best-performing algorithms for predicting pig leg weakness using a small set of simple measurements that can be taken at an early stage of animal development. Measurements of Muscle Thickness, Back Fat amount, and Average Daily Gain were found to be significant predictors of the conformation of pig limbs. Our work demonstrates the utility and relative ease of using machine learning algorithms to assess the state of limbs in pigs based on growth rate and meat characteristics.

scholarly journals Research on dairy products detection based on machine learning algorithm

2022 ◽  
Vol 355 ◽  
pp. 03008
Author(s):  
Yang Zhang ◽  
Lei Zhang ◽  
Yabin Ma ◽  
Jinsen Guan ◽  
Zhaoxia Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Electronic Nose ◽  
Milk Fat ◽  
Dairy Products ◽  
Machine Learning Algorithms ◽  
Gradient Boosting ◽  
Support Vector ◽  
Extreme Gradient Boosting

In this study, an electronic nose model composed of seven kinds of metal oxide semiconductor sensors was developed to distinguish the milk source (the dairy farm to which milk belongs), estimate the content of milk fat and protein in milk, to identify the authenticity and evaluate the quality of milk. The developed electronic nose is a low-cost and non-destructive testing equipment. (1) For the identification of milk sources, this paper uses the method of combining the electronic nose odor characteristics of milk and the component characteristics to distinguish different milk sources, and uses Principal Component Analysis (PCA) and Linear Discriminant Analysis , LDA) for dimensionality reduction analysis, and finally use three machine learning algorithms such as Logistic Regression (LR), Support Vector Machine (SVM) and Random Forest (RF) to build a milk source (cow farm) Identify the model and evaluate and compare the classification effects. The experimental results prove that the classification effect of the SVM-LDA model based on the electronic nose odor characteristics is better than other single feature models, and the accuracy of the test set reaches 91.5%. The RF-LDA and SVM-LDA models based on the fusion feature of the two have the best effect Set accuracy rate is as high as 96%. (2) The three algorithms, Gradient Boosting Decision Tree (GBDT), Extreme Gradient Boosting (XGBoost) and Random Forest (RF), are used to construct the electronic nose odor data for milk fat rate and protein rate. The method of estimating the model, the results show that the RF model has the best estimation performance( R2 =0.9399 for milk fat; R2=0.9301for milk protein). And it prove that the method proposed in this study can improve the estimation accuracy of milk fat and protein, which provides a technical basis for predicting the quality of dairy products.

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