Abstract 16545: Sinus Rhythm Dynamics and Ventricular Ectopy in an Experimental Model of Aging

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Martina Comelli ◽  
Emanuele Pizzo ◽  
Marianna Meo ◽  
Daniel O Cervantes ◽  
Aaron Plosker ◽  
...  
Keyword(s):  
Heart Rate ◽  
Sinus Rhythm ◽  
Low Frequency ◽  
Heart Rhythm ◽  
Frequency Domain Analysis ◽  
Ventricular Ectopy ◽  
Before And After ◽  
Frequency Components ◽  
Ectopic Beats ◽  
Effects Of Aging

Aging is coupled with alterations of heart rate and heart rate variability (HRV), together with increased incidence of arrhythmias and sudden cardiac death. But whether changes of sinus rhythm properties of the aged heart correlate with enhanced occurrence of ventricular ectopic discharge remains unclear. Thus, we studied the effects of aging on heart rate, HRV, and occurrence of premature ventricular complexes (PVCs) in aging C57Bl/6 mice. Electrocardiograms (ECG) were obtained in male and female conscious mice at ~4, ~12, ~18, and ~24 months of age (n=37-66). Heart rate was preserved at ~4, ~12, and ~18 months (729±30, 730±22, and 725±20 bpm) and reached a minimum at ~24 months (708±37 bpm). Standard deviation of RR intervals, an indicator of HRV, was maximal at ~4 months (3.5±1.7 ms) and was reduced at ~12, ~18, and ~24 months (2.6±1.5, 2.5±1.3, and 2.6±1.3 ms). By frequency domain analysis, high-frequency components of RR interval variations, indicative of parasympathetic influence, were preserved with aging. In contrast, low frequency components, comprising the influence of sympathetic and parasympathetic axis, were maximal in young animals and progressively decrease at ~12, ~18, and ~24 months. PVCs were observed in only 3% of mice at ~4 months, a fraction that increased to 11%, 10%, and 22% at ~12, ~18, and ~24 months, respectively. For each age interval, heart rate and HRV parameters for animals with PVCs were distributed within the range observed in mice not experiencing ventricular ectopy. Moreover, for animals with PVCs, parameters of HRV before the occurrence of ectopic beats were comparable to those observed during undisturbed sinus rhythm, although a tendency for lower heart rate was seen. To address the role of the autonomic nervous system on incidence of ectopic events, ECGs were collected before and after block of the sympathetic and parasympathetic axis in mice at ~4 months (n=30) and ~24 months (n=26). This intervention reduced heart rate in both groups of animals and attenuated HRV exclusively in young. Moreover, combine autonomic block decreased incidence of PVCs by 50% and 57% in young and old animals, respectively. Collectively, these results suggest that occurrence of ventricular ectopy does not correlate with heart rhythm dynamics.

Diurnal heart rate variability in healthy subjects: effects of aging and sex difference

1996 ◽  
Vol 271 (1) ◽  
pp. H303-H310 ◽  
Author(s):  
Y. Yamasaki ◽  
M. Kodama ◽  
M. Matsuhisa ◽  
M. Kishimoto ◽  
H. Ozaki ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sex Difference ◽  
Low Frequency ◽  
Frequency Domain Analysis ◽  
And Gender ◽  
Effects Of Aging ◽  
Parasympathetic Function ◽  
Male Subjects ◽  
Female Subjects

To study the effects of aging and gender, circadian profiles of heart rate variability were evaluated for 105 healthy volunteers by frequency domain analysis of a Holter electrocardiogram record. The low-frequency (LF) component representing cardiac beta-adrenergic function showed high values for the 0800-1200 period in male subjects and the 1200-2400 period in female subjects. The high-frequency (HF) component representing parasympathetic function showed a peak for the 0000-0600 period in both male and female subjects independent of age. Male subjects showed significantly higher %LF [LF/(LF + HF) x 100] than female subjects. LF showed consistently highly significant correlation with age. These basic findings can help elucidate the diurnal profile of cardiac nerve function and how it is affected by aging and sex difference.

Characteristics of heart rate variability in patients with acute coronary syndrome without ST segment elevation in comparison with clinical and biochemical parameters

2021 ◽  
Vol 29 (3) ◽  
pp. 369-378
Author(s):  
Aleksej A. Nizov ◽  
Aleksej I. Girivenko ◽  
Mihail M. Lapkin ◽  
Aleksej V. Borozdin ◽  
Yana A. Belenikina ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Acute Coronary Syndrome ◽  
Creatine Phosphokinase ◽  
Spectral Power ◽  
Low Frequency ◽  
Heart Rhythm ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment

BACKGROUND: The search for rational methods of primary, secondary, and tertiary prevention of coronary heart disease. To date, there are several publications on heart rate variability in ischemic heart disease. AIM: To study the state of the regulatory systems in the organism of patients with acute coronary syndrome without ST segment elevation based on the heart rhythm, and their relationship with the clinical, biochemical and instrumental parameters of the disease. MATERIALS AND METHODS: The open comparative study included 76 patients (62 men, 14 women) of mean age, 61.0 0.9 years, who were admitted to the Emergency Cardiology Department diagnosed of acute coronary syndrome without ST segment elevation. On admission, cardiointervalometry was performed using Varicard 2.51 apparatus, and a number of clinical and biochemical parameters were evaluated RESULTS: Multiple correlations of parameters of heart rate variability and clinical, biochemical and instrumental parameters were observed. From this, a cluster analysis of cardiointervalometry was performed, thereby stratifying patients into five clusters. Two extreme variants of dysregulation of the heart rhythm correlated with instrumental and laboratory parameters. A marked increase in the activity of the subcortical nerve centers (maximal increase of the spectral power in the very low frequency range with the underlying reduction of SDNN) in cluster 1 was associated with reduction of the left ventricular ejection fraction: cluster 147.0 [40.0; 49.0], cluster 260.0 [58.0; 64.0], cluster 360.0 [52.5; 64.5] % (the data are presented in the form of median and interquartile range; Me [Q25; Q75], p 0,05). Cluster 5 showed significant reduction in SDNN (monotonous rhythm), combined with increased level of creatine phosphokinase (CPC): cluster 5446,0 [186.0; 782.0], cluster 4141.0 [98.0; 204.0] IU/l; Me [Q25; Q75], p 0.05) and MВ-fraction of creatine phosphokinase; cluster 532.0 [15.0; 45.0], 4 cluster 412.0 [9.0; 18.0] IU/l; Me [Q25; Q75], p 0.05). CONCLUSIONS: In patients with acute coronary syndrome without ST segment elevation, cluster analysis of parameters of heart rate variability identified different peculiarities of regulation of the heart rhythm. Pronounced strain of the regulatory systems of the body was found to be associated with signs of severe pathology: the predominance of VLF (spectral power of the curve enveloping a dynamic range of cardiointervals in the very low frequency range) in spectral analysis with an underlying reduced SDNN is characteristic of patients with a reduced ejection fraction, and a monotonous rhythm is characteristic of patients with an increased level of creatine phosphokinase and MB-fraction of creatine phosphokinase.

Comparative study on effect of neutral spinal bath and neutral spinal spray on blood pressure, heart rate and heart rate variability in healthy volunteers

2018 ◽  
Vol 16 (2) ◽  
Author(s):  
Arundhati Goley ◽  
A. Mooventhan ◽  
NK. Manjunath
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Healthy Volunteers ◽  
Group Analysis ◽  
Low Frequency ◽  
Single Session ◽  
Arterial Blood ◽  
Before And After ◽  
Instantaneous Heart Rate

Abstract Background Hydrotherapeutic applications to the head and spine have shown to improve cardiovascular and autonomic functions. There is lack of study reporting the effect of either neutral spinal bath (NSB) or neutral spinal spray (NSS). Hence, the present study was conducted to evaluate and compare the effects of both NSB and NSS in healthy volunteers. Methods Thirty healthy subjects were recruited and randomized into either neutral spinal bath group (NSBG) or neutral spinal spray group (NSSG). A single session of NSB, NSS was given for 15 min to the NSBG and NSSG, respectively. Assessments were taken before and after the interventions. Results Results of this study showed a significant reduction in low-frequency (LF) to high-frequency (HF) (LF/HF) ratio of heart rate variability (HRV) spectrum in NSBG compared with NSSG (p=0.026). Within-group analysis of both NSBG and NSSG showed a significant increase in the mean of the intervals between adjacent QRS complexes or the instantaneous heart rate (HR) (RRI) (p=0.002; p=0.009, respectively), along with a significant reduction in HR (p=0.002; p=0.004, respectively). But, a significant reduction in systolic blood pressure (SBP) (p=0.037) and pulse pressure (PP) (p=0.017) was observed in NSSG, while a significant reduction in diastolic blood pressure (DBP) (p=0.008), mean arterial blood pressure (MAP) (p=0.008) and LF/HF ratio (p=0.041) was observed in NSBG. Conclusion Results of the study suggest that 15 min of both NSB and NSS might be effective in reducing HR and improving HRV. However, NSS is particularly effective in reducing SBP and PP, while NSB is particularly effective in reducing DBP and MAP along with improving sympathovagal balance in healthy volunteers.

Preeclamptic pregnancy is associated with increased sympathetic and decreased parasympathetic control of HR

2000 ◽  
Vol 278 (4) ◽  
pp. H1269-H1273 ◽  
Author(s):  
Cheryl C. H. Yang ◽  
Te-Chang Chao ◽  
Terry B. J. Kuo ◽  
Chang-Sheng Yin ◽  
Hsing I. Chen
Keyword(s):  
Heart Rate ◽  
Low Frequency ◽  
Normal Pregnancy ◽  
Frequency Domain Analysis ◽  
Natural Logarithm ◽  
Sympathetic Regulation ◽  
History Of ◽  
Low Frequency Power ◽  
Normalized Units ◽  
Frequency Power

Previous work from our laboratory using heart rate variability (HRV) has demonstrated that women before menopause have a more dominant parasympathetic and less effective sympathetic regulations of heart rate compared with men. Because it is still not clear whether normal or preeclamptic pregnancy coincides with alternations in the autonomic functions, we evaluated the changes of HRV in 17 nonpregnant, 17 normotensive pregnant, and 11 preeclamptic women who were clinically diagnosed without history of diabetic neuropathy, cardiac arrhythmia, and other cardiovascular diseases. Frequency-domain analysis of short-term, stationary R-R intervals was performed to evaluate the total variance, low-frequency power (LF; 0.04–0.15 Hz), high-frequency power (HF; 0.15–0.40 Hz), ratio of LF to HF (LF/HF), and LF in normalized units (LF%). Natural logarithm transformation was applied to variance, LF, HF, and LF/HF for the adjustment of the skewness of distribution. We found that the normal pregnant group had a lower R-R value and HF but had a higher LF/HF and LF% compared with the nonpregnant group. The preeclamptic group had lower HF but higher LF/HF compared with either the normal pregnant or nonpregnant group. Our results suggest that normal pregnancy is associated with a facilitation of sympathetic regulation and an attenuation of parasympathetic influence of heart rate, and such alterations are enhanced in preeclamptic pregnancy.

Dynamics of spectral components of heart rate variability during changes in autonomic balance

1998 ◽  
Vol 275 (1) ◽  
pp. H213-H219 ◽  
Author(s):  
Michael V. Højgaard ◽  
Niels-Henrik Holstein-Rathlou ◽  
Erik Agner ◽  
Jørgen K. Kanters
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Supine Position ◽  
Low Frequency ◽  
Power Spectral Analysis ◽  
Frequency Domain Analysis ◽  
Autonomic Balance ◽  
Power Spectral ◽  
Normalized Units ◽  
Semiquantitative Method

Frequency domain analysis of heart rate variability (HRV) has been proposed as a semiquantitative method for assessing activities in the autonomic nervous system. We examined whether absolute powers, normalized powers, and the low frequency-to-high frequency ratio (LF/HF) derived from the HRV power spectrum could detect shifts in autonomic balance in a setting with low sympathetic nervous tone. Healthy subjects were examined for 3 h in the supine position during 1) control conditions ( n = 12), 2) acute β-blockade ( n = 11), and 3) chronic β-blockade ( n = 10). Heart rate fell during the first 40 min of the control session (72 ± 2 to 64 ± 2 beats/min; P < 0.005) and was even lower during acute and chronic β-blockade (56 ± 2 beats/min; P < 0.005). The powers of all spectral areas rose during the first 60 min in all three settings, more so with β-blockade ( P < 0.05). LF/HF was found to contain the same information as powers expressed in normalized units. LF/HF detected the shift in autonomic balance induced by β-blockade but not the change induced by supine position. In conclusion, none of the investigated measures derived from power spectral analysis comprehensively and consistently described the changes in autonomic balance.

Heart rate variability and dissociation in panic disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 147-147
Author(s):  
T. Diveky ◽  
D. Kamaradova ◽  
A. Grambal ◽  
K. Latalova ◽  
J. Prasko ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Panic Disorder ◽  
Frequency Band ◽  
High Frequency ◽  
Power Spectra ◽  
Low Frequency ◽  
Very Low Frequency ◽  
Significant Difference ◽  
Before And After

The aim of our study is to measure very low frequency band (VLF), low frequency band (LF) and high frequency band (HF) components of R-R interval during orthostatic experiment in panic disorder patients before and after treatment.MethodsWe assessed heart rate variability in 19 patients with panic disorder before and after 6-weeks treatment with antidepressants combined with CBT and 18 healthy controls. They were regularly assessed on the CGI, BAI and BDI. Heart rate variability was assessed during 5 min standing, 5 min supine and 5 min standing positions before and after the treatment. Power spectra were computed using a fast Fourier transformation for very low frequency - VLF (0.0033 - 0.04 Hz), low-frequency - LF (0.04-0.15 Hz) and high frequency - HF (0.15-0.40 Hz) powers.Results19 panic disorder patients entered a 6-week open-label treatment study with combination of SSRI and cognitive behavioral therapy. A combination of CBT and pharmacotherapy proved to be the effective treatment of patients. They significantly improved in all rating scales. There were highly statistical significant differences between panic patients and control group in all components of power spectral analysis in 2nd and in two component of 3rd (LF and HF in standing) positions. There was also statistically significant difference between these two groups in LF/HF ratio in supine position (2nd). During therapy there was tendency to increasing values in all three positions in components of HRV power spectra, but there was only statistically significant increasing in HF1 component.Supported by project IGA MZ ČR NS 10301-3/2009

Effect of Acupuncture at Ht7 on Heart Rate Variability: An Exploratory Study

2015 ◽  
Vol 33 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Huanlin Huang ◽  
Zheng Zhong ◽  
Junqi Chen ◽  
Yong Huang ◽  
Jixuan Luo ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Low Frequency ◽  
Sham Acupuncture ◽  
Acupuncture Group ◽  
Control Groups ◽  
Parasympathetic System ◽  
Registration Number ◽  
Frequency Components ◽  
Random Number Table

Objective To explore the effect of acupuncture at HT7 on heart rate variability (HRV) in healthy volunteers. Methods 120 subjects were divided into four groups using a random number table. The following groups of acupuncture interventions were used: HT7 verum acupuncture; HT7 non-penetrating sham acupuncture; acupuncture at a sham point; and no acupuncture. HRV was recorded 10 min before, during and after each stimulation using an Actiheart ECG recorder. Results The HT7 verum acupuncture group had higher very-low frequency, low frequency and high frequency components of HRV compared with the control groups during but not after acupuncture. The HT7 verum acupuncture group also had higher SD of normal intervals compared with the sham needling and no acupuncture control groups. Conclusions Our preliminary study suggests, subject to limitations, that acupuncture at HT7 could affect cardiac autonomic neural regulation in healthy subjects, manifest as increased HRV, most likely via the parasympathetic system. Trial Registration Number ChiCTR-TRC-08000302.

scholarly journals Assessment of Heart Rate Variability in Fibromyalgia after Micro-physiotherapy.

2014 ◽  
Vol 12 ◽  
pp. 189
Author(s):  
Adriano Pinto Pereira ◽  
Eluciene Maria dos Santos Carvalho ◽  
Ivo Ilvan Kerppers ◽  
Meiriélly Furmann ◽  
Juliana Aparecida Wosch Pires ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Low Frequency ◽  
Treatment Method ◽  
The Body ◽  
Autonomous Nervous System ◽  
Self Healing ◽  
Non Invasive ◽  
A Value ◽  
Before And After

Introduction: Fibromyalgia syndrome is characterized by musculo-skeletal pain. Heart rate variability (HRV) is a versatile and promising non-invasive marker of the autonomous nervous system. Micro-physiotherapy involves manual physiotherapy that seeks to identify the primary cause of a disease or symptom and to stimulate self-healing, in which the body recognizes the aggressor (antigen) and begins the elimination process, through cellular and tissue reprogramming. Method: The sample was composed of 15 individuals, aged between 35 and 40 years, with fibromyalgia. The Nerve Express method was used to assess the variability of the heart rate. Two sessions of micro-physiotherapy were conducted using global methods, with an interval of 45 days between sessions. Results: Based on the HRV results, the high frequency band was confirmed at p=0.203, with the low frequency recording a statistically significant value of p=0.001, thereby demonstrating sympathetic activity. Upon comparison of the mean heartbeat before and after treatment, a value of p=0.0006 was obtained. A value of p=0.049 was recorded in the analysis of the median R-R interval values. Conclusion: The use of micro-physiotherapy as a treatment method for fibromyalgia effectively improved the lives of patients by promoting sympathicotonia.

scholarly journals HEART RATE TURBULENCE INDICATORS IN CLINICAL PRACTICE

2021 ◽  
Vol 14 (5) ◽  
pp. 62-67
Author(s):  
GRIGORIY A. FADEEV ◽  
◽  
NIKOLAY A. TSIBULKIN ◽  
OLGA YU. MIKHOPAROVA ◽  
GRIGORIY G. BATYRSHIN ◽  
...  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Sinus Rhythm ◽  
Cardiac Rhythm ◽  
Heart Rhythm ◽  
Holter Monitoring ◽  
Left Ventricular ◽  
Heart Rate Turbulence ◽  
Autonomic Nervous

Background. Heart disease is the leading cause of death in developed countries. Approximately half of these fatalities are due to sudden cardiac death. Electrocardiogram recording from the body surface allows stratification of patients according to the risk of cardiac arrest without the use of invasive methods. Arrhythmias, particularly ventricular extrasystole, can affect the sinus rhythm pattern. The change in sinus rhythm that occurs after an extrasystole is defined as heart rate turbulence. This phenomenon is not pathological, but some variants are associated with a risk of fatal arrhythmias. Aim. To analyze the indices and clinical significance of cardiac rhythm turbulence according to Holter monitoring in patients with various cardiological abnormalities at the hospital profile department. Material and methods. The study included 54 patients who were routinely treated in a cardiac hospital. Cardiac rhythm turbulence indices were obtained by Holter monitoring. Patients in severe and moderately severe clinical condition were not included in the study. Concomitant and past somatic diseases affecting the state of heart and cardiovascular system were considered. Results and discussion. Deviations in heart rhythm turbulence indices can be detected both in life- threatening arrhythmias and in benign extrasystoles. They are associated with the influence of the autonomic nervous system, but probably have different mechanisms. Deviations of heart rhythm turbulence indices were associated with left ventricular myocardial hypertrophy of concentric remodeling type and with an increased number of low-risk ventricular extrasystoles. To identify patients with arrhythmias of different risk, various threshold values of cardiac rhythm turbulence indices can be used. Conclusion. Factors likely to affect the indices of cardiac rhythm turbulence such as left ventricular myocardial remodeling and hypertrophy were revealed, as well as changes in autonomic nervous system regulatory function, including those associated with the constitutional features of the patient.

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