Abstract 17128: Sleep Irregularity is Associated With Increased All-Cause Mortality
Introduction: Circadian rhythm disruptions are associated with increased cardiovascular disease risk. We aim to investigate if day-to-day variation in sleep duration and onset of sleep are associated with cardiovascular and all-cause mortality. Methods: 388 subjects with sleep data from Midlife in the United States(MIDUS) 2 Biomarker study(2004-09) were included. Objective sleep data was measured using the Actiwatch® device. Sleep onset, duration, sleep-wake cycles were collected for 7 consecutive days. Mean and standard deviations in sleep duration and time of onset of sleep over 7 days were calculated to assess for sleep irregularity and tertiles created. Mortality data was available with a follow up until December 2016. Cox proportional regression analysis was performed. Competing risk analysis for cardiovascular mortality was done with fine and gray subdistribution hazard. Results: Mean age 54.56±11.79 years; females 230(59.3%). BMI 30.56±7.06 kg/m 2. Over a median of 8.6 years follow up, 37 patients died including 10 deaths due to cardiovascular mortality. Sleep duration SD tertiles ranges were: 11-41 minutes, 42-67 minutes and 68-257 minutes in lowest to highest tertiles respectively. There was no statistically significant increase in cardiovascular mortality with variation in sleep duration. Tertile 3 vs 1: HR 4.00(0.45-35.48,p 0.21), but there was statically significant increase in all-cause mortality tertile 2vs1 and 3vs1 -HR 3.63(1.19-10.99, p 0.02), HR 3.99(1.33-11.94, p 0.01) respectively. Fully adjusted model showed tertile 2vs1 and 3vs1 HR 3.51(1.12-10.99, p 0.03), HR 4.85(1.52-15.49, P < 0.01) respectively. Conclusions: Day to day variation in sleep duration is associated with increased all-cause mortality but not cardiovascular mortality after adjusting for mean sleep duration, inflammation, diabetes, age, BMI, renal function and blood pressure.