Abstract MP14: The Effect Of Time-restricted Feeding On 24-hour Ambulatory Blood Pressure: Results From The Time-restricted Intake Of Meals (TRIM) Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Ruth-Alma N Turkson-Ocran ◽  
Edgar R Miller ◽  
Di Zhao ◽  
Scott Pilla ◽  
Daisy Duan ◽  
...  

Introduction: Some studies suggest that time-restricted feeding may decrease blood pressure (BP), but the current evidence is inconclusive. Objective: To determine the effect of a time-restricted feeding pattern compared to a usual feeding pattern on ambulatory 24-hour BP in adults. Hypothesis: An isocaloric, time-restricted feeding pattern will lower 24-hour BP more than an isocaloric usual feeding pattern over 12 weeks. Methods: Forty-one persons with prediabetes (HbA1c 5.7-6.9%) and obesity (BMI 30-50 kg/m 2 ) were randomized to consume 80% of their total calories before 1 pm (i.e., time-restricted feeding) or more than 50% of their calories after 5 pm (i.e., usual feeding) with identical macronutrient content. We used ambulatory BP monitoring to measure BP over 24-hours at baseline and 12-weeks. Outcomes of interest were mean systolic and diastolic 24-hr, daytime (7 am - 11 pm), and nighttime (11 pm - 7 am) BP. To examine the difference in BP patterns between time-restricted feeding and usual feeding pattern groups in change in BP outcomes from baseline to 12 weeks, we used linear mixed-effects regression models with participant-specific random intercepts and fixed effects for visit and intervention group. To assess whether feeding patterns affected BP levels over the 12 week intervention period, we tested whether there was an intervention-by-time interaction. Results: Thirty-five adults (mean age 60.4 years; 91% female, 91% African American) had sufficient data. We found reductions from baseline in systolic and diastolic BP for both groups for the 24-hour, daytime, and nighttime periods. The decrease in BP was larger in the usual feeding pattern group compared to the time-restricted feeding group (Table). Conclusion: Time-restricted feeding may attenuate the effect of a healthy isocaloric diet on BP compared to typical feeding patterns, and at this time, should not be recommended as a way to lower BP more than simply adopting a healthy diet.

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Matthew J Singleton ◽  
Lin Chen ◽  
Sean P Whalen ◽  
Prashant Bhave ◽  
Elijah Beaty ◽  
...  

Introduction: The effect of intensive versus standard blood pressure (BP) lowering on the risk of atrial fibrillation (AF) is uncertain. Hypothesis: Intensive BP lowering is associated with a lower risk of AF among patients with hypertension. Methods: We searched PubMed, EMBASE, and CENTRAL for trials published between inception and June 5, 2020 for randomized controlled trials evaluating the effect of intensive versus standard (target systolic BP < 140 mmHg) BP lowering on incident AF. We assessed heterogeneity using the I 2 statistic then used fixed-effects meta-analysis models to report pooled treatment effects and 95% confidence intervals. We also tested for publication bias by three funnel plot-based methods. The quality of each study was assessed with the Cochrane Risk of Bias tool. Results: We assessed 16 candidate studies for eligibility from 2,312 published articles, but only three randomized clinical trials were eligible for inclusion and included a combined 12,219 participants with hypertension: Cardio-Sis (Studio Italiano Sugli Effetti Cardiovascolari del Controllo della Pressione Arteriosa Sistolica), ACCORD-BP (Action to Control Cardiovascular Risk in Diabetes Blood Pressure trial), and SPRINT (Systolic Blood Pressure Intervention Trial). The target systolic BP in the intensive BP arm was <120 mmHg for participants in SPRINT and ACCORD-BP, but <130 mmHg for participants in Cardio-Sis. Participants randomized to intensive BP lowering had significantly lower risk of incident AF compared with those randomized tostandard BP lowering (AF incidence 2.2% vs. 3.0%, respectively; pooled hazard ratio (95% confidence interval ): 0.74 (0.59 - 0.93)). Conclusions: Intensive BP lowering is associated with a significantly lower risk of incident AF in patients with hypertension. These findings add to the current evidence supporting the benefits of intensive BP control.


2021 ◽  
Vol 2 (2) ◽  
pp. 156-169
Author(s):  
Christina Murni Yuliastuti ◽  
Th.Tatik Pujiastuti ◽  
Sr. Lucilla Suparmi, CB

ABSTRACT Background:Hemodialysis defines as a process of cleaning the blood from waste substances through a filtering process outside the body. Patients with chronic renal failure undergoing hemodialysis often experience complications including hypotension. Several references state an alternative intervention to prevent complications of hypotension in hemodialysis patients with an Intradialytic exercise. Intradialytic exercise is a planned and gradual form of exercise that includes various stages of flexibility exercise, strengthening exercise and cardiovascular exercise performed during hemodialysis. Intradialytic exercise is aimed to improve the work of the heart, respiration and improve hemodialysis regulation for the better. Objective:This study was aimed to determine the difference in blood pressure before and after intradialytic exercise in patients undergoing hemodialysis. Methods:This research design used a quasi-experimental design with pre-test and post-test with control design. The samples were 38 respondents who taken by total sampling at the Hemodialysis Unit of Panti Rahayu Hospital. The samples were divided into the intervention group who undertook intradialytic exercise for 4 weeks, each respondent experiences twice a week, while the control group who did routine hemodialysis and independent exercise. Results:The results showed that the distribution of the characteristics of the respondents was 51-54 years old (18.41%) the sex was mostly male (63.2%) Most of them (55.3%) underwent hemodialysis for less than 2 years. Statistically, it was known that there was no significant difference in blood pressure before and after intradialytic exercise inside patient’s body of the control and intervention groups. There was no significant difference in blood pressure between the intervention group compared to the control group, but there was a dynamic difference in blood pressure in patients who did intradialytic exercise. Conclusion:There was dynamics of differences in blood pressure in patients undergoing intradialytic exercise, it is recommended that hemodialysis nurses at Panti Rahayu Hospital take care patients during hemodialysis so that these interventions are routinely carried out.


2019 ◽  
Vol 61 (3) ◽  
pp. 78
Author(s):  
A. O. Ayodapo ◽  
T. A.V. Olukokun

Background: In spite of the availability of myriads of antihypertensive medications, the control of high blood pressure is still low. Studies on effect of lifestyle behavioural changes through counselling on blood pressure control are scant in Nigeria. Therefore, this study set out to determine the role of lifestyle counselling on behavioural change among hypertensive patients attending the Federal Medical Centre, Ido-Ekiti.Methods: A total of 322 adult hypertensive participants who had been on treatment for at least three consecutive months were randomised into two groups. Relevant data were collected using an interviewer-administered semi-structured questionnaire and clinical parameters were measured pre- and post-intervention. The intervention group was counselled on lifestyle behaviours, namely regular exercise, eating adequate fruits and vegetables, moderate alcohol intake and cessation of smoking.Results: Post-intervention, among the intervention group 22.4%, 71.4% and 100%, as compared with the control group at 6.2%, 41.0% and 87.6%, met recommendations for physical activity, fruit and vegetable consumption and alcohol consumption respectively. The difference in each category was statistically significant (p 0.001). However, the difference in smoking habits between the two groups (83.9% vs. 79.5%) was not statistically significant (p = 0.313). There was a statistically significant difference (p ≤ 0.001) in the difference in mean arterial pressure (96.4 ± 8.1 vs 106.2 ± 7.6 mmHg) between the intervention and control group post-intervention.Conclusion: Lifestyle modifications form part of an important and effective treatment modality for hypertension. It is desirable that primary care physicians devise and implement clinical and public health strategies that promote and maintain a combination of pharmacologic interventions and lifestyle modifications.


PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254222
Author(s):  
Michael Hoffer-Hawlik ◽  
Andrew Moran ◽  
Lillian Zerihun ◽  
John Usseglio ◽  
Jennifer Cohn ◽  
...  

Hypertension remains the leading cause of cardiovascular disease worldwide and disproportionately impacts patients living in low- and middle-income countries (LMICs). Telemedicine offers a potential solution for improving access to health care for vulnerable patients in LMICs. Objectives The purpose of this scoping review was to summarize the evidence for telemedicine interventions for blood pressure management in LMICs and assess the relationships between the telemedicine intervention characteristics and clinical outcomes. Design Published studies were identified from the following databases (from their inception to May 2020): PubMed, Scopus, and Embase. Search terms related to “Low and Middle Income Countries,” “Telemedicine,” and “Hypertension” were used, and clinical outcomes were extracted from the screened articles. Results Our search resulted in 530 unique articles, and 14 studies were included in this review. Five studies assessed telemedicine interventions for patient-provider behavioral counseling, four assessed patient-provider medical management, and five assessed provider-provider consultation technologies. Out of fourteen individual studies, eleven demonstrated a significant improvement in systolic or diastolic blood pressure in the intervention group. Of the eight studies that reported difference-in-differences changes in systolic blood pressure, between-arm differences ranged from 13.2 mmHg to 0.4 mmHg. Conclusions The majority of the studies in this review demonstrated a significant reduction in blood pressure with use of the telemedicine intervention, though the magnitude of benefit was not consistently large. Limitations of the studies included small sample sizes, short duration, and intervention heterogeneity. Current evidence suggests that telemedicine may provide a promising approach to increase access to care and improve outcomes for hypertension in LMICs, especially during events that limit access to in-person care, such as the COVID-19 pandemic. However, high-quality clinical trials of sufficient size and duration are needed to establish the impact and role of telemedicine in hypertension care. The protocol for this review was not registered.


2009 ◽  
Vol 6 (1) ◽  
pp. 21
Author(s):  
Suwarni Suwarni ◽  
Ahmad Husein Asdie ◽  
Herni Astuti

Background : Hypertension is one of the most common worldwide diseases that can be an important public health challenge. The causes of hypertension are high consumption of salt and fat, obesity, stress, age, sex, family history, smoking, and consumption of alcoholic drinks. The prevalence of hypertension in the world, Asia, and Indonesia are 15-20%, 8-18%, and 1,8-28,6%, respectively. The solution to this problem is not only depend on drugs but also counseling through leaflet as the process of assisting clients in facing the problem of hypertension.Objectives : To know the effect of nutrition counseling on nutrition intake and blood pressure of hypertension outpatients at local hospital of the Province of Southeast Sulawesi. Methods : The study was quasi experimental with pre- and post-control design. Samples were divided into 2 groups; intervention group was given nutrition counseling and leaflet and the second (control) was only given leaflet. Samples were hypertension outpatients who fulfilled inclusions and exclusions criteria, and there were 25 samples per group. Data of nutrient intake were processed using Nutrisurvey. Chi-square test was used to identify the difference between the intervention group and the control group; whereas t-test was used to identify independent as well as dependent variables.Results : There were no significant differences in intake of fat, natrium, potassium, and magnesium between the intervention group and control group (p > 0.05); but there were differences between them at the end of study (p < 0.05). Blood pressures of both of them were also not different (p > 0.05); however, at the end of study there was difference between them (p < 0.05).Conclusion : Nutrition counseling could improve nutrition intake and blood pressure of hypertension outpatients at local hospital of the Province of Southeast Sulawesi.


2021 ◽  
Vol 2 (2) ◽  
pp. 156-169
Author(s):  
Christina Murni Yuliastuti ◽  
Th.tatik Pujiastuti ◽  
Sr. Lucilla Suparmi, CB

ABSTRACT Background: Hemodialysis defines as a process of cleaning the blood from waste substances through a filtering process outside the body. Patients with chronic renal failure undergoing hemodialysis often experience complications including hypotension. Several references state an alternative intervention to prevent complications of hypotension in hemodialysis patients with an Intradialytic exercise. Intradialytic exercise is a planned and gradual form of exercise that includes various stages of flexibility exercise, strengthening exercise and cardiovascular exercise performed during hemodialysis. Intradialytic exercise is aimed to improve the work of the heart, respiration and improve hemodialysis regulation for the better. Objective: This study was aimed to determine the difference in blood pressure before and after intradialytic exercise in patients undergoing hemodialysis. Methods: This research design used a quasi-experimental design with pre-test and post-test with control design. The samples were 38 respondents who taken by total sampling at the Hemodialysis Unit of Panti Rahayu Hospital. The samples were divided into the intervention group who undertook intradialytic exercise for 4 weeks, each respondent experiences twice a week, while the control group who did routine hemodialysis and independent exercise. Results: The results showed that the distribution of the characteristics of the respondents was 51-54 years old (18.41%) the sex was mostly male (63.2%) Most of them (55.3%) underwent hemodialysis for less than 2 years. Statistically, it was known that there was no significant difference in blood pressure before and after intradialytic exercise inside patient’s body of the control and intervention groups. There was no significant difference in blood pressure between the intervention group compared to the control group, but there was a dynamic difference in blood pressure in patients who did intradialytic exercise. Conclusion: There was dynamics of differences in blood pressure in patients undergoing intradialytic exercise, it is recommended that hemodialysis nurses at Panti Rahayu Hospital take care patients during hemodialysis so that these interventions are routinely carried out.


2017 ◽  
Vol 3 (3) ◽  
pp. 229-237 ◽  
Author(s):  
Nikmah Jalilah Ritonga ◽  
Onny Setiani ◽  
Umaroh Umaroh ◽  
Kamilah Budhi R ◽  
Faisal Amri

Background: Roselle flower (Hibiscus sabdariffa) has been used as a food and herbal drinks, in hot and cold beverages, as a herbal medicine.Objective: To examine the effect of consuming roselle dried flower petals on changes in maternal hypertensive blood pressure during postpartum period.Methods: This was a quasi-experimental study with non-equivalent control group design conducted in 2016. There were 30 samples recruited using consecutive sampling with 15 samples in the intervention group and control group. Data were analyzed using paired t-test to know the difference of blood pressure value before and after intervention in the intervention and control group, and Independent t-test  to determine the difference of blood pressure decrease between intervention and control group. Mann-whitney and Wilcoxon test were also performed for data analysis.Results: Findings showed that there were statistically significant differences in systolic and diastolic blood pressure values before and after intervention in the intervention and control group with p-value 0.000 <0.05 with systolic blood pressure decrease was 5 mmHg and diastolic was 5.33 mmHg. Additionally, there was a significant effect in the duration of healing in the intervention group with p-value 0.000 <0.05, with the average duration of healing was 2 days.Conclusion: There was significant effects of dried petals of rosella flowers (Hibiscus sabdariffa) brewed with 200 ml of hot water with temperature 90oC in lowering blood pressure, and there was significant differences in systolic and diastolic blood pressure and duration of healing between the intervention and control group of mothers who consumed antihypertensive drugs. The results of this study can be applied by midwives in postpartum care with the cases of hypertension. It is expected that this intervention can help the healing process more quickly through a combination of antihypertensive medicines and sedated petals of rosella flowers.


Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Nisa Maruthur ◽  
Scott Pilla ◽  
May T Maw ◽  
Daisy Duan ◽  
Di Zhao ◽  
...  

Introduction: Time-restricted feeding (TRF) may improve cardiometabolic outcomes. Prior studies of TRF in humans were limited by lack of randomization and controlled feeding, inadequate sample size and short duration. Hypothesis: Participants following a TRF pattern will lose more weight at 12 weeks than those following a Usual Feeding Pattern (UFP). Methods: We randomized 41 adults with BMI 30-49.9 kg/m 2 and HbA1c 5.7-6.9% to either TRF (80% of total calories before 1 pm) or a UFP (50% of calories after 5 pm) for 12 weeks. Dietary caloric requirement for weight maintenance was determined at baseline for each participant and held constant during the intervention. Participants in both arms consumed the same diet with the same nutrient and food content and only consumed food prepared by the study metabolic kitchen. The primary outcome was weight. Weight and office blood pressure were measured at baseline and 4, 8, and 12 weeks and were analyzed using a linear mixed effects model with an unstructured covariance with indicators for visit and intervention interacted with visit. Results: All participants completed the study (TRF, n=21; UFP, n=20). Demographics were similar across arms; mean age was 59 years, and over 90% of participants were female and were black. Baseline weight and systolic BP were higher in the UFP than TRF arm (Table). Weight and blood pressure decreased in both arms during the study, but these decreases did not differ by arm. Conclusions: In this controlled feeding study, TRF did not reduce weight and blood pressure compared to UFP.


2020 ◽  
Vol 6 (2) ◽  
pp. 59
Author(s):  
La Rangki

Benson relaxation therapy to be used alternative therapy to normalize blood pressure. The aim of this study was to determine the effect of benson relaxation therapy on blood pressure in eldery hypertension and to know the difference in blood pressure between the intervention group and the control group at Social Institution of Tresna Werdha Minaula Kendari. This study used the Quasi experimental pre-post test with control group.The sampling techique used total sampling with 14 respondents. Data analysis used paired T-test to test one group in the intervention and control group and Mann Whitney test to see differences between the two groups ( p = < 0,05). The results showed a significant effect of benson relaxation therapy on stystolic and diastolic blood pressure in the intervention group (p = 0,000 for systolic and p = 0,004 for diastolic). ). Whereas in the control group there was no change in systolic blood pressure ( p = 0,069 for systolic and diastolic show blood pressure p = 0,016).


Author(s):  
Mohammadreza Rajabloo ◽  
Ali Mohammadpour ◽  
Moosa Sajjadi

Background & Aim: Hypertension is a prevalent and significant health problem; moreover, lack of treatment adherence can cause precarious complications. The present study aims to determine the effect of education based on Leventhal's model on adherence to treatment and control of blood pressure in patients with hypertension. Methods & Materials: This quasi-experimental study was performed on 59 patients with hypertension in Gonabad in 2020. The participants were selected based on convenience sampling; they were randomly assigned to the intervention and control groups. In addition to the routine treatment for hypertension, the patients in the intervention group received a training program based on Leventhal's model in 45-minute sessions and three times a week. In contrast, the patients in the control group received only the routine treatment for hypertension. A demographic and Hill-Bone Adherence Questionnaires were completed for the participants. Moreover, their blood pressure was recorded using the blood pressure record form. The data were analyzed in SPSS v.22 software, at the significance level of p<0.05. Results: The two groups were homogeneous in adherence to treatment (P=0.63) before the intervention; yet, there was a substantial difference between the groups once the intervention was implemented (P<0.001). Besides, the average systolic and diastolic blood pressure was not significantly different between the two groups before the intervention. After the intervention, though, the difference was reported significant (p<0.05). Conclusion: Education based on Leventhal's model caused an improvement in adherence to treatment and reduced blood pressure among patients with hypertension.


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