Abstract 178: Metabolomic Approach by 1 H NMR Spectroscopy of Plasma for the Assessment of heart-function in Patients with Chronic Heart Failure

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Wang Juan ◽  
Luo Liangtao ◽  
Li Zhongfeng ◽  
Chen Jianxin ◽  
Chen Chan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Nmr Spectroscopy ◽  
Chronic Heart Failure ◽  
Heart Function ◽  
Clinical Syndrome ◽  
The Body ◽  
Heart Failure Patients ◽  
Nyha Classification ◽  
Therapeutic Decisions ◽  
Function Impairment

Chronic heart failure (CHF) is a progressive clinical syndrome characterized by inability of the heart to adequately pump blood to meet metabolic demands of the body, and assessment of heart function in chronic heart failure patients is needed to make therapeutic decisions. New York Heart Association( NYHA) classification is usually performed to evaluate heart-function of CHF patients. Nevertheless, this does not take into account metabolic perturbations produced by heart-function impairment. In contrast, metabolomics can investigate many metabolic perturbations within biological systems.The purpose of this study was to assess whether metabolomic profiles of plasma, obtained by proton NMR spectroscopy from CHF patients, are affected by the severity of heart-function impairment. An orthogonal projection to latent-structure analysis was performed to compare NMR spectra of 49 chronic heart failure patients according to NYHA classification.The statistical model obtained showed a good explained variance (R 2 X = 0.13 and R 2 Y = 0.92) and a good predictability (Q 2 Y = 0.68). Metabolomic profiles showed significant differences regarding various metabolites depending of severity of heart-function impairment: levels of high-density lipoprotein, glycol-protein, glutamine, glutamate, were significantly higher in patients with mild CHF compared to severe CHF. Other metabolites such as lactate and amino acids were significantly higher in patients with severe CHF than mild CHF. Our conclusion is that metabolomic NMR analysis provides new insights into metabolic processes related to the severity of heart function impairment in chronic heart failure.

Acute heart failure

2018 ◽  
Author(s):  
Kazem Rahimi
Keyword(s):  
Heart Failure ◽  
Cardiac Output ◽  
Chronic Heart Failure ◽  
Acute Exacerbation ◽  
Acute Heart Failure ◽  
Clinical Features ◽  
Clinical Syndrome ◽  
The Body ◽  
Cardiac Structure ◽  
New Onset

Heart failure is a clinical syndrome characterized by an inadequate cardiac output for the needs of the body in the absence of low filling pressures, and reflects abnormal cardiac structure or function. Although various definitions for acute heart failure (AHF) exist, here AHF is defined as new-onset heart failure or an acute exacerbation of chronic heart failure, requiring urgent therapy. Patients with AHF typically have clinical features of organ hypoperfusion, with or without pulmonary and peripheral oedema.

Cross-sectional relationship of a Mediterranean type diet to diastolic heart function in chronic heart failure patients

2011 ◽  
Vol 27 (6) ◽  
pp. 576-584 ◽  
Author(s):  
Christina Chrysohoou ◽  
Christos Pitsavos ◽  
George Metallinos ◽  
Christos Antoniou ◽  
Evaggelos Oikonomou ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Heart Function ◽  
Cross Sectional ◽  
Heart Failure Patients ◽  
Relationship Of

scholarly journals Evaluation of the role of enhanced external counter pulsation in patients with chronic heart failure

2017 ◽  
Vol 4 (4) ◽  
pp. 932 ◽  
Author(s):  
Sabapathy Kannappan ◽  
Thirumal Babu Kannappan
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Functional Capacity ◽  
Hospital Admissions ◽  
Lv Function ◽  
Walk Test ◽  
Heart Failure Patients ◽  
Six Minute Walk Test ◽  
Nyha Classification ◽  
Minute Walk

Background: The incidence of Chronic Heart failure (CHF) has reached epidemic proportions in developing countries. The prevalence also increases as the patient population ages. Heart failure accounts for between 5% and 10% of all hospital admissions and is the most frequent cause of hospitalization in the elderly. The aim of this single centre observational study was to find out the efficacy of EECP in improving functional capacity and LV function in symptomatic chronic heart failure patients with mild to moderate LV dysfunction irrespective of their etiology.Methods: Thirty-six symptomatic patients in NYHA class II and III were included in this study. All the patients underwent one hour EECP therapy for thirty-five sessions over a period of seven weeks. NYHA classification, six-minute walk test, two dimensional and Tissue Doppler Echocardiographic examination were done before and after EECP therapy.Results: At the end of EECP therapy there was improvement in functional class. Eleven out of thirty-six patients were asymptomatic. The mean distance covered in six-minute walk test was also significantly increased after the therapy. The Echocardiographic parameters like Ejection Fraction (EF), Systolic excursion of mitral valve annulus (S'), Ratio between mitral flow E Velocity & Mitral annular E velocity (E/E’) significantly improved after EECP.Conclusions: In this study, it was concluded that there was significant improvement in symptoms, functional capacity and LV function in Chronic Heart Failure patients after EECP therapy.

scholarly journals Hubungan gagal jantung dan gangguan fungsi hati

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Adhytia B. C. P. Masola ◽  
Agnes L. Panda ◽  
Ventje Kawengian
Keyword(s):  
Heart Failure ◽  
Liver Dysfunction ◽  
Nyha Class ◽  
Liver Function Tests ◽  
The Body ◽  
P Value ◽  
Chi Square ◽  
Heart Failure Patients ◽  
Cardiac Symptoms ◽  
Nyha Classification

Abstract: Heart failure is characterized by perfusion malfunction to fulfill the metabolism of the body caused by malfunction of heart pumps. It is oftenly associated with non-cardiac symptoms, such as liver dysfunction marked by increasing of liver function tests inter alia AST and ALT. This was a descriptive retrospective study using total sampling method. Subjects were medical records of heart failure patients who were hospitalized in Internal Medicine Department of Prof. Dr. R. D. Kandou Hospital Manado in 2013. Data included name, age, NYHA classification, as well as AST and ALT levels of heart failure patients. There were 36 subjects consisted of 23 males and 13 females. Based on NYHA classification, there were 24 patients with third class of NYHA and 12 patients with fourth class of NYHA. Most patients had increased AST and ALT levels over 100 U/L. The chi-square test analyzing the relationship between NYHA and AST-ALT showed a p-value of 0.058. Conclusion: There was a relationship between heart failure and liver dysfunction, however, it was not statistically significant.Keywords: heart failure, liver dysfunction, NYHA Class, AST, ALTAbstrak: Gagal jantung ditandai oleh ketidakmampuan perfusi sistemik memenuhi metabolisme tubuh yang disebabkan disfungsi pompa jantung. Gagal jantung dapat disertai gejala gangguan nonkardiak seperti gangguan fungsi hati ditandai dengan naiknya tes fungsi hati seperti AST dan ALT. Penelitian ini bertujuan untuk mengetahui hubungan gagal jantung dan gangguan fungsi hati. Jenis penelitian ialah deskriptif retrospektif dengan metode total sampling. Subjek penelitian ialah pasien gagal jantng di Bagian Ilmu Penyakit Dalam RSUP Prof. Dr. R. D. Kandou, Manado tahun 2013 yang diperoleh dengan metode total sampling. Data penderita gagal jantung berupa nama, jenis kelamin, usia, kelas NYHA, kadar AST, dan ALT diperoleh dari rekam medik. Jumlah subyek sebanyak 36 orang, terdiri dari 23 laki-laki dan 13 perempuan. Hasil penelitian memperlihatkan jumlah pasien gagal jantung kelas III NYHA 24 orang dan kelas IV NYHA 12 orang. Kebanyakan penderita mengalami peningkatan AST dan ALT diatas 100 U/L. Analisis uji chi square terhadap kelas gagal jantung NYHA dengan AST dan ALT mendapatkan OR 3,6 dengan nilai p=0,058 (p<0,05). Simpulan: Terdapat hubungan antara gagal jantung dan gangguan fungsi hati walau secara statistik tidak bermakna.Kata kunci: gagal jantung, gangguan fungsi hati, kelas NYHA, AST, ALT

scholarly journals THE ROLE OF VASODILATION FACTORS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE OF ISCHEMIC ORIGIN IN ATRIAL FIBRILLATION

2021 ◽  
Author(s):  
V. I. Denesiuk ◽  
O. I. Afanasiuk ◽  
O. V. Denesiuk ◽  
N. O. Muzyka
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chronic Heart Failure ◽  
Heart Function ◽  
Nyha Classification ◽  
Stable Coronary Heart Disease ◽  
Comparative Group

The purpose of the study is to study the possible role of vasodilation factors in the pathogenesis of chronic heart failure (CHF) in persistent atrial fibrillation (AF) in patients with stable coronary heart disease. Materials and methods. A survey of 86 patients with stable coronary heart disease complicated by CHF II-III FC according to the NYHA classification. There was 1 group - 22 patients with CHF with reduced LV EF ≤ 40.0% and AF; I (comparative group) - 20 patients with CHF with reduced LV EF without AF; 2-nd group - 24 patients with preserved LV EF ≥ 40.1% and AF and II (comparative group) - 20 patients with CHF with preserved LV EF without AF. The content of endothelial nitric oxide synthase (eNOS), nitrites (NO2-) and nitrates (NO3-) was determined. All patients underwent electrocardiographic examination (ECG) for the initial screening of arrhythmias and conduction, diagnosis of focal changes in the ventricular myocardium. Structural and hemodynamic characteristics of the heart muscle were determined by echocardiography.Results. In the examined patients of the 1st group with CHF of ischemic origin and reduced LV EF ≤ 40.0% and AF in comparison with the 2nd group of patients with CHF with preserved LV EF and AF, a significant increase in the values of ICO, ICD, IMML, the size of LA and a decrease in LV EF (p <0.01), indicating the development of LVH (remodeling) and a decrease in isotropic heart function. When comparing the levels of vasodilation factors in patients with CHF with low LV EF and AF and data from the CHF comparison group without AF, a significant decrease in eNOS by 96.8% (almost twice) and a significant decrease in serum nitrite and nitrate levels (p < 0.01), indicating the development of endothelial dysfunction. Conclusions. In patients with CHF of ischemic origin in the development of persistent forms of AF pathogenetic role is played by a significant decrease in vasodilating factors (content of eNOS, nitrites and nitrates). At decrease in EF of LV ≤ 40,0% there is a significant decrease in vasodilating factors, as a result of disturbance of endothelial function that testifies to need of correction of the revealed changes directed on slowing down of disease progression.

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