scholarly journals QT Dispersion: A Predictor of Outcome Following Acute Neurologic Events

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 343-343
Author(s):  
Elzbieta J Wirkowski ◽  
Joseph Moonjely ◽  
Todd J Cohen ◽  
Stephanie M Manzella ◽  
Richard H Smith ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional Outcome ◽  
Qt Dispersion ◽  
Neurological Injury ◽  
Disease States ◽  
Qt Intervals ◽  
The Central Nervous System ◽  
The Difference ◽  
Adjusted Logistic Regression

P26 BACKGROUND: QT dispersion (QTD) reflects heterogeneity of myocardial repolarization, which is modulated by the central nervous system. Pervious studies have shown increased QTD to be a predictor of adverse outcome in various cardiac disease states. However, the central nervous system effects on QTD and its relation to functional outcomes have not been previously studied in patients with acute neurological events (NE). The objective of this study was to determine whether increased QTD is related to functional outcome in patients with cerebrovascular accidents (CVA) and transient ischemic attacks (TIA). METHODS: We studied 140 consecutive pts. aged 72±10 yrs. (48% male) admitted to our institution with NE from 1/98 to 4/98. QTD was calculated from admission EKG as the difference between maximum and minimum QT intervals. 120 pts. had interpretable EKGs with measurable QT intervals in at least 11 of 12 leads. Three separate functional scales (NIHSS, Barthel, and Rankin) were obtained on admission and discharge were recorded. RESULTS: QTD was higher in pts. with intracerebral hemorrhage as compared to CVA and TIA (70±15 vs. 53±27 vs. 48±31 msecs. p=0.03). Increased QTD was associated with lower functional outcome on all 3 scales (all p<0.05) and with higher mortality (p=0.02). QTD was higher in pts. with congestive heart failure (80±43 vs. 47±24 msecs. p=0.006) and carotid disease (59±32 vs. 46±27 msecs. p=0.045) as compared to those without. QTD was not associated with atrial fibrillation or coronary disease. All patients with TIA survived. On multivariate analysis, other independent predictors of poorer outcome were QTD (OR 1.35, 95% CI 1.08–1.68) and a trend towards age (OR 1.07, 95% CI 0.99–1.16). On age-adjusted logistic regression, mortality increased by an OR 1.28, 95% (CI 1.02–1.61) for every 10 msec increase in QTD. CONCLUSION: QTD is an independent predictor of functional outcome and mortality following acute neurological events. In this setting, QTD reflects acute neurological injury as well as underlying heart disease. The mechanism of these findings merits further study.

Central site for pressor action of blood-borne angiotensin in rat

1980 ◽  
Vol 239 (3) ◽  
pp. R358-R361 ◽  
Author(s):  
G. D. Fink ◽  
J. R. Haywood ◽  
W. J. Bryan ◽  
W. Packwood ◽  
M. J. Brody
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Angiotensin Ii ◽  
Pressor Response ◽  
Third Ventricle ◽  
Central Component ◽  
The Third ◽  
Electrolytic Lesions ◽  
The Central Nervous System ◽  
The Difference

A previous study demonstrated that the threshold dose of intra-arterial angiotensin II required to induce a pressor response in the rat was significantly lower when the drug was administered into the carotid artery than when administered into the abdominal aorta. This result was interpreted to indicate that part of the increase in arterial pressure produced by low concentrations of blood-borne angiotensin in this species was the result of an effect on structures in the central nervous system selectively accessible via the carotid vascular bed. The purpose of the present study was to establish more precisely the site of the pressor action of angiotensin within the central nervous system. The central component of the pressor effect of angiotensin was quantified as the difference in pressor responses to intracarotid and intra-aortic infusions of angiotensin II (delta c-a). In conscious rats, delta c-a was attenuated by administration of the angiotensin antagonist, saralasin, into the third cerebral ventricle. In rats with chronic electrolytic lesions of the anteroventral third ventricle (AV3V), delta c-a was abolished. Periventricular structures surrounding the third ventricle appear to mediate the central component of the pressor action of blood-borne angiotensin in the rat.

Transection of the Spinal Cord in Developing Xenopus Laevis

Development ◽  
1962 ◽  
Vol 10 (2) ◽  
pp. 115-126
Author(s):  
R. T. Sims
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Embryonic Development ◽  
Xenopus Laevis ◽  
Adult Fish ◽  
Regenerative Capacity ◽  
The Central Nervous System ◽  
The Difference ◽  
Development Proceeds

The literature on regeneration in the central nervous system of vertebrates has been reviewed exhaustively by Windle (1955, 1956). Adult fish and urodeles reestablish physiological and anatomical continuity of the spinal cord after it has been completely transected while adult anurans (Piatt & Piatt, 1958) and mammals on the whole do not. In all groups of vertebrates regeneration is more successful in the period of early embryonic development, and becomes less so as development proceeds. Experiments designed to investigate the factors responsible for this change demand an animal in which the difference in the regenerative capacity of embryonic and adult form is marked, and all stages of development are easily accessible for operative procedures. These criteria are satisfied by Anura. For this reason regeneration in the anuran central nervous system merits further investigation. After spinal cord transection in urodele larvae, Piatt (1955) found that the Mauthner axons did not regenerate although other axons around them did.

Vestibular effects of intravenous lidocaine used in the treatment of tinnitus

1986 ◽  
Vol 100 (11) ◽  
pp. 1249-1253 ◽  
Author(s):  
Saumil N. Merchant ◽  
Milind V. Kirtane
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Auditory System ◽  
Treatment Modalities ◽  
Positional Nystagmus ◽  
Intravenous Lidocaine ◽  
The Central Nervous System ◽  
The Difference ◽  
Ocular System ◽  
Two Sides

AbstractIntravenous lidocaine is known to have an effect on the auditory system in that it is useful for suppressing tinnitus, albeit temporarily. We have used intravenously administered lidocaine as one of the treatment modalities for refractory, disturbing, tinnitus. Its effects on the vestibulo-ocular system were determined by elec-tronystagmography performed before and immediately after injecting lidocaine: smooth pendular stimulus tracking was unaffected; spontaneous and positional nystagmus tended to be suppressed; directional preponderance was reduced or reversed; and the difference between the nystagmus responses in the two directions during the pendular rotation chair test was also reduced or reversed. These changes in the caloric and rotation tests were statistically significant. Lidocaine also appeared to have altered the balance between the two sides in the vestibulo-spinal system as indicated by the results of the stepping test during craniocorpography. The results lend support to the hypothesis that intravenous lidocaine acts at the level of the central nervous system rather than at the periphery.

scholarly journals THE PROTECTIVE ACTION OF TRYPAN RED AGAINST INFECTION BY A NEUROTROPIC VIRUS

1945 ◽  
Vol 82 (5) ◽  
pp. 297-309 ◽  
Author(s):  
Harland G. Wood ◽  
Irving I. Rusoff
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Congo Red ◽  
Protective Action ◽  
High Concentration ◽  
Critical Test ◽  
Poliomyelitis Virus ◽  
Cotton Rats ◽  
The Central Nervous System ◽  
The Difference

Trypan red, when injected intraperitoneally into mice, has been found greatly to lower the incidence of the infection of mice inoculated intraperitoneally with the neurotropic MM virus. The protective action of the dye is overcome if the virus is inoculated in too high concentration. The lowered incidence of infection was observed in mice inoculated with virus for as long as 29 days after the last dye injection. Of a number of dyes tested, trypan red, brilliant vital red, and Congo red were found effective. In cotton rats inoculated intraperitoneally with MM virus, trypan red was likewise found to lower the incidence of infection. With monkeys and a typical poliomyelitis virus no protection was observed against the virus inoculated intraperitoneally. The latter experiment is considered to have been inadequate for a critical test of the effect of trypan red on poliomyelitis infection. When either the MM virus or Lansing virus were inoculated intracerebrally into mice, the effect of the dye on incidence of infection was small. In the case of the Lansing virus the difference was statistically significant, however. The possible relation of alteration in the permeability of the barrier between the blood and the central nervous system as a cause of the effect of trypan red is discussed.

scholarly journals III. Contributions to the anatomy of the central nervous system of plagiostomata

1886 ◽  
Vol 40 (242-245) ◽  
pp. 10-14 ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cranial Nerves ◽  
Macroscopic Appearance ◽  
Short Account ◽  
The Third ◽  
Branchial Arches ◽  
The Central Nervous System ◽  
The Subject ◽  
The Difference

After referring to the literature of the subject, the author gives a short account of the macroscopic appearance of the brains of the following species of Plagiostomata, viz., Raja batis, Rhina squatina, Scyllium catulus , and Acanthias vulgaris . He then refers to the distribution of the cranial nerves, especially of the trifacial and vagus, pointing out the resemblance of the distribution of the last-mentioned nerve in Rhina to that described by Gegenbaur in Hexanthus; the difference lying in the fact that in the former the rami branchiales of this nerve, the number of which correspond the number of the branchial arches, divide into two terminal branches only, the rami anteriores and posteriores, the third, the rami pharyngei, being absent.

scholarly journals Translational profiling of microglia reveals artifacts of cell sorting

2017 ◽  
Author(s):  
Silvia S. Kang ◽  
Kelsey E. Baker ◽  
Xuewei Wang ◽  
Jeanne-Pierre Kocher ◽  
John D. Fryer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Sorting ◽  
Local Environment ◽  
Innate Immune ◽  
Immune Challenge ◽  
Cellular Activation ◽  
Disease States ◽  
Tissue Dissociation ◽  
The Central Nervous System

AbstractMicroglia are the resident innate immune population of the central nervous system that constantly survey and influence their local environment. Transcriptomic profiling has led to significant advances in our understanding of microglia in several disease states, but tissue dissociation and purification of microglia is known to lead to cellular activation. Here we use RiboTag translational RNAseq profiling to demonstrate that commonly used cell sorting methods lead to a fundamental alteration of the microglial transcriptome, with several transcripts that can be used to mark artifacts of isolation. Microglial RiboTag RNAseq profiling after peripheral immune challenge with lipopolysaccharide demonstrates unique transcriptional targets that are not evident using cell sorting methodology. Finally, we applied our technique to reveal novel shared and distinct pathways when comparing microglial transcriptomes after peripheral challenge with bacterial or viral mimetics. This study has broad implications for approaches that examine microglial transcriptomes in normal and pathological states.SummaryKang et al. demonstrate artifactual induction of microglial transcripts associated with cell sorting. Using RiboTag translational profiling methodology, several markers of cell sorting artifact were revealed. Furthermore, RiboTag isolation unveiled changes in microglial transcriptomes following systemic inflammation that would otherwise have been masked by artifacts of cell sorting.

scholarly journals Regulation of solute and water balance and cell volume in the central nervous system.

1992 ◽  
Vol 3 (1) ◽  
pp. 12-27
Author(s):  
K Strange
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Glial Cells ◽  
Molecular Mechanisms ◽  
Mammalian Brain ◽  
Ionic Balance ◽  
Total Brain Volume ◽  
Disease States ◽  
The Central Nervous System ◽  
Physiological Problem

The mammalian brain is composed of four distinct fluid compartments: blood, cerebral spinal fluid, interstitial fluid surrounding glial cells and neurons, and intracellular fluid. Maintenance of the ionic and osmotic composition and volume of these fluids is crucial for the normal functioning of the brain. Small changes in intracellular or extracellular solute composition can dramatically alter neuronal signaling and information processing. Because of the rigid confines of the skull and complex brain architecture, changes in total brain volume can cause devastating neurological damage. As a result, it is not surprising to find that the composition and volume of brain intracellular and extracellular fluids are controlled tightly under both normal conditions and in various disease states. Osmotic and ionic balance in the central nervous system is regulated by solute and water transport across the blood-brain barrier, the choroid plexus, and the plasma membrane of glial cells and neurons. Despite its clinical and physiological significance, however, little is known about the underlying cellular and molecular mechanisms by which the central nervous system's osmotic and ionic balance is maintained. In this review, the current understanding of osmoregulation in the mammalian brain and its role in various disease processes such as hyponatremia, renal failure, and hypernatremia will be summarized. A detailed understanding of brain osmoregulatory processes represents a fundamental physiological problem and is required for the treatment of numerous disease states, particularly those encountered in the practice of nephrology.

scholarly journals Neurodynamic indicators of the sensorimotor response of primary school age children with orthophoria and hetero-tropia

2020 ◽  
pp. 85-90
Author(s):  
O. V. Larionova ◽  
L. V. Dravitsa
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Primary School ◽  
School Age Children ◽  
School Age ◽  
Low Velocity ◽  
Flicker Fusion Frequency ◽  
The Central Nervous System ◽  
The Difference ◽  
Primary School Age

Objective: to analyze the neurodynamic indicators of the sensorimotor response of primary school age children with orthophoria and heterotropia. Material and methods. 51 children (102 eyes) aged 6-11 were examined. 2 groups that could be compared in terms of age and sex were formed. The first group consisted of 20 patients (40 eyes) with orthophoria associated with moderate hypertropia of Hm 3.5 (2.3; 5.3) diopters, the second group included children with concomitant convergent strabismus associated with moderate hypertropia of Hm 4.25 (2.0; 6.5) diopters - 31 patients (62 eyes). To study the properties of the nervous system (NS), the computer appliance «NS-Psychotest» (LLC «Neurosoft», Ivanovo, http://neurosoft. com/ru) was used. The neurodynamic indicators of the sensorimotor response were identified with the techniques «Simple Visual Motor Response» (SVMR), «Discrimination reaction» (DR), «Moving Object Response» (MOR), «Critical Flicker-Fusion Frequency» (CFF). Results. Concomitant strabismus in the children of the second group reliably leads to an increase in the time of SVMR, DR by 65.5 ms and 42.4 ms, respectively (p < 0.05), in comparison with the group of the children with orthophoria. The difference between the indices of DR and SVMR in the children of group 1 - 51.5 ms, of group 2 - 28.4 ms, verifies a decrease of the rate of the neurodynamic processes of the NS in the children with heretotropia. In the study with the MOR technique, the time of response in the first group was - -31 (-127; 50) ms, in the second group - 22 (-29; 94) ms (р = 0.000008), a positive value of the indicator of the response time in the children of the second group is a consequence of the prevalence of inhibition processes in the central nervous system in most the examined patients. Conclusion . The obtained results show that the presence of heterotropia in the children of the second group reliably leads to decreased mobility of nervous processes and predominance of inhibition processes in the central nervous system. The combination of the low velocity of the response and expressed inertness of nervous processes in the children of the second group are indicative of a lack of coordination of the interrelations between the centers of the visual and motor analyzers.

Electrophysiological Generators in Clinical Neurophysiology

2016 ◽  
pp. 31-34
Author(s):  
Terrence D. Lagerlund
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
The Body ◽  
Sweat Glands ◽  
Pathological Changes ◽  
Anatomical Structures ◽  
Disease States ◽  
Neurophysiological Studies ◽  
The Central Nervous System ◽  
Clinical Interest

The variety of clinical neurophysiological studies corresponds to a variety of structural generators in the body, including muscles, sweat glands, peripheral nerves, and various components of the central nervous system. Each structural generator may have associated with it several different types of physiological potential. This chapter reviews the generators of electrophysiological potentials in terms of basic cellular electrophysiology and the anatomical structures that generate electrophysiological potentials of clinical interest. Knowledge of the generators of the potentials recorded in clinical neurophysiological studies is helpful in understanding the characteristics and distribution of the recorded potentials and is the first step in correlating the alterations seen in disease states with the pathological changes demonstrated in the underlying generators.

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