Abstract T P159: Cardiovascular Health and Subsequent Cognitive Function in Patients with Pre-existing Coronary Heart Disease.

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
David Tanne ◽  
Galit Weinstein ◽  
Noa Molshatzki ◽  
Uri Goldbourt
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cognitive Function ◽  
Health Behavior ◽  
Educational Level ◽  
Early Life ◽  
Sensitivity Analyses ◽  
Cognitive Score ◽  
Early Life Environment ◽  
Health Factors

Background: Cardiovascular (CV) health factors are associated with lower risk of CV disease, stroke and all-cause mortality. We used a CV health metric in order to examine association with subsequent cognitive function. Methods: A subset of patients with coronary heart disease (CHD) that participated in the secondary prevention BIP trial were assessed for cognitive function (Mindstream Computerized Cognitive Battery) after an average of 9.8 ±1.7 years. A CV health metric at baseline was calculated including 3 health factors (glucose, LDL cholesterol, and blood pressure), 4 health behaviors (BMI, physical activity, adherence to a Mediterranean diet, and cigarette smoking), and one marker assessing in-part early life environment (body height), categorizing each of these 8 factors into ideal (2 points), intermediate (1 point), and poor levels (0 points). Results: Among 310 patients (mean age 62 yrs, 96.5% men) higher CV health scores were positively associated with educational level (p<0.001) and inversely with age (p=0.003), while no significant associations were identified with ultrasound indices of cerebrovascular disease (impaired CVR, increased common carotid IMT and carotid plaques). In linear regression models adjusted for age, educational level, sex and BIP study arm, increment in the overall CV health score (per 1 point) was associated with higher scores in executive function (p=0.002), memory (p=0.06), visuospatial function (p=0.005), attention (p=0.024) as well as in a global cognitive function score [B coefficient ± SE, 1.19±0.35 (p=0.001)] assessed a decade later. Increment (per 1-point) in the health behavior component was associated with 1.28±0.49 (p=0.009) higher cognitive score, in the early life environment component with 2.55±0.75 (p=0.001) higher cognitive score, while the health factors component was not associated with subsequent cognitive scores [0.24±0.52 (p=0.64)]. In sensitivity analyses excluding patients with stroke similar findings were observed. Conclusion: Among patients with pre-existing CHD, better CV health is associated with subsequent higher cognitive functions. Our findings suggest that health behavior and early life environment are important determinants of late-life cognitive function.

No causal effects of plasma homocysteine levels on the risk of coronary heart disease or acute myocardial infarction: A Mendelian randomization study

2019 ◽  
pp. 204748731989467 ◽  
Author(s):  
Liu Miao ◽  
Guo-Xiong Deng ◽  
Rui-Xing Yin ◽  
Rong-Jun Nie ◽  
Shuo Yang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Mendelian Randomization ◽  
Plasma Homocysteine ◽  
Sensitivity Analyses ◽  
Nucleotide Polymorphisms ◽  
Genome Wide ◽  
Artery Disease

Background Although many observational studies have shown an association between plasma homocysteine levels and cardiovascular diseases, controversy remains. In this study, we estimated the role of increased plasma homocysteine levels on the etiology of coronary heart disease and acute myocardial infarction. Methods A two-sample Mendelian randomization study on disease was conducted, i.e. “coronary heart disease” ( n = 184,305) and “acute myocardial infarction” ( n = 181,875). Nine single nucleotide polymorphisms, which were genome-wide significantly associated with plasma homocysteine levels in 57,644 subjects from the Coronary ARtery DIsease Genome wide Replication and Meta-analysis (CARDIoGRAM) plus The Coronary Artery Disease (C4D) Genetics (CARDIoGRAMplusC4D) consortium genome-wide association study and were known to be associated at p < 5×10–8, were used as an instrumental variable. Results None of the nine single nucleotide polymorphisms were associated with coronary heart disease or acute myocardial infarction ( p > 0.05 for all). Mendelian randomization analysis revealed no causal effects of plasma homocysteine levels, either on coronary heart disease (inverse variance weighted; odds ratio = 1.015, 95% confidence interval = 0.923–1.106, p = 0.752) or on acute myocardial infarction (inverse variance weighted; odds ratio = 1.037, 95% confidence interval = 0.932–1.142, p = 0.499). The results were consistent in sensitivity analyses using the weighted median and Mendelian randomization-Egger methods, and no directional pleiotropy ( p = 0.213 for coronary heart disease and p = 0.343 for acute myocardial infarction) was observed. Sensitivity analyses confirmed that plasma homocysteine levels were not significantly associated with coronary heart disease or acute myocardial infarction. Conclusions The findings from this Mendelian randomization study indicate no causal relationship between plasma homocysteine levels and coronary heart disease or acute myocardial infarction. Conflicting findings from observational studies might have resulted from residual confounding or reverse causation.

scholarly journals Cognitive function in patients with stable coronary heart disease: Related cerebrovascular and cardiovascular responses

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0183791 ◽  
Author(s):  
Mathieu Gayda ◽  
Vincent Gremeaux ◽  
Louis Bherer ◽  
Martin Juneau ◽  
Joffrey Drigny ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cognitive Function ◽  
Cardiovascular Responses ◽  
Stable Coronary Heart Disease

scholarly journals ANALISIS FAKTOR – FAKTOR YANG MEMPENGARUHI UPAYA PENCEGAHAN PENYAKIT JANTUNG KORONER (PJK) DI DESA PANDES TASIKMADU KARANGNYAR

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Diyono Diyono ◽  
Nisma Ayu Ambarwati
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Educational Level ◽  
Education Level ◽  
Influential Factor ◽  
Average Value ◽  
Regression Test ◽  
Analytical Research ◽  
Level Of Knowledge ◽  
The Village

Coronary Heart Disease (CHD) is still the leading cause of death in Indonesia. The bestmanagement of CHD is primary prevention, but not many people who do well with a widevariety of factors that influence. Objective: (1) know the description of prevention ofcoronary heart disease (2) Analyze the factors that affect the prevention of coronary heartdisease, including age, education level, and the level of knowledge of the CHD disease.Method: analytical research correlational. Subjects 65 people in the village PandesTasikamadu Karanganyar. Samples taken purposive sampling. Data were analyzed withMultiple Linear Regression Test using SPSS 18.Results: (1) In general, respondents are already doing prevention of coronary heartdisease as well with an average value of 22.85. (2) Age (p = 0.474) and educational level(p = 498) did not significantly influence the prevention of coronary heart disease (3) Thelevel of knowledge and perception of coronary heart disease significantly influence theprevention of coronary heart disease (4) perceptions of coronary heart disease is themost influential factor towards the prevention of coronary heart disease (p = 0.001; β =0.665). Conclusions: factors that influence the prevention of coronary heart disease is thelevel of knowledge (p = 0.015) and perception (p = 0.001).Keywords: Coronary Heart Disease, Age, Education Level, Knowledge

scholarly journals Size at birth, lifecourse factors, and cognitive function in late life: findings from the MYsore study of Natal effects on Ageing and Health (MYNAH) cohort in South India

2021 ◽  
pp. 1-14
Author(s):  
Murali Krishna ◽  
Ghattu V. Krishnaveni ◽  
Veena Sargur ◽  
Kalyanaraman Kumaran ◽  
Mohan Kumar ◽  
...  
Keyword(s):  
Birth Weight ◽  
Cognitive Function ◽  
Brain Development ◽  
Educational Level ◽  
Early Life ◽  
South India ◽  
Late Life ◽  
Positive Effects ◽  
Cardiometabolic Disorders ◽  
Size At Birth

ABSTRACT Objective: To examine if smaller size at birth, an indicator of growth restriction in utero, is associated with lower cognition in late life, and whether this may be mediated by impaired early life brain development and/or adverse cardiometabolic programming. Design: Longitudinal follow-up of a birth cohort. Setting: CSI Holdsworth Memorial Hospital (HMH), Mysore South India. Participants: 721 men and women (55–80 years) whose size at birth was recorded at HMH. Approximately 20 years earlier, a subset (n = 522) of them had assessments for cardiometabolic disorders in mid-life. Measurements: Standardized measurement of cognitive function, depression, sociodemographic, and lifestyle factors; blood tests and assessments for cardiometabolic disorders Results: Participants who were heavier at birth had higher composite cognitive scores (0.12 SD per SD birth weight [95% CI 0.05, 0.19] p = 0.001) in late life. Other lifecourse factors independently positively related to cognition were maternal educational level and participants’ own educational level, adult leg length, body mass index, and socioeconomic position, and negatively were diabetes in mid-life and current depression and stroke. The association of birth weight with cognition was independent cardiometabolic risk factors and was attenuated after adjustment for all lifecourse factors (0.08 SD per SD birth weight [95% CI −0.01, 0.18] p = 0.07). Conclusions: The findings are consistent with positive effects of early life environmental factors (better fetal growth, education, and childhood socioeconomic status) on brain development resulting in greater long-term cognitive function. The results do not support a pathway linking poorer fetal development with reduced late life cognitive function through cardiometabolic programming.

Coronary heart disease is associated with regional grey matter volume loss: implications for cognitive function and behaviour

2008 ◽  
Vol 38 (7) ◽  
pp. 599-606 ◽  
Author(s):  
O. P. Almeida ◽  
G. J. Garrido ◽  
C. Beer ◽  
N. T. Lautenschlager ◽  
L. Arnolda ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cognitive Function ◽  
Grey Matter ◽  
Grey Matter Volume ◽  
Volume Loss ◽  
Matter Volume

scholarly journals Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ting Zhang ◽  
Shiu Lun Au Yeung ◽  
C. Mary Schooling
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Dental Caries ◽  
Multiple Testing ◽  
Mendelian Randomization ◽  
Association Studies ◽  
Sensitivity Analyses ◽  
Genome Wide Association Studies ◽  
Standard Deviation Increase

AbstractWe assessed the associations of genetically instrumented blood sucrose with risk of coronary heart disease (CHD) and its risk factors (i.e., type 2 diabetes, adiposity, blood pressure, lipids, and glycaemic traits), using two-sample Mendelian randomization. We used blood fructose as a validation exposure. Dental caries was a positive control outcome. We selected genetic variants strongly (P < 5 × 10–6) associated with blood sucrose or fructose as instrumental variables and applied them to summary statistics from the largest available genome-wide association studies of the outcomes. Inverse-variance weighting was used as main analysis. Sensitivity analyses included weighted median, MR-Egger and MR-PRESSO. Genetically higher blood sucrose was positively associated with the control outcome, dental caries (odds ratio [OR] 1.04 per log10 transformed effect size [median-normalized standard deviation] increase, 95% confidence interval [CI] 1.002–1.08, P = 0.04), but this association did not withstand allowing for multiple testing. The estimate for blood fructose was in the same direction. Genetically instrumented blood sucrose was not clearly associated with CHD (OR 1.01, 95% CI 0.997–1.02, P = 0.14), nor with its risk factors. Findings were similar for blood fructose. Our study found some evidence of the expected detrimental effect of sucrose on dental caries but no effect on CHD. Given a small effect on CHD cannot be excluded, further investigation with stronger genetic predictors is required.

scholarly journals Study on the Correlation among Sleep Quality, Cognitive Function, and Self-Management Ability in Hospitalized Elderly Patients with Coronary Heart Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Zhoumin Shen ◽  
Huali Chen ◽  
Yimin Cai ◽  
Bifang Zhou ◽  
Hongjiao Chen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cognitive Function ◽  
Elderly Patients ◽  
Sleep Quality ◽  
Self Management ◽  
Hospitalized Elderly ◽  
Management Ability ◽  
Hospitalized Elderly Patients

Background. Coronary heart disease (CHD) is the leading cause of death worldwide. The incidence of cardiovascular disease is especially common in low-level and middle-income countries. With the increase in the number of patients with CHD and the complexity of treatment on patients with CHD, many hospitals are devoted to developing new models of care and management for patients with CHD. Understanding the unique characteristics of the patient’s condition, including factors related to self-management, cognitive function, and sleep quality, will lead to a substantial reduction in cardiovascular disease and related mortality. Objective. To investigate the correlation among sleep quality, cognitive function, and self-management ability in hospitalized elderly patients with coronary heart disease (CHD). Methods. 120 hospitalized elderly patients with coronary heart disease (CHD) were investigated by using a self-designed general data questionnaire, Pittsburgh Sleep Quality Index (PSQI), Montreal Cognitive Function Assessment (MoCA) scale, and Coronary Heart Disease Self-management Behavior Scale (CSMS). Results. The Spearman analysis showed that sleep quality was positively correlated with cognitive function in hospitalized elderly CHD patients ( P < 0.05 ). Sleep quality was positively correlated with self-management ability in CHD patients ( P < 0.05 ). Conclusion. Improving the cognitive function and self-management ability of elderly patients with coronary heart disease can improve their sleep quality.

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