Abstract WMP43: Long-term Mortality in Moyamoya Patients According to Presentation Type and Bypass Surgery in South Korea

Background: Survival outcomes in moyamoya patients according to initial presentation type and bypass surgery have not been clearly revealed. Methods: We investigated mortality in moyamoya disease (MMD) patients using Korean National Health Insurance database from 2006 to 2015 allowing wash-out period of previous 4 years. MMD type was classified into ischemic, hemorrhagic, and asymptomatic MMD. Bypass surgery group included the patients who underwent bypass surgery within 1 year after MMD diagnosis. Survival analysis was performed according to initial presentation type and bypass surgery using Kaplan-Meier method and Cox proportional hazard model. Results: The total number of patients with newly diagnosed MMD was 12146 with a female-to-male ratio of 1.81, of which ischemic type was identified in 3671 (30.2%), hemorrhagic type was in 2449 (20.2%), and asymptomatic type was in 6026 (49.6%) patients, respectively. There were 3942 (32.5%) patients in bypass surgery group and 8204 (67.5%) patients in non-bypass group. The 5- and 10-year survival rates in ischemic, hemorrhagic, and asymptomatic type were 92.5% and 88.9%, 85.3% and 76.3%, and 96.3% and 94.3%, respectively (Log-rank test; P<0.001, P<0.001). After adjusting age, sex, and presentation type, bypass surgery demonstrated HRs of 0.597 (95% CI 0.486-0.733, P<0.001) and 0.595 (95% CI 0.429-0.719, P<0.001) for 5- and 10-year mortality, respectively. Conclusion: This study showed that MMD patients had different survival courses according to initial presentation type. Adult MMD patients with hemorrhagic presentation had the worst survival outcome. Bypass surgery group survived longer than non-bypass group did in MMD patients in real-world setting.

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Mortality and Survival Rates after Elective Hepatic Surgery in a Low-Volume Centre Are Comparable to Those of High-Volume Centres

ISRN Surgery ◽

10.5402/2012/783932 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

I. E. Nygård ◽

K. Lassen ◽

J. Kjæve ◽

A. Revhaug

Keyword(s):

Overall Survival ◽

Liver Resection ◽

Survival Rates ◽

Disease Free Survival ◽

High Volume ◽

Colorectal Metastases ◽

Rank Test ◽

Cox Proportional Hazard ◽

Kaplan Meier ◽

Low Volume

Background. Over the last decades, liver resection has become a frequently performed procedure in western countries because of its acceptance as the most effective treatment for patients with selected cases of metastatic tumours. The purpose of this study was to evaluate the results after hepatic resections performed electively in our centre since 1979 and compare the results to those of larger high-volume centres. Methods. Medical records of all patients who underwent liver resection from January 1979 to December 2011 were reviewed. Disease-free survival and overall survival were determined by Kaplan-Meier analysis. Risk factors for complications were tested with the log-rank test and the Cox proportional hazard model. Complications were classified according to the modified Clavien classification system. Results. 290 elective liver resections were performed between January 1979 and December 2011. There were 171 males (59.0%) and 119 females (41.0%). Median age was 63 years, range 1–87. Overall survival ranged from 0 to 383 months, with a median of 31 months. Five-year survival rate for patients who underwent liver resection for colorectal metastases was 35.8% (34/95). Discussion. Hepatic resections are safely performed at a low-volume centre, with regard to perioperative- and in-house mortality and 5-year survival rates.

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Outcomes of Surgical and Nonsurgical Treatment for Colorectal Cancer in Nonagenarian Patients

The American Surgeon ◽

10.1177/0003134821995060 ◽

2021 ◽

pp. 000313482199506

Author(s):

Youngbae Jeon ◽

Kyoung-Won Han ◽

Won-Suk Lee ◽

Jeong-Heum Baek

Keyword(s):

Colorectal Cancer ◽

Overall Survival ◽

Surgical Treatment ◽

Postoperative Complications ◽

Postoperative Mortality ◽

Nonsurgical Treatment ◽

Perioperative Outcomes ◽

Rank Test ◽

Kaplan Meier ◽

Number Of Patients

Purpose This study is aimed to evaluate the clinical outcomes of surgical treatment for nonagenarian patients with colorectal cancer. Methods This retrospective single-center study included patients diagnosed with colorectal cancer at the age of ≥90 years between 2004 and 2018. Patient demographics were compared between the operation and nonoperation groups (NOG). Perioperative outcomes, histopathological outcomes, and postoperative complications were evaluated. Overall survival was analyzed using Kaplan-Meier methods and log-rank test. Results A total of 31 patients were included (16 men and 15 women), and the median age was 91 (range: 90‐96) years. The number of patients who underwent surgery and who received nonoperative management was 20 and 11, respectively. No statistical differences in baseline demographics were observed between both groups. None of these patients were treated with perioperative chemotherapy or radiotherapy. Surgery comprised 18 (90.0%) colectomies and 2 (10.0%) transanal excisions. Short-term (≤30 days) and long-term (31‐90 days) postoperative complications occurred in 7 (35.0%) and 4 (20.0%) patients, respectively. No complications needed reoperation, such as anastomosis leakage or bleeding. No postoperative mortality occurred within 30 days: 90-day postoperative mortality occurred in two patients (10.0%), respectively. The median overall survival of the operation group was 31.6 (95% confidence interval: 26.7‐36.5) and that of NOG was 12.5 months (95% CI: 2.4‐22.6) ( P = 0.012). Conclusion Surgical treatment can be considered in carefully selected nonagenarian patients with colorectal cancer in terms of acceptable postoperative morbidity, with better overall survival than the nonsurgical treatment.

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Serum Endocan as a Survival Predictor for Patients with Liver Cirrhosis

Canadian Journal of Gastroenterology and Hepatology ◽

10.1155/2015/153805 ◽

2015 ◽

Vol 29 (8) ◽

pp. 427-430 ◽

Cited By ~ 5

Author(s):

Nobuyuki Toshikuni ◽

Kazuaki Ozaki ◽

Joseph George ◽

Mikihiro Tsutsumi

Keyword(s):

Liver Cirrhosis ◽

Proportional Hazards Model ◽

Survival Rates ◽

Elevated Serum ◽

Cox Proportional Hazards Model ◽

Rank Test ◽

Hepatic Decompensation ◽

Cumulative Survival ◽

Kaplan Meier ◽

Survival Predictor

BACKGROUND: The relationship between endocan expression and outcome in patients with chronic liver disease is not fully understood.OBJECTIVE: To examine whether serum endocan level is predictive of outcome in patients with liver cirrhosis.METHODS: A total of 68 patients with liver cirrhosis were enrolled. Outcome predictors were analyzed using the Cox proportional hazards model. The overall survival rates were calculated using the Kaplan-Meier method, and differences were evaluated using the log-rank test.RESULTS: During the median follow-up period (7.1 years), nine patients had hepatocellular carcinoma (HCC) and 10 patients died. Of the deceased patients, nine died due to hepatic decompensation or associated conditions. No significant factors were found to be predictive of the occurrence of HCC. In contrast, an elevated serum endocan level (≥2.0 ng/mL; HR 2.34 [95% CI 1.05 to 7.03]; P=0.037) and high Child-Pugh grade B/C (HR 2.65 [95% CI 1.30 to 6.89; P=0.006) were predictive of poor survival. Kaplan-Meier analysis revealed that the respective cumulative survival rates at five and 10 years were 97.1% and 87.4% in patients with serum endocan levels <2.0 ng/mL and 85.8% and 64.4% in patients with levels ≥2.0 ng/mL (P=0.009), respectively. Moreover, the cumulative survival rates were significantly different among the patient groups divided according to serum endocan level and Child-Pugh grade (P=0.002).CONCLUSION: These findings suggest that serum endocan level may be a survival predictor for patients with liver cirrhosis.

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Effect of body mass index (BMI) on outcomes after surgical resection and adjuvant therapy for pancreatic cancer patients.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.4_suppl.185 ◽

2011 ◽

Vol 29 (4_suppl) ◽

pp. 185-185

Author(s):

M. R. Khawaja ◽

N. Zyromski ◽

M. Yu ◽

H. R. Cardenes ◽

C. M. Schmidt ◽

...

Keyword(s):

Pancreatic Cancer ◽

Adjuvant Therapy ◽

Cancer Patients ◽

Surgical Resection ◽

Survival Rates ◽

Disease Free Survival ◽

University Hospital ◽

Rank Test ◽

Kaplan Meier ◽

Significant Difference

185 Background: Obesity is one of the factors commonly associated with pancreatic cancer risk, but its prognostic role for survival is debatable. This study aimed to determine the role of BMI in treatment outcomes of pancreatic cancer patients (pts) undergoing surgical resection followed by adjuvant therapy. Methods: We retrospectively reviewed 165 consecutive pts with pancreatic cancer undergoing pancreaticoduodenectomy at Indiana University Hospital between 2004 and 2008. Fifty-three pts who received adjuvant treatment [gemcitabine alone (C-group): n=19; gemcitabine + radiotherapy (CRT-group): n=34] at our institution were included in the analysis. The Kaplan-Meier method was used to estimate the disease-free survival (DFS) and overall survival (OS); log-rank test was used to compare these outcomes between BMI groups (normal 18.5-24.99 kg/m2 vs. overweight/obese ≥ 25 kg/m2). Results: The sample comprised 53 pts (28 males; median age 62 yrs) with a median follow-up of 18.6 months (mos). Thirty pts (56.6%) had their BMIs recorded before the date of surgery, and 23 pts prior to starting adjuvant therapy. Two (3.8%) pts were underweight, 21 (39.6%) had a normal BMI and 30 (56.6%) were overweight/obese. There was no statistically significant difference in the median DFS of obese/overweight and normal BMI pts irrespective of adjuvant therapy (C or CRT) (14.47 vs. 11.80 mos; p= 0.111). Obese/overweight pts had a better median OS [25.2 vs. 14.6 mos; p=0.045 overall (25.7 vs. 16.9 mos; p= 0.143 for the CRT-group and 17.3 vs. 13.4 mos; p= 0.050 for the C-group)], 1-year survival [96.7% vs. 61.9%; p < 0.0001 overall (95% vs. 64.3%; p= 0.001 for the CRT-group, and 90% vs. 57.1%; p=0.016 with C)], and 2-year survival [52.6% vs. 25.4%; p < 0.0001 overall (60.0% vs. 30.0%; p=0.0001 for the CRT-group and 37.5% vs. 14.3%; p=0.0002 for the C-group)] than patients with normal BMI. Conclusions: In our experience, overweight/obese pts undergoing surgery followed by adjuvant therapy have better survival rates than patients with normal BMI. [Table: see text] No significant financial relationships to disclose.

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The Distribution of Yin-Deficient Symptoms and Their Relationship on Survival Rate in Cancer Patients with Yin-Deficiency

The American Journal of Chinese Medicine ◽

10.1142/s0192415x08006120 ◽

2008 ◽

Vol 36 (04) ◽

pp. 655-663 ◽

Cited By ~ 10

Author(s):

Shu-Chuan Lin ◽

Ming-Feng Chen ◽

Tsai-Chung Li ◽

Yu-Ho Hsieh ◽

Shwu-Jiuan Liu

Keyword(s):

Survival Rate ◽

Cancer Patients ◽

Survival Rates ◽

Rank Test ◽

Yin Deficiency ◽

Rate Analysis ◽

Log Rank Test ◽

Kaplan Meier ◽

Product Limit ◽

Cumulative Probabilities

Yin-Deficiency (YD), representing a status of the human body under lack of nutrition and fluid in traditional Chinese medicine, is commonly seen in late stage of cancer patients. It is not known whether the severity of YD related symptoms/signs can predict the survival rate of cancer patients. This study evaluated the distribution of Yin-deficiency symptoms/signs (YDS) in cancer patients with YD, and investigated whether the severity of YDS can predict the survival rate of cancer patients with YD. From 5 January 2007 to 5 May 2007, we selected 43 cancer patients with diagnosis of YD from hospitalized patients and outpatients. The severity of YD was evaluated by a questionnaire. We further estimated the cumulative probabilities of the survival rates over 4 months since the start of study by the Kaplan-Meier product-limit method, and compared the differences among groups with various severities in each symptom/sign with the use of the log-rank test. The results revealed that, the 3 most common YDS were sleeplessness with annoyance, less or non-coated tongue with or without redness and dry mouth. In the survival rate analysis, only 2 parameters, rapidly small pulse (p = 0.002) and less-or non-coated tongue with paleness (p = 0.017), were found to be related to the decrease of cancer patients with YD. This suggests that, both rapidly small pulse and less-or non-coated tongue without redness may be used as predictors for the estimation of survival rate in cancer patients with YD.

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Determination of Affected Factor on Survival Rates In Referral Gastric Cancer Patients to Imam Khomeini Clinic in Hamadan Province from 2004-2017

Journal of Shahid Sadoughi University of Medical Sciences ◽

10.18502/ssu.v27i12.2832 ◽

2020 ◽

Author(s):

Fatemeh Gohari-Ensaf ◽

Zeinab Berangi ◽

Mohamad Abbasi ◽

Ghodratollah Roshanaei

Keyword(s):

Gastric Cancer ◽

Survival Rate ◽

Screening Program ◽

Survival Rates ◽

Tumor Stage ◽

Rank Test ◽

Significance Level ◽

Kaplan Meier ◽

One Year ◽

Gastric Cancer Patients

Introduction: Gastric cancer is the fourth most common cancer and the second leading cause of death in the world. Despite the recent advances in controlling and treating the disease, the survival rate of this cancer is relatively low. Various factors can affect the survival of the patients with gastric cancer. The aim of this study was to determine the survival rates and the effective factors in the patients with gastric cancer. Methods: The study population included all the patients diagnosed with gastric cancer in Hamadan Province who were referred to Hamadan Imam Khomeini Specialized Clinic between 2004 to 2017. Patients were followed up by periodical referrals and/or telephone contact. The survival rate of the patients was calculated using Kaplan-Meier method and effective survival factors with Cox proportional regression. Data were analyzed using SPSS 23 software at a significance level of 0.05. Results: Out of the 350 patients with gastric cancer, 74.3% were male and 25.7% were female. One-year, three-year and five-year survival rates were 67%, 36% and 27%, respectively. The log -rank test showed that age, type of tumor, stage of disease, type of Surgery and metastasis of the disease were effective on the survival of patients. In Cox's multivariate analysis, the only age variables at the time of diagnosis and chemotherapy were survival variables. (P<0.05). Conclusion: The results of this study showed that age variable is a strong factor in survival, so it is essential to diagnose the disease at the early age and early stages of the disease using a screening program.

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A comparison of the prognostic significance of changes in NT-proBNP levels in HFrEF and HFpEF.

10.22541/au.161978616.62769552/v1 ◽

2021 ◽

Author(s):

Nishant Sahni ◽

Umesh Sharma ◽

Rashi Arora

Keyword(s):

Regression Models ◽

Cox Regression ◽

Survival Rates ◽

Prognostic Significance ◽

Rank Test ◽

Log Rank Test ◽

Kaplan Meier ◽

Regional Health Care ◽

Comorbidity Scores ◽

Blood Pressures

Background: Rising NT-proBNP are associated with reduced survival patients with HFrEF. However, it remains to be conclusively and formally demonstrated that the temporal trend in NT-proBNP level carries prognostic significance in HFpEF. Objective: To determine whether there is an association between rising NT-proBNP levels and 6-month survival in patients with HFpEF and HFrEF. Methods: We examined a cohort of 5203 patients to 5 hospitals in a regional health care system — who had at least one admission to the hospital with diagnoses of heart failure over a 3-year period. Kaplan-Meier survival curves were constructed for patients with downtrending (>25% net decrease), stable or uptrending (>25% net increase) NT-proBNP levels in HF, HFpEF and HFrEF patients. The log-rank test was used to test for differences in 6-month survival amongst the groups. Multivariate extended Cox regression models were constructed for 6-month survival with NT-proBNP as a time-varying covariate. Age, albumin, sex, race, serum creatinine, systolic and diastolic blood pressures and Charlson comorbidity scores at baseline were used as covariates in the model. Separate analyses were done for HFpEF and HFrEF patients. Results: HFpEF and HFrEF patients with up-trending levels had significantly lower 6-month survival rates than patients with downtrending or stable NT-proBNP levels. A doubling of the NT-proBNP level in patients was significantly associated with reduced 6-month survival in patients with in both subgroups of HF, HFpEF and HFrEF (HFpEF-HR: 1.53(1.49-2.57), HFrEF HR: 1.45(1.43-1.48) after adjusting for covariates.

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Competing risks analysis of under-five child mortality in Bangladesh

Bangladesh Journal of Scientific Research ◽

10.3329/bjsr.v27i1.26222 ◽

2016 ◽

Vol 27 (1) ◽

pp. 27-38 ◽

Cited By ~ 1

Author(s):

Tasnuva Tabassum ◽

Wasimul Bari

Keyword(s):

Competing Risks ◽

Disease Model ◽

Wealth Index ◽

Rank Test ◽

Index Child ◽

Under Five ◽

Cox Proportional Hazard ◽

Kaplan Meier ◽

Competing Risks Analysis ◽

Competing Causes

This study implements an analysis of under five mortality to the Bangladesh Demographic and Health Survey, 2011 data from a competing risks perspective. Kaplan - Meier overall survival curves along with log-rank test p-values are employed to determine the prospective covariates for the Cox proportional hazard (PH) model. Later the typical Cox PH model is used to model the causespecific hazard for the two competing causes, namely disease and non-disease on the selected covariates. It is revealed that mothers primary and secondary education, birth order of the index child in case of disease model; mothers higher education, wealth index of the index child in case of non-disease model and mothers aged greater than 30 years at the time of giving birth, home as a place of child delivery in both model played significant role in decreasing under five child mortality.Bangladesh J. Sci. Res. 27(1): 27-38, June-2014

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Survival of Patients With Testicular Cancer in Lithuania During 1999–2002

Medicina ◽

10.3390/medicina47010008 ◽

2011 ◽

Vol 47 (1) ◽

pp. 8 ◽

Cited By ~ 1

Author(s):

Agnius Juška ◽

Albertas Ulys ◽

Laura Kairevičė ◽

Giedrė Smailytė ◽

Edgaras Stankevičius ◽

...

Keyword(s):

Survival Rate ◽

Testicular Cancer ◽

Cancer Patients ◽

Cancer Registry ◽

Survival Rates ◽

Tumor Stage ◽

Rank Test ◽

Log Rank Test ◽

Kaplan Meier ◽

Younger Age

The aim of this study was to evaluate the survival of patients with testicular cancer in Lithuania during 1998–2002 and factors that influenced the survival.Material and methods. The survival rates of testicular cancer patients were evaluated using the data of the Lithuanian Cancer Registry for 1998–2002. The survival was evaluated using the Kaplan-Meier method and log-rank test in order to compare the survival rates. The observed survival rates were calculated.Results. The 5-year observed survival rate in Lithuania was 71.2% (95% CI, 64.4%–77.5%). The survival of testicular cancer patients depended on age at the time of diagnosis, histology of tumor, stage and extent of disease.Conclusions. The survival of patients with testicular cancer in Lithuania was substantially lower than in other European countries. The better survival was associated with younger age and lesser extent of metastases.

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Endoscopic thermal ablation therapies for hepatocellular carcinoma; multi-center study

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.4147 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 4147-4147

Author(s):

H. Sakaguchi ◽

S. Seki ◽

S. Iwai ◽

H. Kadoya ◽

K. Ido ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Local Anesthesia ◽

Scoring System ◽

Thermal Ablation ◽

Survival Rates ◽

Rank Test ◽

Test Results ◽

Kaplan Meier ◽

Multi Center Study ◽

Center Study

4147 Background: Differences of efficacy between radiofrequency ablation (RFA) and microwave coagulation (MWC) for hepatocellular carcinoma (HCC) is still unknown. So we performed multi-center study to assess factors contributing to survival among patients treated by endoscopic thermal ablation for single HCC. Methods: 396 patients in six institutions with single HCC who were firstly treated by endoscopic thermal ablation were enrolled in this study and assessed retrospectively. Among 396 patients, 347 were treated under general anesthesia and 49 were treated local anesthesia. 144 were treated by MWC and 252 were treated by RFA. 383 were ablated laparoscopically and 13 were done thoracoscopically. 230 HCCs were located superficial position of liver and 166 were deep position. Classification with Child-Turcotte-Pugh score, the Japan Integrated Staging score, and the Cancer of the Italian Program scoring system were performed. All patients were analyzed survival rates by Kaplan-Meier method and differences among groups were compared by the log-rank test. Results: Five year survival rates of all 396 patients were 63% and ten year survival rates were 42%. Differences between general and local anesthesia were not significant (p = 0.28). Differences between MWC and RFA were not significant (p = 0.77). Location of HCCs were not significant (p = 0.89). Differences among groups classified by Child-Turcotte-Pugh score were significant (p = 0.017). Classification by the Japan Integrated Staging score was not significant (p = 0.24). However, classification by the Cancer of the Italian Program scoring system were significant (p = 0.001). Conclusions: Endoscopic thermal ablation therapies for HCC was effective. Differences of efficacy between RFA and MWC were not found. No significant financial relationships to disclose.

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