scholarly journals Using Psilocybin to Investigate the Relationship between Attention, Working Memory, and the Serotonin 1A and 2A Receptors

2005 ◽  
Vol 17 (10) ◽  
pp. 1497-1508 ◽  
Author(s):  
Olivia L. Carter ◽  
David C. Burr ◽  
John D. Pettigrew ◽  
Guy M. Wallis ◽  
Felix Hasler ◽  
...  
Keyword(s):  
Working Memory ◽  
Receptor Agonist ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Healthy Human ◽  
Human Volunteers ◽  
Attentional Performance ◽  
Pharmacological Data ◽  
Tracking Ability ◽  
The Relationship

Increasing evidence suggests a link between attention, working memory, serotonin (5-HT), and prefrontal cortex activity. In an attempt to tease out the relationship between these elements, this study tested the effects of the hallucinogenic mixed 5-HT1A/2A receptor agonist psilocybin alone and after pretreatment with the 5-HT2A antagonist ketanserin. Eight healthy human volunteers were tested on a multiple-object tracking task and spatial working memory task under the four conditions: placebo, psilocybin (215 Ag/kg), ketanserin (50 mg), and psilocybin and ketanserin. Psilocybin significantly reduced attentional tracking ability, but had no significant effect on spatial working memory, suggesting a functional dissociation between the two tasks. Pretreatment with ketanserin did not attenuate the effect of psilocybin on attentional performance, suggesting a primary involvement of the 5-HT1A receptor in the observed deficit. Based on physiological and pharmacological data, we speculate that this impaired attentional performance may reflect a reduced ability to suppress or ignore distracting stimuli rather than reduced attentional capacity. The clinical relevance of these results is also discussed.

scholarly journals Task Monitoring and Working Memory as Executive Components Predictive of General and Specific Academic Achievements in 6–9-Year-Old Children

2021 ◽  
Vol 18 (13) ◽  
pp. 6681
Author(s):  
Alberto Quílez-Robres ◽  
Nieves Moyano ◽  
Alejandra Cortés-Pascual
Keyword(s):  
Academic Achievement ◽  
Working Memory ◽  
Academic Performance ◽  
Executive Functions ◽  
Language Arts ◽  
Memory Task ◽  
Academic Achievements ◽  
Predictive Role ◽  
And Mathematics ◽  
The Relationship

Academic achievement has been linked to executive functions. However, it is necessary to clarify the different predictive role that executive functions have on general and specific academic achievement and to determine the most predictive executive factor of this academic achievement. The relationship and predictive role between executive functions and their components (initiative, working memory, task monitoring, organization of materials, flexibility, emotional control, inhibition, self-monitoring) with academic achievement are analyzed in this study, both globally and specifically in the areas of Language Arts and Mathematics, in 133 students from 6 to 9 years of age. The relationship obtained in Pearson’s correlation analysis does not differ substantially between overall achievement (r = 0.392) and specific achievement (r = 0.361, r = 0.361), but task monitoring (r = 0.531, r = 0.455, r = 0.446) and working memory (r = 0.512, r = 0.475, r = 0.505) had a greater relationship with general and specific achievement. Finally, regression analyses based on correlation results indicate that executive functions predict general academic performance (14.7%) and specific performance (12.3%, 12.2%) for Language Arts and Mathematics, respectively. Furthermore, working memory and task supervision represent 32.5% of general academic performance, 25.5% of performance in Language Arts, and 27.1% of performance in Mathematics. In conclusion, this study yielded exploratory data on the possible executive functions (task supervision and working memory) responsible for good general academic achievements and specific academic achievements in Mathematics and Language Arts.

scholarly journals Brain hemodynamic response in Examiner–Examinee dyads during spatial short-term memory task: an fNIRS study

2021 ◽  
Author(s):  
Francesco Panico ◽  
Stefania De Marco ◽  
Laura Sagliano ◽  
Francesca D’Olimpio ◽  
Dario Grossi ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Processes ◽  
Short Term Memory ◽  
Spatial Working Memory ◽  
Brain Activity ◽  
Memory Task ◽  
Neural Correlates ◽  
Short Term ◽  
Term Memory ◽  
The Real

AbstractThe Corsi Block-Tapping test (CBT) is a measure of spatial working memory (WM) in clinical practice, requiring an examinee to reproduce sequences of cubes tapped by an examiner. CBT implies complementary behaviors in the examiners and the examinees, as they have to attend a precise turn taking. Previous studies demonstrated that the Prefrontal Cortex (PFC) is activated during CBT, but scarce evidence is available on the neural correlates of CBT in the real setting. We assessed PFC activity in dyads of examiner–examinee participants while completing the real version of CBT, during conditions of increasing and exceeding workload. This procedure allowed to investigate whether brain activity in the dyads is coordinated. Results in the examinees showed that PFC activity was higher when the workload approached or reached participants’ spatial WM span, and lower during workload conditions that were largely below or above their span. Interestingly, findings in the examiners paralleled the ones in the examinees, as examiners’ brain activity increased and decreased in a similar way as the examinees’ one. In the examiners, higher left-hemisphere activity was observed suggesting the likely activation of non-spatial WM processes. Data support a bell-shaped relationship between cognitive load and brain activity, and provide original insights on the cognitive processes activated in the examiner during CBT.

Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance

2003 ◽  
Vol 33 (3) ◽  
pp. 455-467 ◽  
Author(s):  
F. C. MURPHY ◽  
A. MICHAEL ◽  
T. W. ROBBINS ◽  
B. J. SAHAKIAN
Keyword(s):  
Working Memory ◽  
Negative Feedback ◽  
Performance Feedback ◽  
Visual Discrimination ◽  
Negative Reinforcement ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Depressive Illness ◽  
Reversal Task ◽  
Depressed Patients

Background. Recent evidence suggests that an abnormal response to performance feedback may contribute to the wide-ranging neuropsychological deficits typically associated with depressive illness. The present research sought to determine whether the inability of depressed patients to utilize performance feedback advantageously is equally true for accurate and misleading feedback.Method. Patients with major depression and matched controls completed: (1) a visual discrimination and reversal task that featured intermittent and misleading negative feedback; and (2) feedback and no-feedback versions of a computerised test of spatial working memory. In the feedback version, negative feedback was accurate, highly informative, and could be used as a mnemonic aid.Results. On the Probability Reversal task, depressed patients were impaired in their ability to maintain response set in the face of misleading negative feedback as shown by their increased tendency to switch responding to the ‘incorrect’ stimulus following negative reinforcement, relative to that of controls. Patients' ability to acquire and reverse the necessary visual discrimination was unimpaired. On the Spatial Working Memory task, depressed patients made significantly more between-search errors than controls on the most difficult trials, but their ability to use negative feedback to facilitate performance remained intact.Conclusions. The present results suggest that feedback can have different effects in different contexts. Misleading, negative feedback appears to disrupt the performance of depressed patients, whereas negative but accurate feedback does not. These findings are considered in the context of recent studies on reinforcement systems and their associated neurobiological substrates.

Reproducibility of fMRI Results across Four Institutions Using a Spatial Working Memory Task

NeuroImage ◽  
1998 ◽  
Vol 8 (3) ◽  
pp. 249-261 ◽  
Author(s):  
B.J. Casey ◽  
Jonathan D. Cohen ◽  
Kathy O'Craven ◽  
Richard J. Davidson ◽  
William Irwin ◽  
...  
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Memory Task

scholarly journals Phenomenology of Visuo-spatial Working Memory Task Performance

2021 ◽  
Author(s):  
Aleš Oblak ◽  
Anka Slana Ozimič ◽  
Grega Repovš ◽  
Urban Kordeš
Keyword(s):  
Working Memory ◽  
Cognitive Psychology ◽  
Task Performance ◽  
Present Article ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Bodily Feelings ◽  
Psychological Tasks

In experimental cognitive psychology, objects of inquiry have typically been operationalized with psychological tasks. If we are interested in measuring the target phenomena, we must inquire into the validity of the task; that is, to what extent does the task elicit the phenomenon in question. If we subscribe to the second view, evaluating the validity and the interpretation of the gathered data can be supplemented by understanding the experience of solving psychological tasks. The aim of the present article is to investigate how individuals experience performing a psychological task, specifically, a visuo-spatial working memory task. We present ethnographic descriptions of different ways individuals can experience the same task. We focus on aspects of experience that comprise the overall sense of experience (e.g., bodily feelings, emotional atmosphere, mood). We discuss the methodological implications of our findings and the possibility of conducting a neurophenomenology of visuo-spatial working memory.

scholarly journals Declined functional connectivity of white matter during rest and working memory tasks associates with cognitive impairments in schizophrenia

2020 ◽  
Author(s):  
Yurui Gao ◽  
Muwei Li ◽  
Anna S Huang ◽  
Adam W Anderson ◽  
Zhaohua Ding ◽  
...  
Keyword(s):  
Working Memory ◽  
White Matter ◽  
Functional Connectivity ◽  
Resting State ◽  
Spatial Working Memory ◽  
Cognitive Impairments ◽  
Memory Task ◽  
Brain Network ◽  
Blood Oxygenation ◽  
Cerebral Peduncle

BACKGROUND: Schizophrenia, characterized by cognitive impairments, arises from a disturbance of brain network. Pathological changes in white matter (WM) have been indicated as playing a role in disturbing neural connectivity in schizophrenia. However, deficits of functional connectivity (FC) in individual WM bundles in schizophrenia have never been explored; neither have cognitive correlates with those deficits. METHODS: Resting-state and spatial working memory task fMRI images were acquired on 67 healthy subjects and 84 patients with schizophrenia. The correlations in blood-oxygenation-level-dependent (BOLD) signals between 46 WM and 82 gray matter regions were quantified, analyzed and compared between groups under three scenarios (i.e., resting state, retention period and entire time of a spatial working memory task). Associations of FC in WM with cognitive assessment scores were evaluated for three scenarios. RESULTS: FC deficits were significant (p<.05) in external capsule, cingulum, uncinate fasciculus, genu and body of corpus callosum under all three scenarios. Deficits were also present in the anterior limb of the internal capsule and cerebral peduncle in task scenario. Decreased FCs in specific WM bundles associated significantly (p<.05) with cognitive impairments in working memory, processing speed and/or cognitive control. CONCLUSIONS: Decreases in FC are evident in several WM bundles in patients with schizophrenia and are significantly associated with cognitive impairments during both rest and working memory tasks. Furthermore, working memory tasks expose FC deficits in more WM bundles and more cognitive associates in schizophrenia than resting state does.

scholarly journals Spontaneous Eye Blink Rate during the Working Memory Delay Period Predicts Task Performance

2021 ◽  
Author(s):  
Jefferson Ortega ◽  
Chelsea Reichert Plaska ◽  
Bernard A Gomes ◽  
Timothy M Ellmore
Keyword(s):  
Working Memory ◽  
Task Performance ◽  
Memory Task ◽  
Delay Period ◽  
Blink Rate ◽  
Indirect Measure ◽  
Eye Blink ◽  
Non Invasive ◽  
Relationship Of ◽  
The Relationship

Spontaneous eye blink rate (sEBR) has been found to be a non-invasive indirect measure of striatal dopamine activity. Dopamine (DA) neurons project to the prefrontal cortex (PFC) through the mesocortical dopamine pathway and their activity is implicated in a range of cognitive functions, including attention and working memory (WM). The goal of the present study was to understand how fluctuations in sEBR during different phases of a working memory task relate to task performance. Across two experiments, with recordings of sEBR inside and outside of a magnetic resonance imaging bore, we observed sEBR to be positively correlated with WM performance during the WM delay period. Additionally we investigated the non-linear relationship between sEBR and WM performance, and modeled a proposed Inverted-U-shape relationship between DA and WM performance. We also investigated blink duration, which is proposed to be related to sustained attention, and found blink duration to be significantly shorter during the encoding and probe periods of the task. Taken together, these results provide support towards sEBR as an important correlate of working memory task performance. The relationship of sEBR to DA activity and the influence of DA on the PFC during WM maintenance is discussed.

scholarly journals Negative Effects of Embodiment in a Visuo-Spatial Working Memory Task in Children, Young Adults, and Older Adults

2021 ◽  
Vol 12 ◽  
Author(s):  
Gianluca Amico ◽  
Sabine Schaefer
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Young Adults ◽  
Spatial Information ◽  
Spatial Working Memory ◽  
Cognitive Task ◽  
Memory Performance ◽  
Age Groups ◽  
Memory Task ◽  
Negative Effects

Studies examining the effect of embodied cognition have shown that linking one’s body movements to a cognitive task can enhance performance. The current study investigated whether concurrent walking while encoding or recalling spatial information improves working memory performance, and whether 10-year-old children, young adults, or older adults (Mage = 72 years) are affected differently by embodiment. The goal of the Spatial Memory Task was to encode and recall sequences of increasing length by reproducing positions of target fields in the correct order. The nine targets were positioned in a random configuration on a large square carpet (2.5 m × 2.5 m). During encoding and recall, participants either did not move, or they walked into the target fields. In a within-subjects design, all possible combinations of encoding and recall conditions were tested in counterbalanced order. Contrary to our predictions, moving particularly impaired encoding, but also recall. These negative effects were present in all age groups, but older adults’ memory was hampered even more strongly by walking during encoding and recall. Our results indicate that embodiment may not help people to memorize spatial information, but can create a dual-task situation instead.

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