Alzheimer's Electroencephalogram Event Scalp and Source Localization

Author(s):  
Pedro Miguel Rodrigues ◽  
João Paulo Teixeira ◽  
Diamantino R. S. Freitas

Alzheimer's disease is the most common cause of dementia which causes a progressive and irreversible impairment of several cognitive functions. The aging population has been increasing significantly in recent decades and this disease affects mainly the elderly. Its diagnostic accuracy is relatively low and there is not a biomarker able to detect AD without invasive tests. Despite the progress in better understanding the disease there remains no prospect of cure at least in the near future. The electroencephalogram (EEG) test is a widely available technology in clinical settings. It may help diagnosis of brain disorders, once it can be used in patients who have cognitive impairment involving a general decrease in overall brain function or in patients with a located deficit. This study is a new approach to improve the scalp localization and the detection of brain anomalies (EEG temporal events) sources associated with AD by using the EEG.

2013 ◽  
Vol 2 (3) ◽  
pp. 44-61 ◽  
Author(s):  
Pedro Miguel Rodrigues ◽  
Diamantino Rui Freitas ◽  
João Paulo Teixeira

Alzheimer’s Disease (AD) is a chronic progressive and irreversible neurodegenerative brain disorder. The aging population has been increasing significantly in recent decades. Therefore, AD will continue to increase because the disease affects mainly the elderly. Its diagnostic accuracy is relatively low, and there is not a biomarker able to detect AD without invasive tests. The electroencephalogram (EEG) test is a widely available technology in clinical settings. It may help diagnosis of brain disorders, once it can be used in patients who have cognitive impairment involving a general decrease in overall brain function or in patients with a located deficit. This study is a new approach to detect EEG temporal events in order to improve the AD diagnosis. For that, K-means and Self-Organized Maps were used, and the results suggested that there are sequences of EEG energy variation that appear more frequently in AD patients than in healthy subjects.


2021 ◽  
Vol 13 (1) ◽  
pp. 401
Author(s):  
Woong Bee Choi ◽  
Dongyeol Lee ◽  
Woo Chang Kim

The Korean National Pension Service (NPS) is a partially funded and defined-benefit system. Although the accumulated Fund of the NPS has been increased gradually, this large fund is concerned about depletion in the near future due to the unprecedented aging population and the low fertility rate. In this study, we have developed an asset-liability management (ALM) model that endogenizes variables which were regarded as being exogenous by including them in investable assets. We present the multistage stochastic programming (MSP) formulation incorporating the population structure as a variable that is new to ALM. The optimal portfolio encompassing the investment in raising the fertility rate is obtained. Extending the scope of ALM to social investment is a new approach that has not been attempted in other ALM studies. We demonstrate that socially driven investments can also be a good investment asset in which the NPS should consider to invest.


Author(s):  
Violet Cunningham ◽  
Alexander Tilton ◽  
Dylon Maertens ◽  
Shawn Duan

Abstract People with disabilities often struggle with mobility issues, so there is a strong desire for devices such as powerchairs, which can provide more freedom. Currently, wheelchair demand in the US is increasing due to an upsurge in the elderly population. Often electric powerchairs suitable for outdoor use are extremely expensive, cannot be used indoors, and are not covered by medical insurance. In this project, these problems are addressed through the design of a chair which is suitable for both rough outdoor terrain and indoor use. This project is based on a request for a powerchair which our client’s son, who has cerebral palsy, can use on family trips in outdoor environments including grass, gravel, and sand. A photo of a previous nonfunctional prototype was provided to the team as a reference, and a full redesign was performed to resolve the problems identified. Before proceeding with the design, various sources were consulted to gain a thorough understanding of currently available technology and design methods. Many different adjustment methods and features were considered, including an adjustable frame, tracks, and a lifting system for curb mounting. The overall design selected is a welded sheet metal frame with wheels, and it was determined that the chair should have an adjustable wheelbase width to provide both outdoor stability and indoor maneuverability. Key considerations for the design include battery life, motor torque, maximum load, seat size, door width, and cost. The final specifications are based on the needs of the client, Kevin Sample, as well as an analysis of the wider consumer market. The width adjustment design uses an axle above the driving wheels, which are connected to it by sliding sleeves. Automatic adjustment is accomplished using a linear actuator. The drive wheels are large and run at low pressure to surmount obstacles and damp vibrations. Differential steering combined with rear caster wheels gives the chair a small turning radius, and its length is comparable to that of standard manual wheelchairs. The seat can be easily removed to access the battery and control system or to load the chair into a vehicle. A joystick is used to control the speed and direction of the chair, while a separate momentary switch is used for the linear actuator. Throughout the modeling process, stress analysis was performed using simulations in Inventor. Any necessary adjustments were made to ensure that none of the parts will fail, considering both failure theory and fatigue. Various grades of aluminum were selected for the majority of the manufactured parts, due to their corrosion resistance and light weight. The device is currently in the prototype manufacturing stage. If it is later marketed, a curb mounting device may also be included; this was decided against mainly due to cost and time restrictions. Space has also been left for a carrying basket, which will likely be added to the first prototype. The initial goal is to produce a single chair for our client, although the design may later be submitted for Medicare and ADA approval.


Author(s):  
Sérgio Correia ◽  
Marko Beko ◽  
Luís Cruz ◽  
Slavisa Tomic

This work addresses the energy-based source localization problem in wireless sensors networks. Instead of circumventing the maximum likelihood (ML) problem by applying convex relaxations and approximations (like all existing approaches do), we here tackle it directly by the use of metaheuristics. To the best of our knowledge, this is the first time that metaheuristics is applied to this type of problems. More specifically an elephant herding optimization (EHO) algorithm is applied. Through extensive simulations, the key parameters of the EHO algorithm are optimized such that they match the energy decay model between two sensor nodes. A detailed analysis of the computational complexity is presented, as well as performance comparison between the proposed algorithm and existing non-metaheuristic ones. Simulation results show that the new approach significantly outperforms the existing solutions in noisy environments, encouraging further improvement and testing of metaheuristic methods.


2009 ◽  
Vol 297 (1) ◽  
pp. R116-R123 ◽  
Author(s):  
Rong Zhang ◽  
Jurgen A. H. R. Claassen ◽  
Shigeki Shibata ◽  
Sinem Kilic ◽  
Kristin Martin-Cook ◽  
...  

To assess baroreflex function under closed-loop conditions, a new approach was used to generate large and physiological perturbations in arterial pressure. Blood pressure (BP) and R-R interval were recorded continuously in 20 healthy young (33 ± 8 yr) and eight elderly subjects (66 ± 6 yr). Repeated squat-stand maneuvers at the frequencies of 0.05 and 0.1 Hz were performed to produce periodic oscillations in BP to provoke the baroreflex. To assess the effects of the muscle reflex and/or central command on the baroreflex, passive squat-stand maneuvers were conducted using a pulley system to assist changes in body position. Transfer function between changes in BP and R-R interval was estimated to assess the arterial-cardiac baroreflex. Relative to resting conditions, large and coherent oscillations in BP and R-R interval were produced during both active and passive squat-stand maneuvers. However, changes in BP were smaller during passive than during active maneuvers. Changes in R-R interval were reduced commensurately. Therefore, transfer function gain did not change between the two maneuvers. Compared with the young, transfer function gain was reduced and the phase became more negative in the elderly, demonstrating the well-known effects of aging on reducing baroreflex sensitivity. Collectively, these findings suggest that the changes in R-R interval elicited by BP perturbations during squat-stand maneuvers are mediated primarily by a baroreflex mechanism. Furthermore, baroreflex function can be assessed using the transfer function method during large perturbations in arterial pressure.


Leonardo ◽  
2017 ◽  
Vol 50 (2) ◽  
pp. 195-196
Author(s):  
Eugen Bogdan Petcu

Cancer patients require a complex multidisciplinary therapy. In this context the 3D additive biological manufacturing could represent a significant development with potential significant medical and social consequences. This article reviews the 3D bioprinting methods and clinical settings in which this new revolutionary method could be applied. Apart from the actual field of post-cancer therapy prosthetics and medical education, this method could be applied in the actual molecular cancer research and organ regeneration/fabrication. Considering all of these, it is possible that in the future, 3D biological printing could be used on a regular basis in clinical oncology.


Author(s):  
Saori Donkai ◽  
Chieko Mizoue

This chapter describes the present conditions of our aging society, with a particular focus on Japan as a typical example of such a society. In Japan, one in every four individuals is over 65 years of age, and one in eight is over 75 years of age. Further, based on this demographic change to an older population, this chapter discusses a new library service designed to enhance the lives of elderly citizens. The authors explore this new service from the viewpoint of lifelong learning, utilizing the results of recent government surveys and some case studies, such as those done at the Izumo City Hikawa Library and the Akita Prefectural Library in Japan. Although the elderly have been placed within the category of “disabled library patrons,” in recent years, it has become more common to consider the elderly, as a whole, as an individual service category. We should, in the near future, pay more attention to supporting elderly citizens at public libraries to engage them in the development and maintenance of their own communities.


2019 ◽  
Vol 5 (1) ◽  
pp. 26 ◽  
Author(s):  
Diewertje Bink ◽  
Noelia Lozano-Vidal ◽  
Reinier Boon

Cardiovascular diseases are the most prominent cause of death in Western society, especially in the elderly. With the increasing life expectancy, the number of patients with cardiovascular diseases will rise in the near future, leading to an increased healthcare burden. There is a need for new therapies to treat this growing number of patients. The discovery of long non-coding RNAs has led to a novel group of molecules that could be considered for their potential as therapeutic targets. This review presents an overview of long non-coding RNAs that are regulated in vascular disease and aging and which might therefore give insight into new pathways that could be targeted to diagnose, prevent, and/or treat vascular diseases.


Author(s):  
Caroline Pigeon ◽  
Evelyne Blais ◽  
Roxanne Grondin ◽  
Esther Bolduc-Rouleau ◽  
Laura Fontaine-Pagé ◽  
...  

AbstractThe cessation of driving is a difficult transition for the elderly, but it can be facilitated through interventions. The purpose of this study was to explore the satisfaction, usefulness and applicability of the CarFreeMe intervention in the French-Canadian context. A qualitative clinical research device was used on ten older adults aged between 61 and 90 years. The participants had stopped driving within the last twelve months or were planning to stop driving in the near future and did not have cognitive impairments. After the intervention, the participants were generally satisfied and reported on its usefulness and applicability in a French-Canadian context. In addition, they identified the positive impacts related to their social involvement as they re-engaged in or pursued their significant activities. Further research is required to assess the intervention’s effects and the practicability of implementing it in Canada.


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