Race/Ethnicity, Spirometry Reference Equations and Prediction of Incident Clinical Events: The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study

Dietary protein has been shown to increase urinary Ca excretion in randomised controlled trials, and diets high in protein may have detrimental effects on bone health; however, studies examining the relationship between dietary protein and bone health have conflicting results. In the present study, we examined the relationship between dietary protein (total, animal and vegetable protein) and lumbar spine trabecular volumetric bone mineral density (vBMD) among participants enrolled in the Multi-Ethnic Study of Atherosclerosis (n 1658). Protein intake was assessed using a FFQ obtained at baseline examination (2000–2). Lumbar spine vBMD was measured using quantitative computed tomography (2002–5), on average 3 years later. Multivariable linear and robust regression techniques were used to examine the associations between dietary protein and vBMD. Sex and race/ethnicity jointly modified the association of dietary protein with vBMD (P for interaction = 0·03). Among white women, higher vegetable protein intake was associated with higher vBMD (P for trend = 0·03), after adjustment for age, BMI, physical activity, alcohol consumption, current smoking, educational level, hormone therapy use, menopause and additional dietary factors. There were no consistently significant associations for total and animal protein intakes among white women or other sex and racial/ethnic groups. In conclusion, data from the present large, multi-ethnic, population-based study suggest that a higher level of protein intake, when substituted for fat, is not associated with poor bone health. Differences in the relationship between protein source and race/ethnicity of study populations may in part explain the inconsistent findings reported previously.

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Socioeconomic Position, Race/Ethnicity, and Inflammation in the Multi-Ethnic Study of Atherosclerosis

Circulation ◽

10.1161/circulationaha.107.706226 ◽

2007 ◽

Vol 116 (21) ◽

pp. 2383-2390 ◽

Cited By ~ 100

Author(s):

Nalini Ranjit ◽

Ana V. Diez-Roux ◽

Steven Shea ◽

Mary Cushman ◽

Hanyu Ni ◽

...

Keyword(s):

Socioeconomic Position ◽

Ethnic Study ◽

Race Ethnicity

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Abstract P315: Is Self-rated Health Associated With Ideal Cardiovascular Health? The Multi-Ethnic Study of Atherosclerosis

Circulation ◽

10.1161/circ.137.suppl_1.p315 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Olatokunbo I Osibogun ◽

Oluseye Ogunmoroti ◽

Erica S Spatz ◽

Gregory L Burke ◽

Erin D Michos

Keyword(s):

Cardiovascular Health ◽

Reference Group ◽

Multinomial Logistic Regression ◽

Heart Association ◽

Cross Sectional ◽

Ethnic Study ◽

Ideal Cardiovascular Health ◽

Health Insurance Status ◽

Self Rated Health ◽

Race Ethnicity

Introduction: Self-rated health (SRH) is a commonly used indicator of health status. It has been identified as a determinant of health-promoting behaviors and a predictor of morbidity and mortality. However, little is known about the association between SRH and ideal cardiovascular health (CVH) as measured by the American Heart Association Life’s Simple 7 (LS7) criteria. We examined whether SRH was associated with ideal CVH, for the overall cohort and by sex and race/ethnicity. Methods: We conducted a cross-sectional analysis of 6457 men and women of 4 race/ethnicities, aged 45 to 84 years, who participated in the Multi-Ethnic Study of Atherosclerosis. SRH was measured on a 5-point Likert scale (excellent, very good, good, fair and poor). CVH was determined using the LS7 score with each of the 7 metrics scored from 0-2, and a total score ranging from 0-14. Scores of 0-8 indicate an inadequate score, 9-10, average and 11-14, optimal. Odds ratios (OR) and 95% confidence intervals were calculated for the associations between SRH and LS7 score categories using multinomial logistic regression, adjusted for age, sex, race/ethnicity, education, income, marital status, health insurance status and chronic diseases Results: The mean age (SD) of participants was 62 (10) years; 53% were women. Approximately, 16% of participants rated their health as excellent, 33% very good, 41% good and 9% poor-fair. In this population, 47% had inadequate LS7 scores, 33%, average and 20% optimal. The odds of having a higher LS7 score increased as SRH improved. Using participants who rated their health as poor-fair as the reference group, the adjusted OR for having an optimal LS7 score in the overall cohort was: excellent 3.0 (2.1-4.3); very good 1.6 (1.1-2.1); good 1.2 (0.9-1.7). A similar trend was observed in the stratified analyses by sex and race/ethnicity ( Table ) Conclusion: A more favorable SRH was associated with better CVH irrespective of sex or race/ethnicity. Further research could explore whether optimization of SRH predicts cardiovascular outcomes.

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Race/Ethnicity-Specific Associations between Smoking, Serum Leptin, and Abdominal Fat: The Multi-Ethnic Study of Atherosclerosis

Ethnicity & Disease ◽

10.18865/ed.28.4.531 ◽

2018 ◽

Vol 28 (4) ◽

pp. 531-538

Author(s):

Sina Kianoush ◽

Andrew P. DeFilippis ◽

Carlos J. Rodriguez ◽

Mahmoud Al Rifai ◽

Emelia J. Benjamin ◽

...

Keyword(s):

African Americans ◽

Abdominal Fat ◽

Linear Regression Models ◽

Serum Leptin ◽

Ethnic Study ◽

Outcomes Measures ◽

Former Smokers ◽

Race Ethnicity ◽

The Difference ◽

Never Smokers

Objective: Smoking is a well-known cardiovascular risk factor associated with weight loss. We aimed to evaluate the association between smoking, serum leptin levels, and abdominal fat.Design: Cross-sectionalSetting: Data from examinations 2 or 3 (2002-2005) of the Multi-Ethnic Study of Atherosclerosis (MESA)Participants: 1,875 asymptomatic, community-dwelling adultsMain Outcomes Measures: We used multivariable linear regression models to assess the race/ethnicity-specific associations between smoking, serum loge-leptin levels, and computed tomography ascertained abdominal fat. Results were adjusted for demographic and relevant clinical covariates.Results: Participants (mean age 64.5±9.6 years; 50.6% women; 42.2% former, 11.4% current smokers) were White (40.1%), Hispanic (25.8%), African American (21.1%), and Chinese (13.0%). Overall, median (25th – 75th percentile) leptin levels were significantly lower among current (11.14 ng/mL; 4.13 – 26.18) and former smokers (11.68 ng/mL; 4.72 – 27.57), as compared with never smokers (15.61 ng/mL; 3.05 – 30.12) (P<.001). The difference in median leptin levels between current and never smokers were significantly higher for Hispanics (Δ9.64 ng/mL) and African Americans (Δ8.81 ng/mL) than Whites (Δ2.10 ng/mL) and Chinese (Δ4.70 ng/mL) (P<.001). After adjustment for total abdominal fat, loge- leptin levels remained lower for former (-.14 [-.22 – -.07]) and current (-.17 [-.28 – -.05]) smokers, compared with never smokers. Results differed by race/ethnicity, with significantly lower loge-leptin levels observed only among current and former African Americans and Hispanic smokers, compared with their never smoker counterparts. (Ps for interaction <.05)Conclusions: Among smokers, leptin levels significantly vary by race/ethnicity. Former and current smoking are associated with lower leptin levels, although this may be restricted to Hispanics and African Americans. Ethn Dis. 2018;28(4):531-538; doi:10.18865/ed.28.4.531

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Impact of Race, Ethnicity, and Multimodality Biomarkers on the Incidence of New-Onset Heart Failure With Preserved Ejection Fraction (from the Multi-Ethnic Study of Atherosclerosis)

The American Journal of Cardiology ◽

10.1016/j.amjcard.2016.02.017 ◽

2016 ◽

Vol 117 (9) ◽

pp. 1474-1481 ◽

Cited By ~ 29

Author(s):

Michael G. Silverman ◽

Birju Patel ◽

Ron Blankstein ◽

Joao A.C. Lima ◽

Roger S. Blumenthal ◽

...

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Preserved Ejection Fraction ◽

Ethnic Study ◽

Race Ethnicity ◽

New Onset

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Race/Ethnicity, Residential Segregation, and Exposure to Ambient Air Pollution: The Multi-Ethnic Study of Atherosclerosis (MESA)

American Journal of Public Health ◽

10.2105/ajph.2014.302135 ◽

2014 ◽

Vol 104 (11) ◽

pp. 2130-2137 ◽

Cited By ~ 64

Author(s):

Miranda R. Jones ◽

Ana V. Diez-Roux ◽

Anjum Hajat ◽

Kiarri N. Kershaw ◽

Marie S. O’Neill ◽

...

Keyword(s):

Air Pollution ◽

Residential Segregation ◽

Ambient Air ◽

Ambient Air Pollution ◽

Ethnic Study ◽

Race Ethnicity

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Interactions Between Race/Ethnicity and Anthropometry in Risk of Incident Diabetes: The Multi-Ethnic Study of Atherosclerosis

American Journal of Epidemiology ◽

10.1093/aje/kwq100 ◽

2010 ◽

Vol 172 (2) ◽

pp. 197-204 ◽

Cited By ~ 24

Author(s):

P. L. Lutsey ◽

M. A. Pereira ◽

A. G. Bertoni ◽

N. R. Kandula ◽

D. R. Jacobs

Keyword(s):

Incident Diabetes ◽

Ethnic Study ◽

Race Ethnicity

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Spirometric reference values for Malagasy adults aged 18–73 years

European Respiratory Journal ◽

10.1183/09031936.00114914 ◽

2014 ◽

Vol 45 (4) ◽

pp. 1046-1054 ◽

Cited By ~ 12

Author(s):

Julia Ratomaharo ◽

Olinto Linares Perdomo ◽

Dave S. Collingridge ◽

Rabezanahary Andriamihaja ◽

Matthew Hegewald ◽

...

Keyword(s):

African American Male ◽

Vital Capacity ◽

Healthy Adult ◽

Forced Expiratory Volume ◽

Nhanes Iii ◽

Prediction Equations ◽

European Respiratory Society ◽

Health And Nutrition ◽

Reference Equations ◽

Race Ethnicity

The American Thoracic Society (ATS) and European Respiratory Society (ERS) recommend that spirometry prediction equations be derived from samples of similar race/ethnicity. Malagasy prediction equations do not exist. The objectives of this study were to establish prediction equations for healthy Malagasy adults, and then compare Malagasy measurements with published prediction equations.We enrolled 2491 healthy Malagasy subjects aged 18–73 years (1428 males) from June 2006 to April 2008. The subjects attempted to meet the ATS/ERS 2005 guidelines when performing forced expiratory spirograms. We compared Malagasy measurements of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with predictions from the European Community for Steel and Coal (ECSC), the third National Health and Nutrition Examination Survey (NHANES III) and the ERS Global Lung Function Initiative (GLI) 2012 study.A linear model for the entire population, using age and height as independent variables, best predicted all spirometry parameters for sea level and highland subjects. FEV1, FVC and FEV1/FVC were most accurately predicted by NHANES III African-American male and female, and by GLI 2012 black male and black and South East Asian female equations. ECSC-predicted FEV1, FVC and FEV1/FVC were poorly matched to Malagasy measurements.We provide the first spirometry reference equations for a healthy adult Malagasy population, and the first comparison of Malagasy population measurements with ECSC, NHANES III and GLI 2012 prediction equations.

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