"Fullarazirman" Nano Water Soluble Fullerene C60-Manganese (II) Tri-Adduct Complex with Anti-Cancer Activity Comparable to Doxorubicin

2020 ◽  
Vol 16 (4) ◽  
pp. 481-491
Author(s):  
Sujeet Kumar Thakur ◽  
Saibal Saha ◽  
Prasenjit Guchhait ◽  
Sambasivan Venkat Eswaran
Keyword(s):  
Materials Science ◽  
Ultra Violet ◽  
Water Soluble ◽  
Complex Iii ◽  
Cancer Drug ◽  
Ionization Mass ◽  
Gravimetric Analysis ◽  
X Ray ◽  
Anti Cancer ◽  
Cancer Activity

There is continued interest in Nano Carbon Materials (NCMs) and two of these, Fullerene C60 and Graphene have received Nobel prizes. Low solubility in most solvents has been a stumbling block in their industrial use. We report here the successful synthesis of a new water soluble tri-adduct of Fullerene C60 using a two-step procedure to obtain the water soluble s-Tri-(1-aziridino-2, 3-dimethoxy-benzene-5-carboxylato-6-carboxylic acid)-H-Fullerene C60-Manganese (II) Complex ( III ). Matrix Assisted Laser Desorption Ionization Mass Spectrometry (MALDI-MS) and Electron Paramagnetic Resonance (EPR) studies critically helped recognize the presence of an atom of Manganese in the complex. The new complex was also characterized by Ultra violet-Visible (UV-Vis.). Fourier Transform-Infra Red (FT-IR) spectroscopy, Energy Dispersive X-ray analysis (EDAX), Scanning Electron Microscopy (SEM), Thermal Gravimetric Analysis (TGA), and powder X-ray diffraction. The new compound has been shown to possess anti-cancer activity comparable to Doxorubicin, currently the most used anti-cancer drug. This new water soluble Fullerene C60-Manganese (II) tri-adduct complex ( III ) thus holds much promise for the fields of biology, biochemistry, medicine, and materials science.

Surfactant-Based Anhydrous Nano Carrier System for Poorly Aqueous Soluble Anti-Cancer Drugs

2021 ◽  
pp. 413-432
Author(s):  
Shekhar Verma ◽  
Nagendra Chandrawanshi ◽  
Vishal Jain
Keyword(s):  
Controlled Release ◽  
Primary Objective ◽  
Water Soluble ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
Carrier System ◽  
Anti Cancer ◽  
New Chemical Entities ◽  
Poorly Water Soluble ◽  
Nano Emulsion

Around 40% of new chemical entities and drugs are lipophilic or poor aqueous soluble in nature. Among them many anti-cancer drugs are also consist lipophilic properties. Available poorly water soluble anti-cancer drugs are paclitaxel, etoposide, and docetaxel. To get better stability of those anti-cancer drug via encapsulation and searching suitable carrier system for the controlled release, design and development requires of anhydrous nano carrier system. However, to deliver and entrapment of these kind of anti-cancer drugs are very essential with avoidance of water free preparation to get suitable controlled release application and achieve targeting site. The primary objective of proposed chapter is to develop and design novel stable anhydrous or non-aqueous nano emulsion carrier system and provide suitable carrier system for poorly aqueous soluble anti-cancer drugs. Another important aim is to design and develop better stabilizing agent by combining different type of surfactant, co-surfactant, and co-solvent.

scholarly journals Electron density of a new EGFR Tyrokinase-inhibitor at 100 K, consideration of different models

2008 ◽  
Vol 223 (8) ◽  
Author(s):  
Stefan Mebs ◽  
Anja Lüth ◽  
Wolfgang Löwe ◽  
Carsten Paulmann ◽  
Peter Luger
Keyword(s):  
High Resolution ◽  
Synchrotron Radiation ◽  
Electron Density ◽  
Electron Shell ◽  
Cancer Drug ◽  
Outer Electron ◽  
Data Set ◽  
X Ray ◽  
Atomic Properties ◽  
Anti Cancer

AbstractThe electron density (ED) of a substituted 4-(indol-3-yl)-quinazoline, a newly developed anti-cancer drug, was determined from a high resolution X-ray data set measured at 100 K using synchrotron radiation. Because the structure contains a chlorine atom, which has a diffuse outer electron shell and is therefore beyond standard modeling, the influence of the model on the bond topological and atomic properties was studied following Bader's approach of ‘Atoms In Molecules’ (AIM). The expansion/contraction parameters

scholarly journals Nelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activity

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 9 ◽  
Author(s):  
Tomas Koltai
Keyword(s):  
Cancer Treatment ◽  
Anticancer Activity ◽  
Protease Inhibitors ◽  
Mode Of Action ◽  
Fatty Acid Synthase ◽  
Molecular Mechanisms ◽  
Cancer Drug ◽  
Cancer Type ◽  
Anti Cancer ◽  
Cancer Activity

Objective:To review the mechanisms of anti-cancer activity of nelfinavir and other protease inhibitors (PIs) based on evidences reported in the published literature.Methods:We extensively reviewed the literature concerning nelfinavir (NFV) as an off target anti-cancer drug and other PIs. A classification of PIs based on anti-cancer mode of action was proposed. Controversies regarding nelfinavir mode of action were also addressed.Conclusions:The two main mechanisms involved in anti-cancer activity are endoplasmic reticulum stress-unfolded protein response pathway and Akt inhibition. However there are many other effects, partially dependent and independent of those mentioned, that may be useful in cancer treatment, including MMP-9 and MMP-2 inhibition, down-regulation of CDK-2, VEGF, bFGF, NF-kB, STAT-3, HIF-1 alfa, IGF, EGFR, survivin, BCRP, androgen receptor, proteasome, fatty acid synthase (FAS), decrease in cellular ATP concentration and upregulation of TRAIL receptor DR5, Bax, increased radiosensitivity, and autophagy. The end result of all these effects is slower growth, decreased angiogenesis, decreased invasion and increased apoptosis, which means reduced proliferation and increased cancer cells death.PIs may be classified according to their anticancer activity at clinically achievable doses, in AKT inhibitors, ER stressors and Akt inhibitors/ER stressors.Beyond the phase I trials that have been recently completed, adequately powered and well-designed clinical trials are needed in the various cancer type settings, and specific trials where NFV is tested in association with other known anti-cancer pharmaceuticals should be sought, in order to find an appropriate place for NFV in cancer treatment.The analysis of controversies on the molecular mechanisms of NFV hints to the possibility that NFV works in a different way in tumor cells and in hepatocytes and adipocytes.

Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2(NH3)2(salH)2] (salH2=salicylic acid)

2004 ◽  
Vol 98 (8) ◽  
pp. 1361-1366 ◽  
Author(s):  
Barry Coyle ◽  
Malachy McCann ◽  
Kevin Kavanagh ◽  
Michael Devereux ◽  
Vickie McKee ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Salicylic Acid ◽  
X Ray ◽  
Anti Cancer ◽  
Anti Fungal ◽  
Cancer Activity

MICROWAVE-ASSISTED RAPID BIOSYNTHESIS OF STABLE SILVER NANOPARTICLES USING CLOVE BUDS (SYZYGIUM AROMATICUM) SOLUTION

Nano LIFE ◽  
2012 ◽  
Vol 02 (02) ◽  
pp. 1250012 ◽  
Author(s):  
RAGHUNANDAN DESHPANDE ◽  
MAHESH D. BEDRE ◽  
BASAVARAJA SALIMATH ◽  
BALAJI D. SAWLE ◽  
MANJUNATH S. YALAGATTI ◽  
...  
Keyword(s):  
Bathochromic Shift ◽  
Ultra Violet ◽  
Water Soluble ◽  
Noble Metal Nanoparticles ◽  
Syzygium Aromaticum ◽  
X Ray Diffraction ◽  
X Ray ◽  
Ftir Studies ◽  
Microwave Assistance ◽  
Extended Work

This is an extended work on the biosynthesis of noble metal nanoparticles using dried clove buds. Here microwave assistance is taken not only for accelerating the reaction rate but also for denaturing the proteins and other enzymes, which will prevent obtaining desired functionalized nanoparticles. FTIR studies infer that nanoparticles thus obtained are found adsorbed with water soluble organic moieties, mostly flavonoids. The bathochromic shift from 320 nm in ultra-violet range indicates the involvement of water soluble bio-moieties of the clove in the formation of AgNP . X-ray diffraction (XRD) spectrum confirmed that the AgNP are crystalline in nature. The surface morphology is studied using FESEM, TEM and AFM techniques infer that the AgNP are well dispersed, roughly spherical in shape and are in the range of 30–60 nm. The AgNP with the organic moiety will have synergic antimicrobial action.

scholarly journals Case report of a laryngeal squamous cell carcinoma treated with artesunate

2002 ◽  
Vol 10 (4) ◽  
pp. 279-280 ◽  
Author(s):  
Narenda Singh ◽  
Krishna Verma
Keyword(s):  
Quality Of Life ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Present Report ◽  
Water Soluble ◽  
Cancer Drug ◽  
Anti Cancer

This present report describes the treatment of a laryngeal squamous cell carcinoma patient with the water-soluble artemisinin analog, artesunate Artemisinin is a novel anti-cancer drug with demonstrated results in killing cancer cells. Artesunate injections and tablets were administered to the patient over a period of nine months. The tumor was significantly reduced (by 70%) after two months of treatment. Overall, the artesunate treatment of the patient was beneficial in prolonging and improving the quality of life Artemisinin and its analogs offer promise for cancer therapy.

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