Honokiol-Based Nanomedicine Decorated with Ethylene Glycols Derivatives Promotes Antitumor Efficacy

Honokiol-loaded nanoparticles (HK-loaded NPs) exhibit potential antitumor activity; however, the factors affecting their antitumor efficacy are still unclear and need to be explored. This research was aimed to systematically estimate the influence of feed weight ratio (FWR) and nanocarrier structure on antitumor activity. Accordingly, three types of ethylene glycol derivatives, including linear poly(ethylene glycol) with molar mass of 2000 (PEG45), first and second generation oligo(ethylene glycol) dendrons (G1 and G2) were used as nanocarriers, and a series of HK-loaded NPs with different FWR were prepared successfully using the evaporation-ultrasonication method. These NPs showed similar stability but demonstrated differences with respect to particle size, morphology, cumulative profile, and antitumor efficacy. The influence of the FWR was studied using G1 dendrons as nanocarriers; the results indicated that the particle size and morphology of G1 NPs were significantly affected, and G1 NPs (8/1), with the FWR of 8/1 for HK versus G1 dendron, exhibited the highest antitumor activity among all G1 NPs. Furthermore, the influence of nanocarrier structure was investigated at the FWR of 4/1; the findings revealed reduction in the particle diameter from 280 nm to 109 nm and change in morphology from sphere to flower-like structure with an increase in the branch degree from linear to dendron. Moreover, G2 NPs (4/1), with the FWR of 4/1 for HK versus G2 dendron, carrying the highest branch degree exhibited the greatest antitumor efficacy among all. These results are suggestive of influence of particle size and morphology on antitumor efficacy of HK-loaded NPs. Conclusively, this study demonstrated nanocarrier structure and the FWR significantly affect the antitumor efficacy of NPs, which should be optimized for designing nanoscale delivery systems.

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Direct manipulation of particle size and morphology of ordered mesoporous silica by flow synthesis

RSC Advances ◽

10.1039/c4ra16679e ◽

2015 ◽

Vol 5 (18) ◽

pp. 13331-13340 ◽

Cited By ~ 27

Author(s):

T. N. Ng ◽

X. Q. Chen ◽

K. L. Yeung

Keyword(s):

Particle Size ◽

Mesoporous Silica ◽

Hollow Spheres ◽

Ordered Mesoporous Silica ◽

Direct Manipulation ◽

Flow Synthesis ◽

Precise Control ◽

Ordered Mesoporous ◽

Particle Size And Morphology ◽

Size And Morphology

Flow-synthesis of mesoporous silica allows deliberate and precise control over the size and shapes and enables the preparation of complex microstructures (i.e., hollow spheres).

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Dehumidified Air-Assisted Spray-Drying of Cloudy Beetroot Juice at Low Temperature

Applied Sciences ◽

10.3390/app11146578 ◽

2021 ◽

Vol 11 (14) ◽

pp. 6578

Author(s):

Aleksandra Jedlińska ◽

Alicja Barańska ◽

Dorota Witrowa-Rajchert ◽

Ewa Ostrowska-Ligęza ◽

Katarzyna Samborska

Keyword(s):

Particle Size ◽

Physicochemical Properties ◽

Spray Drying ◽

Low Temperatures ◽

Beetroot Juice ◽

Particle Size And Morphology ◽

Size And Morphology ◽

Tapped Density ◽

Lower Loss ◽

Better Than

This paper discusses the physicochemical properties of powders obtained by spray drying of cloudy beetroot juice, using dehumidified air in variants with or without carriers. The inlet air temperature was 130 °C or 90 °C, and the addition of the carriers was at a ratio of juice to carrier solids of 3:2. In the obtained powders, the following physicochemical properties were determined: water content and water activity, apparent density, loose and tapped density, porosity, flowability, particle size and morphology, and the content and retention of betalains. It was possible to dry cloudy beetroot juice without the use of carriers at low temperatures (90 or 130 °C). The 100% beetroot powders were characterized by satisfactory physicochemical properties, often better than those with carriers (including lower hygroscopicity and higher color saturation and yield). A lower loss of betalains was found for the powders with the addition of carriers. The best process yields were obtained for the powder without carriers at 130 °C and 90 °C.

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Synthesis and Properties of (Bi0.5Na0.5)TiO3 Powders by Hydrothermal Method

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.336-338.140 ◽

2007 ◽

Vol 336-338 ◽

pp. 140-142

Author(s):

Jun Jie Hao ◽

Xiao Hui Wang ◽

Shi Yun Lin ◽

Long Tu Li

Keyword(s):

Particle Size ◽

Hydrothermal Method ◽

Single Phase ◽

Piezoelectric Ceramics ◽

Treatment Temperature ◽

Lead Free ◽

Excellent Candidate ◽

Traditionally Prepared ◽

Particle Size And Morphology ◽

Size And Morphology

Na0.5Bi0.5TiO3 (NBT) is considered to be an excellent candidate for lead-free piezoelectric ceramics. In this study, we propose a hydrothermal method for the preparation of single phase NBT powder at relatively low treatment-temperature. The particle size and morphology of the synthesized powders were examined by SEM. The powders were further pressed into disk and sintered at 1120°C/2h in air, and its properties and microstructure were compared with traditionally prepared samples.

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Synthesis of Spherical Silica by Sol-Gel Method and Its Application as Catalyst Support

ASEAN Journal of Chemical Engineering ◽

10.22146/ajche.50086 ◽

2011 ◽

Vol 10 (2) ◽

pp. 25

Author(s):

Anirut Leksomboon ◽

Bunjerd Jongsomjit

Keyword(s):

Particle Size ◽

Ethylene Glycol ◽

Specific Surface ◽

Surface Area ◽

Specific Surface Area ◽

Sol Gel ◽

Weight Ratio ◽

Gel Method ◽

Sol Gel Method ◽

Spherical Silica

In this present study, the spherical silica support was synthesized from tetraethyloxysilane (TEOS), water, sodium hydroxide, ethylene glycol and n-dodecyltrimethyl ammonium bromide (C12TMABr). The particle size was controlled by variation of the ethylene glycol co-solvent weight ratio of a sol-gel method preparation in the range of 0.10 to 0.50. In addition, the particle size apparently increases with high weight ratio of co-solvent, but the particle size distribution was broader. The standard deviation of particle diameter is large when the co-solvent weight ratio is more than 0.35 and less than 0.15. However, the specific surface area was similar for all weight ratios ranging from 1000 to 1300 m2/g. The synthesized silica was spherical and has high specific surface area. The cobalt was impregnated onto the obtained silica to produce the cobalt catalyst used for CO2 hydrogenation.</

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Effect of particle size and morphology on surface thermodynamics and photocatalytic thermodynamics of nano-Cu 2 O

Journal of Environmental Chemical Engineering ◽

10.1016/j.jece.2017.08.034 ◽

2017 ◽

Vol 5 (5) ◽

pp. 4447-4453 ◽

Cited By ~ 6

Author(s):

Huanfeng Tang ◽

Xiaolin Liu ◽

Ming Xiao ◽

Zaiyin Huang ◽

Xuecai Tan

Keyword(s):

Particle Size ◽

Surface Thermodynamics ◽

Effect Of Particle Size ◽

Particle Size And Morphology ◽

Size And Morphology

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Particle-size and morphology dependence of the preferred interface orientation in LiFePO4 nano-particles

Journal of Materials Chemistry A ◽

10.1039/c4ta02935f ◽

2014 ◽

Vol 2 (37) ◽

pp. 15437-15447 ◽

Cited By ~ 28

Author(s):

Aziz Abdellahi ◽

Oncu Akyildiz ◽

Rahul Malik ◽

Katsuyo Thornton ◽

Gerbrand Ceder

Keyword(s):

Particle Size ◽

First Principles ◽

Nano Particles ◽

Particle Size And Morphology ◽

Interface Orientation ◽

Size And Morphology

Using calculations based on first principles, we demonstrate that the preferred interface in singles LiFePO4 particles depends both on the particle size and morphology.

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Solution-SBR Powders

Rubber Chemistry and Technology ◽

10.5254/1.3534940 ◽

1976 ◽

Vol 49 (1) ◽

pp. 126-139

Author(s):

D. N. Schulz ◽

L. E. Calihan ◽

D. P. Tate

Keyword(s):

Powder Particle Size ◽

Factors Affecting ◽

Molecular Weights ◽

Bound Rubber ◽

Powder Blends ◽

Powder Particles ◽

Filler Dispersion ◽

Particle Size And Morphology ◽

Size And Morphology ◽

Powdered Rubber

Abstract This paper describes the advantageous cross-fertilization of solution-masterbatch technology and powdered-rubber processing. A nonlatex method has been developed for the preparation of free-flowing solution-SBR powders. The factors affecting powder particle size and morphology have been identified. Optimization of the preparative variables has resulted in dry-blendable solution-SBR powders. As a consequence of a low shear history, the solution-SBR powder blends show distinctive rubber-filler, rheological, and physical properties. For example, unvulcanized solution-SBR powder compounds evince higher molecular weights and lower bound-rubber contents than conventional mixes. Yet, the microscopic filler dispersion of these two types of compounds appears similar. Uncured solution-SBR powder blends also exhibit stiffer rheological behavior than conventional mixes. Furthermore, this stiffness tends to persist in the vuleanizates derived from these powdered compounds. Vulcanizate excellence depends primarily upon fineness of the powder particles and absence of free filler. Conditions have been found which permit the direct ribbon extrusion of tire tread, without prior compacting or milling. Conventional single-screw ribbon- tread extruders are sufficient to produce treads of high quality.

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