Novel Drug Delivery System Based on Ginsenoside Rb1 Loaded to Chitosan/Alginate Nanocomposite Films

2019 ◽  
Vol 19 (6) ◽  
pp. 3293-3300 ◽  
Author(s):  
Thai Hoang ◽  
Kavitha Ramadass ◽  
Thach Thi Loc ◽  
Tran Thi Mai ◽  
Le Duc Giang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Panax Notoginseng ◽  
Nanocomposite Films ◽  
Burst Release ◽  
Herbaceous Plant ◽  
Ginsenoside Rb1 ◽  
Scanning Calorimetry ◽  
Release Process

Recently, drug delivery using natural and biodegradable nanoparticles has attracted huge attention. This study focused to deliver an anti-cancer and anti-inflammatory drug Ginsenoside Rb1 through chitosan-Alginate nanocomposite film prepared by solution method. Ginsenoside Rb1 is a dammaran saponin group, which is extracted from an herbaceous plant Panax notoginseng. Ginsenoside loaded alginate-chitosan nanocomposite films were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) methods. The FTIR spectra of alginate/chitosan/ginsenoside Rb1 nanocomposite films show that chitosan, alginate, and ginsenoside Rb1 are linked through the hydrogen bonding and dipolar–dipolar interactions. The FESEM image indicates that the chitosan and ginsenoside Rb1 dispersed well in the alginate matrix. The DSC diagrams display that melting temperature of alginate/chitosan/ginsenoside Rb1 nanocomposite films higher than that of chitosan and lower than that of alginate. It means that alginate and chitosan interact together. Investigation of the ginsenoside Rb1 release from alginate/chitosan/ginsenoside Rb1 nanocomposite films at different pH solutions and different ginsenoside Rb1 content has been carried out by ultraviolet-visible spectroscopy method. The rate of drug release is proportional to the increase in pH solution and inversely proportional to the content of loaded ginsenoside Rb1. The Rb1 release process includes two stages: burst release in the first 10 hours, then constant release afterwards. The suitable ratio of alginate/chitosan to prepare the alginate/chitosan/ginsenoside Rb1 nanocomposite films for further investigations was found out to be 8:2. Ginsenoside Rb1 release process from alginate/chitosan/ginsenoside Rb1 nanocomposite films was believed to be first-order kinetics in the first stage, and then the Rb1 release complies with Higuchi kinetic model in the slow release stage. This study demonstrated the novel synthesis methodology to design drug delivery system based on ginsenoside Rb1 loaded to chitosan/alginate nanocomposite films.

scholarly journals Applicability of Gum Karaya in the Preparation and in Vitro Evaluation of Losartan Potassium as Chronotherapeutic Drug Delivery System

2015 ◽  
Vol 7 (1-2) ◽  
pp. 65-74
Author(s):  
K. Latha ◽  
V. V. Srikanth ◽  
S. A. Sunil ◽  
N. R. Srinivasa ◽  
M. U. Uhumwangho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tensile Strength ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lag Time ◽  
Losartan Potassium ◽  
In Vitro Dissolution ◽  
Burst Release ◽  
Gum Karaya

The objective of this investigation is to study the applicability of gum karaya, the natural gum for the preparation and in vitro evaluation of losartan potassium, as Chronotherapeutic Drug Delivery System (ChDDS). The compression-coated timed-release tablets (CCT) containing losartan potassium in the core tablet were prepared by dry coating technique with different ratios of gum karaya as the outer coat. The parameters investigated were tensile strength, friability, in vitro dissolution studies and drug concentration. The optimized formulation was further characterized by powder XRD and FTIR to investigate interactions and no interactions observed. The tensile strength and friability of all the CCT were between 1.06-1.23 MN/m2 and < 0.3% respectively.  All the CCT showed a clear lag time before a burst release of drug. However, the lag time of drug release increased as the amount of gum karaya in the outer layer increased. For instance, the lag time of LGK1, LGK2, LGK3, LGK4, LGK5, LGK6 and LGK7 were 16, 10.5, 5.5, 3, 2, 1.5 and 0.5 hrs respectively.  The drug content of all the CCT was >98%. Formulation LGK3 was taken as an optimized formulation which can be exploited to achieve ChDDS of losartan potassium for the treatment of hypertension. 

DEVELOPMENT AND EVALUATION OF ZIPRASIDONE LOADED SOLID SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEM

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (08) ◽  
pp. 53-60
Author(s):  
Purushottam Patil ◽  
Malik Shaikh ◽  
Paresh Mahaparale
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Physical Adsorption ◽  
Gastrointestinal Transit ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Scanning Calorimetry ◽  
Poorly Water Soluble

Solid self-micro emulsification technique is the new approach for poorly water-soluble and poorly bioavailable drugs by allowing the drug substance to be incorporated into the oil phase and thus having the ability to permeate the GI membrane to a faster extent. Oleic acid, Tween 80, methanol and colloidal silicon dioxide were used as penetrant, surfactant, co-surfactant and adsorbent, respectively. The interaction between drug and excipients was examined by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The results of DSC and FTIR studies did not reveal any possible drug-excipient interactions. The conversion of liquid self-microemulsifying drug delivery system (SMEDDS) into the solid SMEDDS increases the stability of the emulsion formulation achieved by physical adsorption of an adsorbent material. The release of drug from SMEDDS formulation is justified by in-vitro dissolution studies. SMEDDS increases the solubility of the drug and improves the bioavailability, without disturbing gastrointestinal transit. SMEDDS has the potential to provide a useful oral solid dosage form for the poorly water-soluble drug ziprasidone.

scholarly journals ASSESSMENT OF SELF-EXTRACTED CELLULOSE FROM ORYZA SATIVA FOR DESIGN OF CONTROLLED DRUG DELIVERY SYSTEM OF DALFAMPRIDINE

2019 ◽  
pp. 338-345
Author(s):  
JEEVANA JYOTHI B ◽  
MOUNIKA M
Keyword(s):  
Drug Delivery ◽  
Oryza Sativa ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Delivery ◽  
Magnesium Stearate ◽  
Dicalcium Phosphate ◽  
Burst Release ◽  
Dsc Analysis ◽  
Controlled Drug Delivery System

Objectives: The main objective of the present work includes extraction of cellulose from Oryza sativa (OS), characterization of cellulose, development of controlled release tablet dalfampridine using cellulose of OS, and in vitro evaluation. Methods: Dry powdered OS husk sample was extracted with a mixture of hexane and methanol (2:1, v/v) using soxhlation method and was characterized by solubility, melting point determination, differential scanning calorimetry (DSC), and Fourier-transform infrared (FTIR) analysis. Compatibility between dalfampridine and the mixture of cellulose with dalfampridine was confirmed by FTIR and DSC analysis. Then, controlled drug delivery system of dalfampridine were prepared as directly compressed tablets using various compositions containing OS cellulose, hydroxypropyl methylcellulose (HPMC), dicalcium phosphate, and magnesium stearate (8 nos. F1 to f8) and were evaluated. Results: Cellulose was extracted from OS extract to possess its ideal characteristics. Dalfampridine and its mixture with cellulose were compatible according to FTIR and DSC analysis. Directly compressed tablets made with 10 mg of dalfampridine and OS cellulose, HPMC, dicalcium phosphate, and magnesium stearate evidenced prolonged and controlled drug delivery of dalfampridine for 12 h. Formulation made with OS cellulose 250 mg, HPMC 20 mg, dicalcium phosphate 40 mg, and magnesium stearate 5 mg was ideal without burst release. Conclusion: Cellulose extracted from OS is used successfully for the production of directly compressed tablets of dalfampridine to elicit optimum characteristics including controlled drug delivery for 12 h.

Ginsenoside nanoparticle: a new green drug delivery system

2016 ◽  
Vol 4 (3) ◽  
pp. 529-538 ◽  
Author(s):  
Lin Dai ◽  
Kefeng Liu ◽  
Chuanling Si ◽  
Luying Wang ◽  
Jing Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Ginsenoside Rb1 ◽  
Anticancer Effects ◽  
System P

Ginsenoside Rb1 is shown to self-assemble with anticancer drugs to form stable nanoparticles, which have greater anticancer effectsin vitroandin vivothan the free drugs.

Formulation and Evaluation of Pulsatile Drug Delivery System of Atenolol

2020 ◽  
Vol 6 (1) ◽  
pp. 45-49
Author(s):  
Sudipta Das ◽  
Baishali Ghosh ◽  
Surita Basu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ethyl Cellulose ◽  
Methyl Cellulose ◽  
Burst Release ◽  
Direct Compression ◽  
Optimum Result ◽  
Pulsatile Drug Delivery ◽  
Model Drug

The objective of the present study was formulation and evaluation of pulsatile release tablets of Atenolol. A tablet system consisting of cores which was coated with layers of swelling and rupturable coatings. Cores containing Atenolol as model drug were prepared by direct compression with appropriate ratios of lactose and microcrystalline cellulose and then coated sequentially with different ratios of an inner swelling layer containing HPMC and an outer rupturable layer of Ethyl Cellulose. The effect of level of swelling layer and rupturable coating was investigated. The different formulation press coated by using different weight ratios of Hydroxy Propyl Methyl Cellulose (HPMC) / Ethyl Cellulose (EC) / both HPMC and EC. The optimum result was achieved in formulation containing HPMC: EC weight ratios. The F3 batch achieved a highest burst release after the lag time which is applicable pulsatile drug delivery system of Atenolol.

Chronomodulated Delivery of Pantoprazole for Nocturnal Hyperacidity

2015 ◽  
Vol 8 (4) ◽  
pp. 3038-3044
Author(s):  
Mahalakshmi P ◽  
Suriyaprakash T N K ◽  
S. Lakshmana Prabu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Lag Time ◽  
Delivery Systems ◽  
Burst Release ◽  
Dependent Manner ◽  
Compression Technique ◽  
Pulsatile Drug Delivery

The objective of this work was to design and evaluate an oral site-specific, pulsatile drug delivery system containing Pantoprazole sodium which can be targeted to colon in a pH and time dependent manner, to modulate the drug level in synchrony with the circadian rhythm of nocturnal hyperacidity. Five different composition of Core tablets were prepared by direct compression technique. Based on the release studies of core tablets, nine different compositions of press coated tablets were prepared and analyzed. The press coated tablet further coated by using five different proportions of Eudragit RS PO for providing consistent, reproducible chronomodulated release profile. Formulation FPC3 is more suitable among the formulations to design pulsatile release formulations of pantoprazole sodium for 6 hours lag time. After this lag time burst release was observed which exhibited sigmodial release pattern and that was considered to be an ideal for the pulsatile drug delivery system. The chronomodulated drug delivery systems for pantoprazole sodium for the treatment of hyperacidity was successfully developed and the release of the drug was sharp and complete after the lag time which is necessary for any pulsatile drug delivery systems.   

Electrospun MWCNTs/Poly(lactic-co-glycolic acid) Composite Nanofibrous Drug Delivery System

2012 ◽  
Vol 424-425 ◽  
pp. 1220-1223 ◽  
Author(s):  
Rui Ling Qi ◽  
Hui Juan Liu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carriers ◽  
Mouse Fibroblast ◽  
Burst Release ◽  
Vis Spectroscopy ◽  
Multi Walled Carbon Nanotubes ◽  
Model Drug

In this study, nanotubular materials multi-walled carbon nanotubes (MWCNTs) were used to encapsulate a model drug, doxorubicine hydrochloride (DOX). Then, the drug-loaded nanotubes (DOX/CNTs) with an optimized drug encapsulation percentage were mixed with poly (lactide-co-glycolide) (PLGA) polymer solution for subsequent electrospinning to form drug-loaded composite nanofibrous mats. The morphology was characterized using scanning electron microscopy (SEM). The proliferation of mouse fibroblast cells cultured on both PLGA and CNTs-doped PLGA fibrous scaffolds were compared through 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyl tetrazolium bromide (MTT) assay of cell viability and SEM observation of cell morphology. In vitro drug release behavior was examined using UV-vis spectroscopy. We show that the incorporation of CNTs and DOX/CNTs within the nanofibrous mats does not significantly change the morphology of the mats. In addition, our results indicate that this double-container drug delivery system (both PLGA polymer and CNTs are drug carriers) is beneficial to avoid the burst release of the drug. The drug loaded elctrospinning composite nanofibrous mats developed in this study may find various applications in tissues engineering and pharmaceutical sciences.

scholarly journals Preparation and Evaluation of a Self-Nanoemulsifying Drug Delivery System Loaded with Heparin Phospholipid Complex

2021 ◽  
Vol 22 (8) ◽  
pp. 4077
Author(s):  
Xiao-Lei Qiu ◽  
Zi-Rui Fan ◽  
Yang-Yang Liu ◽  
Ding-Fu Wang ◽  
Shi-Xin Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Thrombin Time ◽  
Phospholipid Complex ◽  
Scanning Calorimetry ◽  
Ft Ir ◽  
Preparation And Evaluation ◽  
Ft Ir Spectroscopy

A self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of heparin after oral administration, in which heparin was compounded with phospholipids to achieve better fat solubility in the form of heparin-phospholipid (HEP-Pc) complex. HEP-Pc complex was prepared using the solvent evaporation method, which increased the solubility of heparin in n-octanol. The successful preparation of HEP-Pc complex was confirmed by differential scanning calorimetry (DSC), Fourier-transform infrared (FT-IR) spectroscopy, NMR, and SEM. A heparin lipid microemulsion (HEP-LM) was prepared by high-pressure homogenization and characterized. HEP-LM can enhance the absorption of heparin after oral administration, significantly prolong activated partial thromboplastin time (APTT) and thrombin time (TT) in mice, and reduce fibrinogen (FIB) content. All these outcomes indicate that HEP-LM has great potential as an oral heparin formulation.

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