Recent Advances in Colorectal Cancer-Specific Nucleic Acid Aptamers for Diagnostic and Therapeutic Applications

2020 ◽  
Vol 12 (1) ◽  
pp. 38-43
Author(s):  
Linlin Zhou ◽  
Mengdie Zou ◽  
Wanming Li
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Chemical Properties ◽  
Tissue Penetration ◽  
Long Term Stability ◽  
Systematic Evolution ◽  
Exponential Enrichment ◽  
Cancer Diagnosis And Therapy ◽  
Single Stranded Oligonucleotide

Colorectal cancer is the third leading cause of cancer death, and its incidence is continuing to increase rapidly in developing countries. Thus, it is clinically important to achieve an early diagnosis and early treatment for colorectal cancer. Aptamers, also known as chemical antibodies, are short, single-stranded oligonucleotide ligands selected by systematic evolution of ligands by exponential enrichment (SELEX). Because of their excellent chemical properties, such as easy synthesis, controllable modifications, long-term stability, low immunogenicity, and fast tissue penetration, aptamers have good application prospects in cancer diagnosis as well as therapy, and some are in clinical trials. In this review, we discuss aptamers that have been developed for colorectal cancer, and then briefly highlight applications of aptamers in colorectal cancer diagnosis and therapy.

scholarly journals Cell-SELEX-based aptamer-conjugated nanomaterials for cancer diagnosis and therapy

2015 ◽  
Vol 2 (1) ◽  
pp. 71-84 ◽  
Author(s):  
Hong-Min Meng ◽  
Ting Fu ◽  
Xiao-Bing Zhang ◽  
Weihong Tan
Keyword(s):  
Cancer Diagnosis ◽  
Metallic Nanoparticles ◽  
Carbon Nanomaterials ◽  
Polymeric Nanoparticles ◽  
High Specificity ◽  
Diagnosis And Therapy ◽  
Systematic Evolution ◽  
Exponential Enrichment ◽  
Cancer Diagnosis And Therapy ◽  
Significant Attention

Abstract Nucleic acid aptamers, which are generated by a novel technique called SELEX (systematic evolution of ligands by exponential enrichment), have recently attracted significant attention in the field of early detection and treatment of cancer based on their numerous merits, such as high affinity, high specificity, small size, little immunogenicity, stable structures, and ease of chemical modification. Furthermore, aptamers can gain more flexibility as cancer cell targeting tools when conjugated to nanomaterials, including metallic nanoparticles, carbon nanomaterials, DNA nanodevices, and polymeric nanoparticles. We discuss the progress achieved in cancer diagnosis and therapy through the conjugation of cell-SELEX-based aptamers with different nanomaterials.

Epigenetic Modifiers and Their Potential Application in Colorectal Cancer Diagnosis and Therapy

2020 ◽  
Vol 25 (2) ◽  
pp. 95-109
Author(s):  
Sapnita Shinde ◽  
Saurabh Saxena ◽  
Vineeta Dixit ◽  
Atul K. Tiwari ◽  
Naveen K. Vishvakarma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Potential Application ◽  
Diagnosis And Therapy ◽  
Epigenetic Modifiers ◽  
Cancer Diagnosis And Therapy

scholarly journals Long-term weight loss after colorectal cancer diagnosis is associated with lower survival: The Colon Cancer Family Registry

Cancer ◽  
2017 ◽  
Vol 123 (23) ◽  
pp. 4701-4708 ◽  
Author(s):  
Jonathan M. Kocarnik ◽  
Xinwei Hua ◽  
Sheetal Hardikar ◽  
Jamaica Robinson ◽  
Noralane M. Lindor ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Weight Loss ◽  
Cancer Diagnosis ◽  
Cancer Family ◽  
Lower Survival ◽  
Colon Cancer Family Registry

Radiation Damage in Materials – Effects of Disorder

2009 ◽  
Vol 1193 ◽  
Author(s):  
Karl R. Whittle ◽  
Mark G. Blackford ◽  
Gregory R. Lumpkin ◽  
Katherine L. Smith ◽  
Nestor J. Zaluze
Keyword(s):  
Critical Temperature ◽  
Radiation Damage ◽  
Chemical Properties ◽  
Waste Form ◽  
Physical And Chemical Properties ◽  
Long Term Stability ◽  
Effects Of Disorder ◽  
Physical And Chemical ◽  
And Chemical Properties

AbstractRadiation damage and the effect on physical and chemical properties is an important component in the prediction of the long-term stability of waste form materials. As part of the ongoing goal of increasing the accuracy of long-term predictions of radiation damage, two types of material, based on proposed materials with a waste form application have been irradiated. Results have shown that Y2TiO5 (Y2.67Ti1.33O6.67), and Yb2TiO5 (Yb2.67Ti1.33O6.67), both of which are non-stoichiometric, disordered pyrochlore-based compounds, behave significantly different to the stoichiometric, ordered pyrochlore equivalent. For example the critical temperature, the temperature above which materials remain crystalline during irradiation, is found to decrease from the ordered equivalents, e.g. Y2Ti2O7. ⁡ A second material based on La2TiO5 has been found to behave differently to both La2/3TiO3 and La2Ti2O7, with a change in Tc of ∼ 200 K.

Novel biotechnology approaches in colorectal cancer diagnosis and therapy

2017 ◽  
Vol 39 (6) ◽  
pp. 785-803 ◽  
Author(s):  
Soudabeh Kavousipour ◽  
Fathemeh Khademi ◽  
Mozhdeh Zamani ◽  
Bahareh Vakili ◽  
Pooneh Mokarram
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Diagnosis And Therapy ◽  
Cancer Diagnosis And Therapy

scholarly journals Current Advances in Aptamers for Cancer Diagnosis and Therapy

Cancers ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 9 ◽  
Author(s):  
Shin-ichiro Hori ◽  
Alberto Herrera ◽  
John Rossi ◽  
Jiehua Zhou
Keyword(s):  
Cancer Diagnosis ◽  
Biomarker Discovery ◽  
Selection Process ◽  
Three Dimensional ◽  
High Affinity ◽  
Diagnosis And Therapy ◽  
Target Molecules ◽  
Exponential Enrichment ◽  
Cancer Diagnosis And Therapy ◽  
Simple Selection

Nucleic acid aptamers are single-stranded oligonucleotides that interact with target molecules with high affinity and specificity in unique three-dimensional structures. Aptamers are generally isolated by a simple selection process called systematic evolution of ligands by exponential enrichment (SELEX) and then can be chemically synthesized and modified. Because of their high affinity and specificity, aptamers are promising agents for biomarker discovery, as well as cancer diagnosis and therapy. In this review, we present recent progress and challenges in aptamer and SELEX technology and highlight some representative applications of aptamers in cancer therapy.

scholarly journals Bioapplications of Cell-SELEX-Generated Aptamers in Cancer Diagnostics, Therapeutics, Theranostics and Biomarker Discovery: A Comprehensive Review

Cancers ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 47 ◽  
Author(s):  
Xuehui Pang ◽  
Cheng Cui ◽  
Shuo Wan ◽  
Ying Jiang ◽  
Liangliang Zhang ◽  
...  
Keyword(s):  
Biomarker Discovery ◽  
Drug Carriers ◽  
Cancer Diagnostics ◽  
High Affinity ◽  
Protein Receptors ◽  
Target Molecules ◽  
Systematic Evolution ◽  
Multifunctional Molecules ◽  
Exponential Enrichment ◽  
Single Stranded Oligonucleotide

Currently, functional single-stranded oligonucleotide probes, termed aptamers, generated by an iterative technology, Systematic Evolution of Ligands by Exponential Enrichment (SELEX), are utilized to selectively target molecules or cells with high affinity. Aptamers hold considerable promise as multifunctional molecules or conjugates for challenging nanotechnologies or bioapplications now and in the future. In this review, we first describe recent endeavors to select aptamers towards live cancer cells via cell-SELEX. We then introduce several characteristic applications of selected aptamers, especially in imaging, drug delivery and therapy. In part, these advances have been made possible via synthesis of aptamer-based nanomaterials, which, by their sizes, shapes, and physicochemical properties, allow such aptamer-nanomaterial complexes to function as signal reporters or drug carriers. We also describe how these aptamer-based molecular tools contribute to cancer biomarker discovery through high-affinity recognition of membrane protein receptors.

Properties of Materials from Activated Fly Ash from Fluidized Burning

2014 ◽  
Vol 1000 ◽  
pp. 338-341
Author(s):  
Jaromír Poláček ◽  
Rostislav Šulc
Keyword(s):  
Fly Ash ◽  
Chemical Properties ◽  
Accelerated Aging ◽  
Long Term Stability ◽  
Mechanical And Physical Properties ◽  
Properties Of Materials ◽  
Physical And Chemical ◽  
Alkali Activated

This article deals with the basic properties of materials based on alkali-activated fly ash which contains a portion of fly ash produced during fluid burning. The primary task of our research was characterization of physical and chemical properties of each type of fly ash and fly ash mixture. The new materials composed of fly ash mixture and fly ash may have the similar mechanical and physical properties. The work focused on findingan appropriate technological procedure, the optimum composition of mixtures. Long-term stability was simulated by means of accelerated aging of these materials.

Nd-Sr Isotope and REE Evidence for the Long-Term Stability of HLW Glass Products and Trace Metal Migration in a Salt Repository: Corroding Basaltic Dykes in Evaporites as Natural Analogues

1997 ◽  
Vol 506 ◽  
Author(s):  
M. Steinmann ◽  
P. Stille ◽  
K. Mengel ◽  
M. Siemann ◽  
W. Bernotat
Keyword(s):  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Sr Isotope ◽  
Long Term Stability ◽  
Natural Analogues ◽  
Metal Migration ◽  
High Level ◽  
Physical And Chemical ◽  
And Chemical Properties

Basaltic dykes in salt rocks can be used in two different ways as natural analogues for high level radioactive waste (HLW) in a salt repository: In the first approach the basalts serve as analogues for the corrosion behavior of HiLW glass products during millions of years because of many similarities in their physical and chemical properties.

Long-term risk of cardiovascular disease among colorectal cancer survivors in a population-based cohort study.

2018 ◽  
Vol 36 (7_suppl) ◽  
pp. 113-113 ◽  
Author(s):  
David Baraghoshi ◽  
Makenzie L. Hawkins ◽  
Sarah Abdelaziz ◽  
Jihye Park ◽  
Yuan Wan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cardiovascular Disease ◽  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Cvd Risk ◽  
Colorectal Cancer Survivors ◽  
Increased Risk ◽  
After Cancer

113 Background: In the United States, colorectal cancer is the fourth most common cancer and one of the leading causes of cancer death. Few studies have examined the relationship between colorectal cancer survivorship and long-term cardiovascular disease (CVD) risk. Methods: Individuals diagnosed with colorectal cancer were identified using the Utah Population Database. For a comparison group, up to 5 cancer-free individuals were matched by birth year, birth state, follow-up time and sex to each cancer case. For individuals with > 10 years of follow-up, we estimated CVD risk > 10 years after cancer diagnosis. Cox regression models were used to estimate hazard ratios (HR) and 95% Confidence Intervals. Results: Among 1,749 colorectal cancer survivors who had survived for at least 10 years, 1,001 (57.2%) were diagnosed with CVD > 10 years after cancer diagnosis. Compared to the general population, colorectal cancer survivors had an increased risk of CVD > 10 years after cancer diagnosis: HR = 2.84 (95% CI = 2.59, 3.11) for hypertension; HR = 2.66 (95% CI 2.37, 2.98) for diseases of the heart; HR = 3.91 (95% CI = 3.33, 4.58) for diseases of the arteries, arterioles and capillaries; HR = 2.58 (95% CI = 2.46, 2.99) for diseases of the veins and lymphatics; HR = 2.98 (95% CI = 2.36, 3.76) for cerebrovascular disease. Colorectal cancer survivors with ≥1 comorbidity had an increased risk of CVD > 10 years after cancer diagnosis compared to survivors with no comorbidities (HR = 1.7, 95% CI = 1.49, 1.95). Colorectal cancer survivors who were ≥65 years had an increased risk of CVD > 10 years after cancer diagnosis. Colorectal cancer survivors who were obese at the time of diagnosis had an increased risk of CVD > 10 years after cancer diagnosis when compared to survivors with normal BMIs (HR = 1.25; 95% CI = 1.06, 1.49). Conclusions: Compared to the general population, colorectal cancer survivors had an increased risk of CVD during the > 10 year follow-up period. Within colorectal cancer survivors, there was an increased risk of CVD for those that were older, had ≥1 comorbidity and were obese. The increased risk of CVD among survivors may be attributable to the lifestyle risk factors shared by colorectal cancer and CVD.

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