Long-Term Visual and Refractive Outcomes following Surface Ablation Techniques in a Large Population for Myopia Correction

Most species now have fragmented distributions, often with adverse genetic consequences. The genetic impacts of population fragmentation depend critically upon gene flow among fragments and their effective sizes. Fragmentation with cessation of gene flow is highly harmful in the long term, leading to greater inbreeding, increased loss of genetic diversity, decreased likelihood of evolutionary adaptation and elevated extinction risk, when compared to a single population of the same total size. The consequences of fragmentation with limited gene flow typically lie between those for a large population with random mating and isolated population fragments with no gene flow.

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Severe Corneal Morphological Alterations after Excimer Laser Surface Ablation for a High Astigmatism

Case Reports in Ophthalmology ◽

10.1159/000516311 ◽

2021 ◽

pp. 492-496

Author(s):

Anna M. Roszkowska ◽

Giovanni W. Oliverio ◽

Giuseppe A. Signorino ◽

Mario Urso ◽

Pasquale Aragona

Keyword(s):

Excimer Laser ◽

Corneal Stroma ◽

Corneal Topography ◽

Laser Surface ◽

Slit Lamp ◽

Slit Lamp Examination ◽

Morphological Alterations ◽

Surface Ablation ◽

Confocal Images

We report long-term alterations of anterior corneal stroma after excimer laser surface ablation for a high astigmatism. The patient claimed progressive visual loss in his right eye (RE) during the last 3 years after bilateral laser-assisted subepithelial keratectomy (LASEK) surgery. His examination comprised visual acuity (UDVA and CDVA), slit-lamp examination, corneal topography and tomography, AS-OCT, and confocal microscopy. The UDVA was 0.1 in his RE and 1.0 in the left eye. The CDVA in the RE was 0.8. The slit-lamp examination showed a stromal lesion in the inferior paracentral corneal zone, with multiple vertical tissue bridges and severe thinning. Corneal topography and tomography showed central flattening with inferior steepening and severe alteration in elevation maps. AS-OCT showed void areas in the anterior stroma with thinning of the underlying tissue, and confocal images were not specific. In this case, progressive corneal steepening and thinning that manifest topographically as inferior ectasia occurred in correspondence to the singular stromal alterations after LASEK.

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The potential of forest-derived bioenergy to contribute to China's future energy and transportation fuel requirements

The Forestry Chronicle ◽

10.5558/tfc2012-104 ◽

2012 ◽

Vol 88 (05) ◽

pp. 547-552

Author(s):

Ling Li ◽

Sergios Karatzos ◽

Jack Saddler

Keyword(s):

Cellulosic Ethanol ◽

First Generation ◽

Fossil Fuel ◽

Large Population ◽

Forest Biomass ◽

Marginal Land ◽

Transportation Fuel ◽

Transportation Fuels ◽

Energy Dependent

Increasing concerns of oil security, greenhouse gas emissions, and sustainability have encouraged nations to consider the contribution that agriculture/forestry for bioenergy (and biofuels in particular) could make as alternatives to current fossil-based energy and transportation fuels. Despite China's large population and geographical size, it has only relatively recently developed into a highly industrialized and energy-dependent economy. Coal is, and will remain, China's dominant energy source. However, over the last few years with China's growing middle class, increasing growth in production and sale of cars/trucks and a growing chemical based sector, oil and its derivatives are predicted to experience the fastest fossil fuel growth. China's ability to produce so-called “first-generation” or conventional biofuels from sugar, starch or vegetable oil based plants is very restricted because of “food vs. fuel” issues. Thus, biomass-based and forest-based biofuels, in particular, can form a medium-to-long-term solution that could contribute to China's national biofuels targets. Oilseed trees have been suggested as an initial forest-based biodiesel strategy with about 13 million ha of marginal land identified for possible plantation. It is also estimated that 17 million tonnes of cellulosic ethanol per annum could be derived from forest biomass that is currently available in China.

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Early Stent Thrombosis in Patients Undergoing Primary Coronary Stenting for Acute Myocardial Infarction: Incidence, a Simple Risk Score, and Prognosis

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029609342092 ◽

2009 ◽

Vol 16 (1) ◽

pp. 33-41 ◽

Cited By ~ 5

Author(s):

Mehmet Ergelen ◽

Huseyin Uyarel ◽

Damirbek Osmonov ◽

Erkan Ayhan ◽

Emre Akkaya ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Stent Thrombosis ◽

Risk Score ◽

Cardiovascular Mortality ◽

Large Population ◽

Coronary Stenting ◽

Therapy Discontinuation ◽

Clopidogrel Therapy

Background: One of the major concerns remaining in the treatment with stenting of patients with acute myocardial infarction (AMI) is the occurrence of stent thrombosis (ST). The aim of the current study is to investigate the incidence, predictors, and long-term outcomes of early ST after primary coronary stenting for AMI in a large population. Methods: We reviewed 1960 consecutive patients (mean age 56 ± 11.6 years, 1658 males) treated with primary coronary stenting for AMI between 2003 and 2008. All clinical, angiographic, and follow-up data were retrospectively collected. Early ST was defined as thrombosis that occurred in the first 30 days after primary coronary stenting. Results: Early ST was observed in 89 (4.5%) patients. Five variables, selected from the multivariate analysis, were weighted proportionally to their respective odds ratio (OR) for early ST (premature clopidogrel therapy discontinuation [10 points], stent diameter ≤3 mm [5 points], current smoker [4 points], diabetes mellitus [DM; 3 points], and age >65 years [2 points]). Three strata of risks were defined (low risk, score 0-4; intermediate risk, score 5-12; and high risk, score 13-24) and had a strong association with early ST and long-term cardiovascular mortality. Long-term cardiovascular mortality was 5-fold more in patients with early ST than that without ST (24.1% vs 4.7%, respectively, P < .001). Conclusions: Early ST after primary coronary stenting in AMI is strongly related with increased long-term cardiovascular mortality. Premature clopidogrel therapy discontinuation is the most powerful predictor of early ST.

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DETERMINAN PEMILIHAN METODE KONTRASEPSI JANGKA PANJANG PADA AKSEPTOR KB AKTIF DI PUSKESMAS PEDAMARAN

Contagion: Scientific Periodical Journal of Public Health and Coastal Health ◽

10.30829/contagion.v1i01.4819 ◽

2019 ◽

Vol 1 (01) ◽

Author(s):

Lusia Weni ◽

Muhammad Yuwono ◽

Haerawati Idris

Keyword(s):

Multivariate Analysis ◽

Family Planning ◽

Information Needs ◽

Large Population ◽

Univariate Analysis ◽

Bivariate Analysis ◽

Contraceptive Methods ◽

Long Acting ◽

Selection Of

Determinant of the selection of long-term contraceptive methods on family planning acceptors in Pedamaran community health center. The population problem faced by Indonesia is a large population with a low quality of life. Uncontrolled population rate will cause baby booming so information needs to be disseminated about the benefits of family planning (FP). Long-term contraceptive method has a high level of effectiveness and can reduce the rate of population growth. This study aim to determine the factors that affect the selection of long-term contraceptive methods in active family planning acceptors.This study used a cross-sectional study design and using simple random sampling technique, consisted of 243 acceptors. Analyzes of data were univariate analysis, bivariate analysis using chi-square test with α = 0.05 and 95% confidence interval value, and multivariate analysis using binary logistic regression.Based on multivariate analysis was the variables significantly related to the selection of long-acting contraception include age (p = 0.01; OR = 2,24; 95% CI: 1,17-4,29), education (p = 0.01; OR = 0,31; 95% CI: 0,13-0,75) and number of children (p = 0.03; OR = 2; 95% CI: 1,05-3,81). Thus, age was the variable that had the greatest impact on determining the selection of long-acting contraception.The acceptors with ≥ 35 years old, low educated and have >2 children more likely to choose long-acting contraception. It is hoped that family planning workers can educate and persuade people of all ages with different educational backgrounds so total fertility rate can be reduce.

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One-Year Visual and Refractive Outcomes following LASIK for Myopia and Myopic Astigmatism with MEL 90 versus Schwind Amaris 750S Excimer Laser: A Comparative Study

Journal of Ophthalmology ◽

10.1155/2021/9929181 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Sheetal Brar ◽

Dishitha P. Rathod ◽

C. R. Roopashree ◽

Sri Ganesh

Keyword(s):

Comparative Study ◽

Clinical Outcomes ◽

Excimer Laser ◽

Infectious Keratitis ◽

Safety And Efficacy ◽

Refractive Outcomes ◽

The Mean ◽

One Year ◽

Myopic Astigmatism

Purpose. To compare clinical outcomes following LASIK for myopia performed with MEL 90 vs. Schwind Amaris 750S excimer laser. Methods. Data were collected retrospectively for patients who underwent Femto-LASIK, using the MEL 90 and Schwind Amaris 750S excimer laser for correction of myopia and myopic astigmatism within the range of −1.00 to −10.00 D SE from January 2013 till June 2018. Outcomes were analysed at 12 months for safety, efficacy, enhancement rate, and long-term complications. Results. A total of 328 eyes of 328 patients were analysed. One hundred and sixty-three eyes were treated with Schwind Amaris and the remaining 165 eyes with the MEL 90 laser. Twelve months postoperatively, the mean UDVA, CDVA, residual SE, and cylinder in the Amaris group were −0.10 ± 0.09 logMAR, −0.14 ± 0.06 logMAR, −0.21 ± 0.22 D, −0.13 ± 0.18 D versus −0.05 ± 0.07 logMAR, −0.09 ± 0.08 logMAR, −0.23 ± 0.23 D, and −0.14 ± 0.21 D for the MEL 90 group ( p values >0.05). For the Amaris group, safety and efficacy indices were 1.12 and 1.02, whereas for the MEL 90 group, these indices were 1.08 and 1.00, respectively. No eye in either group had any postop flap-related complications, infectious keratitis, diffuse lamellar keratitis, or keratectasia. Two eyes in the Amaris and 4 eyes in MEL 90 group required enhancement for the progression of myopia. Conclusion. At 12 months, both Schwind Amaris 750S and MEL 90 lasers demonstrated comparable clinical outcomes for myopic LASIK in a single surgeon setting.

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Surface Ablation Techniques for Myopia – A Review of the Advances Over the Past 25 Years

European Ophthalmic Review ◽

10.17925/eor.2017.11.01.31 ◽

2017 ◽

Vol 11 (01) ◽

pp. 31

Author(s):

Jesper Hjortdal ◽

Keyword(s):

Excimer Laser ◽

Clinical Results ◽

Review Article ◽

Ablation Techniques ◽

Photorefractive Keratectomy ◽

Excimer Lasers ◽

The Past ◽

Surface Ablation ◽

Meta Analyses

Photorefractive keratectomy for correction of myopia was the first excimer laser-based technique to be developed. During the last 25 years, excimer lasers have improved technologically, several variations of the technique have been developed and pre- and postoperative pharmaceutical therapies have been investigated. This review article summarises these developments and the published meta-analyses on comparison of surface ablation techniques and laser in situ keratomileusis. The main conclusion is that there seem to be no differences between the clinical results obtained with the different variations of surface ablation techniques.

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Abstract 2248: Prevalence and Long-term Clinical Significance of Aortic Root Dilatation in Competitive Athletes

Circulation ◽

10.1161/circ.118.suppl_18.s_693-c ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Fernando M Di Paolo ◽

Elvira De Blasiis ◽

Emanuele Guerra ◽

Cataldo Pisicchio ◽

Filippo M Quattrini ◽

...

Keyword(s):

Clinical Significance ◽

Aortic Root ◽

Large Population ◽

Multivariate Regression Analysis ◽

Left Ventricular ◽

Normal Limits ◽

Competitive Athletes ◽

Clinical Surveillance ◽

Aortic Root Dilatation

OBJECTIVES: Prevalence, clinical significance, and long-term consequences of aortic root (AoR) dilatation in competitive athletes are not yet investigated. Our aim was to assess the distribution and determinants of AoR size in a large population of competitive athletes. METHODS: AoR dimension were assessed by echocardiography in 2,361 athletes participating in 48 different sports. Of them, 43 were excluded because aortic structural abnormalities, such as bicuspid aortic valve, Marfan’s Syndrome, aortic prosthesis. The remaining 2,318, including 1,301 (56%) males and 1,017 (44%) females were the study population. Arbitrary cut-off of ≥ 40 mm, according to #36 th Bethesda Conference, was used as upper normal limits for AoR. RESULTS: AoR dimension was 32.2 ± 2.7 mm (23 to 44) in males, and 27.5 ± 2.6 mm (20 to 36) in females. AoR dimension exceeded accepted upper limits in only 18 male athletes (0.8%). Figure . Multivariate regression analysis showed left ventricular (LV) mass and body size explaining majority of AoR variability (R 2 = 0,59). Surprisingly, type of sport was not a determinant for AoR dimension. The 18 athletes with enlarged AoR were periodically followed for 7.0 ± 4.2 years. None developed cardiovascular events or symptoms. Two showed progression of AoR dilatation (from 40 to 48, and 43 to 46 mm, respectively), one had incident myocarditis and one developed moderate aortic regurgitation with enlarged LV cavity. CONCLUSIONS: Dilated aortic root is an uncommon finding in competitive athletes and do not represent expression of physiologic cardiac remodelling of the athlete’s heart. Therefore, athletes with dilated AoR deserves continued clinical surveillance.

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Abstract TMP56: Differential Effect of Left versus Right White Matter Hyperintensity Burden on Functional Decline: The Northern Manhattan Study

Stroke ◽

10.1161/str.48.suppl_1.tmp56 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Mandip S Dhamoon ◽

Ying-Kuen Cheung ◽

Ahmet M Bagci ◽

Dalila Varela ◽

Noam Alperin ◽

...

Keyword(s):

White Matter ◽

Large Population ◽

Functional Decline ◽

Frontal Lobes ◽

White Matter Hyperintensity ◽

Periventricular White Matter ◽

Parietal Lobes ◽

Brain White Matter ◽

The Right

Background: We previously showed that overall brain white matter hyperintensity volume (WMHV) was associated with accelerated long-term functional decline. Asymmetry of brain dysfunction may disrupt brain network efficiency. We hypothesized that greater left-right WMHV asymmetry was associated with functional trajectories. Methods: In the Northern Manhattan MRI study, participants had brain MRI with axial T1, T2, and fluid attenuated inversion recovery sequences, with baseline interview and examination. Volumetric WMHV distribution across 14 brain regions (brainstem, cerebellum, and bilateral frontal, occipital, temporal, and parietal lobes, and bilateral anterior and posterior periventricular white matter) was determined separately by combining bimodal image intensity distribution and atlas based methods.. Participants had annual functional assessments with the Barthel index (BI, range 0-100) over a mean of 7.3 years. Generalized estimating equations models estimated associations of regional WMHV and regional left-right asymmetry with baseline BI and change over time, adjusted for baseline medical risk factors, sociodemographics, and cognition, and stroke and myocardial infarction during follow-up. Results: Among 1195 participants, mean age was 71 (SD 9) years, 39% were male, 67% had hypertension and 19% diabetes. Greater WMHV asymmetry in the frontal lobes (-3.53 BI points per unit greater WMHV on the right compared to left, 95% CI -0.18, -6.88) and whole brain (-7.23 BI points, 95% CI 0.07, -14.54) was associated with lower overall function. Greater WMHV asymmetry in the frontal lobes (-0.74 additional BI points per year per unit greater WMHV on the right compared to left, 95% CI 0.05, -1.54) and parietal lobes (1.11 additional BI points per year, 95% CI 0.30, 1.93) was independently associated with accelerated functional decline. Periventricular WMHV asymmetry was not associated with function. Conclusions: In this large population-based study with long-term repeated measures of function, greater regional WMHV asymmetry was associated with lower function and functional decline, especially with greater WMHV on the right. In addition to global WMHV, WHMV asymmetry may be an important predictor of long-term functional decline.

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