The Role of Carcinoembryonic Antigen as a Predictor of the Need for Preoperative Computed Tomography in Colon Cancer Patients

2006 ◽  
Vol 72 (10) ◽  
pp. 897-901
Author(s):  
Alicia D. Holt ◽  
Justin T. Kim ◽  
Zuri Murrell ◽  
Richard Huynh ◽  
Michael J. Stamos ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Colon Cancer ◽  
Ct Scan ◽  
Carcinoembryonic Antigen ◽  
Cancer Patients ◽  
Clinical Utility ◽  
Stage Iv ◽  
Stage Iv Disease ◽  
Preoperative Ct

A retrospective study of 117 patients with the diagnosis of colon cancer was performed to evaluate the clinical utility of the preoperative computed tomography (CT) scan and to assess the role of carcinoembryonic antigen (CEA) as a predictor of the need for CT scan in colon cancer patients. Forty-nine patients had a CT scan that altered their treatment. One hundred per cent of stage IV patients versus only 26.5 per cent of stage I, II, and III patients had their operative and/or treatment planning altered by the preoperative CT. The sensitivity of CT scan in predicting metastatic disease was 90.3 per cent. All patients with stage IV disease had an abnormal CEA (>3 ng/mL). There was 89.7 per cent of stage IV patients who had a CEA twice that of normal or above. By using a CEA level of 3.1 ng/mL or above as a prerequisite for preoperative tomography, 34 nonmetastatic patients would not have had preoperative CT scans. Using a prerequisite of 6.1 ng/mL or above, 49 nonmetastatic patients would not have had a preoperative CT scan, and 90 per cent of the stage IV patients would have been imaged. We recommend obtaining a preoperative CT scan on those patients with a CEA value twice that of normal or greater.

Selection of colon cancer patients for neoadjuvant chemotherapy by preoperative CT scan

2013 ◽  
Vol 49 (2) ◽  
pp. 202-208 ◽  
Author(s):  
Anne Nørgaard ◽  
Claus Dam ◽  
Anders Jakobsen ◽  
John Pløen ◽  
Jan Lindebjerg ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Ct Scan ◽  
Cancer Patients ◽  
Preoperative Ct ◽  
Selection Of

Role of chemotherapy in improving survival in stage IV colon cancer patients without surgery: An NCDB analysis.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15058-e15058
Author(s):  
Lakshmi Manogna Chintalacheruvu ◽  
Avanija Buddam ◽  
Osama Diab ◽  
Peter T. Silberstein ◽  
Ryan W Walters
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Median Survival ◽  
Statistical Significance ◽  
Tumor Resection ◽  
Stage Iv ◽  
Cancer Data ◽  
Co Morbidity ◽  
Significant Difference

e15058 Background: Approximately 20% of patients with colorectal cancer have metastases at the time of presentation. Use of systemic chemotherapy for stage IV colon cancer has greatly increased over past several years with newer advancements. With advancements in chemotherapy annual rate of Primary tumor resection dropped from 74.5 percent in 1988 to 57.4 percent in 2010 with improved survival rates. Methods: A total of 39,428 patients with stage IV colon cancer were analyzed from the national cancer data base (NCDB). Differences in demographic and clinical co-variates were compared using Fisher’s exact test, where as survival differences were estimated by the Kaplan-Meier method and associated log-rank test; p < 0.05 indicated statistical significance. Results: The log-rank tests indicated statistically significant difference in survival (p < 0.001), such that patients receiving chemotherapy survived significantly longer (median survival = 12.0 months, 95% CI = 11.8 to 12.2 months) compared to patients not receiving chemotherapy (median survival = 1.5 months, 95% CI = 1.5 to 1.5 months). Patients receiving chemotherapy were younger (63.2 +/- 13.2 vs 73.8 +/- 13.0 ) with lesser co morbidity when compared to people who did not receive chemotherapy. Conclusions: Patients receiving chemotherapy are considerably younger, with less co-morbidity, and they survive significantly longer. This study signifies the survival advantage with chemotherapy in Stage IV colon cancer patients who did not get any type of surgery. Further studies need to be establish to define the role of chemotherapy comparing to surgery in stage 4 colon cancer patients.

Evaluating the Prognostic Role of Elevated Preoperative Carcinoembryonic Antigen Levels in Colon Cancer Patients: Results from the National Cancer Database

2016 ◽  
Vol 23 (5) ◽  
pp. 1554-1561 ◽  
Author(s):  
Adan Z. Becerra ◽  
Christian P. Probst ◽  
Mohamedtaki A. Tejani ◽  
Christopher T. Aquina ◽  
Maynor G. González ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Carcinoembryonic Antigen ◽  
Cancer Patients ◽  
National Cancer Database ◽  
Prognostic Role

scholarly journals The role of lumbar puncture in the diagnosis of subarachnoid hemorrhage when computed tomography is unavailable

CJEM ◽  
2002 ◽  
Vol 4 (02) ◽  
pp. 102-105 ◽  
Author(s):  
David Mann
Keyword(s):  
Computed Tomography ◽  
Differential Diagnosis ◽  
Subarachnoid Hemorrhage ◽  
Ct Scan ◽  
Lumbar Puncture ◽  
Uncommon Condition ◽  
Noncontrast Computed Tomography ◽  
Acute Headache ◽  
Interpretation Of Results

ABSTRACTSubarachnoid hemorrhage (SAH) is an important but uncommon condition in the differential diagnosis of acute headache. Most authorities recommend that patients with suspected SAH undergo noncontrast computed tomography (CT) as a first diagnostic intervention. If the results of the CT scan are negative, a lumbar puncture should be performed. Many nonurban Canadian hospitals do not have CT scanners and must either transfer patients or consider performing lumbar puncture prior to CT. In selected patients, performing lumbar puncture first may be an option, but timing of the procedure and the interpretation of results is important.

scholarly journals Role of Radiologic Computed Tomography in Evaluating Coronavirus (COVID-19) Patients

2021 ◽  
pp. 39-44
Author(s):  
Mwahib Sayed Ahmed Aldosh
Keyword(s):  
Computed Tomography ◽  
Ct Scan ◽  
Ct Scanning ◽  
Viral Disease ◽  
Human Beings ◽  
Complementary Method ◽  
High Incidence ◽  
High Incidence Rate ◽  
The Common

Objective: Coronavirus (Covid 19) is a dangerous viral disease that principally targets the respiratory system of human beings. The main objective of this study is to evaluate the significant effects resulting from Covid19 using radiologic CT scanning technology. Methods: The recent study was conducted in order to evaluate covid19 among the local public. The sample size for this study consisted of two hundred and thirty (230) patients diagnosed with coronavirus and underwent a chest computed tomography scan. The study was conducted at Najran city, between the period from September to December 2020. Results: The results showed that it is possible to diagnose the complications of coronavirus that affects the respiratory tract in an accurate manner using chest CT imaging and the main results revealed that coronavirus COVID-19 affected all, but males more than female. (50-60) Age group was the big distribution while acute respiratory failure is the most common clinical etiology. The CT scan findings revealed that bilateral pneumonia was the common complication with a high incidence rate of 32% percent and blood coagulation achieved 5% percent as the minimum distribution result. Conclusion: The sensitivity of the CT scans in assessing COVID-19 was significantly high, it has the efficiency to assess complications of COVID-19 in an accurate manner, and therefore it has been proposed to use CT scan as a complementary method in covid-19 diagnosis. More studies on coronavirus disease were recommended by the author.

scholarly journals Assessment of the Clinical Usefulness of Preoperative Computed Tomography in Colorectal Cancer Patients Who Received Unplanned Reoperation

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Rui Wang ◽  
Yi Gao ◽  
Jia-Yi Li ◽  
Zhong-Hui Wang ◽  
Qin-qing Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Computed Tomography ◽  
Postoperative Complications ◽  
Cancer Patients ◽  
Ct Imaging ◽  
Preoperative Imaging ◽  
Imaging Evaluation ◽  
Preoperative Ct ◽  
Colorectal Cancer Patients ◽  
Statistical Indicators

Background. In the unplanned reoperation of colorectal cancer patients, computed tomography (CT) is increasingly utilized to locate postoperative complications and previously unlocalized lesions. The purpose of this study is to explore the application of CT in the mortality and complications of the reoperation of colorectal cancer. Patients and Methods. We performed a retrospective review of collected data from the colorectal surgeries of 90 identified colorectal cancer patients who received an unplanned reoperation from 2010 to 2018. Patients were stratified according to those with preoperative CT imaging (CT group, n=36) and those without preoperative CT imaging (NCT group, n=54). Twenty-four statistical indicators of each patient were studied, including their preoperative risk, surgical characteristics, and postoperative outcomes, and satisfaction was evaluated. All data were statistically analysed for predicting postoperative complications by univariate and multivariate logistic regression analyses. Results. Ninety patients received an unplanned reoperation in the study, and 40% (36/90) of these patients underwent preoperative CT examination. Patients’ risk factors were similar between CT and NCT groups. Preoperative imaging was more commonly performed for reoperative new anastomosis + ileostomy but less common for reoperative Dixon’s procedure. The operative duration of the NCT group was longer (139 vs. 104 min, respectively, P=0.01). Preoperative NCT examination (OR 1.24; 95% CI=1.09‐1.42; P=0.01) was an independent predictor of postoperative complications. Importantly, three patients died after an unplanned reoperation for colorectal cancer, which occurred only in the NCT group (5.6% vs. 0.0%, P=0.01). Conclusion. The use of conventional preoperative CT optimizes the choice of the surgical site and the strategy of laparotomy, so as to reduce the length of operation. Preoperative imaging evaluation should be performed for patients undergoing repeat abdominal surgery.

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