Initial Experience Using a Hyaluronate-Iodine Complex for Wound Healing

2011 ◽  
Vol 77 (3) ◽  
pp. 355-359 ◽  
Author(s):  
Robert A. Brenes ◽  
Michael S. Ajemian ◽  
Shady H. Macaron ◽  
Lucian Panait ◽  
Stanley J. Dudrick
Keyword(s):  
Wound Healing ◽  
Surgical Techniques ◽  
Antimicrobial Properties ◽  
Healing Time ◽  
Complete Healing ◽  
The European Union ◽  
Iodine Complex ◽  
Healing Agent ◽  
Lost To Follow Up

Hyaluronate-iodine complex is a wound healing adjuvant approved for use in the European Union. The objective of this study is to validate hyaluronate-iodine as a potential wound healing agent. Patients were recruited from the hospital, the outpatient clinic, and the wound healing center. Hyaluronate-iodine soaked gauze was applied to wounds either daily or every other day depending on the amount of wound exudate. Wounds were measured weekly, and progression was documented with digital photography. All wounds were debrided as needed using standard surgical techniques. Fourteen patients (19 wounds) were entered into this prospective study, and 10 patients completed treatment. Fourteen wounds progressed to complete healing with a mean healing time of 18.1 ± 15.1 weeks. Treatment was interrupted in four patients. One patient discontinued treatment due to pain related to application of hyaluronate-iodine, another patient for transportation issues, and the other two patients were lost to follow-up due to relocation out of state and noncompliance with scheduled appointments. Hyaluronate-iodine was helpful in the healing of all types of wounds treated in this pilot study. The antiadhesive and antimicrobial properties of hyaluronate-iodine create a desirable environment conducive to wound healing without apparent detrimental effects.

scholarly journals Excision of Lower Lip Mucocele Using Injection of Hydrocolloid Dental Impression Material in a Pediatric Patient: A Case Report

2021 ◽  
Vol 11 (13) ◽  
pp. 5819
Author(s):  
Gianluca Botticelli ◽  
Marco Severino ◽  
Gianmaria Fabrizio Ferrazzano ◽  
Pedro Vittorini Velasquez ◽  
Carlo Franceschini ◽  
...  
Keyword(s):  
Minor Salivary Gland ◽  
Surgical Techniques ◽  
Surgical Excision ◽  
Complete Healing ◽  
Surgical Removal ◽  
Clinical Approach ◽  
Lower Lip ◽  
Impression Material ◽  
Dental Impression

Oral mucocele is a benign cystic exophytic lesion affecting the minor salivary gland and is especially present in pediatric patients (3% under 14 years). It is characterized by an extravasation or retention of fluid or mucus in the submucosal tissue of the minor salivary glands. Several surgical techniques have been proposed over the years, including the excision of the mucocele by using the injection of a hydrocolloid impression material in the light of the cyst to prevent the collapse of the cystic wall and solidify the lesion, resulting in a better cleavage plan. The combined clinical approach between the combination of Shira’s technique and the surgical excision of the cystic lesion results in a conservative surgical removal of the lesion. Here, we reported the removal of a labial mucocele in a 14-year-old male patient, using the injection of a hydrocolloid impression material. At a 12 months follow up, the patient showed complete healing of the surgical site, showing a pinkish lip lining mucosa without scarring or recurrence of the primary lesion. The combined therapeutic approach between Shira’s technique and surgical excision allows a safe and predictable excision of the labial mucocele, minimizing the risk of recurrence.

Extensive curettage using a high-speed burr versus dehydrated alcohol instillation for the treatment of enchondroma of the hand

2013 ◽  
Vol 40 (4) ◽  
pp. 384-391 ◽  
Author(s):  
S. M. Cha ◽  
H. D. Shin ◽  
K. C. Kim ◽  
I. Y. Park
Keyword(s):  
Analogue Scale ◽  
High Speed ◽  
Proximal Phalanx ◽  
Healing Time ◽  
Complete Healing ◽  
Pathological Fractures ◽  
Active Motion ◽  
The Mean ◽  
High Speed Burr

The purpose of this retrospective study was to compare the clinical and radiological outcomes of patients treated with different adjuvant methods after curettage for enchondromas of the hand. Sixty-two patients with enchondroma were treated with high-speed burring (29 patients) or alcohol instillation (33 patients) after curettage. The mean follow-up was 40.8 months. No significant differences in the visual analogue scale, Disabilities of the Arm, Shoulder, and Hand scores, total range of active motion, grip strength, and complete healing time were observed between the groups. The distribution of the results of the formula by Wilhelm and Feldmeier were not significantly different between the groups. No surgery-related complications, postoperative pathological fractures, or recurrence was found in either group. For the treatment of enchondroma in the metacarpal and proximal phalanx, alcohol instillation immediately after curettage was as effective as extensive curettage using a high-speed burr.

scholarly journals Aminogam® Gel Allows Faster Wound Healing after Oral Surgery by Formation of Mature Connective Tissue with Low Vascular Density and Reducing Inflammatory Infiltration. A Retrospective Study on 580 Cases with Histological and Confocal Laser Investigation

2020 ◽  
Vol 10 (3) ◽  
pp. 1105
Author(s):  
Saverio Capodiferro ◽  
Angela Tempesta ◽  
Sabina Bucci ◽  
Eugenio Maiorano ◽  
Gianfranco Favia ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diode Laser ◽  
Oral Surgery ◽  
Vascular Malformations ◽  
Sodium Hyaluronate ◽  
Healing Time ◽  
Complete Healing ◽  
Confocal Laser ◽  
Vascular Density ◽  
Inflammatory Infiltration

Reduction of the wound healing time after surgical procedures along with good hemostasis, and the reduction of post-surgical edema, pain and infective complications are generally desirable to both clinicians and patients. Recently, a gel compound containing sodium hyaluronate and four synthetic aminoacids (glycine, leucine, proline, lysine) and marketed as Aminogam® (Errekappa Euroterapici, Italy), has been proposed as a medical device promoting faster wound healing after oral surgery procedures. To assess its achievable clinical benefits, we studied retrospectively 580 cases (290 study cases and 290 control cases) undergoing oral surgery and receiving Aminogam ® gel application. More precisely, cases were divided into 7 groups on the bases of the kind of surgery (teeth extraction, oral surgery in patients taking bisphosphonates, surgical treatment of jaw osteonecrosis related to bisphosphonates therapy, placement of endosseous implants, diode laser surgery of oral mucosa lesions with second intention healing without stitches, diode laser photocoagulation of slow flow vascular malformations and bone surgery). In all instances, Aminogam® gel was applied at least five times a day until the wound healed completely. We compared the elapsed time between surgery and complete healing with Aminogam® application compared to control cases receiving no other drug treatment. Our results confirmed that the overall time of healing is certainly reduced in cases receiving Aminogam® gel regardless of the kind of oral surgery.

scholarly journals HEALING OF A TRAUMATIC WOUND WITH HERBO-MEDICINAL OINTMENT; MARHAM-E-RAAL: A CASE STUDY

2020 ◽  
Vol 9 (6) ◽  
pp. 152-155
Author(s):  
Saiyad Shah Alam ◽  
Waseem Ahmad ◽  
Md Rizwanullah ◽  
Mohammad Muzammil
Keyword(s):  
Wound Healing ◽  
Treatment Plan ◽  
Type Ii Diabetes Mellitus ◽  
Management Plan ◽  
Complete Healing ◽  
Mucus Membrane ◽  
Traumatic Wound ◽  
Large Wound

Introduction: A wound can be defined as the discontinuity in skin or mucus membrane. Healing is nothing but neogranulation in the depth and neo-epithelialization at the edges of the wound which ultimately results in the complete repair of such discontinuity. This case report deals with a patient of traumatic large wound at the heel who receives Unani management for wound healing. He was diagnosed as avulsion of pad of right heel with type-II diabetes mellitus. The treatment plan included mechanical debridement, cleaning with solution of alum powder (Sufuf-e-zaaj/alusol) and dressing with Marham-e-raal. The patient was advised to continue oral hypoglycemic agent with subcutaneous injection of insulin. On 85th day of treatment, the wound was healed by almost 98% and on subsequent 1st and 2nd follow up, each with a gap of 15 days, no recurrence of wound was recorded. Methodology: A male patient of traumatic wound was taken into study and given Unani management plan which included debridement, cleaning and washing with solution of Alum powder (Alusol)/ or, in Unani, Sufuf-e-zaaj and dressing of the wound with Marham-e-raal with full aseptic precautions for a period of about 3 months. Discussion: Wound healing is credited to muhallil(anti-inflammatory), daf’eta’ffun (antimicrobial), mujaffif (desiccant) and mundamil (wound healing) properties of Marham-e-raal due to presence of several phytoconstituents like camphor, linalool, borneol, cineole, terpenoids, Bergenin, Phenols and flavonoids, hopeaphenol, Oligostilbenoids, Monoterpenes, kaempferol, Quercetin and Catechin. Result: The wound completely healed at the end of 3 months with no recurrence noted on the 15th day of follow up after complete healing.

scholarly journals Role of topical cyclosporine in prevention of pterygium recurrence, after primary excision.

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Munawar Ahmed
Keyword(s):  
Healing Time ◽  
Complete Healing ◽  
P Value ◽  
Eye Drops ◽  
Fellow Eye ◽  
Department Of Ophthalmology ◽  
Prospective Comparative Study ◽  
Recurrent Pterygium

Role of topical cyclosporine in prevention of pterygium recurrence, after primary excision. Purpose: To evaluate the effect of cyclosporine on pterygium recurrence after primary excision Study Design: Non randomized prospective comparative study. Place and Duration of Study: The study was conducted in the department of Ophthalmology Liaquat University of Medical and Health Sciences Jamshoro from 2015 to 2017 Material and Methods: One hundred and thirty eyes of 65 patients having bilateral pterygium, at least 2mm encroaching on the cornea, were randomly selected for study. After informed consent patient was seen on slit lamp, the dimensions of pterygium was measured. The eye with more pterygium was selected for post-operative cyclosporine and was named as cyclo- eye and fellow eye was selected for simple excision and was named as non-cyclo eye. Immediate post-operative treatment was tobramycin dexamethasone eye ointment twice and moxifloxacine eye drops three times daily until corneal epithelium was restored, followed by moxifloxacine and Cyclosporine eye drops twice daily until complete healing of ocular surface occurred and then cyclosporine 0.05% alone once daily in the evening up to three months. In the fellow eye tobramycin dexamethasone eye ointment and moxifloxacine eye drops were used for complete healing time followed by tears alone three times for three months. Recurrence was defined as 1mm encroachment of pterygium on the cornea. Follow up was done for six months. Results: Fifty-three patients who completed 6 months follow were only included in the results. In cyclo-eyes recurrent pterygium was observed only in 04(07.55%) and in non-cyclo eyes recurrence was observed in 23(43.40%). Therefore, cyclosporine was able to reduce pterygium recurrence further in 19(35.85%) eyes, but healing time increased. Mean healing time in cyclo-eyes 21.1354 days and in non-cyclo-eyes 15.0213 days. Standard deviation in cyclo-eyes 1.3412 and in non-cyclo-eyes 1.0413. P-value was 0.002 and 0.004 respectively. Conclusion: Cyclosporine is effective in reducing the recurrence rate of pterygium. Key words: Pterygium, cyclosporine, recurrence  

scholarly journals Surgical treatment of chronic hidradenitis suppurativa in the gluteal and perianal regions

2012 ◽  
Vol 59 (2) ◽  
pp. 91-95 ◽  
Author(s):  
Sokol Bilali ◽  
Vangjel Todi ◽  
Ali Lila ◽  
Valbona Bilali ◽  
Julian Habibaj
Keyword(s):  
Wound Healing ◽  
Successful Treatment ◽  
Hidradenitis Suppurativa ◽  
Surgical Excision ◽  
Healing Time ◽  
Complete Healing ◽  
Sweat Glands ◽  
Apocrine Glands ◽  
Treatment Methods ◽  
Complete Wound Healing

Introduction: Verneuil disease, or perianal hidradenitis suppurativa (HS), is a chronic suppurative disease with a tendency to develop sinus formation, fibrosis, and sclerosis, having a great impact on quality of life. HS affect the apocrine sweat glands or sebaceous glands and may arise in each of the regions where the apocrine glands are prominent: the axilla, breast aureole, umbilicus, perineum, groin, and buttocks. We present here moderate and extensive HS cases, with their respective treatment methods and outcomes. Methods: A retrospective re-view of 6 patients? medical records from January 2001 to December 2010. Results: The 6 patients underwent treatment for HS in the gluteal and perianal regions with surgical excision. Five of the patients were male (83%). The median age was 42.5 years. We performed a total of 8 operations on these patients. In 3 patients, the wound was left open for secondary healing, and the mean time for complete wound healing was 11.3 weeks (range: 9.5-19 weeks). Delayed skin grafting was used for 2 patients in whom the wounds had been left open after the first operation. In this group, complete wound healing took 2 months in total. One patient underwent primary wound closure using rotation flaps, with a complete healing time of 2 weeks. Successful treatment without recurrence was accomplished in 5 (83.3%) of the patients. Conclusion: The conservative treatment methods had little effect, particularly on gluteal and perianal/perineal HS. The only successful treatment was wide surgical excision. Management of the wound after wide excision should be tailored to the individual patient.

Treatment of Complex Anal Fistula by Video-Assisted Anal Fistula Treatment Combined with Anal Fistula Plug: A Single-Center Study

2021 ◽  
pp. 155335062199292
Author(s):  
Yuru Zhang ◽  
Fei Li ◽  
Tuanjie Zhao ◽  
Feng Cao ◽  
Yamin Zheng ◽  
...  
Keyword(s):  
Wound Healing ◽  
Anal Fistula ◽  
Healing Time ◽  
Sphincter Function ◽  
Anal Sphincter Function ◽  
Fistula Plug ◽  
Anal Fistula Plug ◽  
Fistula Treatment ◽  
Wound Healing Time

Objective. The surgical treatment of complex anal fistulae is very challenging because of the incidence of incontinence after traditional approaches. There are no studies on the role of video-assisted anal fistula treatment (VAAFT) combined with anal fistula plug (AFP) in the complex anal fistulae. The aim of this study was to demonstrate the efficacy of treating complex anal fistulae using VAAFT combined with AFP. Method. This was a retrospective, nonrandomized observational study. 57 consecutive patients with complex anal fistulae who had undergone the VAAFT with AFP in our hospital between April 2016 and December 2019 were included. The primary outcomes were the cure rate, recurrence rate, and Wexner incontinence scores; the secondary outcomes were surgery time, blood loss, wound healing time postoperatively, pain, and patient satisfaction. Results. All 57 patients completed the surgery and follow-up, with an average follow-up time of 28 months; 6 patients suffered with recurrence (recurrence rate: 10.5%). The average surgery time was 57.9 minutes, and the average wound healing time was 46 days. There were no severe postoperative complications, and anal sphincter function was protected in all patients. Conclusions. The treatment of complex anal fistula by VAAFT combined with AFP is safe and effective, has a high healing rate and few postoperative complications, and is a promising surgery that can effectively protect the patient’s anal sphincter function.

scholarly journals Effect of marsupialization on the healing of fistulotomy wounds of simple anal fistula: a randomized control trial

2018 ◽  
Vol 5 (6) ◽  
pp. 2035
Author(s):  
Mohamed M. Raslan
Keyword(s):  
Postoperative Pain ◽  
Anal Fistula ◽  
Operative Time ◽  
Operating Time ◽  
Healing Time ◽  
Complete Healing ◽  
Female Ratio ◽  
Inadequate Sample Size ◽  
Male Female Ratio

Background: An anal fistula is traditionally treated by fistulotomy, adding marsupialization of fistulotomy wounds is optional. The aim of the current study was to compare the outcomes of fistulotomy with marsupialization and fistulotomy alone for simple anal fistula on healing rates and post-operative complicationsMethods: 50 patients with simple anal fistula randomly allocated to two groups fistulotomy alone group (F)and fistulotomy with marsupialization group(FM). The primary outcome was the healing time secondary outcomes included postoperative pain, operating time, incontinence and recurrence.Results: Mean age of group (F) patients was 37.55 ± 1.96 years with a male: female ratio of 19:6 while the mean age of group (FM) patients was 36.30 ± 3.03 years with a male: female ratio of 21:4. Mean operative time in the group (F) was 23.5±3.3 minutes while in the group (FM) It was 29.00± 4.595 minutes difference is statistically significant. Mean time for complete healing in group (F) was 6.9 ±0.73 weeks while in group (FM) was 4.80 ±0.96 weeks difference is significant statistically. Mean postoperative pain score by visual analogue scale in the group (F) was 3.4 ± 1.2 while in the group (FM) it was 3.3 ± 1.3 this difference is statistically non-significant. No recurrences or incontinence.Conclusions: Study demonstrated faster-wound healing when adding marsupialization to fistulotomy compared to fistulotomy alone. There is an increase operative time with marsupialization. This effect is minimal when compared with the benefits of enhanced healing. Limitations are mainly the inadequate sample size and inadequate follow-up period. 

scholarly journals Role of Topical Cyclosporine in Prevention of Pterygium Recurrence, after Primary Excision

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Munawar Ahmed, Atif Mansoor Noman Ahmed, Ghazi Khan Mari Azfer Ahmed Mirza
Keyword(s):  
Controlled Trial ◽  
Healing Time ◽  
Complete Healing ◽  
Eye Drops ◽  
Once Daily ◽  
Randomized Controlled ◽  
Department Of Ophthalmology ◽  
Recurrent Pterygium

Purpose: To study the effect of cyclosporine on pterygium recurrence after primary excision Study Design: Non randomized controlled trial. Place and Duration of Study: The study was conducted in the department of Ophthalmology, Liaquat University of Medical and Health Sciences, Jamshoro from 2015 to 2017. Material and Methods: One hundred and thirty eyes of 65 patients having bilateral pterygium, at least 2 mm encroaching on the cornea, were selected for study. Dimensions of pterygium were measured on slit lamp. Half of the eyes were selected for post-operative cyclosporine and was named as cyclo- eye and fellow other eye was named as non-cyclo eye. Immediate post-operative treatment was tobramycin dexamethasone eye ointment twice and moxifloxacin eye drops three times daily until corneal epithelium was restored, followed by moxifloxacin and Cyclosporine eye drops twice daily until complete healing of ocular surface occurred and then cyclosporine 0.05% alone once daily in the evening up to three months. In the fellow eye tobramycin dexamethasone eye ointment and moxifloxacin eye drops were used for complete healing time followed by tears alone three times for three months. Follow up was done for six months. Results: Only Fifty-three patients who completed 6 months of follow-up were included in the results. In cyclo-eyes recurrent pterygium was observed only in 4 (07.55%) and in non-cyclo eyes recurrence was observed in 23 (43.40%) eyes. Mean healing time in cyclo-eyes was 21.1354 days and in non-cyclo-eyes, 15.0213 days. Conclusion: Cyclosporine is effective in reducing the recurrence rate of pterygium. Key Words: Pterygium, Cyclosporine, Cornea.

The Use of a Novel Super-Oxidized Solution on Top of Standard Treatment in the Home Care Management of Postsurgical Lesions of the Diabetic Foot Reduces Reinfections and Shortens Healing Time

2018 ◽  
Vol 17 (4) ◽  
pp. 268-274
Author(s):  
Elisabetta Iacopi ◽  
Lorenza Abbruzzese ◽  
Chiara Goretti ◽  
Nicola Riitano ◽  
Alberto Piaggesi
Keyword(s):  
Diabetic Foot ◽  
Chronic Wounds ◽  
Standard Of Care ◽  
Healing Time ◽  
Complete Healing ◽  
Group A ◽  
Reduced Rate ◽  
Group B ◽  
Time Required

There are still many unmet needs in the treatment of chronic wounds, especially regarding microenvironment modulation. Nexodyn is a novel super-oxidized solution capable of contrast bacterial proliferation. We aimed to evaluate if this solution, on top of standard of care, was safe and effective in improving diabetic foot outcome. We selected 50 patients admitted in our department to be submitted to surgery for acute diabetic foot infection. All patients were left open to heal for secondary intent. We divided patients into 2 groups: Group A (n = 25, male/female = 17/8, age = 67.3 ± 12.1 years, hemoglobin A1C = 7.9 ± 1.1%), patients treated with standard of care and, on top of this, Nexodyn solution, and Group B, treated only with standard of care. After discharge, patients continued Nexodyn application. We followed up patients until complete healing or up to 6 months. No differences between groups in healing rate, while time required for complete healing was significantly shorter in Group A (64.9 ± 12.1 days vs 147.4 ± 23.1 days, P < .01). During follow-up, the group treated with Nexodyn showed a reduced rate of reinfections (12 patients in Group B vs 3 patients in Group A, P < .05) and of further debridement procedures (1 patient in Group A vs 10 patients in Group B, P < .05). Nexodyn provided effective protection against reinfections in diabetic foot patients, thus reducing the necessity for debridement procedures and their healing time and presents a safety profile similar to saline solution.

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