Verrucous Carcinoma of the Larynx Management by Radiotherapy and Surgery

1976 ◽  
Vol 85 (4) ◽  
pp. 538-543 ◽  
Author(s):  
Hugh P. Burns ◽  
A. W. Peter Van Nostrand ◽  
Douglas P. Bryce
Keyword(s):  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Combined Therapy ◽  
Surgical Excision ◽  
Real Risk ◽  
Anaplastic Transformation ◽  
Carcinoma Of The Larynx ◽  
Radiotherapy Alone ◽  
Considerable Controversy ◽  
Well Differentiated

Verrucous carcinoma is an unusual and distinct variant of well differentiated squamous cell carcinoma, and accounts for approximately 1 to 2% of all primary squamous cell carcinomas of the larynx. There has been considerable controversy regarding the role of radiotherapy in the management of these tumors, as they are said to be radioresistant, and in a number of instances “anaplastic transformation” has apparently occurred following such therapy. We have reviewed 18 patients with verrucous carcinoma of the larynx in which eight received surgical therapy alone, eight received radiotherapy alone, and two received combined therapy. We conclude that radiotherapy and surgery are equally effective in eradicating the disease. “Anaplastic transformation” of these tumors represents a small but nevertheless real risk following radiotherapy. Accordingly, our current therapeutic policy is to treat by surgical excision those smaller tumors which can be removed by conservation laryngectomy procedures, reserving radiotherapy for those large tumors which would require total laryngectomy if treated surgically.

Verrucous Carcinoma of the Larynx

1998 ◽  
Vol 107 (5) ◽  
pp. 391-395 ◽  
Author(s):  
Thomas V. McCaffrey ◽  
Mark Witte ◽  
M. Troy Ferguson
Keyword(s):  
Residual Disease ◽  
Verrucous Carcinoma ◽  
Statistical Significance ◽  
Clinical Stage ◽  
Surgical Excision ◽  
Laryngeal Function ◽  
Primary Treatment Modality ◽  
Anaplastic Transformation ◽  
Exophytic Tumor ◽  
Carcinoma Of The Larynx

Verrucous carcinoma is a well-differentiated squamous cell carcinoma with minimal cytologic atypia. Characteristically, the surface shows papillary fronds with prominent hyperkeratosis. Its benign appearance makes diagnosis difficult and often delays treatment. This is a review of 52 histologically confirmed cases of verrucous carcinoma of the larynx treated at the Mayo Clinic between 1960 and 1987. The follow-up ranged from 2 to 304 months. The most common primary treatment modality was surgery. Two patients died of laryngeal cancer. In both cases, the recurrence was a high-grade carcinoma histologically distinct from the original verrucous carcinoma. The T stage, clinical stage, and type of surgical excision failed to predict survival. The presence of extensive leukoplakia surrounding the exophytic tumor approached statistical significance (p =.08) in predicting recurrence. Four patients were treated with radiotherapy — in each, to control residual disease. One of these patients developed a local recurrence. None of the irradiated tumors in this series showed anaplastic dedifferentiation, and none of the irradiated patients died of uncontrolled local or regional disease. We conclude that verrucous carcinoma of the larynx should be treated by conservative surgical resection when possible. Radiotherapy can be effectively used for disease that cannot be resected with preservation of laryngeal function. Total laryngectomy should be reserved for recurrent disease or the rare case of anaplastic transformation.

Verrucous carcinoma of the maxillary antrum

1998 ◽  
Vol 112 (4) ◽  
pp. 399-402 ◽  
Author(s):  
B. Ram ◽  
H. A. Saleh ◽  
A. R. Baird ◽  
R. E. Mountain
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Maxillary Antrum ◽  
Verrucous Carcinoma ◽  
Review Of The Literature ◽  
Well Differentiated

AbstractVerrucous carcinoma is a distinct variant of well differentiated squamous cell carcinoma. Its occurrence in the maxillary antrum is rare. Only three cases have previously been documented. We present a case report of verrucous carcinoma in the maxillary antrum and a review of the literature.

A Case of Verrucous Carcinoma (Epithelioma Cuniculatum) of the Heel Mimicking Infected Epidermal Cyst and Gout

2008 ◽  
Vol 1 (5) ◽  
pp. 297-299 ◽  
Author(s):  
Mahbod Arefi ◽  
Elizabeth Philipone ◽  
Russell Caprioli ◽  
John Haight ◽  
Hugh Richardson ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Rare Variant ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Epidermal Cyst ◽  
Diagnostic Challenge ◽  
Epithelioma Cuniculatum ◽  
Well Differentiated

Verrucous carcinoma is a rare variant of well-differentiated squamous cell carcinoma. It usually occurs in the oral cavity, genital area, and sole. Verrucous carcinoma of the sole, also called epithelioma cuniculatum, often presents a diagnostic challenge both clinically and histopathologically. The authors report such a case that mimics infected epidermal cyst and gout clinically

Squamous Cell Carcinoma of the Base of the Tongue

1983 ◽  
Vol 91 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Robert W. Riley ◽  
Willard E. Fee ◽  
Donald Goffinet ◽  
Richard Cox ◽  
Richard L. Goode
Keyword(s):  
Squamous Cell ◽  
Therapy Group ◽  
Survival Curve ◽  
Combined Therapy ◽  
Survival Rates ◽  
Cancer Staging ◽  
Neck Disease ◽  
Group A ◽  
Well Differentiated ◽  
Histopathologic Findings

The squamous cell carcinomas of 119 patients treated between 1958 and 1980 were retrospectively reclassified according to the 1977 American Joint Committee for Cancer Staging-End Results Reporting guidelines. Analysis of the information was performed with an interactive computer program that allows the analysis of a large number of medical factors with numerous variables. The following factors show the statistically significant improved survival rates: well-differentiated histopathologic findings, small T-stage lesions, and clinically negative neck disease. Although the survival curve was similar in the planned combined therapy and radiation therapy groups, local control was statistically superior in the combined therapy group. A similar trend is seen in those patients who receive interstitial implants in addition to external beam therapy. A randomized prospective study is needed to determine the optimum mode of therapy.

Verrucous Carcinoma of the Nail Bed

1998 ◽  
Vol 19 (5) ◽  
pp. 327-328 ◽  
Author(s):  
Jean P. Van Geertruyden ◽  
Catherine Olemans ◽  
Marianne Laporte ◽  
Jean-Christophe Noël
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Surgical Excision ◽  
Nail Bed ◽  
Wide Surgical Excision ◽  
Epithelioma Cuniculatum

Verrucous carcinoma is a rare, highly keratinizing variant of squamous cell carcinoma of the skin or mucosae characterized by a local aggressiveness but a low potential for metastasis. The plantar form is also known as epithelioma cuniculatum. Fingers and toes are rarely affected, and tumors of the nail bed are exceptional. Clinically, the lesion presents like a wart and is then often misdiagnosed. Treatment of choice is wide surgical excision. A case of verrucous carcinoma of the nail apparatus is presented, and diagnosis is discussed.

scholarly journals Diagnosis dan Penatalaksanaan Tumor Ganas Laring

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Dolly Irfandy ◽  
Sukri Rahman
Keyword(s):  
Laryngeal Cancer ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Combined Therapy ◽  
Glottic Carcinoma ◽  
Respiratory Obstruction ◽  
Upper Aerodigestive Tract ◽  
Laryngeal Tumour ◽  
Carcinoma Of The Larynx ◽  
Laryngeal Tumors

Abstrak Laring berperan dalam koordinasi fungsi saluran aerodigestif atas seperti bernafas, berbicara dan menelan.Laring terbagi tiga yaitu supraglotis, glotis dan subglotis. Laring merupakan daerah tersering kedua untuk kasuskarsinoma sel skuamosa kepala-leher, biasanya berhubungan dengan tembakau dan alkohol. Lebih dari 95% kasustumor ganas laring adalah karsinoma sel skuamosa. Pasien tumor ganas laring datang dengan berbagai keluhanseperti disfonia, obstruksi jalan napas, disfagia, odinofagi dan hemoptisis. Diagnosis tumor ganas laring ditegakkanberdasarkan anamnesis, pemeriksaan klinis menggunakan endoskopi kaku, serat optik dan biopsi. Penatalaksanaantumor ganas laring tergantung stadium dengan modalitas berupa operasi, kemoterapi, radiasi atau terapi kombinasi.Dilaporkan kasus laki-laki 53 tahun dengan karsinoma glotis stadium III (T3N0M0) squamous cell ca keratinized welldifferentiated. Penatalaksanaan pada pasien ini dengan melakukan laringektomi total.Kata kunci: Tumor ganas laring, karsinoma, laringektomi, tembakau Abstract Larynx plays a certain role in coordinating functions of the upper aerodigestive tract, such as respiration,speech, and swallowing. The larynx is divided into three region; supraglottic, glottic, and subglottic. Larynx is thesecond most common site for squamous cell carcinoma in the head and neck and usually related to tobacco andalcohol exposure. Primary malignant tumors of the larynx are squamous cell carcinomas can found more than 95% ofcases. Patients with laryngeal tumors usually present with complaints of hoarseness, respiratory obstruction,dysphagia, odynophagia and hemoptysis. Diagnosis of laryngeal cancer is made by medical history, clinicalexamination using a rigid or fiberoptic endoscope and biopsy. Management of laryngeal tumour depends on stadiumwith various modality included surgery, chemotheraphy, radiotheraphy or combined therapy. Reported case of 53years old male with Glottic carcinoma of the larynx stage III (T3N0M0) squamous cell ca keratinized well differentiatedis presented. The treatment undergoes with total laryngectomy.Keywords:  Laryngeal cancer, carcinoma, laryngectomy, tobacco

scholarly journals Verrucous Carcinoma of Buccal Mucosa in Female: A Rare Case Report of Traumatic Tooth Origin

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
V. Keerthi Narayan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Rare Case ◽  
Verrucous Carcinoma ◽  
Benign Lesion ◽  
Surgical Excision ◽  
Low Grade ◽  
Case Scenario

Verrucous carcinoma or Ackermann’s tumor is considered a low-grade variant of squamous cell carcinoma frequently presenting at the oral mucosa and skin. Oral verrucous carcinoma clinically presents as a proliferative or cauliflower-like lesion or as ulceroproliferative lesion on the buccal mucosa followed by other sites such as the gingiva, tongue, and hard palate. Tobacco in both smoking and smokeless form, alcohol, and opportunist viral infections are the most associated etiologies in most of the reported literature cases. Here, in this paper, we discuss a rare case scenario of a 52-year-old female diagnosed with verrucous carcinoma of the left buccal mucosa with constant traumatic irritation caused by tooth as etiology for the occurrence of lesion, though verrucous carcinoma is described as a benign lesion with minimum aggressive potential but long-standing cases have shown transformation into squamous cell carcinoma. Therefore, early diagnosis and surgical excision of the lesion are the most appropriate treatment modality of verrucous carcinoma.

scholarly journals Optimal treatment for penile verrucous carcinoma: a systematic literature review

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dong In Jo ◽  
Song Hyun Han ◽  
Soon Heum Kim ◽  
Hye Young Kim ◽  
Hong Chung ◽  
...  
Keyword(s):  
Local Excision ◽  
Verrucous Carcinoma ◽  
Surgical Excision ◽  
Metastatic Potential ◽  
Biological Behavior ◽  
Publication Date ◽  
Low Grade ◽  
Clinical Prognosis ◽  
Impact Function ◽  
Well Differentiated

Abstract Background Verrucous carcinoma, a rare low-grade well-differentiated squamous cell carcinoma, is known for its favorable biological behavior and lack of metastatic potential. However, aggressive resection is problematic in terms of compromised function and aesthetics. Hence, more conservative treatments are needed. Methods: To identify the up-to-date general biological behavior, diagnosis, and treatment trends, we searched PubMed using the keyword “penile verrucous carcinoma” without restrictions on publication date. Results: Current treatments for penile verrucous carcinoma include wide surgical excision, seldom preventive lymphadenectomy, and conservative chemotherapy without surgery or local excision with safe margins. Despite the advent of partial penectomy to minimally impact function and aesthetics, affected patients experience psychosexual problems. Local excision can be used to save the penile shaft and glans penis without preventive lymphadenectomy or adjuvant therapy and can achieve good clinical prognosis with rare recurrence. Conclusions: To preserve the functional and cosmetic aspects, we recommend local excision, especially for tumors measuring < 3 cm and classified as stage T1 according to the 2016 tumor node metastasis clinical and pathological classification for penile cancer.

Combined therapy for carcinoma of the nasopharynx: a report of 49 cases

1993 ◽  
Vol 107 (3) ◽  
pp. 201-204 ◽  
Author(s):  
Sheng Hongzheng ◽  
Jia Haixia
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Combined Therapy ◽  
Combined Treatment ◽  
Complete Response ◽  
Regional Chemotherapy ◽  
Chemotherapeutic Agents ◽  
Well Differentiated ◽  
One Year

From April, 1986 to June 1989 49 Patients (29 male, 20 female) aged 20 to 70 years old whod developed carcinomea of naospharynx (included 15 with relapses) were trated with neoadjuvant regional chemothrapy, followed by radiotherapy, or crysurgery and radiotherapy.Thirty-three of the patients had squamous cell carcinoma with poor differentiated, four with well differentiated squamous cell carcinoma were included. Tumours were treated with three moalities: (I) Induction regional chemotherapy with temporal aftery catheterization as well as superselective intra-arterial chemotherapy of the femoral artery (chemotherapeutic agents: pingyangmycinum (P), Cisplatin (D), Vomcromstine (V), Methotrexate (M) and P.D.M. programmes); (2)Liquid cryosurgery in 25 cases; (3) Radiotherapy was carried out for two weeks after crysosurgery after chemotherapy.The date showed CR (complete response—all tumour gone) and PR (partial response—more than 50 percent reduction) in 40 cases (81.6 per cent) and NR (no response—less than 50 per cent or no response) in nine cases (18.3 per cent) following regional chemotherapy. All of the patients were followed up for more than one year, and 48 of them survived (97.9 per cent). Thirty-five cases were followed up over two years and 28 of them survived (80 per cent). Twenty cases were followed up over three years, and 12 of them survived (60 per cent).The effect of regional chemotherapy and crysurgery in combined treatment for carcinoma of the nasopharynx is discussed in this paper.

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