Sodium Loading of Inner Ear Fluids

1976 ◽  
Vol 85 (6) ◽  
pp. 769-775 ◽  
Author(s):  
Herbert Silverstein ◽  
Tiero Takeda
Keyword(s):  
Sodium Chloride ◽  
Serum Sodium ◽  
Total Concentration ◽  
Sodium Concentration ◽  
Ionic Balance ◽  
Low Sodium ◽  
Minute Period ◽  
Concentration Of Ions ◽  
Before And After ◽  
Inner Ear Fluids

A slow intracarotid infusion of hypertonic sodium chloride solution, 350 mEq/L, and potassium chloride, 5 mEq/L, was used to increase serum sodium chloride over a 90-minute period in 85 cats. A slow, steady rise in serum sodium occurred, which reached almost 208 mEq/L at the end of 90 minutes. A concomitant rise in sodium occurred in the cerebrospinal fluid and perilymph. In contrast, the sodium showed only a transient slight increase in the cochlear and vestibular endolymph. Endolymph potassium appeared to rise in order to balance out the increase in sodium concentration of the surrounding and extracellular fluids. The ratio of sodium to potassium ions in both the endolymph and perilymph compartment remained relatively constant before and after the infusion with hypertonic NaCl. After infusion, the total concentration of ions in endolymph was similar to that of perilymph. These experiments indicate that the endolymph compartment has a built-in mechanism for maintaining a low-sodium concentration while keeping ionic balance with the surrounding perilymph and serum.

scholarly journals How to Adjust the Sodium Concentration in Dialysate Individually and Practically?

2021 ◽  
Vol 1 (2) ◽  
pp. 161-163
Author(s):  
Jingjing Zhang
Keyword(s):  
Serum Sodium ◽  
Observational Studies ◽  
Serum Sodium Level ◽  
Volume Overload ◽  
Sodium Concentration ◽  
Study Data ◽  
Chronic Hemodialysis ◽  
Low Sodium ◽  
Large Cohort Study ◽  
Dialysate Sodium

The optimal dialysate sodium concentration for chronic hemodialysis patients remains controversial. Conflicting data from small observational studies and large cohort study data have not convinced nephrologists to choose either a high or low sodium dialysate. Despite a lack of evidence, I would prescribe individualized dialysate sodium concentrations for patients with a risk of hypertension or volume overload, aligning the dialysate sodium concentration with patients’ predialysis serum sodium level. The concentration of dialysate sodium would usually be 0–2 mEq/L below the patient’s serum sodium concentration. I believe that this strategy would help improve hypertension, intradialytic weight gain, cardiac outcomes, and deliver precision medicine.

scholarly journals Weighing the prognostic role of hyponatremia in hospitalized patients with metastatic solid tumors: the HYPNOSIS study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Giovanni Fucà ◽  
Luigi Mariani ◽  
Salvatore Lo Vullo ◽  
Giulia Galli ◽  
Rossana Berardi ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Serum Sodium ◽  
Tumor Development ◽  
Sodium Concentration ◽  
Prognostic Impact ◽  
Multivariable Model ◽  
Low Sodium ◽  
Extracellular Sodium

Abstract Previous works linked low sodium concentration with mortality risk in cancer. We aimed at weighing the prognostic impact of hyponatremia in all consecutive patients with metastatic solid tumors admitted in a two-years period at our medical oncology department. Patients were included in two cohorts based on serum sodium concentration on admission. A total of 1025 patients were included, of whom 279 (27.2%) were found to be hyponatremic. The highest prevalence of hyponatremia was observed in biliary tract (51%), prostate (45%) and small-cell lung cancer (38.9%). With a median follow-up of 26.9 months, median OS was 2 months and 13.2 months for the hyponatremia versus control cohort, respectively (HR, 2.65; P < 0.001). In the multivariable model, hyponatremia was independently associated with poorer OS (HR, 1.66; P < 0.001). According to the multivariable model, a nomogram system was developed and validated in an external set of patients. We weighed over time the influence of hyponatremia on survival of patients with metastatic solid tumors and pointed out the possibility to exploit serum sodium assessment to design integrated prognostic tools. Our study also highlights the need for a deeper characterization of the biological role of extracellular sodium levels in tumor development and progression.

Sodium activity, sodium concentration, and osmolality in plasma in acute and chronic renal failure.

1985 ◽  
Vol 31 (11) ◽  
pp. 1811-1814 ◽  
Author(s):  
E Langhoff ◽  
J Ladefoged
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Sodium Chloride ◽  
Activity Coefficient ◽  
Plasma Osmolality ◽  
Sodium Concentration ◽  
Ionic Activity ◽  
Sodium Activity ◽  
Before And After ◽  
Healthy Persons

Abstract We compared the ionic activity of sodium, as measured with glass electrodes, with sodium concentration in 23 healthy persons, 15 persons with acute renal failure, and before and after dialysis in 46 patients with chronic renal failure. In healthy persons the mean (+/- SEM) sodium concentration was 139.1 +/- 0.6 mmol/L, whereas the ionic activity was equal to that of a 145.2 +/- 0.5 mmol/L solution of sodium chloride. Variation in the concentration of plasma protein was the most important factor influencing the sodium activity coefficient (the ratio between activity and concentration). The sodium activity coefficient in plasma water (corrected for the non-aqueous phase of the plasma) was fairly constant, being 96% of that in a 140 mmol/L solution of sodium chloride. Thus sodium binds to non-protein molecules and sodium ions interact with other substances in uremic plasma only to a very limited extent. The sum of the molar activities of sodium, potassium, urea, and creatinine was closely and linearly correlated with plasma osmolality, both before and after dialysis.

scholarly journals Treatment of severe chronic hypotonic hyponatremia: a new treatment model

2013 ◽  
pp. 26-31
Author(s):  
Antonio Burgio ◽  
Rossana Dovico ◽  
Luca Burgio
Keyword(s):  
Body Weight ◽  
Sodium Chloride ◽  
Serum Sodium ◽  
Sodium Concentration ◽  
The Body ◽  
Serum Sodium Concentration ◽  
Close Monitoring ◽  
Treatment Needs ◽  
Correction Rate ◽  
Wide Range

Recommended treatment of severe hypotonic hyponatremia is based on the infusion of 3% sodium chloride solution, with a daily correction rate below 10 mEq/L of sodium concentration, according to the Adrogué and Madias formula that includes the current desired change in sodium concentrations. However, such treatment needs close monitoring of the rate of infusion and does not take into account the body weight or age of the patient. This may result in hypercorrection and neurological damage. We made an inverse calculation using the same algorithms of the Adrogué and Madias formula to estimate the number of vials of sodium chloride needed to reach a correction rate of the serum sodium concentration below 0.4 mEq/h, taking into account the body weight and age of the patient. Three tables have been produced, each containing the number of vials to be infused, according to the patient’s age and body weight, the serum sodium concentration, and the rate of correction over 24 h to avoid the risk of brain damage. We propose a new practical model to calculate the need of sodium chloride infusate to safely correct the hyponatremia. The tables make treatment easier to manage in daily clinical practice in a wide range of patient ages and body weights.

scholarly journals Effects of correction equation for actual sodium concentration on the reduction in frequency of reports on pseudohyponatremia

2020 ◽  
Vol 44 (1) ◽  
pp. 17-22
Author(s):  
Jooyoung Cho ◽  
Young Uh ◽  
Seong Jin Choi
Keyword(s):  
Serum Sodium ◽  
Sodium Concentration ◽  
Serum Sodium Concentration ◽  
Laboratory Information System ◽  
Severe Hyponatremia ◽  
Appropriate Care ◽  
Before And After ◽  
Treatment Plans ◽  
Excess Glucose ◽  
Real Clinical Practice

Abstract Background Serum sodium concentration could be spuriously reduced by excess glucose or lipid; thus, hyponatremia should be reassessed before reporting in order to exclude the possibility of pseudohyponatremia. Methods In this study, we used the calculation of corrected serum sodium concentration in hyperglycemic or lipemic samples and evaluated its effect on the reduction in frequency of reports on pseudohyponatremia. We retrospectively analyzed 1-year data from the laboratory information system. Results From August 2017 to July 2018, hyponatremia was initially noted in 30,465 results, of which 6614 results reported hyperglycemia. Corrected sodium concentrations were calculated using the results with glucose >170 mg/dL or lipemia index ≥3. The reported frequency of hyponatremia before and after correction of sodium concentration was reduced by 42.9%. Moreover, only 51.9% of the patients with severe hyponatremia had “true” severe hyponatremia. After applying the formula, the degree of hyponatremia was unchanged in only 45.8% of the total results. Conclusions Our report on the corrected sodium concentration reduced the frequency of pseudohyponatremia in hyperglycemic samples. Calculation of corrected sodium concentration is a useful tool to help clinicians establish appropriate care and treatment plans. Further prospective study is required to validate to our system in a real clinical practice.

Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration

2010 ◽  
Vol 30 (8) ◽  
pp. 1137-1142 ◽  
Author(s):  
Mónica Guevara ◽  
María E. Baccaro ◽  
Jose Ríos ◽  
Marta Martín-Llahí ◽  
Juan Uriz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatic Encephalopathy ◽  
Serum Sodium ◽  
Sodium Concentration ◽  
Serum Sodium Concentration ◽  
Refractory Ascites

scholarly journals Sodium Radiofrequency Coils for Magnetic Resonance: From Design to Applications

Electronics ◽  
2021 ◽  
Vol 10 (15) ◽  
pp. 1788
Author(s):  
Giulio Giovannetti ◽  
Alessandra Flori ◽  
Nicola Martini ◽  
Roberto Francischello ◽  
Giovanni Donato Aquaro ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Sodium Concentration ◽  
Resonance Spectroscopy ◽  
Sodium Mri ◽  
Human Organs ◽  
Low Sodium ◽  
Radiofrequency Coils ◽  
Anatomical Imaging ◽  
Strong Gradient

Sodium (23Na) is the most abundant cation present in the human body and is involved in a large number of vital body functions. In the last few years, the interest in Sodium Magnetic Resonance Imaging (23Na MRI) has considerably increased for its relevance in physiological and physiopathological aspects. Indeed, sodium MRI offers the possibility to extend the anatomical imaging information by providing additional and complementary information on physiology and cellular metabolism with the heteronuclear Magnetic Resonance Spectroscopy (MRS). Constraints are the rapidly decaying of sodium signal, the sensitivity lack due to the low sodium concentration versus 1H-MRI induce scan times not clinically acceptable and it also constitutes a challenge for sodium MRI. With the available magnetic fields for clinical MRI scanners (1.5 T, 3 T, 7 T), and the hardware capabilities such as strong gradient strengths with high slew rates and new dedicated radiofrequency (RF) sodium coils, it is possible to reach reasonable measurement times (~10–15 min) with a resolution of a few millimeters, where it has already been applied in vivo in many human organs such as the brain, cartilage, kidneys, heart, as well as in muscle and the breast. In this work, we review the different geometries and setup of sodium coils described in the available literature for different in vivo applications in human organs with clinical MR scanners, by providing details of the design, modeling and construction of the coils.

scholarly journals Antibacterial Efficacy of Synthetic and Natural-Derived Novel Endodontic Irrigant Solutions

2018 ◽  
Vol 29 (5) ◽  
pp. 459-464 ◽  
Author(s):  
Larissa Tais Soligo ◽  
Ediléia Lodi ◽  
Ana Paula Farina ◽  
Matheus Albino Souza ◽  
Cristina de Mattos Pimenta Vidal ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Enterococcus Faecalis ◽  
Grape Seed ◽  
Control Group ◽  
Bacterial Reduction ◽  
Calcium Hypochlorite ◽  
Root Canals ◽  
Colony Forming Units ◽  
Before And After ◽  
Post Hoc

Abstract The aim of this study was to compare the efficacy of grape seed extract (GSE), calcium hypochlorite [Ca(ClO)2], and sodium hypochlorite (NaOCl) irrigant solutions with rotary or reciprocating instrumentation for disinfection of root canals inoculated with Enterococcus faecalis. The mesiobuccal root canals of mandibular molars were prepared and inoculated with Enterococcus faecalis for 21 days. The roots were then randomly divided into the following eight experimental groups (n=11) according to the instrumentation technique and disinfection protocol: ProTaper Next or Reciproc R25 with sodium chloride (control group), 6% NaOCl, 6% Ca(ClO)2, or 50% GSE used for irrigation during instrumentation. The antimicrobial activity was determined on the basis of a reduction in colony-forming units (CFUs) counted on bacterial samples collected before and after root canal instrumentation and expressed as a percentage of reduction. Data were evaluated by two-way ANOVA followed by Tukey HSD post-hoc tests (p<0.05). No significant differences were observed in bacterial reduction between the ProTaper Next and Reciproc R25 systems (p>0.05), regardless of the irrigant solution used. Furthermore, all active solutions (6% NaOCl, 50% GSE, and 6% Ca(ClO)2) showed similar potential to reduce bacterial counts (p>0.05) and were significantly more effective than sodium chloride (control) (p<0.05). The results suggest that the GSE and Ca(ClO)2 have potential clinical application as irrigant solutions in endodontic therapy since they present bactericidal efficacy against Enterococcus faecalis.

Serum Sodium Concentration Changes Are Related to Fluid Balance and Sweat Sodium Loss

2010 ◽  
Vol 42 (9) ◽  
pp. 1669-1674 ◽  
Author(s):  
MATTHEW D. PAHNKE ◽  
JOEL D. TRINITY ◽  
JEFFREY J. ZACHWIEJA ◽  
JOHN R. STOFAN ◽  
W. DOUGLAS HILLER ◽  
...  
Keyword(s):  
Fluid Balance ◽  
Serum Sodium ◽  
Sodium Concentration ◽  
Serum Sodium Concentration ◽  
Concentration Changes ◽  
Sodium Loss ◽  
Sweat Sodium
Sign in / Sign up

Export Citation Format

Share Document