Addiction Careers: Etiology, Treatment, and 12-Year Follow-up Outcomes

1986 ◽  
Vol 16 (1) ◽  
pp. 107-122 ◽  
Author(s):  
D. Dwayne Simpson ◽  
George W. Joe ◽  
Wayne E. K. Lehman ◽  
S. B. Sells
Keyword(s):  
Drug Abuse ◽  
Longitudinal Data ◽  
White Male ◽  
Data System ◽  
Abuse Reporting ◽  
Program Outcomes ◽  
Black And White ◽  
Opioid Drugs ◽  
Over Time

Follow-up interviews were conducted with 405 black and white male opioid addicts 12 years after admission to drug abuse treatments in the Drug Abuse Reporting Program. Outcomes over time in this longitudinal data system showed that the behavioral improvements observed throughout the first 6-year posttreatment follow-up period (compared with pretreatment baselines) tended to stabilize between Years 6 and 12. About one-fourth of the sample still used opioid drugs daily in Year 12. Demographic and background measures generally failed to predict Year 12 outcomes, although Year 6 outcomes were related to those in Year 12. Reasons for starting, continuing, and terminating opioid addiction were also examined, as well as the importance of treatment during addiction careers.

scholarly journals Evaluation of the Trend of CD4 Cell Count Over Time in Case of HIV/AIDS Patients under ART Follow-up

2019 ◽  
pp. 1-8
Author(s):  
Kabtamu Tolosie Gergiso ◽  
Markos Abiso Erango
Keyword(s):  
Longitudinal Data ◽  
Cell Count ◽  
Time Effect ◽  
Visit Time ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Education Status ◽  
Cd4 Cell ◽  
Over Time

Background: Globally 36.7 million people living with HIV, 1.8 million new HIV infection, and 1 million AIDS-related deaths in 2016.Patient mortality was high during the first 6 months after therapy for all patient subgroups and exceeded 40 per 100 patient years among patients who started treatment at low CD4 count. The aim this study was to evaluate the trend of CD4 cell count over time and to determine the progress of patient characteristics measured at baseline on CD4 cell count of HIV-infected patients who were under ART treatment in Arba Minch Hospital.  Methods: This study was retrospective follow up study using data extracted from medical records, patient interviews, and laboratory work-up. The study was employed among 550 adult patients that were selected by simple random sampling. The continuous outcome variable CD4 cell count has measured at months 0, 6, 12, 18, and 24. Longitudinal data analysis were used because the set of measurements on one patient tend to be correlated, measurements on the same patient close in time tend to be more highly correlated than measurements far apart in time, and the variability of longitudinal data often changes with time and the data handled through linear mixed effect models. Result: The fitted result of the linear mixed model showed that linear visit time effect and the baseline characteristics education status, condom, tobacco, degree of Disclosure, and weight effects had significant effect on CD4 measurements. Also, the interaction age with linear visit time effect had significant effect on the evolution of CD4 cell count. However, no significant difference between sex, WHO stage, and marital status groups. Conclusion: This study find that the CD4 cell count of HIV/AIDS patients is significantly determined by the visit time, education status, condom, tobacco, degree of Disclosure, and weight effects of patients.

Follow-Up of Learning Disabled Children

1979 ◽  
Vol 2 (1) ◽  
pp. 60-69 ◽  
Author(s):  
Ruth L. Gottesman
Keyword(s):  
Reading Achievement ◽  
Longitudinal Data ◽  
Learning Disability ◽  
Learning Disabled ◽  
Learning Problems ◽  
Disabled Children ◽  
Learner Characteristics ◽  
And Performance ◽  
Over Time

Limited longitudinal data on learner characteristics and performance are available in the learning disability field. This study, however, follows the course of reading achievement over a five- to seven-year period of a group of children with learning problems. These students' characteristics are described in detail along with their relationship to reading achievement over time. The data support the premise that academically related deficits persist over time in LD populations.

Effectiveness of the Chiari Health Index for Pediatrics instrument in measuring postoperative health-related quality of life in pediatric patients with Chiari malformation type I

2020 ◽  
pp. 1-6
Author(s):  
Georgina E. Sellyn ◽  
Alan R. Tang ◽  
Shilin Zhao ◽  
Madeleine Sherburn ◽  
Rachel Pellegrino ◽  
...  
Keyword(s):  
Surgical Intervention ◽  
Type I ◽  
Health Related Quality ◽  
Health Index ◽  
Chiari Malformation Type I ◽  
Related Quality ◽  
Health Related ◽  
Over Time

OBJECTIVEThe authors’ previously published work validated the Chiari Health Index for Pediatrics (CHIP), a new instrument for measuring health-related quality of life (HRQOL) for pediatric Chiari malformation type I (CM-I) patients. In this study, the authors further evaluated the CHIP to assess HRQOL changes over time and correlate changes in HRQOL to changes in symptomatology and radiological factors in CM-I patients who undergo surgical intervention. Strong HRQOL evaluation instruments are currently lacking for pediatric CM-I patients, creating the need for a standardized HRQOL instrument for this patient population. This study serves as the first analysis of the CHIP instrument’s effectiveness in measuring short-term HRQOL changes in pediatric CM-I patients and can be a useful tool in future CM-I HRQOL studies.METHODSThe authors evaluated prospectively collected CHIP scores and clinical factors of surgical intervention in patients younger than 18 years. To be included, patients completed a baseline CHIP captured during the preoperative visit, and at least 1 follow-up CHIP administered postoperatively. CHIP has 2 domains (physical and psychosocial) comprising 4 components, the 3 physical components of pain frequency, pain severity, and nonpain symptoms, and a single psychosocial component. Each CHIP category is scored on a scale, with 0 indicating absent and 1 indicating present, with higher scores indicating better HRQOL. Wilcoxon paired tests, Spearman correlations, and linear regression models were used to evaluate and correlate HRQOL, symptomatology, and radiographic factors.RESULTSSixty-three patients made up the analysis cohort (92% Caucasian, 52% female, mean age 11.8 years, average follow-up time 15.4 months). Dural augmentation was performed in 92% of patients. Of the 63 patients, 48 reported preoperative symptoms and 42 had a preoperative syrinx. From baseline, overall CHIP scores significantly improved over time (from 0.71 to 0.78, p < 0.001). Significant improvement in CHIP scores was seen in patients presenting at baseline with neck/back pain (p = 0.015) and headaches (p < 0.001) and in patients with extremity numbness trending at p = 0.064. Patients with syringomyelia were found to have improvement in CHIP scores over time (0.75 to 0.82, p < 0.001), as well as significant improvement in all 4 components. Additionally, improved CHIP scores were found to be significantly associated with age in patients with cervical (p = 0.009) or thoracic (p = 0.011) syrinxes.CONCLUSIONSThe study data show that the CHIP is an effective instrument for measuring HRQOL over time. Additionally, the CHIP was found to be significantly correlated to changes in symptomatology, a finding indicating that this instrument is a clinically valuable tool for the management of CM-I.

Coping with longitudinal data in research on developmental psychopathology

2006 ◽  
Vol 30 (1) ◽  
pp. 20-25 ◽  
Author(s):  
David A. Cole
Keyword(s):  
Data Collection ◽  
Longitudinal Data ◽  
Developmental Psychopathology ◽  
Careful Consideration ◽  
Two Dimensions ◽  
The Other ◽  
Outcome Variable ◽  
The Third ◽  
Data Analytic ◽  
Over Time

Many outcome variables in developmental psychopathology research are highly stable over time. In conventional longitudinal data analytic approaches such as multiple regression, controlling for prior levels of the outcome variable often yields little (if any) reliable variance in the dependent variable for putative predictors to explain. Three strategies for coping with this problem are described. One involves focusing on developmental periods of transition, in which the outcome of interest may be less stable. A second is to give careful consideration to the amount of time allowed to elapse between waves of data collection. The third is to consider trait-state-occasion models that partition the outcome variable into two dimensions: one entirely stable and trait-like, the other less stable and subject to occasion-specific fluctuations.

scholarly journals P34 Characteristics, diagnosis and management of Cushing’s disease - A systematic review and meta-analysis

BJS Open ◽  
2021 ◽  
Vol 5 (Supplement_1) ◽  
Author(s):  
Chan Hee Koh ◽  
Danyal Z Khan ◽  
Ronneil Digpal ◽  
Hugo Layard Horsfall ◽  
Hani J Marcus ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cushing’S Disease ◽  
Meta Analysis ◽  
A Priori ◽  
Pituitary Surgery ◽  
Serum Cortisol ◽  
Cushing's Disease ◽  
Diagnosis And Management ◽  
Over Time

Abstract Introduction The clinical practice and research in the diagnosis and management of Cushing’s disease remains heterogeneous and challenging to this day. We sought to establish the characteristics of Cushing’s disease, and the trends in diagnosis, management and reporting in this field. Methods Searches of PubMed and Embase were conducted. Study protocol was registered a-priori. Random-effects analyses were conducted to establish numerical estimates. Results Our screening returned 159 papers. The average age of adult patients with Cushing’s disease was 39.3, and 13.6 for children. The male:female ratio was 1:3. 8% of patients had undergone previous transsphenoidal resection. The ratio of macroadenomas: microadenomas:imaging-undetectable adenomas was 18:53:29. The most commonly reported preoperative biochemical investigations were serum cortisol (average 26.4µg/dL) and ACTH (77.5pg/dL). Postoperative cortisol was most frequently used to define remission (74.8%), most commonly with threshold of 5µg/dL (44.8%). Average remission rates were 77.8% with recurrence rate of 13.9%. Median follow-up was 38 months. Majority of papers reported age (81.9%) and sex (79.4%). Only 56.6% reported whether their patients had previous pituitary surgery. 45.3% reported whether their adenomas were macroadenoma, microadenoma or undetectable. Only 24.1% reported preoperative cortisol, and this did not improve over time. 60.4% reported numerical thresholds for cortisol in defining remission, and this improved significantly over time (p = 0.004). Visual inspection of bubbleplots showed increasing preference for threshold of 5µg/dL. 70.4% reported the length of follow up. Conclusion We quantified the characteristics of Cushing’s disease, and analysed the trends in investigation and reporting. This review may help to inform future efforts in forming guidelines for research and clinical practice.

scholarly journals 325 - Relationship quality in dementia: Preliminary longitudinal analyses of the EU-JPND Actifcare cohort study

2020 ◽  
Vol 32 (S1) ◽  
pp. 83-83
Author(s):  
Maria J. Marques ◽  
Bob Woods ◽  
Eva Y.L. Tan ◽  
Marjolein de Vugt ◽  
Frans Verhey ◽  
...  
Keyword(s):  
Social Support ◽  
Cohort Study ◽  
Relationship Quality ◽  
Sense Of Coherence ◽  
Unmet Needs ◽  
Neuropsychiatric Symptoms ◽  
Longitudinal Analyses ◽  
Family Carers ◽  
Over Time

INTRODUCTIONRelationship quality (RQ) in dyads of persons with dementia and their family carers is important both as a clinical outcome and as a determinant of health and quality of life. In previous work we studied RQ using baseline data of a large-scale European longitudinal study on timely access to and use of community formal services in dementia (EU-JPND Acticare). We concluded that neuropsychiatric symptoms and carer stress contributed to discrepancies in RQ ratings within the dyad, which were less favourable when reported by family carers. This and other associations (e.g. between carer-rated RQ and sense of coherence) were cautiously interpreted, in the context of a cross-sectional analysis.OBJECTIVESTo analyse how carer-reported RQ varies over time and to examine its most important influencing factors.METHODSWe present preliminary longitudinal analyses from the Actifcare cohort study of 451 community-dwelling persons with dementia and their primary carers in eight European countries (12-month follow-up). Comprehensive assessments included the Positive Affect Index (PAI) to assess RQ, persons with dementia’s neuropsychiatric symptoms, persons with dementia and carers’ unmet needs, carers’ anxiety and depression, social support, sense of coherence and stress.RESULTSCarers’ mean PAI scores decreased over the 12 -month period. The person with dementia neuropsychiatric symptoms and unmet needs, and carers’ perceived social support were significant predictors of carers’ RQ change.DISCUSSION AND CONCLUSIONWe analysed carer-reported RQ variation over time and predictors in a large European sample of persons with dementia and their family carers. As expected, RQ decreased over the oneyear follow-up period as the disease progressed. Its main predictors in this sample (neuropsychiatric symptoms and the person’s unmet needs, together with carers’ social support) can all influence the impact that caregiving has on the carer and on how time and energy-consuming caregiving is. The role of increased clinical symptoms (also affecting communication difficulties), together with carers’ exhaustion, must be equated. Overall, these results may help us to tailor interventions addressing RQ and potentially improve dementia outcomes.

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