Pulmonary Sarcoidosis after Ten to Twenty Years

1986 ◽  
Vol 31 (2) ◽  
pp. 72-78 ◽  
Author(s):  
R. N. Johnston
Keyword(s):  
Pulmonary Fibrosis ◽  
Autoimmune Diseases ◽  
Transfer Factor ◽  
Respiratory Function ◽  
Malignant Disease ◽  
Causes Of Death ◽  
Respiratory Function Tests ◽  
Pulmonary Sarcoidosis ◽  
Radiological Evidence

One hundred and fifty-nine patients with Pulmonary Sarcoidosis have been studied ten to 20 years after diagnosis with a 90 per cent follow-up of survivors. Among the 76 patients with a mean follow-up of 22.5 years there is radiological evidence of pulmonary fibrosis in 13 and respiratory function tests revealed 12 with a transfer factor of less than 80 per cent of predicted. Of the further 83 patients followed to ten years there was radiological evidence of pulmonary fibrosis in five and a reduced transfer factor in four. Thirty-one patients received Prednisolone for various complications due to Sarcoidosis. There is no evidence of late respiratory disability. The complications and causes of death at ten and 20 years are examined and among the latter eight developed various forms of malignant disease. Since 1973 a further 139 patients have been studied, i.e. a total of 298 and two of these died from progressive Sarcoidosis despite corticostroid treatment. Six patients have developed late autoimmune diseases.

scholarly journals Survival Rates and Causes of Death in Geriatric Psychiatric Patients: A Six-Year Follow-up Study.

1972 ◽  
Vol 17 (1) ◽  
pp. 17-22 ◽  
Author(s):  
J. Varsamis ◽  
T. Zuchowski ◽  
K. K. Maini
Keyword(s):  
Survival Rate ◽  
Affective Disorders ◽  
Malignant Disease ◽  
Causes Of Death ◽  
Psychiatric Patients ◽  
Survival Rates ◽  
Psychiatric Institute ◽  
Follow Up Study ◽  
Confusional States

This is a six-year follow-up study of one hundred and thirty geriatric psychiatric patients admitted to the Winnipeg Psychiatric Institute in 1964. The main findings were: 1) Survival rates were lowest in senile patients with arteriosclerotic dementias. Those with other dementias and confusional states and male paranoid patients did somewhat better. Female paranoid patients and those with affective disorders did not differ significantly from the general population. 2) The survival rate of patients with senile dementia supports the view that the short-term prognosis has improved in recent years. 3) No significant difference was found between the survival rate of those with senile and arteriosclerotic dementia. 4) The high mortality rate of male paranoid patients was probably due to the high incidence of serious physical illness and alcoholism. It is suggested that a sizeable proportion of these cases were secondary to extracerebral somatic disease. 5) The commonest primary causes of death were: a) Bronchopneumonia in the group with dementias. b) Myocardial infarction in those with confusional states. c) Heart disease and other causes in those in the paranoid group. d) Malignant disease and suicide in those with affective disorders. 6) The frequent occurrence of malignant disease in affective disorders is noted.

Allergic aspergillus sinusitis with proptosis

1992 ◽  
Vol 106 (9) ◽  
pp. 799-803 ◽  
Author(s):  
K. J. Daghistani ◽  
T. S. Jamal ◽  
S. Zaher ◽  
O. I. Nassif
Keyword(s):  
Allergic Rhinitis ◽  
Differential Diagnosis ◽  
Aspergillus Fumigatus ◽  
Malignant Disease ◽  
Signs And Symptoms ◽  
Surgical Removal ◽  
Radiological Evidence

AbstractAllergic aspergillus sinusitis has recently been increasingly recognized. Five cases are discussed. All presented with proptosis, signs and symptoms of allergic rhinitis and radiological evidence of expansile masses with calcification and bony erosions involving multiple sinuses. Greenish cheesy material was seen at surgery. Histologically the lesions contained eosinophils, Charcot-Lyden crystals and fungal septate hyphae. Aspergillus fumigatus was grown from all cases. Surgical removal with drainage and aeration were performed. The follow-up period ranged between three to 18 months. Recurrence occurred in one patient.Allergic aspergillus sinusitis can mimic malignant disease and should be considered in the differential diagnosis of lesions involving multiple sinuses. It should also be considered in all cases of proptosis.

scholarly journals Imaging of pulmonary sequelae described in viral pandemics prior to SARS-CoV-2 as a prediction model

ANALES RANM ◽  
2021 ◽  
Vol 138 (138(01)) ◽  
pp. 52-59
Author(s):  
Pilar Calvillo-Batllés ◽  
Carlos F Muñoz-Núñez ◽  
Enrique Zaldívar Olmeda ◽  
Vicente Belloch-Ripollés ◽  
Luis Martí-Bonmatí
Keyword(s):  
Respiratory Function ◽  
Influenza A ◽  
H1n1 Virus ◽  
Respiratory Function Tests ◽  
Target Organ ◽  
Lung Damage ◽  
Radiological Findings ◽  
Interstitial Disease

Knowledge of lung sequelae after coronavirus disease 2019 (COVID-19) is still limited given the short follow-up time. In this work, publications with a follow-up of radiological findings once the infection caused by other previously described viruses that have the lung as their target organ and that cause probably similar changes are reviewed, including the coronaviruses that cause Severe Acute Respiratory Syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV), and influenza A-subtype H1N1 virus. Lung damage caused by these viruses leads to slow-resolution interstitial disease, with variable correlation with respiratory function tests. The greater extension of the sequelae has been associated with an older age and a greater severity of the infectious clinical picture. However, the pulmonary imaging findings and their long-term functional impact are still unknown.

scholarly journals Polyglandular Autoimmune Syndrome Triggered after CTLA-4 and PD-1L Immunotherapy Treatment

Reports ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Juan Luis Fernández-Morera ◽  
Alfredo Renilla González ◽  
Carmen Elena Calvo Rodríguez ◽  
Judit Romano-García
Keyword(s):  
Immune Response ◽  
Side Effects ◽  
Autoimmune Diseases ◽  
Autoimmune Diabetes ◽  
Hashimoto Thyroiditis ◽  
Polyglandular Autoimmune Syndrome ◽  
Autoimmune Syndrome ◽  
Previous Diagnosis ◽  
Optimal Approach

Background: CTLA-4 and PD-1L are novel immune checkpoint targets for cancer treatment with specific side effects such as autoimmune diseases. Less frequently, the presence of several autoimmune diseases in the same patient has been described. In this communication, we illustrate the case of a 45-year-old patient with a previous diagnosis of advanced cancer that, after starting treatment with this immunotherapy, developed in the following months autoimmune diabetes, lymphocytic hypophysitis, and a Hashimoto thyroiditis in an abrupt and intense manner that would correspond to an autoimmune polyglandular disease. Discussion: The activation of autoimmunity and associated diseases is increasing in parallel with augmented indication of these immunotherapeutic treatments in cancer patients. A closer follow-up of these patients could be necessary for an optimal approach to this type of pathology. Conclusions: Different autoimmune diseases can converge in the same patient when immunotherapy for cancer is indicated to boost immune response against tumor, caused by altering immune tolerance.

scholarly journals Age-dependency in mortality of Finnish family caregivers: a nationwide register-based study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
T M Mikkola ◽  
H Kautiainen ◽  
M Mänty ◽  
M B von Bonsdorff ◽  
T Kröger ◽  
...  
Keyword(s):  
General Population ◽  
Family Caregivers ◽  
Family Caregiver ◽  
Causes Of Death ◽  
Lower Mortality ◽  
All Cause Mortality ◽  
The Difference ◽  
Caregiver Role ◽  
Selection Of

Abstract Purpose Mortality appears to be lower in family caregivers than in the general population. However, there is lack of knowledge whether the difference in mortality between family caregivers and the general population is dependent on age. The purpose of this study was to analyze all-cause mortality in relation to age in family caregivers and to study their cause-specific mortality using data from multiple Finnish national registers. Methods The data included all individuals, who received family caregiver's allowance in Finland in 2012 (n = 42 256, mean age 67 years, 71% women) and a control population matched for age, sex, and municipality of residence (n = 83 618). Information on dates and causes of death between 2012 and 2017 were obtained from the Finnish Causes of Death Register. Flexible parametric survival modeling and competing risk regression adjusted for socioeconomic status were used. Results The total follow-up time was 717 877 person-years. Family caregivers had lower all-cause mortality than the controls over the follow-up (8.1% vs. 11.6%) both among women (hazard ratio [HR]: 0.64, 95% CI: 0.61-0.68) and men (HR: 0.73, 95% CI: 0.70-0.77). Younger adult caregivers had equal or only slightly lower mortality than their controls, but after age 60, the difference increased markedly resulting in over 10% lower mortality in favor of the caregivers in the oldest age groups. Caregivers had lower mortality for all the causes of death studied, namely cardiovascular, cancer, neurological, external, respiratory, gastrointestinal and dementia than the controls. Of these, the lowest was the risk for dementia (subhazard ratio=0.29, 95%CI: 0.25-0.34). Conclusions Older family caregivers have lower mortality than the age-matched controls from the general population while younger caregivers have similar mortality to their peers. This age-dependent advantage in mortality is likely to reflect selection of healthier individuals into the family caregiver role. Key messages The difference in mortality between family caregivers and the age-matched general population varies considerably with age. Advantage in mortality observed in family caregiver studies is likely to reflect the selection of healthier individuals into the caregiver role, which underestimates the adverse effects of caregiving.

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