Coming Off Drugs

2016 ◽  
Vol 43 (4) ◽  
pp. 381-396 ◽  
Author(s):  
Ian Walmsley
Keyword(s):  
Public Health ◽  
Emotional State ◽  
18Th Century ◽  
The Body ◽  
Heroin User ◽  
Critical Perspective ◽  
Policy Makers ◽  
Heroin Users ◽  
Negative Emotional State ◽  
The Brain

Heroin withdrawal is perhaps one of the most taken-for-granted components of the addiction framework. Heroin users as well as researchers, policy makers, and practitioners have become dependent on it for thinking about and acting upon the process of heroin leaving the body. It is thought to be among the most challenging aspects of the recovery journey and has been linked to a range of public health, legal, and social problems. The taken-for-granted nature of heroin withdrawal has arguably limited its scrutiny in sociological and historical analyses. This article offers an alternative and critical perspective that draws attention to the heterogeneity of historical events and strategies that have left their mark on the withdrawing body of the heroin user. It maps changes in the discourse from the 18th century to the present and closes with developments in the neuroscience of addiction, which have relocated withdrawal from the body to the neurocircuitry of the brain and reframed it as a negative emotional state. This new language suggests the future of the discourse of withdrawal might be relatively short. The analysis moves beyond existing understandings of withdrawal as the simple absence of drugs from the body.

scholarly journals Emotions in Motion: Myofascial Interoception

2017 ◽  
Vol 24 (2) ◽  
pp. 110-113 ◽  
Author(s):  
Bruno Bordoni ◽  
Fabiola Marelli
Keyword(s):  
Multidisciplinary Team ◽  
Emotional State ◽  
Shared Vision ◽  
Microscopic Level ◽  
The Body ◽  
Therapeutic Approaches ◽  
Manual Treatment ◽  
Emotional Aspects ◽  
The Brain

There are numerous articles in the literature dealing with the myofascial system, on the physiological, pathological, macroscopic and microscopic level; yet, we still do not have a thorough knowledge of its functions, just as there is still no shared vision of how to classify it. Many professional manual practitioners are involved in its treatment and there are many emerging therapeutic approaches. What is still missing is the awareness that the body is also emotion. The myofascial continuum is able to stimulate the areas of the brain that deal with the emotional state, and manual treatment activates the interoceptive system. To optimize myofascial treatment, a psychologist should work alongside the manual practitioner, creating a multidisciplinary team that takes into account both the physical and emotional aspects.

scholarly journals An Early History of Neuroglial Research: Personalities

Neuroglia ◽  
2018 ◽  
Vol 1 (1) ◽  
pp. 245-281 ◽  
Author(s):  
Alexandr Chvátal ◽  
Alexei Verkhratsky
Keyword(s):  
Brain Function ◽  
Nervous Tissue ◽  
18Th Century ◽  
Natural Philosophy ◽  
Cell Types ◽  
The Body ◽  
Hellenistic World ◽  
Multiple Cell ◽  
The 19Th Century ◽  
The Brain

Neuroscience, like most other divisions of natural philosophy, emerged in the Hellenistic world following the first experimental discoveries of the nerves connecting the brain with the body. The first fundamental doctrine on brain function highlighted the role for a specific substance, pneuma, which appeared as a substrate for brain function and, being transported through the hollow nerves, operated the peripheral organs. A paradigm shift occurred in 17th century when brain function was relocated to the grey matter. Beginning from the end of the 18th century, the existence of active and passive portions of the nervous tissue were postulated. The passive part of the nervous tissue has been further conceptualised by Rudolf Virchow, who introduced the notion of neuroglia as a connective tissue of the brain and the spinal cord. During the second half of the 19th century, the cellular architecture of the brain was been extensively studied, which led to an in-depth morphological characterisation of multiple cell types, including a detailed description of the neuroglia. Here, we present the views and discoveries of the main personalities of early neuroglial research.

scholarly journals Smarter, faster, better vaccines

2015 ◽  
pp. 7-12
Author(s):  
Evin Allen
Keyword(s):  
Public Health ◽  
Immune Response ◽  
18Th Century ◽  
Public Health Intervention ◽  
The Body ◽  
Influenza Vaccines ◽  
Subsequent Infection ◽  
Mortality And Morbidity ◽  
Late 18Th Century ◽  
Live Bacteria

Since Edward Jenner pioneered modern vaccination in the late 18th century, no other public health intervention has saved as many lives. Vaccines keep us safe and dramatically reduce the mortality and morbidity from many infectious diseases such as measles, diphtheria and influenza. Vaccines are safe, non-viable versions of pathogens (viruses, bacteria) that when administered directs the body into producing an immune response against the pathogen, and it is this that prevents any subsequent infection by the live bacteria or virus. Vaccines are composed of proteins, unlike most medicines that we are prescribed which are chemical molecules produced synthetically by a series of chemical reactions. Chemical molecules are quite small in size and are very stable to the environment; in contrast proteins are large and complex and very unstable. This means that generally we can’t give vaccines as tablets because they would be degraded in the stomach by the same enzymes ...

scholarly journals Prolonged Screen Exposure During COVID-19—The Brain Development and Well-Being Concerns of Our Younger Generation

2021 ◽  
Vol 9 ◽  
Author(s):  
Agnes S. K. Wong
Keyword(s):  
Public Health ◽  
Online Learning ◽  
Brain Development ◽  
Screen Time ◽  
Well Being ◽  
Policy Makers ◽  
Developmental Risks ◽  
The Brain ◽  
Screen Use

COVID-19 is a significant public health crisis and it has given a major impact especially in the field of education. The situation has forced educators around the world to shift to an online mode of teaching and children are forced to study online at home. The benefits of online learning are undeniable, but the possible long-term developmental risks of prolonged screen use should not be overlooked. Recent research findings have clearly suggested the negative effects of screen time on the brain development and well-being of our younger generation. Considering the possible long-term developmental risks of prolonged screen use, policy makers should consider appropriate public health policy (e.g., recommendations on screen time) and guideline for the implementations of online learning (e.g., allowing flexibility to suit individual needs). Multidisciplinary collaboration between policy makers, health care professionals, schools, and parents is required to rethink the current situation before it is too late.

Conquest of Pain: Analgesics: From Morphine to Lyrica

2014 ◽  
Author(s):  
Jie Jack Li
Keyword(s):  
18Th Century ◽  
The Body ◽  
Ancient Greek ◽  
Philosophical Perspective ◽  
Hua Tuo ◽  
Postoperative Dental Pain ◽  
Pain Analgesics ◽  
Great Culture ◽  
The Brain ◽  
Surgical Operations

To live is to endure pain has been understood by almost everybody who is mature enough to gain some philosophical perspective on life. C’est la vie! as the French would say. Indeed, pain existed before the dawn of humanity—some research suggests that even plants respond to pain. According to ancient Greek myth, Prometheus stole fire from Olympus to give it to mortals. Zeus punished him by chaining him to a rock and having a great eagle feast on his liver daily, inflicting unbearable agony. Zeus also sent Pandora to Earth, unleashing pain (one of the items in Pandora’s box) and many evils as a vengeance to mankind. Without an understanding of pain, our ancestors resorted to many measures to ease pain; some were successful to some extent, and some were completely futile. Witches and shamans were sought out to exorcise pain from the body. From a psychological perspective, they might be effective for some believers. The hypnotizing technique reached its crescendo in the 18th century in France when Monsieur Anton Mesmer “mesmerized” many French citizens, liberating them from their pains. As civilization progressed, alcohol became more and more a universal painkiller after it was observed that drunkards were oblivious to pain. Chinese surgeon Hua Tuo (115–205 ad) gave his patients an effervescent powder (possibly cannabis) in wine that produced numbness and insensibility before surgical operations. Another ancient invention in Chinese medicine was the use of acupuncture to ease pain. Acupuncture, now an increasingly popular treatment for persistent as well as intermittent pain, is thought to work by increasing the release of endorphins, chemicals that block pain signals from reaching the brain. A recent survey by the National Institute of Health (NIH) indicated that acupuncture showed efficacy in adult postoperative pain, chemotherapy nausea and vomiting, and postoperative dental pain. There is no doubt that acupuncture works for some patients’ minor pain, through either physiological or psychological means, or both. or both. During the hype of the Great Culture Revolution (1966–1976), it was even claimed that major operations were carried out using acupuncture without any other anesthetics.

scholarly journals Japan: What to Do with Dead Bodies? A Burning Issue

2020 ◽  
Vol 42 (1) ◽  
pp. 1-6
Author(s):  
Andy Crump
Keyword(s):  
Public Health ◽  
Environmental Pollution ◽  
Leisure Activities ◽  
High Technology ◽  
The Body ◽  
Policy Makers ◽  
Loved One ◽  
The World ◽  
Dead Bodies ◽  
The Cost

Death, the passing of a loved one, friend, colleague or just someone we may have known, is virtually always sad and often traumatic. However, it is a part of life and has to be coped with. Each year around 60 million people worldwide die from a wide and diverse number of causes. The problem of what to do with all those dead bodies is becoming a major conundrum for the families involved as well as for policy makers and governments. Natural and anthropogenic disasters, together with increasing incidence of major pandemics of infectious diseases is making finding a solution ever more difficult. A problem which is made worse by ever-increasing draconian rules about what can and cannot be done when disposing of a body.Currently, there are two basic choices, either bury the body in the ground where such action is permitted or cremate it and dispose of the ashes in a culturally and legally acceptable fashion. Generally, both options are becoming prohibitively expensive. The cost of land and the burgeoning demand for land to be used for industry, agriculture, urbanised centres or leisure activities is making burial no longer an option for most people. Japan has long led the world in incineration technology and it has also led the world for many years in cremating its dead. Virtually all Japanese are now cremated, the funeral process involving a mixture of high technology and unique routines steeped in history. Despite widespread concerns that cremation can cause environmental pollution and may damage public health as a result, it is still deemed less polluting than burial. It is likely that countries around the globe will increasingly adopt a policy of cremating their deceased citizens and would do well to follow the lead in this respect being shown by Japan.

Research Recommendations for Applying Vitamin A-Labelled Isotope Dilution Techniques to Improve Human Vitamin A Nutrition

2014 ◽  
Vol 84 (Supplement 1) ◽  
pp. 52-59 ◽  
Author(s):  
Sherry A. Tanumihardjo ◽  
Anura V. Kurpad ◽  
Janet R. Hunt
Keyword(s):  
Public Health ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Human Subjects ◽  
The Body ◽  
Pool Size ◽  
Serum Retinol ◽  
Vitamin A Status ◽  
Status Assessment ◽  
Total Body

The current use of serum retinol concentrations as a measurement of subclinical vitamin A deficiency is unsatisfactory for many reasons. The best technique available for vitamin A status assessment in humans is the measurement of total body pool size. Pool size is measured by the administration of retinol labelled with stable isotopes of carbon or hydrogen that are safe for human subjects, with subsequent measurement of the dilution of the labelled retinol within the body pool. However, the isotope techniques are time-consuming, technically challenging, and relatively expensive. There is also a need to assess different types of tracers and doses, and to establish clear guidelines for the use and interpretation of this method in different populations. Field-friendly improvements are desirable to encourage the application of this technique in developing countries where the need is greatest for monitoring the risk of vitamin A deficiency, the effectiveness of public health interventions, and the potential of hypervitaminosis due to combined supplement and fortification programs. These techniques should be applied to validate other less technical methods of assessing vitamin A deficiency. Another area of public health relevance for this technique is to understand the bioconversion of β-carotene to vitamin A, and its relation to existing vitamin A status, for future dietary diversification programs.

Study of the infl uence of information and communication tools on the psychophysiological state of schoolchildren on the basis of subjective evaluation

2020 ◽  
pp. 47-55
Author(s):  
Aleksandra Rakhmanova ◽  
Georgiy Loginov ◽  
Vladimir Dolich ◽  
Nataliya Komleva ◽  
Galina Rakhmanova
Keyword(s):  
High School ◽  
Emotional State ◽  
Statistical Significance ◽  
Subjective Evaluation ◽  
Educational Process ◽  
The Body ◽  
Leningrad Region ◽  
Communication Tools ◽  
Information And Communication ◽  
The Relationship

The relevance of the article is determined by the existence of contradictions between the need to introduce innovative technologies into the educational process at school, as an integral attribute of modern education, and the negative influence of factors on the physical and psycho-emotional state of health of students related to the use of information and communication tools (computers, phones, headphones). The goal of the study was to assess the relationship between the timing of the use of information and communication tools and the frequency of functional and psycho-emotional complaints in groups of middle and high school schoolchildren. 400 schoolchildren of the Saratov Region, the Moscow Region, Leningrad Region and the Republic of Dagestan were surveyed, who made up two groups of research: middle-school schoolchildren (grades 5–6) and high-school schoolchildren (grades 10–11 The survey was carried out by means of the standardized formalized cards which included the questions considering usage time of computers and mobile phones, complaints to a headache, hands pain, other pain and/or feeling of discomfort from visual organ and the organs of hearing, as well as a psycho-emotional state. Statistical analysis of the data was performed using the STATISTICA application software program by StatSoft Inc (USA). To compare the frequencies of a binary feature, a fourfold table of absolute frequencies was constructed and the level of statistical significance for the exact Fisher’s two-tailed test criterion was determined. The study was conducted according to the requirements of bioethics, after signing informed consent statement by teenagers and their parents. The study examined the relationship between the timing of the use of information and communication tools and the frequency of complaints in groups of schoolchildren. The results of the study should be taken into account when developing and implementing preventive measures to prevent negative effects of computers and mobile devices on the body of students.

EXPERIMENTAL ASSESSMENT OF THE NANOPARTICLES TOXICITY OF NICKEL OXIDE IN TWO SIZES IN THE SUBCHRONIC EXPERIMENT

2018 ◽  
pp. 30-35
Author(s):  
M.P. Sutunkova ◽  
B.A. Katsnelson ◽  
L.I. Privalova ◽  
S.N. Solovjeva ◽  
V.B. Gurvich ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Nervous Activity ◽  
Equal Mass ◽  
The Body ◽  
Subchronic Toxicity ◽  
Physiological Mechanisms ◽  
Nickel Oxide Nanoparticles ◽  
The Relationship ◽  
The Brain ◽  
Nanoparticles Toxicity

We conducted a comparative assessment of the nickel oxide nanoparticles toxicity (NiO) of two sizes (11 and 25 nm) according to a number of indicators of the body state after repeated intraperitoneal injections of these particles suspensions. At equal mass doses, NiO nanoparticles have been found to cause various manifestations of systemic subchronic toxicity with a particularly pronounced effect on liver, kidney function, the body’s antioxidant system, lipid metabolism, white and red blood, redox metabolism, spleen damage, and some disorders of nervous activity allegedly related to the possibility of nickel penetration into the brain from the blood. The relationship between the diameter and toxicity of particles is ambiguous, which may be due to differences in toxicokinetics, which is controlled by both physiological mechanisms and direct penetration of nanoparticles through biological barriers and, finally, unequal solubility.

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