Effects of Lifestyles of People with Visual Impairments on Cardiometabolic Risk Markers

2019 ◽  
Vol 113 (5) ◽  
pp. 433-442
Author(s):  
Krystyna Gawlik ◽  
Anna Zwierzchowska ◽  
Barbara Rosołek
Keyword(s):  
Physical Activity ◽  
Cardiometabolic Risk ◽  
Ldl Cholesterol ◽  
Eating Habits ◽  
Visual Impairments ◽  
Density Lipoprotein ◽  
Healthy Lifestyles ◽  
Risk Markers ◽  
Cholesterol Levels ◽  
Cardiometabolic Risk Markers

Introduction: The aim of this study was to identify selected cardiometabolic risk markers and determine their correlation with lifestyles of adults with visual impairments. Methods: The study randomly selected 49 people with visual impairments (25 women and 24 men) aged 17–84 years (mean age 58.5 years). Body build, composition metrics, biochemical parameters, level of physical activity, and eating habits were evaluated. Results: Excessive body mass was found in 65% of respondents (72% women and 58% men). Above-typical blood total cholesterol levels were found in 52% of women and 42% of men, low-density lipoprotein (LDL) cholesterol levels in 33% of men and 20% of women, triglyceride levels in 16% of women and 17% of men and glucose in 56% of women and 42% of men. Reduced levels of high-density lipoprotein cholesterol were found in 25% of men and 20% of women. Results showed that 43% of respondents were not involved in physical activity at the recommended level. The use of nicotine was declared by 18% of respondents. No significant correlations were observed for the relationships between physical activity and somatic and biochemical parameters. Eating habits had a significant effect on the prevalence of above-typical LDL cholesterol levels, whereas smoking led to significant differences between study participants due to body mass index and fat percentage. Discussion: Lifestyles of individuals with visual impairments were not entirely healthy. Due to the characteristics of the disability, people with visual impairments are challenged with barriers to living healthy lifestyles. Implications for practitioners: The information obtained here can be used to implement adequate measures to provide equal opportunities for people who are blind or have low vision to lead healthy lifestyles and improve their quality of life.

scholarly journals Correction to: Physical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents

2019 ◽  
Vol 43 (11) ◽  
pp. 2346-2346
Author(s):  
Jakob Tarp ◽  
◽  
Abbey Child ◽  
Tom White ◽  
Kate Westgate ◽  
...  
Keyword(s):  
Physical Activity ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Risk Markers ◽  
Physical Activity Intensity ◽  
Bout Duration ◽  
Activity Intensity ◽  
Cardiometabolic Risk Markers

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals The Description of Low Density Lipoprotein (LDL) Levels on Smoker and Non Smoker Adolescent in Buyan Hamlet, Pancasari Village, Sukasada District, Buleleng, Bali

2017 ◽  
Vol 4 (1) ◽  
pp. 39-44
Author(s):  
Ni Made Restina Juliani ◽  
I Putu Oka Dharmawan ◽  
Putu Ayu Parwati
Keyword(s):  
Physical Activity ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
The Body ◽  
Low Density ◽  
Blood Samples ◽  
Cholesterol Levels

Introduction: Low Density Lipoprotein (LDL) is a type of low-density lipoprotein and the most widely transported cholesterol in the body. Increased levels of LDL in the body can be affected by genetics, age, gender, obesity, physical activity, lifestyle, drug consumption and smoking. Substances in a cigarette can cause an increase of LDL levels. Increased of LDL cholesterol levels can cause Coronary Heart Disease (CHD). The purpose of this research is to know the description of Low Density Lipoprotein (LDL) levels on smoker and non-smoker adolescent in Buyan Hamlet, Pancasari Village, Sukasada District, Buleleng Bali. Method: The type of this research is descriptive. This research was conducted in April-May 2017, which used fasting blood samples of 42 respondents. Result: From the average result of LDL level in smoker adolescent that is 134,91 mg/dL higher than the average of LDL level in non-smoker adolescent that is 74,90 mg/dL. The result of LDL cholesterol levels was determined by 21 smoker adolescent respondents with the close to optimal category (100-129 mg/dL) as many as 9 people (42,8%), and 12 people (57,3%) with worry category (130-159 mg/dL). Whereas in 21 non-smoker adolescent respondents obtained  result of LDL cholesterol level test with optimal category (<100 mg/dL) counted 18 people (87,71%) and 3 person (14,30%) with close to optimal category (100-129 mg/dL). Discussion: Based on the results of this research can be concluded that in smoker adolescent obtained LDL levels with close to optimal category and worrying whereas in non-smoker adolescents obtained LDL levels in the optimal category and close to optimal.

scholarly journals Palmitic Acid Versus Stearic Acid: Effects of Interesterification and Intakes on Cardiometabolic Risk Markers—A Systematic Review

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 615 ◽  
Author(s):  
Merel A. van Rooijen ◽  
Ronald P. Mensink
Keyword(s):  
Stearic Acid ◽  
Palmitic Acid ◽  
Cardiometabolic Risk ◽  
Ldl Cholesterol ◽  
Positional Distribution ◽  
Metabolic Effects ◽  
Cochrane Library ◽  
Risk Markers ◽  
Cardiometabolic Risk Markers ◽  
Triacylglycerol Molecule

Fats that are rich in palmitic or stearic acids can be interesterified to increase their applicability for the production of certain foods. When compared with palmitic acid, stearic acid lowers low-density lipoprotein (LDL)-cholesterol, which is a well-known risk factor for coronary heart disease (CHD), but its effects on other cardiometabolic risk markers have been studied less extensively. In addition, the positional distribution of these two fatty acids within the triacylglycerol molecule may affect their metabolic effects. The objective was to compare the longer-term and postprandial effects of (interesterified) fats that are rich in either palmitic or stearic acids on cardiometabolic risk markers in humans. Two searches in PubMed/Medline, Embase (OVID) and Cochrane Library were performed; one to identify articles that studied effects of the position of palmitic or stearic acids within the triacylglycerol molecule and one to identify articles that compared side-by-side effects of palmitic acid with those of stearic acid. The interesterification of palmitic or stearic acid-rich fats does not seem to affect fasting serum lipids and (apo) lipoproteins. However, substituting palmitic acid with stearic acid lowers LDL-cholesterol concentrations. Postprandial lipemia is attenuated if the solid fat content of a fat blend at body temperature is increased. How (the interesterification of) palmitic or stearic acid-rich fats affects other cardiometabolic risk markers needs further investigation.

scholarly journals Impact of the Apolipoprotein E (epsilon) Genotype on Cardiometabolic Risk Markers and Responsiveness to Acute and Chronic Dietary Fat Manipulation

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2044 ◽  
Author(s):  
Kumari M. Rathnayake ◽  
Michelle Weech ◽  
Kim G. Jackson ◽  
Julie A. Lovegrove
Keyword(s):  
Dietary Fat ◽  
Cardiometabolic Risk ◽  
Apoe Genotype ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Risk Markers ◽  
Cardiometabolic Risk Markers ◽  
The Impact ◽  
Volume Pulse ◽  
Digital Volume Pulse

Apolipoprotein (APO) E (ε) genotype is considered to play an important role in lipid responses to dietary fat manipulation but the impact on novel cardiometabolic risk markers is unclear. To address this knowledge gap, we investigated the relationship between the APOE genotype and cardiometabolic risk markers in response to acute and chronic dietary fat intakes. Associations with fasting (baseline) outcome measures (n = 218) were determined using data from the chronic DIVAS (n = 191/195 adults at moderate cardiovascular disease risk) and acute DIVAS-2 (n = 27/32 postmenopausal women) studies examining the effects of diets/meals varying in saturated, polyunsaturated and monounsaturated (MUFA) fatty acid composition. Participants were retrospectively genotyped for APOE (rs429358, rs7412). For baseline cardiometabolic outcomes, E4 carriers had higher fasting total and low-density lipoprotein-cholesterol (LDL-C), total cholesterol: high-density lipoprotein-cholesterol (HDL-C) and LDL-C: HDL-C ratios, but lower C-reactive protein (CRP) than E3/E3 and E2 carriers (p ≤ 0.003). Digital volume pulse stiffness index was higher in E2 carriers than the E3/E3 group (p = 0.011). Following chronic dietary fat intake, the significant diet × genotype interaction was found for fasting triacylglycerol (p = 0.010), with indication of a differential responsiveness to MUFA intake between the E3/E3 and E4 carriers (p = 0.006). Test fat × genotype interactions were observed for the incremental area under the curve for the postprandial apolipoprotein B (apoB; p = 0.022) and digital volume pulse reflection index (DVP-RI; p = 0.030) responses after the MUFA-rich meals, with a reduction in E4 carriers and increase in the E3/E3 group for the apoB response, but an increase in E4 carriers and decrease in the E3/E3 group for the DVP-RI response. In conclusion, baseline associations between the APOE genotype and fasting lipids and CRP confirm previous findings, although a novel interaction with digital volume pulse arterial stiffness was observed in the fasted state and differential postprandial apoB and DVP-RI responses after the MUFA-rich meals. The reported differential impact of the APOE genotype on cardiometabolic markers in the acute and chronic state requires confirmation.

scholarly journals Association of objectively measured sedentary behavior and physical activity with cardiometabolic risk markers in older adults

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0210861 ◽  
Author(s):  
Thamara Hübler Figueiró ◽  
Gabriel Claudino Budal Arins ◽  
Carla Elane Silva dos Santos ◽  
Francieli Cembranel ◽  
Paulo Adão de Medeiros ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Sedentary Behavior ◽  
Cardiometabolic Risk ◽  
Risk Markers ◽  
Cardiometabolic Risk Markers ◽  
Objectively Measured

scholarly journals Gestational Diabetes Mellitus Worsens the Profile of Cardiometabolic Risk Markers and Decrease Indexes of Beta-Cell Function Independently of Insulin Resistance in Nondiabetic Women with a Parental History of Type 2 Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Alina Sokup ◽  
Barbara Ruszkowska-Ciastek ◽  
Małgorzata Walentowicz-Sadłecka ◽  
Marek Grabiec ◽  
Danuta Rość
Keyword(s):  
Beta Cell ◽  
Beta Cell Function ◽  
Cardiometabolic Risk ◽  
Ldl Cholesterol ◽  
Cell Function ◽  
Fasting Glucose ◽  
Risk Markers ◽  
History Of ◽  
Cardiometabolic Risk Markers

Background. Women with a history of both parental type 2 diabetes (pt2DM) and previous gestational diabetes (pGDM) represent a group at high risk of cardiovascular events. We hypothesized that pGDM changes cardiometabolic risk markers levels as well as theirs associations with glucose indices in nondiabetic pt2DM women.Methods. Anthropometric parameters, glucose regulation (OGTT), insulin resistance (HOMA-IR), beta-cell function, lipid levels, parameters of endothelial dysfunction, and inflammation were evaluated in 55 women with pt2DM, 40 with both pt2DM and pGDM 2–24 months postpartum, and 35 controls.Results. Prediabetes was diagnosed more frequently in women with both pt2DM and pGDM in comparison with women with only pt2DM (10 versus 8,P=0.04). The pGDM group had higher LDL-cholesterol, sICAM-1, tPa Ag, fibrinogen, and lower beta-cell function after adjustment for HOMA-IR, in comparison with pt2DM group. In pt2DM group postchallenge glucose correlated independently with hsCRP and in pGDM group fasting glucose with HOMA-IR.Conclusions. pGDM exerts a combined effect on cardiometabolic risk markers in women with pt2DM. In these women higher LDL-cholesterol, fibrinogen, sICAM-1, tPa Ag levels and decreased beta cell function are associated with pGDM independently of HOMA-IR index value. Fasting glucose is an important cardiometabolic risk marker and is independently associated with HOMA-IR.

scholarly journals Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness—the LIFE-Adult Study

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Franziska G. Rauscher ◽  
Mengyu Wang ◽  
Mike Francke ◽  
Kerstin Wirkner ◽  
Anke Tönjes ◽  
...  
Keyword(s):  
Renal Function ◽  
Cardiometabolic Risk ◽  
Density Lipoprotein ◽  
Population Based ◽  
Risk Markers ◽  
Regression Analyses ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Cardiometabolic Risk Markers ◽  
Sd Oct

Abstract Background Circumpapillary retinal nerve fiber layer thickness (cpRNFLT) as assessed by spectral domain optical coherence tomography (SD-OCT) is a new technique used for the detection and evaluation of glaucoma and other optic neuropathies. Before translating cpRNFLT into clinics, it is crucially important to investigate anthropometric, biochemical, and clinical parameters potentially affecting cpRNFLT in a large population-based dataset. Methods The population-based LIFE-Adult Study randomly selected 10,000 participants from the population registry of Leipzig, Germany. All participants underwent standardized systemic assessment of various cardiometabolic risk markers and ocular imaging, including cpRNFLT measurement using SD-OCT (Spectralis, Heidelberg Engineering). After employing strict SD-OCT quality criteria, 8952 individuals were analyzed. Multivariable linear regression analyses were used to evaluate the independent associations of various cardiometabolic risk markers with sector-specific cpRNFLT. For significant markers, the relative strength of the observed associations was compared to each other to identify the most relevant factors influencing cpRNFLT. In all analyses, the false discovery rate method for multiple comparisons was applied. Results In the entire cohort, female subjects had significantly thicker global and also sectoral cpRNFLT compared to male subjects (p < 0.05). Multivariable linear regression analyses revealed a significant and independent association between global and sectoral cpRNFLT with biomarkers of renal function and lipid profile. Thus, thinner cpRNFLT was associated with worse renal function as assessed by cystatin C and estimated glomerular filtration rate. Furthermore, an adverse lipid profile (i.e., low high-density lipoprotein (HDL) cholesterol, as well as high total, high non-HDL, high low-density lipoprotein cholesterol, and high apolipoprotein B) was independently and statistically significantly related to thicker cpRNFLT. In contrast, we do not observe a significant association between cpRNFLT and markers of inflammation, glucose homeostasis, liver function, blood pressure, or obesity in our sector-specific analysis and globally. Conclusions Markers of renal function and lipid metabolism are predictors of sectoral cpRNFLT in a large and deeply phenotyped population-based study independently of previously established covariates. Future studies on cpRNFLT should include these biomarkers and need to investigate whether incorporation will improve the diagnosis of early eye diseases based on cpRNFLT.

scholarly journals The Effects of Different Degrees of Carbohydrate Restriction and Carbohydrate Replacement on Cardiometabolic Risk Markers in Humans—A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 991 ◽  
Author(s):  
Eva Fechner ◽  
Ellen T.H.C. Smeets ◽  
Patrick Schrauwen ◽  
Ronald P. Mensink
Keyword(s):  
Total Cholesterol ◽  
Cardiometabolic Risk ◽  
Meta Analysis ◽  
Saturated Fatty Acids ◽  
Low Density Lipoprotein ◽  
Random Effect ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Risk Markers ◽  
Cardiometabolic Risk Markers

Low-carbohydrate diets (LCDs) often differ in their diet composition, which may lead to conflicting results between randomized controlled trials. Therefore, we aimed to compare the effects of different degrees of carbohydrate (CHO) restriction on cardiometabolic risk markers in humans. The experimental LCDs of 37 human trials were classified as (1) moderate-low CHO diets (<45–40 E%, n = 13), (2) low CHO diets (<40–30 E%, n = 16), and (3) very-low CHO diets (<30–3 E%; n = 8). Summary estimates of weighted mean differences (WMDs) in selected risk markers were calculated using random-effect meta-analyses. Differences between the LCD groups were assessed with univariate meta-regression analyses. Overall, the LCDs resulted in significant weight loss, reduced diastolic blood pressure BP, and increased total cholesterol and high-density lipoprotein cholesterol (HDL-C), without significant differences between the three LCD groups. Higher low-density lipoprotein cholesterol (LDL-C) concentrations were found with the very-low CHO diets compared to the moderate-low CHO diets. Decreases in triacylglycerol (TAG) concentrations were more pronounced with the low and very-low CHO diets, compared to the moderate-low CHO diets. Substitution of CHO by mainly saturated fatty acids (SFAs) increased total cholesterol, LDL-C, and HDL-C concentrations. Except for LDL-C and TAGs, effects were not related to the degree of CHO restriction. Potential effects of nutrient exchanges should be considered when following LCDs.

Abstract 13507: The Role of Weight Loss in Mediating the Effects of a 2-year Caloric Restriction Regimen on Cardiometabolic Risk Markers in Individuals Without Obesity

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
James L Dorling ◽  
Leanne Redman ◽  
Eric Ravussin ◽  
Kim Huffman ◽  
Susan B RACETTE ◽  
...  
Keyword(s):  
Weight Loss ◽  
Caloric Restriction ◽  
Cardiometabolic Risk ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Model Assessment ◽  
Risk Markers ◽  
Mediation Analyses ◽  
Cardiometabolic Risk Markers ◽  
The Impact

Introduction: Caloric restriction (CR) improves cardiometabolic risk, even among individuals without obesity. However, it is unclear whether these aging-related benefits are mediated by weight loss. Mediation analyses inform mechanisms underlying relationships between an exposure and outcome. Using mediation analyses, our aim was to test if 2-year weight loss mediates the beneficial effects of CR on cardiometabolic risk markers in individuals without obesity. Methods: Participants without obesity were randomized 2:1 to CR or ad libitum (AL) as part of the 2-year trial, Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE). The CR group aimed to enact 25% CR for 2 years, while AL maintained habitual energy intake. Baseline and year 2 assessments included weight and cardiometabolic risk markers. Using the approaches of Valeri and VanderWeele, mediation was quantified as the natural indirect effect (NIE), defined as the impact of an exposure on an outcome through a mediator. Here, the NIE was the effect of CR (exposure) on cardiometabolic risk markers (outcome) that was accounted for by weight change (mediator). Results: In total, 117 and 71 participants in the CR and AL groups, respectively, completed the trial. The CR group achieved 11.9 (± 0.7)% CR and 7.6 (± 0.3) kg of weight loss ( P < 0.01 versus AL). Weight loss significantly mediated the CR-induced improvements in total cholesterol (NIE = -10.4 ± 3.5 mg/dL), low-density lipoprotein cholesterol (NIE = -8.5 ± 2.8 mg/dL), high-density lipoprotein cholesterol (NIE = 2.9 ± 1.3 mg/dL), triglycerides (NIE = -0.20 ± 0.05 log mg/dL), the homeostatic model assessment of insulin resistance (NIE = -0.22 ± 0.06), and C-reactive protein (NIE = -0.39 ± 0.15 log ug/mL) ( P ≤ 0.02). Weight loss did not mediate CR-induced reductions in systolic (NIE = -0.9 ± 1.4 mmHg) and diastolic (NIE = -1.0 ± 1.1 mmHg) blood pressure ( P ≥ 0.37). Conclusion: In individuals without obesity, CR-induced improvements in multiple cardiometabolic risk markers are driven by weight loss after 2 years. These findings emphasize that, even in individuals without obesity, weight loss after prolonged CR plays a role in improving cardiometabolic disease risk; however, some CR benefits still occur independent of weight loss.

Sign in / Sign up

Export Citation Format

Share Document