The Prevalence and Effect of Asthma on Adults with Chronic Rhinosinusitis

We conducted a retrospective review of 145 consecutively presenting adults treated for chronic rhinosinusitis (CRS) in a tertiary care institution. Our goals were to determine (1) the prevalence of asthma in these patients, (2) the prevalence of specific CRS symptoms in both asthmatic and nonasthmatic patients, and (3) the frequency of surgical treatment for CRS in patients with and without asthma. We found that asthma was present in 23.4% of CRS patients, a much higher rate than the 5% prevalence of asthma in the general adult population. Patients with asthma had a significantly higher prevalence of nasal polyps (47 vs. 22%; p = 0.004), olfactory dysfunction (26 vs. 6%; p = 0.001), and nasal congestion (85 vs. 60%; p = 0.027) than did those without asthma. Patients without asthma had a significantly higher prevalence of headache (72 vs. 53%; p = 0.037) and rhinorrhea (58 vs. 38%; p = 0.047). The prevalence of postnasal drip and environmental allergies in the two groups was similar. Although the difference between the proportions of patients with and without asthma who required primary sinus surgery was not statistically significant (76 vs. 64%; p = 0.175), patients with asthma did require significantly more revision sinus procedures overall (mean: 2.9 vs. 1.5; p = 0.003).

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Patient perspectives on endoscopic sinus surgery for chronic rhinosinusitis

Journal of Otolaryngology - Head and Neck Surgery ◽

10.1186/s40463-021-00515-z ◽

2021 ◽

Vol 50 (1) ◽

Author(s):

Nadim Saydy ◽

Sami Pierre Moubayed ◽

Martin Desrosiers

Keyword(s):

Chronic Rhinosinusitis ◽

Endoscopic Sinus Surgery ◽

Nasal Congestion ◽

A Priori ◽

Tertiary Care ◽

Sinus Surgery ◽

Data Set ◽

Patient Goals ◽

Personalized Approach ◽

Minor Disease

Abstract Background Through shared decision-making, physicians and patients can elect endoscopic sinus surgery (ESS) when maximal medical therapy fails in patients with chronic rhinosinusitis (CRS). In this study, we aim to explore the most important themes with regards to patients’ perspectives on ESS. Our objective was to define the patient experience and ensure that we have congruent physician and patient goals for obtaining success. Methods Semi-structured face-to-face interviews were conducted with 22 patients at a tertiary-care institution in Montreal. Three themes were established a priori: living with CRS, objectives and expectations and criteria for success. This thematic approach allowed the identification, analysis and reporting of patterns found across the data set. A phenomenological methodological orientation was used. Interviews were audio-recorded and transcribed verbatim for continuous analysis. These were coded by hand by a single coder who read the transcripts multiple times and relistened to the recordings. Results Exploration of themes on patients’ perspectives on ESS for CRS yielded multiple anecdotal findings, and some recurring patterns. There is a tendency for patients to focus on one principal symptom that drives their decrease in QoL. Headaches and nasal congestion seemed to impact patients’ QoL the most amongst rhinologic symptoms. Hyposmia was rarely spontaneously by patients but was often a significant source of distress when prompted during interviews. Objectives and expectations seemed to be inversely proportional to number of previous surgeries and severity of symptoms preoperatively. There was a clear association between preoperative expectations and postoperative satisfaction. There was no clear pattern in the improvement magnitude or time improved postoperatively for patients to consider the surgery a success. Conclusions Patients’ level of satisfaction postoperatively and with their care in general is multifactorial. We believe the topic of goals and expectations regarding ESS should be discussed preoperatively for every patient with CRS. This includes patients with seemingly minor disease and patients naive to surgery, as can sometimes have exceedingly high expectations. Preoperative counselling must also include an assessment of what symptom is the most cumbersome to that particular patient, as patients tend to focus a lot on one or two symptoms. Postoperatively, we encourage clinicians to be attentive to the change in each patient’s principal complaints within the context of a personalized approach and to refer back to patients’ preoperative goals in their assessment of operative success. Graphical abstract

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The Effects of Endoscopic Sinus Surgery on Voice Characteristics in Chronic Rhinosinusitis Patients

Annals of Otology Rhinology & Laryngology ◽

10.1177/0003489419861124 ◽

2019 ◽

Vol 128 (12) ◽

pp. 1129-1133

Author(s):

Danny B. Jandali ◽

Ashwin Ganti ◽

Inna A. Husain ◽

Pete S. Batra ◽

Bobby A. Tajudeen

Keyword(s):

Quality Of Life ◽

Chronic Rhinosinusitis ◽

Endoscopic Sinus Surgery ◽

Tertiary Care ◽

Voice Quality ◽

Upper Airway ◽

Sinus Surgery ◽

Perceptual Evaluation ◽

Snot 22

Objectives: Functional endoscopic sinus surgery (FESS) is a standard treatment modality for patients with chronic rhinosinusitis (CRS) who have failed appropriate medical therapy. However, FESS entails modification of the upper airway tract that may alter phonatory resonance and produce voice changes. The effects of FESS on postoperative voice characteristics in patients with CRS have yet to be quantitatively assessed. Methods: Patients with severe CRS who underwent FESS at a tertiary care referral center between May and October 2017 were prospectively enrolled. The Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) and the Voice Handicap Index (VHI) were used to quantitatively evaluate voice characteristics and quality of life, respectively. Preoperative and postoperative CAPE-V and VHI scores were compared with postoperative scores for each patient. Sino-Nasal Outcome Test (SNOT-22) scores were also obtained to assess changes in patient symptoms. Results: 18 CRS patients undergoing FESS were enrolled. The average preoperative Lund-Mackay score was 14, indicating baseline severe CRS. Postoperative assessments demonstrated a statistically significant decrease in CAPE-V (45-27, p = .005) and VHI (10-4.7, p < .001) scores. These correlated with a statistically significant decrease in SNOT-22 scores (42-13, p < .001). Conclusions: Patients with CRS experience a significant improvement in voice characteristics and vocal quality of life following FESS. Furthermore, this appears to correlate with a significant decrease in self-reported disease severity. These findings may augment the discussion of potential benefits of FESS to a new potential domain for voice quality.

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Office-Based Sinus Surgery for Cystic Fibrosis Chronic Rhinosinusitis

ORL ◽

10.1159/000512495 ◽

2020 ◽

pp. 1-4

Author(s):

Daniel B. Spielman ◽

David A. Gudis

Keyword(s):

Cystic Fibrosis ◽

Mechanical Ventilation ◽

Chronic Rhinosinusitis ◽

Local Anesthesia ◽

Endoscopic Sinus Surgery ◽

Care Center ◽

Academic Medical Center ◽

Tertiary Care ◽

Sinus Surgery ◽

Office Setting

Objective: Chronic rhinosinusitis (CRS) is nearly ubiquitous in the cystic fibrosis (CF) population, and many patients require multiple endoscopic sinus surgeries throughout their lifetime. Recent studies have demonstrated the profound pulmonary and systemic health benefits of comprehensive CRS treatment. Both endotracheal intubation with mechanical ventilation and inpatient hospital care represent significant risks for CF patients. The goal of this study is to evaluate the safety and feasibility of performing revision endoscopic sinus surgery for CF patients in the outpatient office setting using only local anesthesia to decrease the need for mechanical ventilation and inpatient hospitalization. Methods: This is a prospective cohort study conducted at a tertiary care academic medical center with a CF Foundation-accredited care center. Patients with CF and refractory CRS despite prior surgery and medical therapy were eligible for inclusion. Comprehensive revision ESS was performed in the office using only local anesthesia. Results: Five patients were enrolled and underwent revision endoscopic sinus surgery without complication. The average preoperative Sinonasal-Outcome Test-22 score was 52.0 ± 12.1 and the average preoperative Lund-Mackay score was 15.2 ± 3.8. No patients requested aborting the procedure early due to pain, discomfort, or any other reason. No subjects required prolonged observation or postoperative hospital admission. Conclusion: This prospective pilot study is the first to demonstrate the safety and feasibility of performing comprehensive revision endoscopic sinus surgery for CF patients in the outpatient office setting using only local anesthesia.

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Sino-nasal assessment questionnaire: a specific outcome measure for rhinosinusitis, but what is the range in the asymptomatic population?

The Journal of Laryngology & Otology ◽

10.1017/s0022215106004531 ◽

2006 ◽

Vol 121 (7) ◽

pp. 650-652

Author(s):

F Younis ◽

S Duvvi ◽

T Walker ◽

B Nirmal Kumar

Keyword(s):

Outcome Measure ◽

Healthy Adult ◽

Normal Population ◽

Adult Population ◽

Sinus Surgery ◽

Asymptomatic Group ◽

Symptom Scores ◽

Specific Outcome ◽

The Difference ◽

Assessment Questionnaire

The sino-nasal assessment questionnaire is a system used for scoring the symptoms of chronic rhinosinusitis. However, the range of scores for this questionnaire in the healthy adult population is unknown. We aimed to establish this by recruiting 100 healthy volunteers and comparing their sino-nasal assessment questionnaire scores with those of 100 individuals who had undergone sinus surgery for rhinosinusitis. The difference in mean scores in the symptomatic group (44.62) and the asymptomatic group (8.46) was statistically significant. However, there was substantial overlap between the scores of the two groups. Factors such as age, gender and smoking did not have a statistically significant impact on the eventual score in the asymptomatic group. We believe that symptom scores can only be used effectively when the range in the asymptomatic population is known. This is so that disease severity can be gauged in the context of the normal population and post-operative improvements can be forecast.

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Role of anatomical variations in chronic rhinosinusitis on diagnostic nasal endoscopy and computed tomography scan of paranasal sinuses

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20195697 ◽

2019 ◽

Vol 6 (1) ◽

pp. 101

Author(s):

Falguni J. Parmar ◽

Avani D. Patel

Keyword(s):

Computed Tomography ◽

Chronic Rhinosinusitis ◽

Paranasal Sinuses ◽

Care Center ◽

Tertiary Care ◽

Middle Turbinate ◽

Anatomical Variations ◽

Sinus Surgery ◽

Nasal Endoscopy ◽

Advantages And Disadvantages

Background: Diagnostic nasal endoscopy (DNE) and computed tomography (CT) of para nasal sinuses play an important role in the diagnosis and treatment of chronic rhinosinusitis (CRS). The aim and objective of the study is to see the anatomical variations of the sinonasal region in CRS on DNE and CT paranasal sinuses (PNS).Methods: A descriptive type retrospective study of 30 patients attending the ENT outpatient department of our tertiary care center clinically diagnosed as CRS with symptoms persisting for 12 weeks or more, along with previously failed medical management, including topical nasal steroids, systemic decongestant and extended courses of antibiotics and who were willing to undergo endoscopic sinus surgery are included. Results: Majority of the patients had septal deviation either an anterior or posterior deviation but majority of the cases are asymptomatic for the deviation. Anatomical variations of uncinate process, middle turbinate, inferior turbinate, frontal recess, agger nasi cells, haller cells were studied as well.Conclusions: Prolonged duration of rhinosinusitis symptoms (more than 8-12 weeks) is the primary reason to evaluate a patient for CRS and making the choice between CT PNS or DNE is patient and disease dependent. Understanding the advantages and disadvantages of each helps us realize that they are of synergistic in nature and not competitive.

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Hubungan Gambaran Histopatologi Dan Derajat Konka Hipertrofi Dengan Sumbatan Hidung Pada Rinosinustis Kronik

Medica Hospitalia : Journal of Clinical Medicine ◽

10.36408/mhjcm.v7i2.516 ◽

2020 ◽

Vol 7 (2) ◽

pp. 427-431

Author(s):

Anna Mailasari Kusuma Dewi ◽

Rano Aditomo ◽

Riece Hariyati ◽

Meira Dewi Kusuma Astuti

Keyword(s):

Chronic Rhinosinusitis ◽

Nasal Obstruction ◽

Histopathological Examination ◽

Hypothesis Test ◽

Nasal Congestion ◽

Choanal Atresia ◽

Sinus Surgery ◽

Histopathological Features ◽

Turbinate Hypertrophy ◽

Symptom Evaluation

Latar belakang : Hidung tersumbat dapat disebabkan karena kelainan struktur hidung seperti deviasi septum, atresia koana, konka hipertrofi, celah palatum, hipertrofi adenoid, dan neoplasma. Dua puluh persen populasi dengan hidung tersumbat disebabkan konka hipertrofi. Konka hipertrofi merupakan pembesaran konka akibat bertambahnya ukuran sel konka, yang disebabkan hiperplasia dan hipertrofi lapisan mukosa dan tulang konka. Gambaran hipertrofi dan hiperplasi dapat dilihat melalui pemeriksaan histopatologi. Tujuan penelitian ini untuk mengetahui hubungan gambaran histopatologi dan derajat konka hipertrofi dengan sumbatan hidung pada pasien rinosinusitis kronik (RSK). Metode : Desain penelitian korelasi dengan metode belah lintang pada pasien RSK dengan konka hipertrofi yang menjalani operasi Bedah Sinus Endoskopik Fungsional (BSEF) dan konkotomi. Derajat konka hipertrofi dinilai berdasarkan nasoendoskopi, sedangkan sumbatan hidung menggunakan kuesioner Nasal Obstruction Symptom Evaluation (NOSE). Uji hipotesis yang digunakan adalah uji korelasi Spearman. Hasil : Karakteristik subyek penelitian sebanyak 33 orang, perempuan 60% lebih banyak daripada laki-laki 40%. Derajat sumbatan hidung ringan (30%), sedang (27%), berat (30%) dan sangat berat (13%). Konka hipertrofi terbanyak yaitu derajat 3 (54,5%). Hasil analisis dengan uji korelasi Spearman menunjukkan terdapat korelasi positif dengan nilai korelasi sedang antara derajat konka hipertrofi dengan derajat sumbatan hidung (p=0.02 dan rho = 0.404. Tidak terdapat hubungan yang bermakna antara derajat sumbatan hidung dengan gambaran histopatologi konka inferior (hiperplasia sel goblet, pembentukan kelenjar submukosa, eosinofil, limfosit, neutrofil). Simpulan : Derajat konka hipertrofi berpengaruh terhadap sumbatan hidung. Gambaran histopatologi konka hipertrofi tidak berpengaruh terhadap derajat sumbatan hidung pada pasien RSK. Kata kunci : Rinosinusitis kronik, sumbatan hidung, konka hipertrofi Background: Nasal congestion can be caused by abnormalities of nasal structures such as deviation of the septum, choanal atresia, turbinate hypertrophy, cleft palate, adenoid hypertrophy, and neoplasms. Twenty percent of the population with nasal congestion is due to turbinate hypertrophy. Turbinate hypertrophy is an enlargement of turbinate due to an increase in the size of turbinate cells, which is caused by hyperplasia and hypertrophy of the mucosal layers and turbinate bones. Description of hypertrophy and hyperplasia can be seen through histopathological examination. The purpose of this study was to determine the relationship between histopathological features and the degree of turbinate hypertrophy with nasal obstruction in patients with chronic rhinosinusitis (CRS). Methode: The correlative study design with a cross-sectional method in CSR patients with turbinate hypertrophy who underwent Functional Endoscopic Sinus Surgery (FESS) and turbinectomy. The degree of turbinate hypertrophy was assessed based on nasoendoscopy, whereas nasal obstruction used the Nasal Obstruction Symptom Evaluation (NOSE) questionnaire. The hypothesis test used is the Spearman correlation test. Result: The characteristics of the study subjects were 33 people, more women (60%) than men (40%). The degree of nasal obstruction is mild (30%), moderate (27%), severe (30%) and very severe (13%). Turbinate hypertrophy grade 3 was the most (54,5%). The analyzed using Spearman correlative test showed a positive correlation with a moderate correlation between the degree of turbinate hypertrophy with the degree of nasal obstruction (p=0.02 dan rho = 0.404). There was no significant relationship between the degree of nasal obstruction with histopathological features of the inferior turbinate (goblet cell hyperplasia, the formation of submucosal glands, eosinophils, lymphocytes, and neutrophils). Conclusion: The degree of turbinate hypertrophy affects nasal obstruction. Histopathological features of turbinate hypertrophy do not affect the degree of nasal obstruction in CSR patients. Keyword: Chronic rhinosinusitis, nasal obstruction, turbinate hypertrophy

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A Cross-sectional Study on Chronic Fungal Rhinosinusitis in a Tertiary Care Hospital in Central Delhi, India

Journal of Pure and Applied Microbiology ◽

10.22207/jpam.15.1.21 ◽

2021 ◽

Author(s):

Prafulla Songara ◽

Gaurav Saxena ◽

Ramesh Agrawal

Keyword(s):

Chronic Rhinosinusitis ◽

Aspergillus Flavus ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Rhizopus Arrhizus ◽

Sinus Surgery ◽

Fungal Sinusitis ◽

Care Hospital ◽

Common Diagnosis ◽

The Mean

Chronic Rhinosinusitis is a common disorder, and its prevalence vary from 1-20% globally. The incidence of fungal sinusitis has increased to such extent in recent years that fungal infection is a common diagnosis in patients with Chronic Rhinosinusitis. The objectives of this current research were objectives of estimating the prevalence of Fungal aetiology in chronic sinusitis patients and their drug sensitivity pattern with common antifungal drugs. A total of 61 Cases present with Chronic Rhinosinusitis (CRS), visited in a tertiary care hospital based in Central Delhi, were included in our study. Excision of sinus tissue, including polyps and masses, were collected in the operation theatre during Functional Endoscopic Sinus Surgery (FESS) procedure in a sterile manner. All the tissues brought in sterile normal saline were processed for bacteriological and mycological examination. Tissues, obtained in 10% formalin were processed for histopathological and cytological analysis. A total of 14 (22.9%) cases of Chronic Rhinosinusitis were affected by fungal etiologies. By E test, the MIC range for isolates of Rhizopus arrhizus after 24 hr of incubation was 1-2 μg/mL, and the mean was 1.5 μg/Ml. Similarly, the MIC range for isolates of Aspergillus flavus after 48 hr of incubation was 0.5-16 μg/mL, and the mean was 4.09μg/mL. By the M38-A broth dilution method, the MIC range for the isolates of Rhizopus arrhizus after 24 hr of incubation was 0.5-2 μg/mL, and the mean was 1.25 μg/ml. Similarly, the MIC range for isolates of Aspergillus flavus after 48 hr of incubation was 0.5-4 μg/mL, and the mean was 1.95 μg/mL.

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Clinical Implications of Psychophysical Olfactory Testing: Assessment, Diagnosis, and Treatment Outcome

Frontiers in Neuroscience ◽

10.3389/fnins.2021.646956 ◽

2021 ◽

Vol 15 ◽

Author(s):

Baihan Su ◽

Benjamin Bleier ◽

Yongxiang Wei ◽

Dawei Wu

Keyword(s):

Clinical Relevance ◽

Adult Population ◽

Olfactory Dysfunction ◽

Diagnosis And Treatment ◽

Sinus Surgery ◽

Olfactory Testing ◽

Assessment And Treatment ◽

General Adult Population ◽

Olfactory Processing ◽

Smell Disorders

Purpose of ReviewOlfactory dysfunction dramatically impairs quality of life with a prevalence of 20% in the general adult population. Psychophysical olfactory testing has been widely used to evaluate the ability to smell due to its validated utility and feasibility in clinic. This review summarizes the current literature regarding psychophysical olfactory testing and the clinical relevance of the olfactory testing with different components. Furthermore, the review highlights the diagnosis and treatment value of olfactory subtests in patients with olfactory dysfunction.Recent FindingsWith the accumulation of studies of psychophysical olfactory testing in olfactory disorders, the clinical relevance of olfactory testing with different components is expanding. Different olfactory domains present with distinct olfactory processing and cortical activity. Psychophysical assessment of olfaction with three domains reveals different levels of olfactory processing and might assist with analyzing the pathophysiologic mechanism of the various olfactory disorders. Furthermore, olfactory thresholds provided the largest amount of non-redundant information to the olfactory diagnosis. Sinonasal olfactory dysfunction and non-sinonasal-related olfactory dysfunction are emerging classifications of smell disorders with certain characteristics of olfactory impairment and different responses to the therapy including steroids, sinus surgery, and olfactory training.SummaryThese recent advancements should promote the understanding of psychophysical olfactory testing, the association between individual subcomponents and neurophysiological processes, and pave the way for precision assessment and treatment of the olfactory dysfunction.

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Ekspresi cyclooxygenase-2 (COX-2) pada penderita rinosinusitis kronis

Oto Rhino Laryngologica Indonesiana ◽

10.32637/orli.v42i2.25 ◽

2012 ◽

Vol 42 (2) ◽

Author(s):

Agus Multazar ◽

Siti Nursiah ◽

Andrina Rambe ◽

Ida Sjailandrawati Harahap

Keyword(s):

Ct Scan ◽

Chronic Rhinosinusitis ◽

Paranasal Sinus ◽

Nasal Congestion ◽

Cyclooxygenase 2 ◽

Sinus Surgery ◽

Descriptive Research ◽

Ostiomeatal Complex ◽

Cox 2 ◽

Frontal Sinuses

Background: Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus mucosa, which are closely related to the involvement of ostiomeatal complex as the drainage pathway of of maxillary and frontal sinuses. Inflammation or edema at the ostiomeatal complex could cause drainage problems leading to rhinosinusitis. Increased expression of COX-2 regulation was considered to play an important role in the development of CRS and increased airway inflammation in the nasal mucosa and paranasal sinuses. Purpose: To find out the expression of Cyclooxygenase-2 in our CRS patients. Methods: This descriptive research was conducted on July 2011 - December 2011 at ENT Department and Pathology Anatomy Department of Medical Faculty of Sumatera Utara University/H. Adam Malik General Hospital, Medan, to all patients diagnosed with CRS and underwent sinus surgery on July 2011 - December 2011. Results: The highest proportion of pain in patients with CRS is facial pain/pressure and headache with nasal congestion which was 78.6%. Multisinusitis on paranasal sinus CT scan was 88.0%. There was a significant correlation between the proportion of pain with the expression of COX-2 (p = 0.033). There was a significant correlation in proportion between the number of sinuses involved with the expression of COX-2 (p = 0.002). Conclusion: This study found positive expression of COX-2 was 84,0%, while negative expression was 16,0% in our rhinosinusitis patients. This lead to conclusion that upregulation of COX-2 expression is thought to play a role as a mediator in the development of CRS. Keywords: chronic rhinosinusitis, ostiomeatal complex, cyclooxygenase-2, immunohistochemical. Abstrak : Latar belakang: Rinosinusitis kronis merupakan peradangan mukosa hidung dan sinus paranasal yang erat hubungannya dengan keterlibatan kompleks ostiomeatal atau celah sempit di etmoid anterior, yang merupakan serambi muka bagi sinus maksila dan frontal. Bila terdapat gangguan di daerah kompleks ostiomeatal seperti inflamasi atau edema maka hal itu akan menyebabkan gangguan drainase sehingga terjadi rinosinusitis. Peningkatan regulasi ekspresi COX-2 diperkirakan memegang peran penting sebagai mediator dalam terjadinya rinosinusitis kronis dan peningkatan inflamasi saluran napas di mukosa hidung dan sinus paranasal. Tujuan: Mengetahui ekspresi cyclooxygenase-2 pada penderita rinosinusitis kronis di RSUP H. Adam Malik, Medan. Metode: Penelitian ini bersifat deskriptif dilakukan di Departemen THT-KL FK USU/RSUP H. Adam Malik, Medan dan Departemen Patologi Anatomi FK USU. Penelitian dilakukan bulan Juli - Desember 2011 pada seluruh penderita yang didiagnosis rinosinusitis kronis, yang menjalani operasi sinus di Divisi Rinologi Departemen THT-KL FK USU/RSUP H. Adam Malik, Medan bulan Juli 2011 - Desember 2011. Hasil: Proporsi rasa nyeri terbanyak pada penderita rinosinusitis kronis adalah rasa nyeri/ nyeri tekan wajah, sakit kepala disertai dengan hidung tersumbat 78,6%. Multi sinusitis pada pemeriksaan CT-Scan sinus paranasal sebanyak 88,0%. Ada hubungan yang bermakna antara jumlah sinus yang terlibat dengan ekspresi COX-2 (p = 0,002). Ada hubungan yang bermakna antara proporsi rasa nyeri dengan ekspresi COX-2 (p=0,033). Kesimpulan: Pada penelitian ini didapati pada penderita rinosinusitis kronis, ekspresi COX-2 yang positif yaitu sebanyak 84,0%, sedangkan yang negatif sebanyak 16,0%. Diperkirakan peningkatan regulasi ekspresi COX-2 berperan sebagai mediator dalam terjadinya rinosinusitis kronis. Kata Kunci: rinosinusitis kronis, kompleks ostiomeatal, cyclooxygenase-2, imunohistokimia.

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Evaluation of MMP-12 expression in chronic rhinosinusitis with nasal polyposis

Rhinology Journal ◽

10.4193/rhin21.320 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

S. Lygeros ◽

G. Danielides ◽

G.C. Kyriakopoulos ◽

K. Grafanaki ◽

F. Tsapardoni ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Gene Expression Regulation ◽

Statistical Significance ◽

Sinus Surgery ◽

Mrna Levels ◽

Tissue Samples ◽

Potential Implication ◽

Protein Levels ◽

Healthy Mucosa ◽

The Difference

Background: The purpose of this study was to evaluate the expression of MMP-12 in patients with chronic rhinosinusitis with polyps (CRSwNP). Methodology: Tissue samples from 37 patients with CRSwNP undergoing functional endoscopic sinus surgery and healthy mucosa specimens from 12 healthy controls were obtained intraoperatively. The mRNA and protein expression levels of MMP-12 were quantified by real-time polymerase chain reaction and Western blotting, respectively. Results: mRNA levels of MMP-12 were significantly elevated in the CRSwNP tissue samples compared to those in control ones. The protein levels of MMP-12 showed a trend of increasing but with no statistical significance. Conclusions: Elevation of MMP-12 in patients with CRSwNP suggests its potential implication in the pathogenesis of the disease. The difference in the expression profile observed between mRNA and protein levels could be due to post-translational gene expression regulation. Our findings provide evidence that MMP-12 along with other MMPs may serve as a biomarker and therapeutic target in the management of the disease.

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