The Role of Fetuin-A and Electrolytes in the Etiology of Sialolithiasis

Objective The aim of this study was to investigate serum and saliva fetuin-A, protein, and electrolyte levels in patients with sialolithiasis. Study Design Prospective randomized controlled study. Setting Tertiary center. Subjects and Methods Twenty patients with recurrent sialadenitis secondary to submandibular salivary gland stones and 20 asymptomatic healthy volunteers without salivary gland stones were included in the study. Bimanual palpation and ultrasonography were performed in the patient and control groups. The electrolyte, protein, and fetuin-A levels of the serum and saliva were measured. Results The serum calcium, phosphorus, and potassium levels of the patients were significantly lower than those of the control group (respectively, P = .04, P = .01, P = .04). There was no statistically significant difference between the serum fetuin-A levels of the 2 groups ( P = .06). The saliva phosphorus values of the patients were higher than those of the control group ( P = .05), as were their saliva fetuin-A and total protein values ( P = .001, P = .01). A positive correlation was determined between the saliva fetuin-A levels and the saliva phosphorus and potassium levels of the patients ( P = .04, P = .02). The magnesium level, which has been argued to be a factor in the prevention of calcification, showed an increased correlation with the total protein in the patient group ( P = .02). Conclusion It is possible that the high levels of saliva fetuin-A, total protein, and phosphorus with insufficient of saliva magnesium levels may make a contribution to the formation of sialoliths.

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Risk for fetal loss and prematurity after 12,413 second trimester amniocenteses in a single center

Journal of Perinatal Medicine ◽

10.1515/jpm-2014-0236 ◽

2015 ◽

Vol 43 (3) ◽

Cited By ~ 4

Author(s):

Marianna Theodora ◽

Aris Antsaklis ◽

Konstantinos Blanas ◽

Panagiotis Antsaklis ◽

George Daskalakis ◽

...

Keyword(s):

Loss Rate ◽

Fetal Loss ◽

Invasive Procedure ◽

Controlled Study ◽

Control Group ◽

Study Group ◽

Second Trimester ◽

Second Trimester Screening ◽

Tertiary Center ◽

Significant Difference

AbstractThe purpose of this retrospective controlled study is to estimate the risk for fetal loss and preterm delivery attributed to second trimester amniocentesis from a single tertiary center.The study group consists of 12,413 singleton pregnancies with consecutive amniocenteses, performed in a single tertiary center during a 15-year period (1996–2010) with known pregnancy outcome. The control group consisted of 6993 pregnancies with negative second trimester screening for aneuploidies during the same period who did not have any invasive test. The two groups were compared in terms of fetal loss rate up to 24 weeks and premature deliveries.Total fetal loss up to 24 weeks in the study group, excluding terminations of pregnancy, was estimated at 1.25% (1.05%–1.45%, confidence interval [CI]: 95%). In the control group the loss rate was 0.65% giving a procedure related fetal loss rate of 0.6% which was not found to be a statistically significant difference. Delivery before the 28The present study has shown that the risk of miscarriage that can be attributed to amniocentesis in our institution is 0.6%, and this is not statistically significant when compared with cases without any invasive procedure during pregnancy. Similarly, the risk for preterm labor was not statistically significant when compared with controls.

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A Comparative Study on the Effects of Using Hydroalcoholic Extracts of Linum Usitatissimum and Rosa Damascena on Liver Function in Adult Male Rats

Quarterly of Horizon of Medical Sciences ◽

10.32598/hms.26.1.3116.1 ◽

2020 ◽

Vol 26 (1) ◽

pp. 54-67

Author(s):

Mohammad Mehdi Padam ◽

◽

Ameneh Khoshvaghti ◽

Keyword(s):

Liver Function ◽

Total Protein ◽

Linum Usitatissimum ◽

Colorimetric Method ◽

Serum Glucose ◽

Male Rats ◽

Control Group ◽

Rosa Damascena ◽

Glucose Levels ◽

Significant Difference

Aims: Damage to liver tissue and its dysfunction is very important and if left untreated, it can cause serious problems and even death. In this study, we aimed to investigate the effects of the hydroalcoholic extracts of Linum usitatissimum and Rosa damascena on liver enzymes, total protein, bilirubin, albumin, and serum glucose levels. Materials and Methods: This is a non-randomized clinical trial conducted on 42 male rats divided into 6 groups; control group (group 1) received only sufficient water and food, groups 1 and 2 received 300 and 500 mg/ kgB.W Linum usitatissimum extract, groups 3 and 4 received 500 and 1000 mg/ kgB.W Rosa damascena, and group 6 received 100 mg/ kgB.W Linum usitatissimum plus 250 mg/ kgB.W Rosa damascena extracts intraperitoneally for 28 days. After the last injection, the rats were weighed and their blood samples were collected. The study parameters were measured using a colorimetric method by a spectrophotometer, and then were analyzed using ANOVA and Tukey’s test in SPSS V. 25 at a significance level of P<0.05. Findings: There was no significant difference between alanine aminotransferase, alkaline phosphatase, total and direct bilirubin levels in the control group in comparison with other groups (P>0.05). In the groups received Rosa damascena extract, there was a significant difference between total protein and albumin levels compared to the control group (P<0.05). Moreover, there was a significant difference between serum glucose and aspartate aminotransferase in the control group compared to other groups (P<0.05). Conclusion: Linum usitatissimum and Rosa damascena have no negative effect on the liver function. The probability of diarrhea occurrence and the possible effects on the total protein and serum albumin after using Rosa damascena, and the effects of different doses of Linum usitatissimum on the glucose levels should be taken into account.

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Evaluation of red cell distribution width (RDW) as a septic marker in comparison with clinical scores and C-reactive protein

QJM ◽

10.1093/qjmed/hcab086.014 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Ali Ahmed Naga ◽

Mohammed Ismaeil Abdel Fattah ◽

Walid Hamed Nofal ◽

Mohammed Abd-elsalam AlMenshawe

Keyword(s):

Septic Shock ◽

Severe Sepsis ◽

Controlled Study ◽

Control Group ◽

Study Group ◽

Distribution Width ◽

Clinical Scores ◽

Group I ◽

Significant Difference ◽

Sepsis And Septic Shock

Abstract Background Challenges of diagnosing and treating sepsis only seem more difficult as incidence increases, patients become older and sicker, and pathogenic organisms evolve. New understanding of inflammatory mediators and pathways, immunity, and genetic variability in this disease state suggests that the current definitions of SIRS, sepsis, severe sepsis, and septic shock are oversimplified. Objective The aim of our study is to evaluate the level of RDW, CRP and clinical scores "SOFA and APACHI" as markers in patients with sepsis and their levels on the outcome and resolution of sepsis in ICU. Methodology We conducted a prospective observational controlled study on 90 adult persons of both sex, 45 of them are adult patients and served as the study group (Group I), and the other 45 are healthy adult volunteers and served as the control group (Group II). The study group represented patients admitted to the ICU of Intensive Care Unit at Damanhour Medical National Institute who fulfilled the diagnostic criteria for sepsis, severe sepsis and septic shock on arrival to ICU according to the SCCM/ ESICM/ ACCP/ ATS/SIS International Sepsis Definitions Conference. Results. In the present study we found that CRP measured on admission was not a predictor of mortality, while that measured at day 5 and day 10 predicted mortality, where there was no statistically significant difference in CRP levels between survivors and non-survivors at the day of admission while there were statistically significant differences between survivors and non survivors according to CRP levels at day 5 (p = 0.001*) and at day 10 (p = 0.001*). It was found also that there were statistically significant differences between survivors and non-survivors according to RDW at day 1(p = 0.011*) and at day 5(p = 0.009*), at day 10 was found there was no statistically significant difference between survivors and non-survivors (p = 0.338). Conclusion RDW is a new promising cheap and readily available biomarker that can be able to diagnose patients with sepsis with accuracy comparable to CRP. Also, RDW at admission is able to predict mortality.

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EVALUATION OF MEAT IN THE INFANT DIET

PEDIATRICS ◽

10.1542/peds.10.4.463 ◽

1952 ◽

Vol 10 (4) ◽

pp. 463-473

Author(s):

HOWARD M. JACOBS ◽

GEORGE S. GEORGE

Keyword(s):

Total Protein ◽

Infant Nutrition ◽

Physical Growth ◽

Morbidity Rate ◽

Control Group ◽

Average Weight ◽

Protein Requirements ◽

Protein Levels ◽

Young Infants ◽

Significant Difference

A commercially prepared lean meat was fed to young infants as a supplement to a diet already adequate in all food factors. In those infants first fed meat under 2 months of age, there was improvement in physical growth as determined by weight and height measurements. The same group demonstrated an improvement in hemoglobin levels; the elimination of the physiologic drop in total protein levels of the serum, with a prompt sustained rise in values, the greater part of which was composed of the globulin fraction. In those infants first fed meat after 2 months of age, there was a slight improvement in average weight gain, but no significant difference was noted in other body measurements, total protein, albumin or globulin fractions, or hemoglobin levels. Illness rates for the two years of the study demonstrated a 40% lower morbidity rate in the meat-fed group as compared to the control group. In striving for the optimum in infant nutrition protein requirements should be evaluated both quantitatively and qualitatively.

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A Prospective Clinical Evaluation of the Effects of Intraoperative Systemic Anticoagulation in Patients Undergoing Arteriovenous Fistula Surgery

The American Surgeon ◽

10.1177/000313481007601020 ◽

2010 ◽

Vol 76 (10) ◽

pp. 1112-1114 ◽

Cited By ~ 5

Author(s):

Bonnie R. Wang ◽

Vincent L. Rowe ◽

Sung Wan Ham ◽

Sukgu Han ◽

Kaushal Patel ◽

...

Keyword(s):

Arteriovenous Fistula ◽

Postoperative Bleeding ◽

Bleeding Complications ◽

Controlled Study ◽

Control Group ◽

Heparin Group ◽

Av Fistula ◽

Fistula Surgery ◽

Significant Difference ◽

The Difference

No standard presently exists for the use of systemic heparin during angioaccess surgery to decrease the incidence of postoperative thrombotic complications. Our objective was to study the effects of intraoperatively administered heparin on 30-day patency and postoperative bleeding complications in patients undergoing autogenous arteriovenous (AV) fistula surgery. A prospective, double-blinded, randomized controlled study was performed on 48 patients undergoing AV fistula creation from April 2007 through November 2009. Of the 48 patients, 22 were randomized to the control group and received no heparin. Twenty-six were randomized to receive heparin (75 units/kg intravenously) before clamping of the artery. There was no significant difference in 30-day patency between the heparin and control groups (92% vs 86%, P = 0.65), respectively. Three patients (12%) developed hematomas in the heparin group compared with one (5%) in the control group; however the difference was not statistically significant ( P = 0.61). The results suggest that intraoperative administration of heparin has no statistically significant effect on 30-day patency rates or postoperative bleeding complications. Larger trials with longer term follow-up and assessment of maturation rates are needed to determine the effect of intraoperative anticoagulation on these outcomes of arteriovenous fistula surgery.

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Acupuncture and Postoperative Vomiting in Day-Stay Paediatric Patients

Anaesthesia and Intensive Care ◽

10.1177/0310057x9602400607 ◽

1996 ◽

Vol 24 (6) ◽

pp. 674-677 ◽

Cited By ~ 20

Author(s):

K. L. Schwager ◽

D. B. Baines ◽

R. J. Meyer

Keyword(s):

Adult Population ◽

Acupuncture Point ◽

Controlled Study ◽

Control Group ◽

Postoperative Vomiting ◽

Double Blind ◽

Paediatric Patients ◽

Transcutaneous Stimulation ◽

Significant Difference ◽

Stimulation Of

The stimulation of the acupuncture point P6 has been used to prevent nausea and vomiting in the adult population. It has, however, been subject to limited comparative evaluation in children. We proposed that stimulation of P6 and the analgesic point Li4 would reduce the incidence of postoperative vomiting. Eighty-four unpremedicated paediatric patients having day-stay surgery (circumcision or herniotomy/orchidopexy) were included in a randomized, double-blind, placebo-controlled study of transcutaneous stimulation of P6 and Li4 or no stimulation. The incidence of vomiting was recorded for 24 hours postoperatively. There was no statistically significant difference in total postoperative vomiting in those patients who were stimulated, compared with the control group (P=0.909), or between any group for postoperative vomiting in the recovery ward, day-stay ward or at home. For all groups, vomiting was more common within the first four hours and more likely to occur in the day-stay ward.

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Evaluating a combined bowel preparation for small-bowel capsule endoscopy: a prospective randomized–controlled study

Gastroenterology Report ◽

10.1093/gastro/goz054 ◽

2019 ◽

Vol 8 (1) ◽

pp. 31-35 ◽

Cited By ~ 1

Author(s):

Stephanie L Hansel ◽

Joseph A Murray ◽

Jeffrey A Alexander ◽

David H Bruining ◽

Mark V Larson ◽

...

Keyword(s):

Small Bowel ◽

Capsule Endoscopy ◽

Bowel Preparation ◽

Diagnostic Yield ◽

Completion Rate ◽

Randomized Controlled Study ◽

Controlled Study ◽

Control Group ◽

Randomized Controlled ◽

Significant Difference

Abstract Background Capsule endoscopy (CE) is frequently hindered by intra-luminal debris. Our aim was to determine whether a combination bowel preparation would improve small-bowel visualization, diagnostic yield, and the completion rate of CE. Methods Single-blind, prospective randomized–controlled study of outpatients scheduled for CE. Bowel-preparation subjects ingested 2 L of polyethylene glycol solution the night prior to CE, 5 mL simethicone and 5 mg metoclopramide 20 minutes prior to CE and laid in the right lateral position 30 minutes after swallowing CE. Controls had no solid food after 7 p.m. the night prior to CE and no liquids 4 hours prior to CE. Participants completed a satisfaction survey. Capsule readers completed a small-bowel-visualization assessment. Results Fifty patients were prospectively enrolled (56% female) with a median age of 54.4 years and 44 completed the study (23 patients in the control group and 21 in the preparation group). There was no significant difference between groups on quartile-based small-bowel visualization (all P > 0.05). There was no significant difference between groups in diagnostic yield (P = 0.69), mean gastric (P = 0.10) or small-bowel transit time (P = 0.89). The small-bowel completion rate was significantly higher in the preparation group (100% vs 78%; P = 0.02). Bowel-preparation subjects reported significantly more discomfort than controls (62% vs 17%; P = 0.01). Conclusions Combined bowel preparation did not improve small-bowel visualization but did significantly increase patient discomfort. The CE completion rate improved in the preparation group but the diagnostic yield was unaffected. Based on our findings, a bowel preparation prior to CE does not appear to improve CE performance and results in decreased patient satisfaction (ClinicalTrials.gov, No. NCT01243736).

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Short-Term Outcomes of Percutaneous Trephination with a Platelet Rich Plasma Intrameniscal Injection for the Repair of Degenerative Meniscal Lesions. A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study

International Journal of Molecular Sciences ◽

10.3390/ijms20040856 ◽

2019 ◽

Vol 20 (4) ◽

pp. 856 ◽

Cited By ~ 9

Author(s):

Rafal Kaminski ◽

Marta Maksymowicz-Wleklik ◽

Krzysztof Kulinski ◽

Katarzyna Kozar-Kaminska ◽

Agnieszka Dabrowska-Thing ◽

...

Keyword(s):

Platelet Rich Plasma ◽

Meniscal Tear ◽

Controlled Study ◽

Control Group ◽

Double Blind ◽

Non Union ◽

Parallel Group ◽

Significant Difference ◽

Clinically Significant ◽

Patient Related Outcome

Meniscal tears are the most common orthopaedic injuries, with chronic lesions comprising up to 56% of cases. In these situations, no benefit with surgical treatment is observed. Thus, the purpose of this study was to investigate the effectiveness and safety of percutaneous intrameniscal platelet rich plasma (PRP) application to complement repair of a chronic meniscal lesion. This single centre, prospective, randomized, double-blind, placebo-controlled study included 72 patients. All subjects underwent meniscal trephination with or without concomitant PRP injection. Meniscal non-union observed in magnetic resonance arthrography or arthroscopy were considered as failures. Patient related outcome measures (PROMs) were assessed. The failure rate was significantly higher in the control group than in the PRP augmented group (70% vs. 48%, P = 0.04). Kaplan-Meyer analysis for arthroscopy-free survival showed significant reduction in the number of performed arthroscopies in the PRP augmented group. A notably higher percentage of patients treated with PRP achieved minimal clinically significant difference in visual analogue scale (VAS) and Knee injury and Osteoarthritis Outcome Score (KOOS) symptom scores. Our trial indicates that percutaneous meniscal trephination augmented with PRP results in a significant improvement in the rate of chronic meniscal tear healing and this procedure decreases the necessity for arthroscopy in the future (8% vs. 28%, P = 0.032).

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The effect of interactive computer play on balance and functional abilities in children with moderate cerebral palsy: a pilot randomized study

Clinical Rehabilitation ◽

10.1177/0269215518821714 ◽

2019 ◽

Vol 33 (4) ◽

pp. 704-710 ◽

Cited By ~ 4

Author(s):

Tamis W Pin ◽

Penelope B Butler

Keyword(s):

Cerebral Palsy ◽

Motor Function ◽

Intervention Group ◽

Controlled Study ◽

Control Group ◽

Gross Motor ◽

Gross Motor Function ◽

Gross Motor Function Measure ◽

Significant Difference ◽

Function Measure

Objectives: To investigate the feasibility and potential efficacy of a six-week interactive computer play training on balance and gross motor function in children with moderate cerebral palsy. Design: A pilot single-blinded matched randomized controlled study. Setting: Community. Participants: In total, 18 children with moderate cerebral palsy were recruited, paired according to age and severity of cerebral palsy and randomized into intervention group or control group. Intervention: The intervention group received additional trunk control training using the interactive computer play in sitting four times per week, 20 minutes per session for six weeks. All study children continued their usual physiotherapy programme. Measurements: All study children were assessed at baseline, week 3, week 6 (completion of intervention) and week 12 using the Pediatric Reach Test, Gross Motor Function Measure–66-Item Set and 2-Minute Walk Test. Results: All intervention children completed and enjoyed the training with no reported adverse event. All children were assessed at all time points. No significant difference was found between the two groups in all assessments. In both groups of children, significant improvements were found in the Gross Motor Function Measure–66-Item Set between week 3 (intervention group: mean 53.41, SD 5.34; control group: mean 52.86, SD 8.33) and week 6 (intervention group: mean 55.00, SD 6.32; control group: mean 54.20, SD 8.35). Conclusion: The intervention protocol of a six-week interactive computer play training was feasible and safe for children with moderate cerebral palsy in special school settings. Future studies with larger sample sizes or using single-subject designs are recommended.

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Telepsychiatry: Psychiatric Consultation through two-way television. A controlled study.

The Canadian Journal of Psychiatry ◽

10.1177/070674378603100107 ◽

1986 ◽

Vol 31 (1) ◽

pp. 32-34 ◽

Cited By ~ 79

Author(s):

M. Dongier ◽

R. Tempier ◽

M. Lalinec-Michaud ◽

D. Meunier

Keyword(s):

Interactive Television ◽

Controlled Study ◽

Control Group ◽

Psychiatric Consultation ◽

Point Scale ◽

Face To Face ◽

The Past ◽

Significant Difference ◽

Control Study ◽

Diagnosis Age

Telepsychiatry (consultation carried out through 2-way interactive television) has been the object of a number of trials in the past twenty years, but to our knowledge there is no previous control study which compares CCTV and face-to-face interviews. Various aspects of the interviews carried out on CCTV were rated on a 5-point scale in questionnaires filled out by: (a) patients; (b) consultees and; (c) consultants. No significant difference was elicited with control interviews in respect to patients’ diagnosis, age and sex. CCTV interview ratings by consultee and consultant were rated only slightly below those of the control group. Such findings should encourage a broader application of interactive CCTV, particularly as a complement to live consultations in distant areas.

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