Evaluation of biomarkers related to zinc nutritional status, antioxidant activity and oxidative stress in rheumatoid arthritis patients

2021 ◽  
pp. 026010602110155
Author(s):  
Graziela Biude Silva Duarte ◽  
Kátia Rau de Almeida Callou ◽  
Kaluce Gonçalves de Sousa Almondes ◽  
Marcelo Macedo Rogero ◽  
Daniel Feldman Pollak ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Nutritional Status ◽  
Sao Paulo ◽  
São Paulo ◽  
Das28 Score ◽  
Zn Status ◽  
The University ◽  
And Oxidative Stress ◽  
Control Study

Background: Oxidative stress (OS) is an important process related to the pathophysiology of rheumatoid arthritis and can be increased by the low intake of antioxidants. Zinc (Zn) is an important antioxidant trace-element for human health and the assessment of the nutritional status of this micronutrient in these patients is of relevance. Aim: This study aimed to evaluate Zn nutritional status in rheumatoid arthritis patients and its relation to OS. Methods: A case–control study was carried out with 51 patients diagnosed with rheumatoid arthritis (RA group) recruited in Hospital São Paulo (São Paulo, Brazil) and 55 healthy women (CO group) from the campus of the University of São Paulo. Blood and 24-hour urine collection were used for biochemical parameters related to Zn status and OS. The assessment of dietary Zn was performed by three 24-hour dietary recalls. Results: The RA group presented significative low Zn intake ( p < 0.001) and plasma concentration ( p = 0.040) of this mineral compared to the CO group. However, both groups were Zn deficient and the disease activity (DAS28 score) for RA patients did not influence Zn biomarkers. In addition, the antioxidant enzymes (superoxide dismutase and glutathione peroxidase) activity and the urinary 8-isoprostanes were reduced in RA patients. Conclusion: The evaluation of dietary intake and biochemical biomarkers indicates that rheumatoid arthritis patients are zinc deficient and have increased OS.

scholarly journals Factors associated with overweight among elementary schoolchildren in Campinas, São Paulo, Brazil

2016 ◽  
Vol 29 (3) ◽  
pp. 401-413 ◽  
Author(s):  
Juliana Melo Teruel Biagi CAMARGO ◽  
Leticia MARÍN-LEÓN
Keyword(s):  
Nutritional Status ◽  
Intervention Studies ◽  
Food Preferences ◽  
Sao Paulo ◽  
São Paulo ◽  
Z Score ◽  
Chicken Nuggets ◽  
Obese Children ◽  
Control Study ◽  
Multiple Analysis

ABSTRACT Objective To assess overweight/obesity of elementary schoolchildren in Campinas , São Paulo , Brazil, and its association with parental nutritional status, children's food consumption, food preferences, and level of physical activity, and familial socioeconomic status. Methods This case-control study included 509 schoolchildren aged 7 to 10 years. Body mass index Z-score was used to determine nutritional status, defining cases (>+1 Z-score) and controls (³-2 ?+1 Z-score). To address association with overweight/obesity, a conceptual model was established and used for multiple analysis, performed by logistic regression. Results The children had an overweight/obesity frequency of 39.5%. Multiple analysis adjusted for socioeconomic level showed that overweight/obese children were more likely to eat at the mall (1.55; 95%CI=1.00-2.40), have overweight and obese parents (OR=1.71; 95%CI=1.08-2.71 and OR=3.55; 95%CI=2.18-5.80 respectively), report use of passive school transport (OR=1.57; 95%CI=1.04-2.36), and consume chicken nuggets on 3 or more days per week (OR=3.03; 95%CI=1.32-6.95). Conclusion These results support the urgent need of strategies to reduce overweight/obesity and promote its prevention in schoolchildren. Moreover, intervention studies involving parents and addressing environmental factors are important for the development of effective programs.

Nutritional status in relation to adipokines and oxidative stress is associated with disease activity in patients with rheumatoid arthritis

Nutrition ◽  
2012 ◽  
Vol 28 (11-12) ◽  
pp. 1109-1114 ◽  
Author(s):  
Hitomi Hayashi ◽  
Keiko Satoi ◽  
Natsuko Sato-Mito ◽  
Tomoko Kaburagi ◽  
Haruka Yoshino ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Nutritional Status ◽  
Disease Activity ◽  
And Oxidative Stress

scholarly journals Mechanism of miR-218-5p in autophagy, apoptosis and oxidative stress in rheumatoid arthritis synovial fibroblasts is mediated by KLF9 and JAK/STAT3 pathways

2021 ◽  
pp. jim-2020-001437
Author(s):  
Ming Chen ◽  
Minghui Li ◽  
Na Zhang ◽  
Wenwen Sun ◽  
Hui Wang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Signaling Pathway ◽  
Synovial Tissue ◽  
Synovial Fibroblasts ◽  
Reverse Transcription Pcr ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Interfering Rna ◽  
And Oxidative Stress

This study was aimed to investigate the effects of miR-218-5p on the proliferation, apoptosis, autophagy, and oxidative stress of rheumatoid arthritis synovial fibroblasts (RASFs), and the related mechanisms. Quantitative reverse transcription–PCR showed that the expression of miR-218-5p in rheumatoid arthritis synovial tissue was significantly higher than that in healthy synovial tissue. Compared with healthy synovial fibroblasts, miR-218-5p expression was obviously upregulated in RASFs, while KLF9 protein expression was markedly downregulated. Mechanistically, miR-218-5p could directly bind to the 3′ untranslated region of KLF9 to inhibit the expression of KLF9. Additionally, transfection of miR-218-5p small interfering RNA (siRNA) inhibited the proliferation but promoted apoptosis and autophagy of RASFs. Simultaneously, miR-218-5p silencing reduced reactive oxygen species and malondialdehyde levels and increased superoxide dismutase and glutathione peroxidase activity to improve oxidative stress in RASFs. More importantly, the introduction of KLF9 siRNA reversed the effects of miR-218-5p siRNA transfection on RASF proliferation, apoptosis, autophagy, and oxidative stress. What is more, silencing miR-218-5p inhibited the activation of JAK2/STAT3 signaling pathway by targeting KLF9. Collectively, knockdown of miR-218-5p could regulate the proliferation, apoptosis, autophagy and oxidative stress of RASFs by increasing the expression of KLF9 and inhibiting the activation of the JAK2/STAT3 signaling pathway, which may provide a potential target for the mechanism research of RA.

Telomere dysfunction-related serological markers and oxidative stress markers in rheumatoid arthritis patients: correlation with diseases activity

2018 ◽  
Vol 37 (12) ◽  
pp. 3239-3246 ◽  
Author(s):  
Rania M. Gamal ◽  
Nevin Hammam ◽  
Madeha M. Zakary ◽  
Marwa Mahmoud Abdelaziz ◽  
Mohamed Raouf Abdel Razek ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Telomere Dysfunction ◽  
Oxidative Stress Markers ◽  
Serological Markers ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals Registry of Hospital das Clínicas of the University of São Paulo Medical School: first official solid organ and tissue transplantation report - 2008

Clinics ◽  
2009 ◽  
Vol 64 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Estela Azeka ◽  
José Otavio Costa Auler Júnior ◽  
Paulo Manuel Pego Fernandes ◽  
Willian Carlos Nahas ◽  
Alfredo Inácio Fiorelli ◽  
...  
Keyword(s):  
Medical School ◽  
Sao Paulo ◽  
Tissue Transplantation ◽  
Solid Organ ◽  
São Paulo ◽  
The University

scholarly journals Internationalization at the University of São Paulo

2016 ◽  
Vol 95 (spe3) ◽  
pp. 5
Author(s):  
Raul Machado Neto
Keyword(s):  
Veterinary Medicine ◽  
Medical School ◽  
Sao Paulo ◽  
Law School ◽  
Human Sciences ◽  
São Paulo ◽  
College Of Agriculture ◽  
Engineering School ◽  
The University

The University of São Paulo, founded in 1934, started under the influence of important foreigners academicians in our campuses. The beginning of our university was the result of a fusion of the already existing colleges – Law School, School of Engineering, School of Pharmacy and Dentistry, College of Agriculture, Medical School, and School of Veterinary Medicine. In addition, in 1934, the School of Philosophy, Sciences and Letters was created being responsible for human sciences – Philosophy, History, Geography, Sociology – and hard sciences – Mathematics, Physics, and Chemistry – that academically amalgamated the professional existing colleges. In the thirties, we benefited from the instabilities in Europe and important professors came to the University of São Paulo contributing remarkably to our successful trajectory.[...]

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