Thermal ablation of saphenous veins is feasible and safe in patients older than 75 years: A prospective study (EVTA study)

2014 ◽  
Vol 30 (8) ◽  
pp. 525-532 ◽  
Author(s):  
C Hamel-Desnos ◽  
P Desnos ◽  
F-A Allaert ◽  
P Kern ◽  
Keyword(s):  
Side Effects ◽  
Prospective Study ◽  
Thermal Ablation ◽  
Cardiac Insufficiency ◽  
Control Group ◽  
Saphenous Veins ◽  
Group 2 ◽  
Multicenter Prospective Study ◽  
A Prospective Study ◽  
Group 1

Objectives To investigate the tolerance and safety of thermal ablation (TA), consisting of radiofrequency or endovenous laser (EVLA) of saphenous veins (SV) in elderly (group 1 ≥75 years), compared with a control group (group 2 <75 years). Method An Observational multicenter-prospective study was conducted, under the aegis of the French and Swiss Societies of Phlebology (18 centers). Ninety patients were included in group 1, 617 in group 2 (mean age 80 years and 53 years; 69% women in both groups), representing 863 SV. Mean trunk diameters were similar in both groups (small SV: 6 mm; great SV: 7 mm). In group 1, comorbidities were more frequent, particularly cardiac insufficiency, diabetes, history of thrombosis, and CEAP clinical class was significantly higher. Results EVLA was used in 86% of cases. Settings used were similar in both groups for each technique. Only 6% of TA was performed in an operating room for group 1 (14% group 2). Tumescent local anaesthesia (TLA) alone was used in 91% of cases in group 1 (85% group 2). The mean pain score was only 1.6 for the procedure itself (VASP 0–10; 10 max.) and 1.4 for the 10 days following the procedure. Side effects were few, but rate of paraesthesia was higher when general anaesthesia was used (11.8%) compared with TLA alone (2.2%). At three months, 100% of SV was occluded in group 1 (99.5% group 2), with high satisfaction score (9.3/10). Conclusion TA is safe and effective in elderly; it should be performed strictly under TLA to minimize side effects.

scholarly journals The Efficacy and Safety of Uractiv Control in Overactive Bladder Treatment

2020 ◽  
Vol 71 (1) ◽  
pp. 390-394
Author(s):  
Calin Bogdan Chibelean ◽  
Veronica Ghirca ◽  
Razvan-Cosmin Petca ◽  
Daniel Porav-Hodade ◽  
Ioan Alin Nechifor-Boila ◽  
...  
Keyword(s):  
Placebo Group ◽  
Side Effects ◽  
Overactive Bladder ◽  
Prospective Study ◽  
Treatment Option ◽  
Alternative Treatment ◽  
Control Group ◽  
Efficacy And Safety ◽  
A Prospective Study ◽  
Safe Treatment Option

The aim of this study is to evaluate the efficacy and safety of Uractiv Control as an alternative treatment with no side effects in Overactive Bladder (OAB). We performed a prospective study over a period of 15 months (May 2018- September 2019) in Department of Urology from Targu-Mureș. We included 165 patients diagnosed with OAB wet (129 patients) and dry form (36 patients) which were fully evaluated over a 3-month period of treatment. 48 patients were treated with placebo 1 month and were evaluated by the same parameters like Uractiv Control group. The frequency of micturition during the day and night after the treatment with Uractiv Control was improved compared to placebo group (p=0.0001) and also the loss of urine episodes (p=0.03). Patients did not report any significant side effects of the treatment. Uractiv Control represents a safe treatment option with no side effects and improvement of the storage in OAB.

scholarly journals Comparative study of efficacy of drotaverine hydrochloride and valethamate bromide with control in first stage of labour

2013 ◽  
Vol 11 (1) ◽  
pp. 38-42 ◽  
Author(s):  
P Dahal ◽  
B Banerjee ◽  
DK Uprety ◽  
BP Das ◽  
A Thakur ◽  
...  
Keyword(s):  
Side Effects ◽  
Mode Of Delivery ◽  
Active Phase ◽  
Fetal Outcome ◽  
Control Group ◽  
P Value ◽  
Drotaverine Hydrochloride ◽  
Group 2 ◽  
And Control ◽  
Group 1

Background: Labour is the most perilous journey a woman has to undertake. Painless and short labour is desired by every woman and is a constant aim for obstetrician.Objective: To analyze and compare the efficacy and safety of drotaverine and valethamate with control group on improving cervical dilatation and promoting progress of labour. Method: Three hundred demographically similar women, both primigravida and multigravida with a term pregnancy in established labour were randomly divided into three groups. One hundred women (group 1) were given injection valethamate intramuscularly,100 women (group 2) were given drotaverine and the rest 100 (group 3) were not given any drug. Comparative analysis was carried out as regards to duration of first stage of labour, mode of delivery, maternal side effects and fetal outcome. Results: The mean duration of active phase of labour in group 1, 2 and 3 was 254.29±96.621 min, 178.31±73.412 min and 346.31±123.351 min respectively. The duration of injection to end of first stage of labour in valethamate and Drotaverine group was 228.12±84.626min and 168.89±69.576min respectively (p value<0.0001). The duration of injection to delivery in Valethamate was 249.13± 88.321 min and in Drotaverine was 192.56±75.479min (p value<0.0001). There were no serious maternal and fetal adverse effects in any group but minor side effects were more common in valethamate group. Conclusion: The reduction of the duration of the first stage of labour was apparently more in drotaverine group as compared to valethamate and control group. Drotaverine was found to be safe with minimal or no adverse effect on the mother and the fetus. Health Renaissance, January-April 2013; Vol. 11 No.1; 38-42 DOI: http://dx.doi.org/10.3126/hren.v11i1.7600

Genital Findings in Sexually Abused, Symptomatic and Asymptomatic, Girls

PEDIATRICS ◽  
1987 ◽  
Vol 79 (5) ◽  
pp. 778-785
Author(s):  
S. Jean Emans ◽  
Elizabeth R. Woods ◽  
Nancy T. Flagg ◽  
Amanda Freeman
Keyword(s):  
Prospective Study ◽  
Sexually Abused ◽  
Asymptomatic Children ◽  
Group 3 ◽  
Group 2 ◽  
A Prospective Study ◽  
Group 1 ◽  
Sexually Abused Girls

Although evaluation of the vulva of sexually abused girls using magnification with a colposcope or pediatric otoscope has become increasingly popular, the incidence of various genital findings in sexually abused and asymptomatic children has not been reported. A prospective study was carried out in which 20 genital findings from three groups of girls (mean age 4.8 ± 2.6 years) were analyzed. The three groups were (1) sexually abused girls (n = 119), (2) normal girls with no genital complaints (n = 127), and (3) girls with other genital complaints (n = 59). Group 1 was more likely than group 2 to have scars on the hymen or posterior forchette (9% v 1%, P = .002), increased friability of the posterior forchette (10% v 1%, P = .001), attenuated hymen (18% v 4%, P = .0003), and synechiae from the hymenal ring to the vagina (8% v 0%, P = .0009). Groups 1 and 3 were remarkably similar with the exception of erythema which was more common in group 3 (34% v 68%, P = .0001). Hymenal diameter was slightly greater in group 1 than 2 but not 3. Although genital findings distinguish some sexually abused girls from asymptomatic girls, many findings also occur in girls with other genital complaints, which suggests that many of these girls have also been molested or that vulvar inflammation may lead to some of these findings.

scholarly journals Daflon use for reducing post-tonsillectomy pain and hemorrhage: a prospective study

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Ahmed Shehata El Sayed Saleh ◽  
Hossam Mohamed Kamal Rabie
Keyword(s):  
Prospective Study ◽  
Pain Control ◽  
Safe Procedure ◽  
Bipolar Diathermy ◽  
Secondary Hemorrhage ◽  
Pain Duration ◽  
Group 2 ◽  
A Prospective Study ◽  
Group 1

Abstract Background Tonsillectomy usually was a safe procedure; in adults, the risk of agonizing pain and secondary hemorrhage could be serious. We introduced Daflon as a safe and effective complementary medication in reducing these risks. This prospective study was designed to evaluate the effect of using (Daflon oral medication) on post-tonsillectomy pain and hemorrhage rates. This study was conducted on 60 patients of both sexes, above 21 years, and underwent tonsillectomy using bipolar diathermy. Patients were randomly distributed between 2 groups; each group has 30 patients and with the same post-operative protocol; in group 2, an addition of Daflon 500 mg tablet twice daily for 14 days post-operatively was given. Results In group 2, agonizing pain start day, pain duration, analgesia duration, and need for another type, all were significantly different from group 1, starting day in group 1 (4.3 ± 4.0) and (7.2 ± 1.3) in group 2, pain duration in group 1 (7.3 ± 1.5) and (4.2 ± 1.4) in group 2 and need for more analgesia 80% in group 1 and 50% in group 2. Post-operative hemorrhage was 4 cases (13.3%) in group 1, and 2 cases (7%) in group 2, also severity of post-operative bleeding were less in group 2. Healing membrane detaching time was (12.2 ± 2.2) in group 1 and (9.1 ± 1.9) in group 2. Conclusion The use of Daflon 500 mg tablet after bipolar tonsillectomy added to effectiveness of pain control also could help in reducing bleeding rates and its severity. Overall, its use enhances recovery and improves quality of life.

EFFICACY OF CAUDAL BLOCK WITH LEVOBUPIVACAINE FOR POSTOPERATIVE ANALGESIA AFTER THE SUBUMBILICAL SURGERY IN CHILDREN

2018 ◽  
Vol 8 (5) ◽  
pp. 58-64
Author(s):  
Nga Bui Thi Thuy ◽  
Minh Nguyen Van
Keyword(s):  
Side Effects ◽  
Postoperative Analgesia ◽  
Laryngeal Mask ◽  
Control Group ◽  
Caudal Block ◽  
Cross Sectional ◽  
Relieve Pain ◽  
Group 2 ◽  
Effective Analgesia ◽  
Group 1

Objectives: To evaluate the efficacy of postoperative analgesia, side effects and complications of caudal block with levobupivacaine 0.25% 1mL/kg for subumbilical surgery. Materials and methods: In a comparative cross-sectional descriptive study, sixty ASA I–II children less than 6 years old scheduled for elective subumbilical surgery were randomized to divide into 2 groups: group 1 (control group) were only used general anethesia with laryngeal mask, group 2 (levo group) were anesthetized under general anaesthesia with laryngeal mask and caudal block with levobupivacaine 0.25% 1mL/kg to relieve pain after surgery. The evaluation variables included the duration of postoperative analgesia, total analgesic used in 12 hours after surgery, FLACC score, Ramsay and Bromage score after extubation of laryngeal mask, side effects and complications. Results: The duration of postoperative analgesia in the caudal block group was 8.25 ± 1.48 hours, in the control group was 0.07 ± 0.37 hours. The total dose of acetaminophen and morphine after surgery in the control group were 574.50 mg ± 23.61mg and 3.94 ± 1.6 mg, while in the levo group were 251.25 mg ± 15.7 mg and 0 mg. In the levo group, at the recovery time, all patients had FLACC score ≤ 3 and most of the patients were co-operative and alert. No side effects occurred between two groups. Conclusion: caudal block for postoperative analgesia was a safe and effective analgesia technique for children. Key words: caudal block, levobupivacaine, subumbilical surgery, children, postoperative analgesia

scholarly journals Cord blood albumin as a predictor of neonatal hyperbilirubinemia in healthy neonates

2017 ◽  
Vol 4 (2) ◽  
pp. 503 ◽  
Author(s):  
Gaurav Aiyappa K. C. ◽  
Ashvij Shriyan ◽  
Bharath Raj
Keyword(s):  
At Risk ◽  
Risk Factor ◽  
Prospective Study ◽  
Exchange Transfusion ◽  
Neonatal Jaundice ◽  
Neonatal Hyperbilirubinemia ◽  
Group 2 ◽  
A Prospective Study ◽  
Group 1

Background: Neonatal jaundice or icterus neonatrum has been observed in newborn babies for many centuries. The objective of this study was to determine the correlation between cord albumin levels and development of hyperbilirubinemia in term healthy neonates.Methods: A prospective study was conducted on 165 term healthy neonates. Gender, gestational age, anthropometric measurements were taken into consideration. It was ascertained that there was no other risk factor for hyperbilirubinemia amongst the neonates. The neonates were divided into two groups A and B based on the cord albumin levels of <2.8 gm/dl and >2.8 gm/dl.Results: Of the 165 babies included in the study, 126 babies were under Group 1 and 39 under Group 2. 44 babies (34%) in group 1 and 28 babies (71.7%) in group 2 (p<0.0005) developed clinical icterus of which 16 in group 1 and 19 in group 2 required phototherapy (p<0.05). 1 baby in group required exchange transfusion. The sensitivity and specificity of cord albumin in detecting neonatal hyperbilirubinemia in this study was determined to be 71.8% and 65.1% respectively.Conclusions: Cord albumin levels help to determine and predict the possibility of hyperbilirubinemia among neonates. Hence this can help to identify the at-risk neonates. So, routine determination of cord albumin can be advocated to keep a track on at risk neonates.

scholarly journals Evaluation of anxiolytic effect of furosemide in Albino rats

2018 ◽  
Vol 7 (2) ◽  
pp. 337
Author(s):  
Malvika Goyal ◽  
Jyothi C. H. ◽  
Rahul H. Damodar
Keyword(s):  
Locomotor Activity ◽  
Side Effects ◽  
Test Group ◽  
Anxiolytic Effect ◽  
Anxiolytic Activity ◽  
Threshold Dose ◽  
Control Group ◽  
Albino Rats ◽  
Group 2 ◽  
Group 1

Background: Anxiety disorders are the most prevalent class of psychiatric condition. Medications commonly given for treatment can elicit several central nervous system (CNS) side-effects that patients find difficult to tolerate. So there is a need for new pharmacotherapeutic approaches to treat anxiety with greater efficacy and fewer side effects. Hence this study has been taken up to evaluate the anxiolytic effect of furosemide at three different doses (75mg/kg, 150mg/kg and 200mg/kg) in Albino rats.Methods: After obtaining approval from the institutional animal ethical committee 30 Albino rats weighing about 150-200gm were taken and divided into 5 groups of 6 rats each. Group 1: Normal Saline 10ml/kg (control); Group 2: Diazepam 2mg/kg (standard); Group 3: Furosemide 150mg/kg (test group 1); Group 4: Furosemide 200mg/kg (test group 2); Group 5: Furosemide 75mg/kg + Diazepam 1mg/kg (sub threshold dose). The anxiolytic activity of furosemide was tested by elevated plus maze and digital actophotometer models. Data was analysed using one way ANOVA followed by Posthoc Tukey’s test.Results: Furosemide (150mg/kg and 200mg/kg) have shown significant increase in open arm entries (p<0.05) and time spent in open arm (p<0.05) compared to control. Also furosemide (150mg/kg and 200mg/kg) have shown statistically significant decrease in locomotor activity (p<0.05) compared to control in actophotometer model. Potentiation of time spent and number of entries in open arm and decrease in locomotor activity were noticed when sub threshold doses of combination of diazepam and furosemide were used.Conclusions: These results suggest that furosemide possesses significant anxiolytic activity at both the doses. Furosemide given in sub threshold dose potentiates the antianxiety effect of sub threshold dose of diazepam when used in combination. Hence, after further studies, furosemide can be used as an anxiolytic drug.

scholarly journals The level of satisfaction with their work and degree of burnout among anesthesiologists and emergency physicians working in the red zone of a COVID hospital

2021 ◽  
Vol 18 (2) ◽  
pp. 17-22
Author(s):  
А. V. Malyarchikov ◽  
K. G. Shapovalov
Keyword(s):  
Intensive Care ◽  
Prospective Study ◽  
Intensive Care Units ◽  
Working Conditions ◽  
Emergency Physicians ◽  
Level Of Satisfaction ◽  
High Satisfaction ◽  
Group 2 ◽  
A Prospective Study ◽  
Group 1

The objective: To determine the level of satisfaction with their work and degree of burnout among anesthesiologists and emergency physicians working in the red zone of a COVID-19 hospital.Subjects and methods. A prospective study was conducted as an anonymous survey of physicians performing their duties in intensive care units of the red zone. 65 specialists were interviewed: Group 1 (52.3%) – trainee physicians, Group 2 (47.7%) – anesthesiologists and emergency physicians.Results. The majority of respondents in both groups noted relatively high satisfaction with their current work. At the same time, the majority of respondents (70.9%) in the group of anesthesiologists and emergency physicians would prefer the previous working conditions to current ones. Also, it was noted that both groups were highly emotionally exhausted.

Combined use of CO2 laser and tissue glue versus conventional surgical techniques for circumcision – A prospective study

2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Akkrapol Mungnirandr ◽  
Suwanna Wiriyakamolphan ◽  
Ravit Ruangtrakool ◽  
Monawat Ngerncham ◽  
Sureerat Tumrongsombutsakul ◽  
...  
Keyword(s):  
Prospective Study ◽  
Co2 Laser ◽  
Surgical Techniques ◽  
Operation Time ◽  
Chromic Catgut ◽  
Tissue Glue ◽  
Combined Use ◽  
Group 2 ◽  
A Prospective Study ◽  
Group 1

AbstractUse of a COThirty boys were divided into two groups. Group 1 (n=17) underwent circumcision using a scalpel with approximation of the wound edges using chromic catgut sutures. Group 2 (n=13) underwent circumcision using a COGroup 1 (scalpel+sutures) had a significantly longer operation time (The combined use of a CO

scholarly journals A Prospective Study to Evaluate the efficacy of Isopropyl Alcohol Irrigations to Prevent Cerumen Impaction

2012 ◽  
Vol 91 (3) ◽  
pp. E25-E28 ◽  
Author(s):  
Herbert Silverstein ◽  
Benjamin J. Wycherly ◽  
Yadiel Alameda ◽  
Mark J. Van Ess
Keyword(s):  
Prospective Study ◽  
Crossover Study ◽  
Isopropyl Alcohol ◽  
Initial Evaluation ◽  
Safety And Efficacy ◽  
Significant Difference ◽  
The Mean ◽  
Group 2 ◽  
A Prospective Study ◽  
Group 1

We conducted a prospective crossover study to assess the safety and efficacy of 70 % isopropyl alcohol delivered from a squeezable bottle with a specially designed tip as a weekly irrigant to reduce cerumen accumulation. Twenty patients were divided into 2 groups of 10 (20 ears in each group). The patients in group 1 instilled 70% isopropyl alcohol once a week for 2 months; this was followed by 2 months of no ear cleaning. The patients in group 2 performed the opposite routine. At each visit (0, 2, and 4 mo), cerumen accumulation was graded on a scale of 0 to 4, indicating 0, 25, 50, 75, and 100% occlusion, respectively. After the accumulation was graded, a cerumenectomy was performed. At the initial evaluation, the mean occlusion scores were 3.1 for group 1 and 3.3 for group 2—not a statistically significant difference. After the first 2 months of the study, there was a significant difference in occlusion scores between groups 1 and 2 (0.75 and 1.55, respectively; p (p = 0.38). At study's end, there were also significant differences within each group between occlusion scores obtained during the treatment and nontreatment periods (group 1: p 0.02; group 2: p.

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