scholarly journals Symptom clusters in patients with colorectal cancer after colostomy: a longitudinal study in Shanghai

2021 ◽  
Vol 49 (12) ◽  
pp. 030006052110631
Author(s):  
Jianling Hao ◽  
Liyan Gu ◽  
Peng Liu ◽  
Lingjuan Zhang ◽  
Honglian Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Psychological Symptom ◽  
Symptom Clusters ◽  
Symptom Cluster ◽  
First Year ◽  
Improve Symptom ◽  
Using Data ◽  
Symptom Trajectory ◽  
Postoperative Quality

Objective Research is lacking regarding the experiences of patients after colostomy, which is needed so as to take necessary specific actions. In this study, we aimed to describe the trajectory of symptom clusters experienced by patients after colostomy over time. Methods This was a longitudinal observational study using data from 149 patients with colorectal cancer after colostomy. We investigated symptoms and symptom clusters at 2 weeks, 1 month, 3 months, 6 months, and 1 year after colostomy. Results Four main symptom clusters were identified, including a psychological symptom cluster, digestive and urinary symptom cluster, lack of energy symptom cluster, and pain symptom cluster in patients after colostomy in the first year after surgery. We further explored the symptom trajectory. Conclusions We explored symptom clusters and the trajectory of symptom resolution in patients after colostomy during the first year after surgery. Four stages were proposed to describe the different statuses of symptom clusters experienced by patients. Our findings may provide insight into how to improve symptom management and postoperative quality of life for patients after colostomy.

The Effect of Symptom Clusters on Quality of Life Among Patients With Type 2 Diabetes

2019 ◽  
Vol 45 (3) ◽  
pp. 287-294
Author(s):  
Hongjin Li ◽  
Meihua Ji ◽  
Paul Scott ◽  
Jacqueline M. Dunbar-Jacob
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Cluster Analysis ◽  
Psychological Symptoms ◽  
Psychological Symptom ◽  
Symptom Clusters ◽  
Improve Medication Adherence ◽  
Time Points

Purpose The purpose of this study was to examine the collective effect of a symptom cluster (depression, anxiety, fatigue, and impaired sleep quality) at baseline on the quality of life (QOL) of patients with type 2 diabetes (T2DM) over time. Methods This was a secondary data analysis of 302 patients with T2DM who presented with both hypertension and hyperlipidemia. All of the participants were enrolled in a randomized controlled intervention study testing strategies to improve medication adherence. The psychological symptoms and QOL were assessed at baseline, 6 months, and 12 months. Cluster analysis was used to identify subgroups of patients based on the severity of symptoms at baseline. Results Hierarchical cluster analysis identified 4 patient subgroups: all low severity, mild, moderate, and all high severity. There were significant differences in patients’ QOL overall among the 4 subgroups. Compared with the all-low-severity subgroup, subgroups with higher severity of the 4 symptoms had poorer QOL across all 3 time points. QOL was most impacted by trait anxiety across the 3 time points. Conclusion QOL was significantly impacted by psychological symptom clusters among patients with T2DM. Healthcare providers should not neglect psychological symptoms that patients experience. It is important to assess and manage these symptoms to improve QOL among patients with diabetes.

scholarly journals The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1247
Author(s):  
Biljana Gigic ◽  
Johanna Nattenmüller ◽  
Martin Schneider ◽  
Yakup Kulu ◽  
Karen L. Syrjala ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Body Composition ◽  
First Year ◽  
Health Related Quality ◽  
Post Surgery ◽  
Related Quality ◽  
Health Related

Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients. Methods: A total of 138 newly diagnosed CRC patients underwent CT scans at diagnosis and completed questionnaires prior to and six and twelve months post-surgery. We investigated the associations of VFA, SFA, and SMM with HRQoL at multiple time points. Results: A higher VFA was associated with increased pain six and twelve months post-surgery (β = 0.06, p = 0.04 and β = 0.07, p = 0.01) and with worse social functioning six months post-surgery (β = −0.08, p = 0.01). Higher SMM was associated with increased pain twelve months post-surgery (β = 1.03, p < 0.01). Conclusions: CT-quantified body composition is associated with HRQoL scales post-surgery. Intervention strategies targeting a reduction in VFA and maintaining SMM might improve HRQoL in CRC patients during the first year post-surgery.

Predictors of Early Postoperative Quality of Life after Elective Resection for Colorectal Cancer

2007 ◽  
Vol 14 (12) ◽  
pp. 3435-3442 ◽  
Author(s):  
A. Sharma ◽  
D. M. Sharp ◽  
L. G. Walker ◽  
J. R. T. Monson
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Elective Resection ◽  
Postoperative Quality

Prospective analysis of quality of life in the first year after colorectal cancer surgery

2007 ◽  
Vol 46 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Akira Tsunoda ◽  
Kentaro Nakao ◽  
Kenshi Hiratsuka ◽  
Yuko Tsunoda ◽  
Mitsuo Kusano
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Surgery ◽  
First Year ◽  
Prospective Analysis ◽  
Colorectal Cancer Surgery

Characteristics of Cancer Symptom Clusters Reported through a Patient-Centered Symptom Cluster Assessment

2021 ◽  
pp. 019394592110124
Author(s):  
Kristine L. Kwekkeboom ◽  
Ann Wieben ◽  
Loyda Braithwaite ◽  
Kaitlyn Hopfensperger ◽  
Kyung Soo Kim ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Temporal Order ◽  
Well Being ◽  
Cross Sectional Study ◽  
Symptom Clusters ◽  
Symptom Cluster ◽  
Patient Centered ◽  
Cross Sectional ◽  
Effective Interventions

In the scope of symptom cluster research, few investigators have obtained patients’ perceptions of their symptom clusters, even though this information is central to designing effective interventions. In this cross-sectional study, 38 adults with cancer completed measures of demographics, health outcomes (functional status, well-being, quality of life) and a symptom cluster assessment that captured symptom occurrence, severity, distress, clustering, a priority cluster, causal attributions, duration, directional relationships, and cluster interference with daily life. Participants described 72 distinct symptom clusters. Symptoms were most frequently attributed to the cancer diagnosis. Participants’ priority symptom cluster typically included two symptoms of continuous duration and one intermittent symptom. Temporal order and direction of symptom relationships varied, with 75 different relationships described among symptom pairs. Greater symptom cluster burden and interference were related to poorer health outcomes. This patient-centered view of symptom clusters revealed substantial variability in symptom cluster characteristics with important implications for symptom management.

Symptom Prevalence, Intensity, and Distress in Patients With Inoperable Lung Cancer in Relation to Time of Death

2007 ◽  
Vol 25 (34) ◽  
pp. 5381-5389 ◽  
Author(s):  
Carol Tishelman ◽  
Lena-Marie Petersson ◽  
Lesley F. Degner ◽  
Mirjam A.G. Sprangers
Keyword(s):  
Lung Cancer ◽  
First Year ◽  
Life Questionnaire ◽  
Time To Death ◽  
Thurstone Scale ◽  
High Prevalence ◽  
High Distress ◽  
Symptom Prevalence ◽  
Using Data

Purpose To examine symptom prevalence, intensity, and association with distress in patients with inoperable lung cancer (LC), using time to death as point of reference. Patients and Methods A consecutive sample of 400 patients completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 plus a 13-item LC-specific scale and the Thurstone Scale of Symptom Distress–Lung Cancer at six time points during the first year after diagnosis. Patients were divided into subgroups, using data from the time point closest to death (< 1; 1 to 2; > 2 to 3; > 3 to 6; > 6 to 12; and > 12 months before death) for analysis. Results More than 50% of patients in all subgroups reported problems related to physical, role, and emotional functioning; fatigue; dyspnea; and cough. In general, functional levels were lower and symptoms higher in subgroups closer to death. Notably, clinically relevant differences were also found in role and social functioning and appetite loss between the two groups furthest from death. A consistent pattern was found among the six subgroups, with breathing, pain, and fatigue rated as the symptoms most associated with distress. Conclusion High prevalence of symptoms was found in all subgroups, with higher intensity in subgroups closer to death, indicating a need for prophylactic and proactive symptom management. Less concordance was found among symptom prevalence, intensity, and association with distress in subgroups further from death. Future studies should investigate longitudinal associations between symptoms with low intensity and high distress, and examine their clinical implications.

scholarly journals Genes Involved in the HPA Axis and the Symptom Cluster of Fatigue, Depressive Symptoms, and Anxiety in Women With Breast Cancer During 18 Months of Adjuvant Therapy

2020 ◽  
Vol 22 (2) ◽  
pp. 277-286 ◽  
Author(s):  
Hongjin Li ◽  
Anna L. Marsland ◽  
Yvette P. Conley ◽  
Susan M. Sereika ◽  
Catherine M. Bender
Keyword(s):  
Breast Cancer ◽  
Depressive Symptoms ◽  
Adjuvant Therapy ◽  
Hpa Axis ◽  
Psychological Symptoms ◽  
Psychological Symptom ◽  
Binary Logistic Regression ◽  
Symptom Cluster ◽  
Increased Risk ◽  
Symptom Trajectory

This study aimed to (1) identify subgroups of women with breast cancer with the psychological symptom cluster (fatigue, depressive symptoms, and anxiety) during the first 18 months of adjuvant therapy and (2) explore associations between demographic and clinical characteristics and variations in genetic polymorphisms related to hypothalamic–pituitary–adrenal (HPA) axis function and predicted symptom trajectory subgroup membership. We obtained symptom data at 4 time points from baseline to 18 months of adjuvant therapy among 292 postmenopausal women with breast cancer. Genetic data were collected in a subgroup at baseline ( N = 184). Group-based multitrajectory modeling was used to classify women into subgroups with similar psychological symptom cluster trajectories. Binary logistic regression was used to explore the associations between each genotypic and phenotypic predictor and predicted subgroup membership. Two distinct symptom subgroups (low and high) were identified based on the trajectories of the symptom cluster of fatigue, depressive symptoms, and anxiety over the first 18 months of adjuvant therapy. Women who were younger, less educated, and who received chemotherapy had greater likelihood of being in the high-symptom subgroup. Variation in genes regulating the HPA axis ( FKBP5 rs9394309 [odds ratio ( OR) = 3.98, p = .015], NR3C2 rs5525 [ OR = 2.54, p = .036], and CRHR1 rs12944712 [ OR = 3.99, p = .021]) was associated with membership in the high-symptom subgroup. These results may help to identify women with breast cancer who are at increased risk for psychological symptoms, facilitating the development of individualized and preemptive interventions to better manage these symptoms during adjuvant therapy.

scholarly journals The place of lymph dissection in the treatment of cancer and the choice of surgical tactics (review article)

2021 ◽  
Vol 11 (12) ◽  
pp. 203-209
Author(s):  
R. Nikitenko ◽  
K. Vorotyntseva
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Early Stage ◽  
Sentinel Lymph Nodes ◽  
Fluorescent Imaging ◽  
Analytical Work ◽  
Surgical Tactics ◽  
Intraoperative Visualization ◽  
Postoperative Quality

Over the past years, due to increase of detection of patients with early-stage stomach cancer and colorectal cancer, and improvement of survival rate, the efforts have been made to gradually develop the concept of sentinel lymph nodes detection in order to improve postoperative quality of life. The article presents the review of the literature on the feasibility of sentinel lymph nodes intraoperative diagnosis the choice of surgical treatment of patients with tumors of the stomach and colon. Analytical work demonstrates that the real time intraoperative visualization of lymph sineses using fluorescent imaging of indocyanine green during laparoscopic surgery for stomach or colorectal cancer is possible and it is a useful method of the lymph nodes mapping, therefore it can lead to intraoperative changes at lymphadenectomy as well as to reduce the surgical injury. It indicates the need in further research and improvement of approach.

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