Asymptomatic Hyperuricaemia and its Early Treatment

1980 ◽  
Vol 8 (1) ◽  
pp. 95-97
Author(s):  
W A McDonald Scott
Keyword(s):  
Uric Acid ◽  
Adverse Effects ◽  
Serum Uric Acid ◽  
Early Treatment ◽  
Laboratory Tests

Sixteen patients with asymptomatic hyperuricaemia were treated with ‘Citro-Soda®”, an urinary alkanlinizing agent, in a dose of 4 g four times daily for one month. Ten of the sixteen patients exhibited a meaningful reduction in serum uric acid (> 15%). No adverse effects were noted and various haematological and urinary laboratory tests were all normal. ‘Citro-Soda®’ could, therefore, be considered a useful and well-tolerated adjunct in the treatment of hyperuricaemia.

scholarly journals The pattern of allopurinol prescription in a university hospital practice

2020 ◽  
Vol 47 (1) ◽  
Author(s):  
Sahar Ahmed Saad ◽  
Maha Mahmoud Sabkar
Keyword(s):  
Uric Acid ◽  
Side Effects ◽  
Adverse Effects ◽  
Serum Uric Acid ◽  
Research Work ◽  
University Hospital ◽  
Hospital Practice ◽  
Inappropriate Use ◽  
The Cost

Abstract Background Allopurinol as a drug is commonly used to treat gout and its complications. The aim usually is to lower the level of serum uric acid. Also, it was found to be prescribed in cases of asymptomatic hyperuricemia. However, this medication has serious side effects and some of these are fatal. So the aim of the current research work is to look at its use, whether properly indicated or not, in a university hospital. Results A total of 427 patients were included in this study. Only 3.7% (16) of the patients had the drug for significant hyperuricemia. Gout was confirmed in 40 (9.4%) patients. Conclusion It is clear that most patients received allopurinol without proper indications. The inappropriate use of allopurinol should be looked at to reduce the cost of medication and more importantly to avoid possible adverse effects.

Outcome of Febuxostat treatment in hyperuricemic pre-dialysis chronic kidney disease patients

2020 ◽  
Vol 7 (2) ◽  
pp. 45-52
Author(s):  
Dineshowri Shrestha ◽  
Anil Baral ◽  
Kashyap Dahal ◽  
Juju Raj Shrestha ◽  
Rajani Hada
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Adverse Effects ◽  
Serum Uric Acid ◽  
Kidney Injury ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Mdrd Equation ◽  
Ckd Stage

Introduction: Hyperuricemia is a cause and effect of chronic kidney disease (CKD), accelerates its progression and predisposes to acute kidney injury. Present study aimed to find out the outcome of Febuxostat treatment in hyperuricemic pre-dialysis CKD patients. Method: This was a cross sectional study conducted in Nephrology department, Bir hospital, Nepal, during from February 2019 to January 2020, among pre-dialysis CKD stage 3-5 non dialysis (ND) patients with serum uric acid (SUA) >7 mg/d L who were treated with Febuxostat 40 mg once a day and followed up at one, two and three months. The baseline SUA, creatinine, estimated glomerular filtration rate (eGFR) calculated by the modification of diet in renal disease (MDRD) equation compared with values at follow up and according to CKD stages. The adverse effects and liver enzymes were recorded. Result: There were total 50 patients, mean age 54.2±16.5 years, male 31 (62%).There were significant reductions of SUA from baseline of 8.9±1.4to 7.1±1.2 vs 5.9±0.9 vs 4.7±1.0) at one, two and three month respectively, p=0.000 and increment of eGFR (ml/min/1.73m2) from 29.6±15.0 to 31.6±16.0, 33.6±16.6, 34.1±17.1, p=0.000.And 41 (82%) patients achieved uric acid < 6 mg/dl at three month. Significant reduction of uric acid in all CKD stages and increment of eGFR in CKD stage 3 and 4 were observed. Adverse effects were epigastralgia in 5 (10%) and joint pain in 13 (26%). Conclusion: Febuxostat is an effective serum uric acid lowering drug in pre-dialysis chronic kidney disease patients with improvement of kidney function.

RAMADAN FASTING – EFFECT ON HEALTHY MUSLIMS

2004 ◽  
Vol 32 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Masahiro Toda ◽  
Kanehisa Morimoto
Keyword(s):  
Mental Health ◽  
Weight Loss ◽  
Uric Acid ◽  
Health Status ◽  
Adverse Effects ◽  
Serum Uric Acid ◽  
Mental Health Status ◽  
Healthy Individuals ◽  
Ramadan Fasting ◽  
Lipid Parameters

The purpose of this review was to ascertain the effects on healthy Muslims of fasting during Ramadan. We found some changes such as weight loss, evidence of dehydration, increase in serum uric acid, and nonpharmacological improvement in lipid parameters. We also observed changes in daily lifestyles and mental-health status. Thus, observance of the Ramadan fasting has both positive and adverse effects on healthy individuals. The adverse effects, however, are unlikely to persist after Ramadan or to lead to other complications. Healthy individuals can observe Ramadan without anxiety about their health.

scholarly journals The effect of vitamin C on laboratory tests in haemodialysis patients: is there a relationship between the administered vitamin C dose and serum uric acid levels?

1999 ◽  
Vol 14 (10) ◽  
pp. 2529-2530 ◽  
Author(s):  
Alpaslan Ersoy ◽  
Kamil Dilek ◽  
Mahmut Yavuz ◽  
Mustafa Güllülü ◽  
Mustafa Yurtkuran
Keyword(s):  
Uric Acid ◽  
Vitamin C ◽  
Serum Uric Acid ◽  
Laboratory Tests

Serum uric acid and obesity in Hawaiians

JAMA ◽  
1966 ◽  
Vol 196 (4) ◽  
pp. 364-365 ◽  
Author(s):  
L. A. Healey
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid

Serum uric acid, cholesterol, and cortisol levels: Interrelationships in normal men under stress.

1970 ◽  
Author(s):  
Robert T. Rubin ◽  
Richard H. Rahe ◽  
Brian R. Clark ◽  
Ransom J. Arthur
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Cortisol Levels ◽  
Normal Men

A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sushma Goad ◽  
Anita Verma ◽  
Subhash Chandra
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Level Elevation ◽  
The Mean

Background: To Study Serum Uric Acid level elevation in Hypertensive Disorders of Pregnancy. Methods: 50 Patients diagnosed as having Pre-eclampsia with age between 18-37 years and 50 controls with similar age group. Results: The mean serum uric acid level in control group was 3.41 ± 0.62 and in patient 7.01 ± 0.58 which was statistically significant (p =0.001). Conclusion: Serum uric acid levels were significantly higher in preeclampsia could be a useful indicator of fetal complication in preeclampsia patients. Keywords: serum uric acid, preeclampsia, laboratory.

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

Meta-analysis of Serum Uric Acid (SUA) and Cardiovascular Events in Diabetes Population

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1565-P
Author(s):  
YIXUE SHAO ◽  
HUI SHAO ◽  
LIZHENG SHI
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Cardiovascular Events ◽  
Meta Analysis
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