Influence of Main Ocular Variables in #TheDress Perception: An Ophthalmic Survey

The objective of this study is to study the influence of ocular variables in the perception of #thedress and to develop a logistic regression model that could help predict it. This is a cross-sectional study on 1,100 subjects. People who did not report one of the two main perceptions were excluded from the study. Dress perception was codified as 0 (white&gold) or 1 (black&blue). The association between dress perception and demographic and main ocular variables (age, gender, binocular visual acuity, grade of nuclear cataract, crystalline lens status [phakic/pseudophakic], spherical equivalent, and ocular health status) was tested using logistic regression. Receiver operation curves were used to test the predictive value of the model. Several variables were found to be related with dress perception. The best model included three variables—Age: adjusted odds ratio (OR) = 1.02 (1.01–1.03), p = 0.08; ocular refraction: adjusted OR = 1.07 (1.02–1.12), p = 0.009; and nuclear cataract grade: adjusted OR = 1.45 (1.05–1.99), p = 0.026. The predictive value of the model was low (area under the curve = 0.62). Older age, nuclear cataract grade, and hyperopia were associated with black&blue perception. The predictive capacity of the developed model was poor. Only a small proportion of the variability in the #thedress perception can be explained by ocular examination.

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A model of visual limitation in patients with keratoconus

Scientific Reports ◽

10.1038/s41598-020-76489-1 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Antonio Pérez-Rueda ◽

Gracia Castro-Luna

Keyword(s):

Visual Acuity ◽

Logistic Regression ◽

Operating Characteristic ◽

Spherical Aberration ◽

Area Under The Curve ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Binary Logistic Regression Model ◽

Cross Sectional ◽

Corrected Visual Acuity

Abstract This paper aims to calculate a relevance model of visual limitation (V.L.) in keratoconus patients based on refractive and topographic parameters. A cross-sectional study was carried out in Torrecárdenas Hospital, Almería, Spain, between February 2018 and July 2019. It included 250 keratoconus patients. Two groups were created according to a grading system of V.L. based on RETICS (Red Temática de Investigación Cooperativa en Salud) classification: keratoconus patients with no V.L. (best spectacle-corrected visual acuity (BSCVA) ≤ 0.05 logMAR) and keratoconus patients with V.L. (BSCVA > 0.05 logMAR). Correlations and a binary logistic regression were established. V.L. was correlated with maximum curvature (r = 0.649, p < 0.001) and root mean square higher-order aberrations (HOARMS) (r = 0.625, p < 0.001). Binary logistic regression included V.L. as the dependent variable and spherical equivalent, HOARMS, spherical aberration and interaction between the anterior and posterior vertical coma as independent variables. The model was a good fit. Area under the curve (A.U.C.) of receiver operating characteristic (R.O.C.) curve was 0.924, sensitivity 91.90%, specificity 83.60%, accuracy 88.94%; and precision 91.17%. Binary logistic regression model of V.L. is a good fit model to predict the early loss of visual acuity in keratoconus patients.

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Investigation of Frequency of the Lethal Triad and Its 24 Hours Prognostic Value among Patients with Multiple Traumas

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.217 ◽

2019 ◽

Vol 7 (6) ◽

pp. 962-966 ◽

Cited By ~ 4

Author(s):

Iraj Goli Khatir ◽

Farzad Bozorgi ◽

Hesam Ghanbari ◽

Fatemeh Jahanian ◽

Mohsen Arabi ◽

...

Keyword(s):

Logistic Regression ◽

Predictive Value ◽

Coagulation Factors ◽

Cross Sectional Study ◽

Care Plan ◽

Cross Sectional ◽

Arterial Blood Gas ◽

Arterial Blood ◽

Lethal Triad ◽

Multiple Traumas

BACKGROUND: Death in multiple trauma (MT) patients is one of the serious concerns of the medical service provider. Any prediction of the likelihood of death on the assessment of the patient's condition is performed using different variables, one of the tools in the triage of patients to determine their condition. AIM: We aimed to investigate the frequency and the predictive value of death in 24 hours triad of death in patients qualified with multiple traumas admitted to Imam Khomeini hospital. METHODS: This was a prospective cross-sectional study to determine the prevalence and predictive value of 24-hour triad of death among patients with MT referred to an emergency department. Three factors including acidosis, hypothermia and coagulopathy and predictive value of 24-hour death were evaluated. Arterial blood gas, oral temperature and blood samples for coagulation factors were analysed. Data were analysed using SPSS version 19. Multivariate analysis (logistic regression) was used to determine the predictive value of the triad of death. RESULTS: A group of 199 MT patients referring to Imam Khomeini hospital during the first 6 months of 2015 were evaluated for the first 24 hours of admission. Logistic regression analysis showed that using the following formula based on the triad of death can predict death in 96% of cases can be based on the triad of a death foretold death upon admission to the emergency room. It should be noted that this prediction tool as 173 people left alive after 24 hours as live predicts (100% correct). CONCLUSION: The triad of death is one of the tools in the triage of patients to determine their condition and care plan to be used, provided valuable information to predict the prognosis of patients with a medical team.

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Diagnostic Value of the13C Methacetin Breath Test in Various Stages of Chronic Liver Disease

Gastroenterology Research and Practice ◽

10.1155/2011/235796 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Hamizah Razlan ◽

Nurhayaty Muhamad Marzuki ◽

Mei-Ling Sharon Tai ◽

Azhar-Shah Shamsul ◽

Tze-Zen Ong ◽

...

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Positive Predictive Value ◽

Predictive Value ◽

Breath Test ◽

Area Under The Curve ◽

Diagnostic Value ◽

Cross Sectional Study ◽

Chronic Liver ◽

Cross Sectional

The accuracy of the13C-methacetin breath test (13C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the13C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis. Seventy-seven patients (47 men/30 women, mean age50±16years) were recruited. Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation. The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively. Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99). The13C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis.

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Assessment of procalcitonin as a diagnostic marker of infection in pediatrics with cancer complicated by fever and neutropenia

Iranian Journal of Pediatric Hematology & Oncology ◽

10.18502/ijpho.v10i1.2165 ◽

2020 ◽

Author(s):

Soheila Zareifar ◽

Anahita Sanaei Dashti ◽

Tayebe Masoomzade ◽

Mojtaba Anvarinejad ◽

Omid Reza Zekavat ◽

...

Keyword(s):

Febrile Neutropenia ◽

Cancer Patients ◽

Predictive Value ◽

Urine Culture ◽

Area Under The Curve ◽

Serum Levels ◽

Cross Sectional Study ◽

Cross Sectional ◽

Mortality And Morbidity ◽

Pediatric Cancer Patients

Background: Febrile neutropenia is still one of the most important complications of treatment in cancer patients. These patients become prone to infection and consequently higher mortality and morbidity. This study aimed to determine the accuracy of serum procalcitonin (PCT) level in the detection of infection in pediatric cancer patients complicated with febrile neutropenia. Materials and Methods: In this cross-sectional study, all pediatric patients affected by cancer and febrile neutropenia following chemotherapy (n=107) were investigated from August 2014 to August 2015. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum levels of PCT, as well as blood and urine culture, were evaluated in all patients. Results: The mean age of the patients was 78 ± 55 months (3 - 214 months), and in terms of gender, 53 patients (49.5%) were male. Overall, 25 patients (23.4%) and 13 patients (12%) showed positive blood and urine culture, respectively. The area under the curve (AUC) receiver operating characteristic (ROC) curve was illustrated to determine how much PCT can couldpredict infection.(AUC =0.74, 95% CI: 0.61-0.87, P<0.001). Considering the cut-off of serum PCT levels as 0.70ng/mL, sensitivity, specificity, and positive and negative predictive valueof PCT were 0.76, 0.744, 0.475, and 0.91, respectively. In addition, PCT showed significant correlations with CRP (rs=0.415, P<0.001) and ESR (rs =0.262, P=0.009). Conclusion: According to the findings of this study, serum PCT levels can be used as a diagnostic test with acceptable sensitivity and specificity and high negative predictive value, but the low positive predictive value in the evaluation of infections in patients affected by cancer and complicated with fever and neutropenia.

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Triglycerides and Glucose Index as Potential Marker of Metabolic Syndrome

International Journal of Human and Health Sciences (IJHHS) ◽

10.31344/ijhhs.v5i1.239 ◽

2020 ◽

Vol 5 (1) ◽

pp. 85

Author(s):

Mariya Tabassum ◽

Miliva Mozaffor ◽

Md Matiur Rahman ◽

Reaz Mahmud Huda

Keyword(s):

Metabolic Syndrome ◽

Predictive Value ◽

Area Under The Curve ◽

Roc Curves ◽

Cross Sectional Study ◽

Serum Glucose ◽

Cross Sectional ◽

Tyg Index ◽

Potential Marker ◽

Sensitivity Specificity

Background:Triglycerides and Glucose Index (TyG index), a product from fasting levels of triglycerides and glucose, presented promising results as apotential marker of metabolic syndrome in different ethnicity. However, no such reports are available in our population to date.Objective: To see the effectiveness of ‘Triglycerides and Glucose Index’ to predict metabolic syndromein a Bangladeshi population.Methods: This cross-sectional study was carried out in Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from March 2016 to February 2017. A total of 200 apparently healthy subjects (127 men and 73 women) were selected for the study, who attended the out-patient-departments of the same institution. Anthropometric measurements were recorded – height, weight, waist circumference (WC) and body mass index (BMI). Overnight fasting blood samples were collected to estimate fasting serum glucose andlipid profile. Then TyG index was calculated and evaluated as a tool in diagnosis of metabolic syndrome in the study subjects.Receiver operating characteristic (ROC) curves were plotted to assess the performance of TyG index in MetS prediction by gender. The power of MetS prediction was quantified by the area under the curve (AUC) with 95% confidence intervals.Results: Sensitivity, specificity, positive predictive value and negative predictive value of TyG index to predict metabolic syndrome were 70.45%, 82.14%, 75.61% and 77.97%in males and 25.00%, 97.32%, 88.00% and 62.29%in females respectively. ROC curve showed optimal cut off value 8.72 and area under the curve 0.72 in male study subjects; in female study subjects, the values were 8.72 and 0.96 respectively (P<0.001).Conclusion:Triglycerides and Glucose Index (TyG index) represents a simple,accessible and effective tool for assessment of metabolic syndrome in Bangladeshi population.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 85-89

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PLATELET COUNT SQUARED/SPLEEN DIAMETER-ASPARTATE AMINOTRANSFERASE RATIO: NON-INVASIVE METHOD TO PREDICT ESOPHAGEAL VARICES

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201700000-26 ◽

2017 ◽

Vol 54 (3) ◽

pp. 222-224 ◽

Cited By ~ 1

Author(s):

Ângelo Zambam de MATTOS ◽

Larissa Faraco DAROS ◽

Angelo Alves de MATTOS

Keyword(s):

Logistic Regression ◽

Platelet Count ◽

Esophageal Varices ◽

Predictive Value ◽

Aspartate Aminotransferase ◽

Univariate Analysis ◽

Cross Sectional Study ◽

Cross Sectional ◽

Predictive Values ◽

Non Invasive

ABSTRACT BACKGROUND - Variceal bleeding has a high mortality among cirrhotics, and screening with endoscopy is indicated at the diagnosis of cirrhosis. Screening with endoscopy implies discomfort, risks and considerable costs. OBJECTIVE - To evaluate platelet count squared/spleen diameter-aspartate aminotransferase ratio (PS/SA), as a non-invasive predictor of esophageal varices in cirrhotics. METHODS - This cross-sectional study evaluated cirrhotics for PS/SA and presence of esophageal varices. Outpatient records of cirrhotic patients were reviewed for the abovementioned data. Sensitivity, specificity, negative and positive predictive values of PS/SA were calculated. After the univariate analysis, variables with P<0.10 were submitted to a logistic regression. RESULTS - The study included 164 cirrhotics, 59.70% male, with a mean age of 56.7 years. Hepatitis C was the most frequent cause of cirrhosis, being present in 90 patients. Patients were classified as Child-Pugh A in 52.44% and as Child-Pugh B or C in 47.56%. Esophageal varices were present in 72.56% of the patients at endoscopy. PS/SA, with a cutoff of 3x108, had a sensitivity of 95.80% (confidence interval of 95% - 95%CI=0.92-0.99), a specificity of 22.70% (95%CI=0.10-0.35), a positive predictive value of 77.20% (95%CI=0.70-0.84) and a negative predictive value of 66.70% (95%CI=0.42-0.91). In the logistic regression, only platelet count and Child-Pugh score were associated to esophageal varices (P<0.05). CONCLUSION - PS/SA has an excellent sensitivity to predict esophageal varices, allowing almost one fourth of patients without esophageal varices to spare endoscopy. Nevertheless, PS/SA is not independently associated to esophageal varices.

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Abstract 98: Bilateral Carotid Intraplaque Hemorrhage Association With Simultaneous Bilateral Stroke

Stroke ◽

10.1161/str.47.suppl_1.98 ◽

2016 ◽

Vol 47 (suppl_1) ◽

Author(s):

Michael McLaughlin ◽

Seong-Eun Kim ◽

Gerald Treiman ◽

Dennis Parker ◽

Joseph S McNally

Keyword(s):

Predictive Value ◽

Brain Mri ◽

Area Under The Curve ◽

Cross Sectional Study ◽

Intraplaque Hemorrhage ◽

Imaging Findings ◽

Cross Sectional ◽

Carotid Mri ◽

Bilateral Carotid ◽

Better Than

Introduction: Bilateral ischemic strokes are often attributed to central or cardiac embolic sources, especially in the absence of severe bilateral carotid stenosis. Carotid MRI detects carotid intraplaque hemorrhage (IPH), a marker of stroke risk independent of stenosis. Hypothesis: MRI-detected carotid IPH better identifies bilateral carotid source strokes compared to stenosis alone. Methods: In this retrospective cross sectional study, patients undergoing stroke workup were imaged with carotid and brain MRI. Stroke was determined by the AHA definition of CNS infarction. Patients with non-carotid stroke sources (e.g. cardiac sources), occluded or near-occluded carotids were excluded. A total of 425 patients were analyzed. Carotid imaging findings were recorded, including IPH and NASCET stenosis along with clinical cerebrovascular risk factors and medications. Receiver operating characteristic (ROC) analysis was performed to determine the predictive value (area under the curve, AUC) of carotid imaging findings. Results: Carotid IPH was present in 89/425 of cases, and was bilateral in 24/89 (27.0%). Bilateral carotid IPH was a good predictor of bilateral stroke (AUC=.808), performing better than bilateral stenosis with ≥50%, ≥60% or ≥70% cutoffs (AUC=.565 p=.001, AUC=.550 p<.001, AUC=.523 p<.001, respectively) but not significantly better than average bilateral stenosis (AUC=.800 p=.90). The combined predictive value of bilateral IPH and average bilateral stenosis was excellent (AUC=.891) and performed better than bilateral IPH alone (p=.07) or average bilateral stenosis alone (p=.002). Conclusions: Bilateral carotid IPH is associated with bilateral stroke, and adds significant discrimination of bilateral carotid stroke sources compared to stenosis. In the setting of bilateral stroke, carotid MRI may help uncover potential stroke sources undetected by lumen imaging alone.

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Stepwise web-based questionnaires for diagnosing cluster headache: LUCA and QATCH

Cephalalgia ◽

10.1177/0333102413479835 ◽

2013 ◽

Vol 33 (11) ◽

pp. 924-931 ◽

Cited By ~ 14

Author(s):

Leopoldine A Wilbrink ◽

Claudia M Weller ◽

Carlo Cheung ◽

Theo Stijnen ◽

Joost Haan ◽

...

Keyword(s):

Logistic Regression ◽

Cluster Headache ◽

Predictive Value ◽

Large Scale ◽

International Headache Society ◽

Primary Headache ◽

Headache Disorder ◽

Cross Sectional Study ◽

Cross Sectional ◽

Web Based

Background Cluster headache (CH) is a primary headache disorder that is diagnosed based on the patient's history. For large-scale epidemiologic and genetic studies, a web-based, preferably short, questionnaire can be a feasible alternative to replace time-consuming clinical interviews. Methods Self-reported CH patients were enrolled via our research website. Participants meeting screening criteria were directed to the Leiden University Cluster headache Analysis program (LUCA) questionnaire. Individual diagnoses were calculated using an algorithm based on International Headache Society criteria. Subsequently, semi-structured telephone interviews were carried out to validate the LUCA questionnaire. The shorter Quick Ascertainment of Cluster Headache (QATCH) questionnaire for diagnosing CH was constructed by using logistic regression to select the most predictive questions. Results Via our website 437 self-reported CH patients were recruited. Of these, 291 patients were included in this cross-sectional study. The LUCA questionnaire was valid and accurate. Using logistic regression, three questions (QATCH) provided similar sensitivity (53.8% vs. 57.2%), specificity (88.9% vs. 87.5%), positive predictive value (95.5% vs. 95.9%) and negative predictive value (30.8% vs. 28.8%) compared with the LUCA questionnaire. Conclusion The web-based LUCA questionnaire was accurate and reliable in diagnosing CH among self-reported patients. Males with headache attacks of short duration and long headache-free intervals (months to years) are very likely to have CH.

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Accuracy of urine calprotectin for diagnosis of acute kidney injury in neonates

10.21203/rs.2.12174/v1 ◽

2019 ◽

Author(s):

Nasrin Khalesi ◽

Shima Mohamadian ◽

Nakysa Hooman ◽

Mahmoud Khodadost

Keyword(s):

Acute Kidney Injury ◽

Predictive Value ◽

Area Under The Curve ◽

Kidney Injury ◽

Cross Sectional Study ◽

P Value ◽

Cross Sectional ◽

Calprotectin Level ◽

Sensitivity Specificity ◽

Kappa Agreement

Abstract Background: Urine calprotectin significantly rises in acute kidney injury (AKI) in adult and pediatrics. The aim of the present study was to investigate the accuracy of urine calprotectin as a diagnostic marker for (AKI) in neonates. Methods In this cross sectional study, we assessed urine calprotectin in 100 neonates, in which 80 of them had AKI and 20 were healthy. Random urine calprotectin measured by ELISA and then compared between two groups. We included neonates who had received at least 48 hour intra venous fluid and met our inclusion and exclusion criteria. . Receiver-operating characteristic (ROC) curve used to set a cut of point for urine calprotectin to predict AKI. The overall accuracy and Kappa coefficient was used for assess the agreement between two methods.. P value below 0.05 considered significant. Results: Urine calprotectin levels were not significantly higher in neonates with AKI than healthy ones (146.2 vs 142.4, p=0.1). The results showed an optimal cutoff value of 123.5 mg/dl for urine calprotectin with area under the curve of 0•515 with sensitivity, specificity, positive predictive value and negative predictive value of 77.5%,40%,83.7% and 30.7%, respectively. The overall accuracy was 70% and the Kappa agreement coefficient was 0.15 (P=0.11.). Conclusion: Although urine calprotectin level can predict the AKI, it is not accurate measure comparing the gold standard.

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Several Components of the Lebanese Mediterranean Diet and Particular Sociodemographic, Medical and Lifestyle Factors may be Associated with Gastroesophageal Reflux Disease in Adults: A Cross-sectional Study in a Middle Eastern Setting

Current Nutrition & Food Science ◽

10.2174/1573401316999200518095448 ◽

2020 ◽

Vol 17 (1) ◽

pp. 82-93

Author(s):

Mary-Joe Youssef ◽

Antoine Aoun ◽

Aline Issa ◽

Lana El-Osta ◽

Nada El-Osta ◽

...

Keyword(s):

Logistic Regression ◽

Gastroesophageal Reflux Disease ◽

Perceived Stress ◽

Dietary Habits ◽

Cross Sectional Study ◽

Lifestyle Factors ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

Gerd Symptoms

Background: The prevalence of gastroesophageal reflux disease (GERD) is increasing worldwide and the related chronic symptoms can be associated with morbidity and poor quality of life. Objective: The objective of this study was to identify foods and beverages consumed by the Lebanese population, dietary habits, socio-demographic and lifestyle factors, health parameters and perceived stress, implicated in increasing GERD symptoms. Methods: This observational cross-sectional study was carried among Lebanese adults in 2016. A convenient sample of 264 participants was equally divided into a GERD group and a control group. Data on socio-demographic characteristics, lifestyle, health status and dietary habits including Lebanese traditional dishes were collected. The perceived stress scale (PSS) was also used to assess the participants’ perception of stress. Logistic regression analyses were conducted with GERD symptoms (presence or absence) being the dependent variable. Results: The GERD symptoms were significantly associated with age (-p-value=0.017), family history of GERD symptoms (-p-value<0.001), smoking (-p-value=0.003) and chronic medical conditions (-p-value<.001). Regarding the dietary factors, participants who ate three meals or less/day, between meals and outside homes were 2.5, 2.9 and 2.4 times at a higher risk of experiencing GERD symptoms than others, respectively. Moreover, the logistic regression model showed that the GERD symptoms were significantly associated with the consumption of coffee (-p-value=0.037), Lebanese sweets (-p-value=0.027), fried foods (-p-value=0.031), ‘Labneh’ with garlic (-p-value<0.001), pomegranate molasses (-p-value=0.011), and tomatoes (-p-value=0.007). Conclusion: Some specific lifestyle factors and components of the Lebanese Mediterranean diet could be associated with GERD symptoms.

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