A Pilot Study on Cord Blood Levels of Erythropoietin and Its Relationship to Periventricular Leukomalacia in Preterm Infants

2007 ◽  
Vol 23 (2) ◽  
pp. 231-234
Author(s):  
Akihisa Okumura ◽  
Hiroyuki Kidokoro ◽  
Toru Kato ◽  
Tetsuo Kubota ◽  
Fumio Hayakawa ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cord Blood ◽  
Preterm Infants ◽  
Periventricular Leukomalacia ◽  
Blood Levels

A pilot study on umbilical venous level of natriuretic peptides in preterm infants and their relation to periventricular leukomalacia and antenatal complications

2002 ◽  
Vol 24 (1) ◽  
pp. 30-32 ◽  
Author(s):  
Akihisa Okumura ◽  
Toru Kato ◽  
Fumio Hayakawa ◽  
Hiroyuki Kidokoro ◽  
Kuniyoshi Kuno ◽  
...  
Keyword(s):  
Pilot Study ◽  
Preterm Infants ◽  
Natriuretic Peptides ◽  
Periventricular Leukomalacia

scholarly journals Impact of Maternal Iron and Zinc Status on Foetal Cord Blood Levels: A Pilot Study

2018 ◽  
Author(s):  
Enas R Abdel Hamid ◽  
Dina Abu Zeid ◽  
Ahmed F Amer ◽  
Nevine R El Baroudy ◽  
Amr S Megawer ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cord Blood ◽  
Blood Levels ◽  
Zinc Status ◽  
Iron And Zinc ◽  
Maternal Iron

scholarly journals Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Xin Xia ◽  
Zhuxiao Ren ◽  
Longli Yan ◽  
Xuaner Zheng ◽  
Haoming Yang ◽  
...  
Keyword(s):  
Cord Blood ◽  
Preterm Infants ◽  
Gestational Age ◽  
Underlying Mechanism ◽  
Full Term ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Levels ◽  
The Third ◽  
Multiple Line ◽  
Assay Result

Objective. ANGPTL7 is a member of the angiogenin-like protein family. Compared to other members, ANGPTL7 is the least known. Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases. However, there is no research about ANGPTL7 in neonates. This study was designed to investigate the concentration of ANGPTL7 in cord blood of preterm infants. Method. Singleton infants born in November 2017 to June 2019 in the study hospital were enrolled in the study. Maternal and neonatal clinical data were collected. ANGPTL7 levels in cord blood and serum on the third day after birth were measured by an enzyme-linked immunosorbent assay. Result. A total of 182 infants were enrolled in this study. Patients were categorized into two groups by gestational age (102 preterm, 80 full-term). ANGPTL7 levels in preterm infants were significantly higher than that in full-term babies ( t = 15.4 , P < 0.001 ). In multiple line regression analysis, ANGPTL7 levels independently correlated with gestational age ( β = − 0.556 , P < 0.001 ). There is also no correlation between preterm outcomes and ANGPTL7 levels. Cord blood levels of ANGPTL7 were significantly higher than those in serum on the third day after birth ( t = 13.88 , P < 0.001 ). Conclusion. Cord blood ANGPTL7 levels are higher in preterm infants than full-term babies. The levels are independently influenced by gestational ages and attenuated significantly after birth. The underlying mechanism needs to be further studied.

scholarly journals Vitamin D deficiency and morbidity among preterm infants in a developing country

2017 ◽  
Vol 4 (2) ◽  
pp. 499 ◽  
Author(s):  
Nitin Srinivasan ◽  
Jayasree Chandramathi ◽  
Aswin S. Prabhu ◽  
Sasidharan Ponthenkandath
Keyword(s):  
Vitamin D ◽  
Clinical Outcome ◽  
Cord Blood ◽  
Preterm Infants ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Blood Levels ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Relationship Of

Background: The association of serum vitamin D levels to clinical outcome in VLBW infants has not been studied. Our objective was to measure the cord blood levels, and the dose response for two doses of vitamin D in preterm infants and correlate the relationship of vitamin D levels to the clinical outcome.Methods: We prospectively obtained cord blood levels in 80 preterm infants under 34 weeks gestation (mean gestation age 29±2 weeks and BW: 1210±350 gms). Infants were supplemented with 400 IU or 800-1000 IU vitamin D daily. Serun vitamin D levels were obtained at 2 - 3 weeks after supplementation and levels were correlated to clinical outcome. Results: The mean cord blood vitamin D level was 12±8.5 ng/ml. Babies who developed sepsis and compared to those who did not develop these morbidities, ROP had vitamin D levels: 13.5±6 (ng/ml) versus 30.5±10 (ng/ml) (p < 0.01) and 15.7±11 (ng/ml) versus 34±18 (ng/ml) (p <0.03) respectively. Supplementation with 400 IU vitamin D resulted in levels of 17±8.6 (ng/ml) and infants given 800-1000 IU vitamin D had levels 46±17(ng/ml) (p <0.001).Conclusions: These data suggest that cord blood vitamin D levels are low in preterm infants and 800-1000 IU vitamin D supplementation is advisable to achieve levels >30 ng/ml. Infants with low levels of vitamin D have higher incidence of sepsis, and ROP.

Abstract #91: Comparison of Cord Blood Insulin in Large-for-Gestational-Age Infants and Appropriate-for-Age Filipino Infants of Nondiabetic Mothers: A Pilot Study

2004 ◽  
Vol 10 ◽  
pp. 31
Author(s):  
Florence M. Amorado-Santos ◽  
Maria Honolina S. Gomez ◽  
Maria Victoria R. Olivares ◽  
Zayda N. Gamilla
Keyword(s):  
Pilot Study ◽  
Cord Blood ◽  
Gestational Age ◽  
Large For Gestational Age ◽  
Blood Insulin

scholarly journals Long-Term Outcome after Asphyxia and Therapeutic Hypothermia in Late Preterm Infants: A Pilot Study

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 994
Author(s):  
Hanne Lademann ◽  
Karl Abshagen ◽  
Anna Janning ◽  
Jan Däbritz ◽  
Dirk Olbertz
Keyword(s):  
Pilot Study ◽  
Preterm Infants ◽  
Perinatal Asphyxia ◽  
Psychomotor Development ◽  
Long Term Outcomes ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Developmental Index ◽  
Mental Developmental Index

Therapeutic hypothermia (THT) is the recommended treatment for neuroprotection in (near) term newborns that experience perinatal asphyxia with hypoxic-ischemic encephalopathy. The benefit of THT in preterm newborns is unknown. This pilot study aims to investigate long-term outcomes of late preterm asphyctic infants with and without THT compared to term infants. The single-center, retrospective analysis examined medical charts of infants with perinatal asphyxia born between 2008 and 2015. Long-term outcome was assessed using the Bayley Scales of Infant Development 2 at the age of (corrected) 24 months. Term (n = 31) and preterm (n = 8) infants with THT showed no differences regarding their long-term outcomes of psychomotor development (Psychomotor Developmental Index 101 ± 16 vs. 105 ± 11, p = 0.570), whereas preterm infants had a better mental outcome (Mental Developmental Index 105 ± 13 vs. 93 ± 18, p = 0.048). Preterm infants with and without (n = 69) THT showed a similar mental and psychomotor development (Mental Developmental Index 105 ± 13 vs. 96 ± 20, p = 0.527; Psychomotor Developmental Index 105 ± 11 vs. 105 ± 15, p = 0.927). The study highlights the importance of studying THT in asphyctic preterm infants. However, this study shows limitations and should not be used as a basis for decision-making in the clinical context. Results of a multicenter trial of THT for preterm infants (ID No.: CN-01540535) have to be awaited.

scholarly journals Carbon dioxide levels in neonates: what are safe parameters?

2021 ◽  
Author(s):  
Sie Kei Wong ◽  
M. Chim ◽  
J. Allen ◽  
A. Butler ◽  
J. Tyrrell ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Systematic Review ◽  
Side Effects ◽  
Preterm Infants ◽  
Periventricular Leukomalacia ◽  
List Type ◽  
Permissive Hypercapnia ◽  
Prisma Statement ◽  
Carbon Dioxide Levels ◽  
Online Software

Abstract There is no consensus on the optimal pCO2 levels in the newborn. We reviewed the effects of hypercapnia and hypocapnia and existing carbon dioxide thresholds in neonates. A systematic review was conducted in accordance with the PRISMA statement and MOOSE guidelines. Two hundred and ninety-nine studies were screened and 37 studies included. Covidence online software was employed to streamline relevant articles. Hypocapnia was associated with predominantly neurological side effects while hypercapnia was linked with neurological, respiratory and gastrointestinal outcomes and Retinpathy of prematurity (ROP). Permissive hypercapnia did not decrease periventricular leukomalacia (PVL), ROP, hydrocephalus or air leaks. As safe pCO2 ranges were not explicitly concluded in the studies chosen, it was indirectly extrapolated with reference to pCO2 levels that were found to increase the risk of neonatal disease. Although PaCO2 ranges were reported from 2.6 to 8.7 kPa (19.5–64.3 mmHg) in both term and preterm infants, there are little data on the safety of these ranges. For permissive hypercapnia, parameters described for bronchopulmonary dysplasia (BPD; PaCO2 6.0–7.3 kPa: 45.0–54.8 mmHg) and congenital diaphragmatic hernia (CDH; PaCO2 ≤ 8.7 kPa: ≤65.3 mmHg) were identified. Contradictory findings on the effectiveness of permissive hypercapnia highlight the need for further data on appropriate CO2 parameters and correlation with outcomes. Impact There is no consensus on the optimal pCO2 levels in the newborn. There is no consensus on the effectiveness of permissive hypercapnia in neonates. A safe range of pCO2 of 5–7 kPa was inferred following systematic review.

Sign in / Sign up

Export Citation Format

Share Document