scholarly journals Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Xin Xia ◽  
Zhuxiao Ren ◽  
Longli Yan ◽  
Xuaner Zheng ◽  
Haoming Yang ◽  
...  
Keyword(s):  
Cord Blood ◽  
Preterm Infants ◽  
Gestational Age ◽  
Underlying Mechanism ◽  
Full Term ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Levels ◽  
The Third ◽  
Multiple Line ◽  
Assay Result

Objective. ANGPTL7 is a member of the angiogenin-like protein family. Compared to other members, ANGPTL7 is the least known. Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases. However, there is no research about ANGPTL7 in neonates. This study was designed to investigate the concentration of ANGPTL7 in cord blood of preterm infants. Method. Singleton infants born in November 2017 to June 2019 in the study hospital were enrolled in the study. Maternal and neonatal clinical data were collected. ANGPTL7 levels in cord blood and serum on the third day after birth were measured by an enzyme-linked immunosorbent assay. Result. A total of 182 infants were enrolled in this study. Patients were categorized into two groups by gestational age (102 preterm, 80 full-term). ANGPTL7 levels in preterm infants were significantly higher than that in full-term babies ( t = 15.4 , P < 0.001 ). In multiple line regression analysis, ANGPTL7 levels independently correlated with gestational age ( β = − 0.556 , P < 0.001 ). There is also no correlation between preterm outcomes and ANGPTL7 levels. Cord blood levels of ANGPTL7 were significantly higher than those in serum on the third day after birth ( t = 13.88 , P < 0.001 ). Conclusion. Cord blood ANGPTL7 levels are higher in preterm infants than full-term babies. The levels are independently influenced by gestational ages and attenuated significantly after birth. The underlying mechanism needs to be further studied.

Neonatal Polycythemia: I. Early Diagnosis and Incidence Relating to Time of Sampling

PEDIATRICS ◽  
1984 ◽  
Vol 73 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Mordechai Shohat ◽  
Paul Merlob ◽  
Salomon H. Reisner
Keyword(s):  
Early Diagnosis ◽  
Cord Blood ◽  
Gestational Age ◽  
Linear Correlation ◽  
Blood Viscosity ◽  
Full Term ◽  
Peripheral Vein ◽  
Dynamic Changes ◽  
Term Infants ◽  
Appropriate For Gestational Age

The dynamic changes occurring in hematocrit and blood viscosity within the first 18 hours of life were studied in 50 full-term infants who were vaginally delivered and had weight appropriate for gestational age. In all cases, the cord was clamped within 30 seconds and cord blood was collected from the vein and artery. Subsequently, samples were taken from a peripheral vein at ages 15 minutes, and 2, 4, 6, and between 12 to 18 hours. Both the Hct and blood viscosity reach their peak at age 2 hours. The incidence of neonatal polycythemia varied greatly with age. Thus at the age of 2 hours, ten infants (20%) were polycythemic, whereas by age 6 hours only six (12%) of these infants were still polycythemic and by age 12 to 18 hours only one infant (2%) was polycythemic. A linear correlation was found between cord Hct levels and peripheral venous Hct levels by age 2 hours. None of the infants with cord blood Hct levels ≤56% had developed polycythemia, whereas ten of the 12 infants with cord Hct levels &gt;56% developed polycythemia. In this particular group of infants, cord blood Hct levels may be used for the screening of neonatal polycythemia.

scholarly journals Circulating Peptide YY Concentrations Are Higher in Preterm than Full-Term Infants and Correlate Negatively with Body Weight and Positively with Serum Ghrelin Concentrations

2005 ◽  
Vol 51 (11) ◽  
pp. 2131-2137 ◽  
Author(s):  
Tania Siahanidou ◽  
Helen Mandyla ◽  
Maria Vounatsou ◽  
Dimitris Anagnostakis ◽  
Ioannis Papassotiriou ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Energy Balance ◽  
Food Intake ◽  
Preterm Infants ◽  
Gestational Age ◽  
Peptide Yy ◽  
Full Term ◽  
Term Infants ◽  
Serum Ghrelin

Abstract Background: Peptide YY (PYY) and ghrelin are gastrointestinal tract–derived hormones that play roles in the regulation of food intake and energy balance. Negative energy balance often occurs in hospitalized preterm infants. Methods: To measure serum concentrations of PYY in preterm and full-term infants and to investigate their correlations with anthropometric characteristics, food intake, and serum ghrelin concentrations, we measured serum PYY and ghrelin concentrations by RIA in 62 healthy preterm infants [mean (SD) gestational age, 32.0 (2.1) weeks; postnatal age, 40.9 (14.8) days] and 15 healthy full-term infants of comparable postnatal age. All of the infants were formula-fed every 3 h. Results: PYY concentrations were significantly higher in preterm [1126.2 (215.4) ng/L] than in full-term infants [825.3 (234.4) ng/L; P &lt;0.001]. In the entire study population, serum PYY concentrations correlated negatively with gestational age and anthropometric measurements (birth weight, body weight, body length, body mass index, and head circumference) and positively with serum ghrelin concentrations, whereas there was no significant correlation between PYY concentration and caloric intake or weight gain. Multiple regression analysis, after correction for prematurity, revealed that serum PYY concentrations correlated independently with serum ghrelin concentrations and infant body weight or body mass index. Conclusions: Circulating concentrations of PYY may increase in preterm infants to compensate for the negative body-weight balance. The physiologic mechanisms behind the correlation between PYY and ghrelin remain to be elucidated.

scholarly journals Cord blood alpha klotho is decreased in small for gestational age preterm infants with placental lesions of accelerated aging

Placenta ◽  
2019 ◽  
Vol 87 ◽  
pp. 1-7 ◽  
Author(s):  
Andrew D. Franklin ◽  
Juanita Saqibuddin ◽  
Kelli Stephens ◽  
Robert Birkett ◽  
Lily Marsden ◽  
...  
Keyword(s):  
Cord Blood ◽  
Preterm Infants ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Accelerated Aging

Clot formation of neonates tested by thromboelastography correlates with gestational age

2010 ◽  
Vol 103 (02) ◽  
pp. 344-350 ◽  
Author(s):  
Tzipi Strauss ◽  
Yael Levy-Shraga ◽  
Bruria Ravid ◽  
Irit Schushan-Eisen ◽  
Ayala Maayan-Metzger ◽  
...  
Keyword(s):  
Cord Blood ◽  
Gestational Age ◽  
Blood Clot ◽  
Full Term ◽  
Clot Formation ◽  
Clotting Time ◽  
Term Infants ◽  
Term Neonates ◽  
Pregnancy And Delivery ◽  
Clot Formation Time

SummaryEvaluation of clot formation in neonates is troublesome. Our aim was to investigate cord blood clot formation of pre-term versus full-term infants and adults, using rotating thromboelastogram (ROTEM®, Pentafarm, Munich, Germany). ROTEM was investigated in cord blood of 184 full-term and 47 pre-term infants. Measurements of the clotting time (CT), clot formation time (CFT) and maximal clot firmness (MCF) were obtained in order to asses reference values for this age group, and compare between full-term and pre-term neonates and compared to adult controls. For each infant demographic information and data regarding pregnancy and delivery were gathered. Infants were prospectively followed until discharge. CT and CFT were significantly shorter among pre-term and term infants as compared to adults [median CT: 185, 194, 293 seconds respectively, p≤0.001, CFT: 80, 76, 103 seconds respectively, p≤0.001). MCF was lower in pre-term and term as compared to adults (p≤0.001) with significantly lower values in pre-term as compared to full-term neonates (p=0.004). Clotting time and MCF correlated with gestational age (R=0.132, p=0.045, R= 0.259, p<0.001, respectively). No association was found between any ROTEM values and the occurrence of post-natal complications in infants of our study group. This is the first study assessing clot formation by ROTEM in pre-term infants. Clot formation parameters of term and premature infants correlated with gestational age. The predictive value of clot formation tests in neonates deserves further attention.

A Pilot Study on Cord Blood Levels of Erythropoietin and Its Relationship to Periventricular Leukomalacia in Preterm Infants

2007 ◽  
Vol 23 (2) ◽  
pp. 231-234
Author(s):  
Akihisa Okumura ◽  
Hiroyuki Kidokoro ◽  
Toru Kato ◽  
Tetsuo Kubota ◽  
Fumio Hayakawa ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cord Blood ◽  
Preterm Infants ◽  
Periventricular Leukomalacia ◽  
Blood Levels

scholarly journals Relationship between plasma creatinine concentration and glomerular filtration in preterm newborn infants

1999 ◽  
Vol 54 (4) ◽  
pp. 121-126 ◽  
Author(s):  
Mário Cícero Falcão ◽  
Yassuhiko Okay ◽  
José Lauro Araújo Ramos
Keyword(s):  
Glomerular Filtration Rate ◽  
Creatinine Clearance ◽  
Glomerular Filtration ◽  
Preterm Infants ◽  
Gestational Age ◽  
Filtration Rate ◽  
Newborn Infants ◽  
Plasma Creatinine ◽  
Preterm Newborn ◽  
The Third

Fluid management and dosage regimens of drugs in preterm infants should be based on the glomerular filtration rate. The current methods to determine glomerular flitration rate are invasive, time-consuming, and expensive. In contrast, creatinine clearance can be easy obtained and quickly determined. The purpose of this study was to compare plasma creatinine on the third and seventh day of life in preterm newborn infants, to evaluate the influence of maternal creatinine, and to demonstrate creatinine clearance can be used as a reliable indicator of glomerular filtration rate. We developed a prospective study (1994) including 40 preterm newborns (gestational age < 37 weeks), average = 34 weeks; birth weight (average) = 1840 g, in the first week of life. Inclusion criteria consisted of: absence of renal and urinary tract anomalies; O2 saturation 3 92%; adequate urine output (>1ml/kg/hr); normal blood pressure; absence of infections and no sympathomimetic amines in use. A blood sample was collected to determine plasma creatinine (enzymatic method) on the third and seventh day of life and creatinine clearance (CrCl) was obtained using the following equation: <IMG SRC="http:/img/fbpe/rhc/v54n4/1065e1.gif" WIDTH=287 HEIGHT=96>, k = 0.33 in preterm infant All plasma creatinine determinations showed normal values [third day: 0.78 mg/dl ± 0.24 (mean ± SD)and seventh day: 0.67 mg/dl ± 0.31 - (p>0.05)]. Also all creatinine clearance at third and seventh day of life were normal [third day: 19.5 ml/min ± 5.2 (mean ± SD) and seventh day: 23.8 ml/min ± 7.3 - (p>0,05)]. All preterm infants developed adequate renal function for their respective gestational age. In summary, our results indicate that, for clinical practice, the creatinine clearance, using newborn length, can be used to estimate glomerular filtration rate in preterm newborn infants.

GLYCOSYLATED FIBRONECTIN AND INHIBIN ARE LOWER AND ANTI-MÜLLERIAN HORMONE IS HIGHER IN UMBILICAL CORD BLOOD WHEN MOTHERS HAVE PREECLAMPSIA

2020 ◽  
Vol 26 (3) ◽  
pp. 318-327
Author(s):  
Bridget DiPrisco ◽  
Ajay Kumar ◽  
Bhanu Kalra ◽  
Gopal V. Savjani ◽  
Zoe Michael ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Immunosorbent Assay ◽  
Plasma Protein ◽  
Umbilical Cord Blood ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Levels ◽  
Insulin Like Growth Factor ◽  
Tertiary Teaching

Objective: Preeclampsia is a common disorder of pregnancy, causing significant morbidity and mortality for mothers and infants. Several molecules, including glycosylated fibronectin (GlyFn), the inhibin-related proteins, anti-müllerian hormone (AMH), and the insulin-like growth factor axis, are altered in maternal plasma in the setting of preeclampsia; however, these molecules have not been previously measured in cord blood of infants born to mothers with preeclampsia, which may represent changes in fetal physiology. We evaluated potential biomarkers of preeclampsia in umbilical cord blood to fill the gap in knowledge. Methods: This is a case-control study of 196 neonates born at a tertiary teaching hospital in Boston from 2010–2017. Forty-nine neonates born to mothers with preeclampsia were matched 1:3 by gestational age, sex, and birth weight z-score with 147 controls. Eleven analytes were measured in cord blood by enzyme-linked immunosorbent assay. Binary logistic regression analyses were performed to evaluate associations between preeclampsia and analytes. Results: Mean cord blood levels of GlyFn and total inhibin were significantly lower in neonates born to mothers with preeclampsia compared to controls, and AMH levels were significantly higher in males born to mothers with preeclampsia than male controls. Associations remained significant after controlling for maternal and neonatal characteristics. Conclusion: Cord blood levels of GlyFn and inhibin are decreased and AMH (male) levels are increased in infants of preeclamptic mothers, which is opposite the pattern these biomarkers show in serum of mothers with preeclampsia. These molecules may be important in the pathophysiology and long-term effects of preeclampsia on the developing fetus. Abbreviations: AMH = anti-müllerian hormone; ELISA = enzyme-linked immunosorbent assay; GlyFn = glycosylated fibronectin; IGF = insulin-like growth factor; IGFBP5 = insulin-like growth factor binding protein 5; LOD = limit of detection; PAPP-A = pregnancy-associated plasma protein A; PAPP-A2 = pregnancy-associated plasma protein A2

scholarly journals Cord Blood Levels of IL-6, IL-8 and IL-10 May Be Early Predictors of Bronchopulmonary Dysplasia in Preterm Newborns Small for Gestational Age

2012 ◽  
Vol 33 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Gustavo Rocha ◽  
Elisa Proença ◽  
Ana Guedes ◽  
Carmen Carvalho ◽  
Augusta Areias ◽  
...  
Keyword(s):  
Cord Blood ◽  
Bronchopulmonary Dysplasia ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Preterm Neonates ◽  
Blood Levels ◽  
Early Predictors ◽  
Blood Cytokines ◽  
Uterine Growth ◽  
Preterm Newborns

Introduction: Various cytokines have been associated to the occurrence of bronchopulmonary dysplasia (BPD) in preterm neonates.AIM: To establish an association between cord blood cytokines and BPD, so that they could be used, in clinical practice, as early markers of BPD.Material and methods: Preterms less than 30 weeks gestational age, were analysed by ELISA microassay for venous cord blood IL-1β, IL-6, IL-8, TNF-αand IL-10, and compared between the BPD and non-BPD groups.Results: One hundred and fifty neonates completed the study; 31 (21%) small for gestational age (SGA); 16 were deceased before 28 days of life; 36 developed mild BPD and 20 developed moderate/severe BPD. Elevated cord blood IL-8 was associated with death or moderate/severe BPD. SGA patients with moderate/severe BPD presented higher cord blood values of IL-8, lower IL-6 and IL-10 when compared with SGA without moderate/severe BPD; and higher IL-8 levels when compared with patients without moderate/severe BPD.Conclusion: These results support an association between cord blood IL-8 and moderate/severe BPD, independently of the intra-uterine growth; and the association of cord blood IL-6 and IL-10 and moderate/severe BPD in SGA preterm newborns.

scholarly journals Bilirubin dosage in cord blood: could it predict neonatal hyperbilirubinemia?

2004 ◽  
Vol 122 (3) ◽  
pp. 99-103 ◽  
Author(s):  
Adélia Jeha Nasser Bernaldo ◽  
Conceição Aparecida de Mattos Segre
Keyword(s):  
Cord Blood ◽  
Blood Group ◽  
Serum Levels ◽  
Full Term ◽  
Neonatal Hyperbilirubinemia ◽  
Cutoff Point ◽  
Unconjugated Bilirubin ◽  
Significant Variable ◽  
The Third ◽  
Term Newborns

CONTEXT: With early discharge, many newborns have to be readmitted to hospital for hyperbilirubinemia to be treated, and this has been held responsible for the reappearance of kernicterus. OBJECTIVE: To evaluate whether bilirubin levels in cord blood could predict neonatal hyperbilirubinemia that would require treatment, in full-term newborns up to their third day of life. TYPE OF STUDY: Prospective study. SETTING: Neonatal Unit of Hospital Israelita Albert Einstein, São Paulo, Brazil. PARTICIPANTS: 380 full-term newborns considered normal: with or without ABO/Rh blood group incompatibility and without other complications. PROCEDURES: Blood was taken from the umbilical cord for analysis of conjugated, unconjugated and total bilirubin serum levels. The newborns were followed up until discharge, and unconjugated bilirubin that required phototherapy was compared to the cord bilirubin assay. Discriminant analysis was used to classify newborns: with or without risk of needing phototherapy by the third day of life. MAIN MEASUREMENTS: Bilirubin assay in cord blood; mother's and newborn's blood groups; phototherapy indication. RESULTS: The mean value for unconjugated bilirubin in cord blood was significantly higher in newborns whose unconjugated bilirubin required phototherapy. The presence of ABO blood group incompatibility was a significant variable in relation to unconjugated bilirubin that required phototherapy. The most useful cutoff point for unconjugated bilirubin in cord blood was 2.0 mg/100 ml. DISCUSSION: Cord blood could be collected, stored and used for further analysis of unconjugated bilirubin levels as a means for considering whether or not to discharge a moderately jaundiced child from hospital, in association with other resources. CONCLUSIONS: Blood incompatibility between mother and child was a predictor for the appearance of hyperbilirubinemia that required treatment. Considering a cutoff point of 2.0 mg/100 ml, it could be concluded that 53% of the newborns who had greater unconjugated bilirubin levels in cord blood would reach levels requiring phototherapy by the third day of life.

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