Dopamine D4 Receptor Gene Polymorphism in a Sample of Egyptian Children With Attention-Deficit Hyperactivity Disorder (ADHD)

2016 ◽  
Vol 32 (2) ◽  
pp. 188-193 ◽  
Author(s):  
Farida ElBaz Mohamed ◽  
Tarek Mostafa Kamal ◽  
Sally Soliman Zahra ◽  
Mona Abdel Hakiem Khfagy ◽  
Azza Mohamed Youssef
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Rating Scale ◽  
Receptor Gene ◽  
Parent Rating ◽  
Children With Adhd ◽  
Repeat Allele ◽  
Hyperactivity Disorder ◽  
Egyptian Children ◽  
Adhd Children

This study aimed to detect DRD4 receptor gene polymorphisms in attention-deficit hyperactivity disorder (ADHD) children and to correlate their phenotype-genotype. Fifty children with ADHD were diagnosed by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria and were subjected to Conners Parent Rating Scale. All cases and controls were subjected to history taking, physical examination, IQ assessment, and dopamine receptor D4 (DRD4) exon 3 genotyping. The 7-repeat allele was present only in controls, whereas 2-repeat allele was present in the ADHD children (heterozygous 2-repeat allele in 16% and homozygous in 26% of cases). Eight percent of cases had homozygous 4-repeat allele vs 28% of controls, whereas 10% of cases had heterozygous 4-repeat allele vs 6% of controls, with its predominance in controls. The 2-repeat and 4-repeat alleles have been associated with more inattention, hyperactivity, and impulsivity phenotypes. In conclusion, children with ADHD had a significant presence of the 2-repeat allele and absence of the 7-repeat allele.

scholarly journals The Impact of an Adapted Climbing Program on Children with Attention-Deficit/Hyperactivity Disorder

2020 ◽  
Vol 9 (4) ◽  
pp. 60-69
Author(s):  
Erin Angelini ◽  
Kathryn N Oriel ◽  
Greta M Myers ◽  
Kyle D.A. Cook ◽  
Ross M Drawbaugh ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Rating Scale ◽  
Route Planning ◽  
Rock Climbing ◽  
Moderate Intensity ◽  
Parent Rating ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
The Impact

Attention-Deficit/Hyperactivity Disorder impacts children’s participation in activities that require attention to instruction, sustained mental effort, and executive functioning. Physical activity has been correlated to improvement in attention in children with ADHD. Rock climbing challenges muscular endurance, attention, and route planning. Five participants, aged 8-13, participated in the climbing program. Attention was measured pre and post climbing intervention with Trail Making Test B (TMT-B) for time to complete. Exercise intensity was measured by heart rate. Parent feedback on behavior was collected with the Conner’s Parent Rating Scale (CPRS). The social validity of the intervention was measured by the IRP-15 measures. Statistically, significant intrasession attention improvements were noted in all 5 climbers (p=.43). Two climbers were consistently working at a moderate intensity (40-60% HRmax) while 3 climbers maintained a light level of intensity (20-40% HRmax). No statistically significant improvements were found on the CPRS, although improvements are noted with qualitative reports from parents. The IRP-15 showed 100% of parents believed rock climbing was an effective intervention for their children with ADHD. Rock climbing at a light to moderate intensity is associated with improvements in attention and behavior in children with ADHD.

scholarly journals Diagnosis Based on Parent and Teacher Rating for Attention Deficit Hyperactivity Disorder

JMS SKIMS ◽  
2010 ◽  
Vol 13 (1) ◽  
pp. 11-14
Author(s):  
Abdul Rouf ◽  
Shabnum Rivees ◽  
A Wahid Khan ◽  
A G Madhosh ◽  
Zeba Zeba
Keyword(s):  
Attention Deficit ◽  
Rating Scales ◽  
Rating Scale ◽  
Teacher Rating ◽  
Parent Rating ◽  
Four Dimensions ◽  
Hyperactivity Disorder ◽  
Significant Difference ◽  
Adhd Children ◽  
Icd 10

Parents and teachers play a significant role in the diagnosis of ADHD in children in the clinical setting. With the same in consideration a study was conducted to compare the perception between parents and teachers on the rating scales for ADHD children. The study was conducted on a sample of parents and teachers of 100 children diagnosed as having ADHD as per ICD-10 diagnostic criteria. A newly constructed and standardized parent rating scale for parents of ADHD children and attention deficit comprehensive teacher rating scale for teachers was administered on the target sample. Results indicate that there was statistically no significant difference in the rating of perception between parents and teachers on four dimensions, viz (i) attention (ii) hyperactivity (iii) social skills (iv) oppositional behaviour of ADHD children. To verify these findings, positive correlation was found between parents and teachers perception on all the four dimensions.J Med Sci.2010;13(1);11-14

scholarly journals Method of Parents in the Development of Child Prayers Attention Deficit Hyperactivity Disorder (ADHD) (Case Study of ADHD Children in Kulam Kemukiman Syamtarail Village, North Aceh)

2019 ◽  
Vol 1 (2) ◽  
pp. 278-290
Author(s):  
Muhajir ◽  
Zahrul Mubarrak ◽  
Amiruddin ◽  
Khaidir ◽  
Fazil Saputra ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Analysis Model ◽  
Case Study Method ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
The Family ◽  
Adhd Children ◽  
Model Technique

Concentration disorders accompanied by hyperactivity in children with ADHD are conditions that show symptoms of lack concentration, hyperactivity and impulsiveness that causes an imbalance of most of their life activities. This makes parents have difficulty in providing prayer guidance to children who have ADHD. Starting from this problem, the researcher tries to make a scientific about Parents' Method in the Development of Child Prayers Attention Deficit Hyperactivity Disorder (ADHD) (Case Study of ADHD Children in Kulam Kemukiman Syamtarail Village, North Aceh)." This study was conducted to describe the method parents in providing prayer services to children with ADHD in  Kulam Kemukiman Syamtarail Village, North Aceh. This thesis research method uses the case study method which is a study that tries to examine individuals or a unit in depth with a qualitative approach. In collecting data researchers conducted observations and direct interviews within formants who have been used as samples, as well as documentation. While the analysis of data through observations in this thesis uses a theme analysis model technique where all data after being collected will be processed one by one. The results showed that ADHD children's prayer guidance involved all family members, namely the father, mother, siblings and cousins ​​of ADHD children. As for the methods carried out by the family in the guidance of prayers in children with ADHD can be concluded as follows:1. Intelegently; 2. Be haviour; 3. By monitoring.

Differential effects of methylphenidate and atomoxetine on intrinsic brain activity in children with attention deficit hyperactivity disorder

2016 ◽  
Vol 46 (15) ◽  
pp. 3173-3185 ◽  
Author(s):  
C. Y. Shang ◽  
C. G. Yan ◽  
H. Y. Lin ◽  
W. Y. Tseng ◽  
F. X. Castellanos ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Brain Activity ◽  
Movement Time ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Lingual Gyrus ◽  
Adhd Children ◽  
Pre Treatment ◽  
Intrinsic Brain Activity

BackgroundMethylphenidate and atomoxetine are commonly prescribed for treating attention deficit hyperactivity disorder (ADHD). However, their therapeutic neural mechanisms remain unclear.MethodAfter baseline evaluation including cognitive testing of the Cambridge Neuropsychological Test Automated Battery (CANTAB), drug-naive children with ADHD (n = 46), aged 7–17 years, were randomly assigned to a 12-week treatment with methylphenidate (n = 22) or atomoxetine (n = 24). Intrinsic brain activity, including the fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), was quantified via resting-state functional magnetic resonance imaging at baseline and week 12.ResultsReductions in inattentive symptoms were related to increased fALFF in the left superior temporal gyrus and left inferior parietal lobule for ADHD children treated with methylphenidate, and in the left lingual gyrus and left inferior occipital gyrus for ADHD children treated with atomoxetine. Hyperactivity/impulsivity symptom reductions were differentially related to increased fALFF in the methylphenidate group and to decreased fALFF in the atomoxetine group in bilateral precentral and postcentral gyri. Prediction analyses in the atomoxetine group revealed negative correlations between pre-treatment CANTAB simple reaction time and fALFF change in the left lingual gyrus and left inferior occipital gyrus, and positive correlations between pre-treatment CANTAB simple movement time and fALFF change in bilateral precentral and postcentral gyri and left precuneus, with a negative correlation between movement time and the fALFF change in the left lingual gyrus and the inferior occipital gyrus.ConclusionsOur findings suggest differential neurophysiological mechanisms for the treatment effects of methylphenidate and atomoxetine in children with ADHD.

scholarly journals THE CORRELATION OF PARENTING STYLE WITH COGNITIVE DEVELOPMENT IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER

2018 ◽  
Vol 4 (2) ◽  
pp. 271-278
Author(s):  
Dwi Fitri Genisti ◽  
Ni Komang Sukra Andini ◽  
Ni Luh Gede Puspita Yanti
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cognitive Development ◽  
Child Development ◽  
Parenting Style ◽  
Attention Deficit ◽  
Learning Disorders ◽  
P Value ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Adhd Children

Background: Child development is a very important phase, which children learn various skills as future generations in the future. Disorders that can impede child development process of Attention Deficit Hyperactivity Disorder (ADHD). Children with ADHD have problems with cognitive abilities, of which about 20-60% of them have learning disorders. The efforts to support cognitive development in ADHD children is to approach the child's environment through parenting parents. Objective: This study aimed to determine the correlation of parenting style with cognitive development in the children with ADHD in SLB Negeri 1 Denpasar. Methods: This study used correlational design with cross sectional approach. The sample size of 30 respondents were taken by purposive sampling technique. Data were collected using parenting style questionnaire (PSQ) and the average value of odd semester report of 2016/2017 academic year. Results:  The result of this research was found that most parents with democratic parenting type were 19 people (63.3%), authoritarian parenting type were 7 people (23.3%) and permissive parenting were 4 people (13.3%). The result of contingency coefficient test with p-value = 0.039 (p <0.05) and correlation value of 0.501, which mean there was high correlation between parenting style with cognitive development in children with ADHD. Conclusion: It is suggested for parents with ADHD children to be able to provide good parenting for the child's development, especially for the child's cognitive development.

scholarly journals The incidence of dysgraphia in Arabic language in children with attention-deficit hyperactivity disorder

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Amira Salah Lotfy ◽  
Mohammed El Sayed Darwish ◽  
Ehab Sayed Ramadan ◽  
Rania Makram Sidhom
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Arabic Language ◽  
Finger Tapping ◽  
Fine Motor ◽  
Normal Children ◽  
Spelling Errors ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Adhd Children

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) is a brain disorder marked by an ongoing pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development. Although children with ADHD made much more spelling errors, they had a distinct pattern of letter insertions, replacements, transpositions, and omissions. This mistake type is sometimes referred to as graphemic buffer errors, and it is caused by a lack of attention required for motor planning. The aim of study was to assess the incidence of dysgraphia in Arabic language in children with ADHD for better helping, diagnosis and management of those children. Results Ten percent of ADHD children had normal handwriting with no disability, 40% had excellent handwriting with a minimum of disability and 50% of ADHD children showed mild to moderate disability. There were significant differences between ADHD children and control children regarding results of each item on the subtest of handwriting of dysgraphia disability scale (DDS), respecting lines, spacing between words, letter direction, spelling a sentence, and punctuation. Drawing affected in ADHD children. The finger tapping speed was affected in almost ADHD children. Conclusions Dysgraphia highly presents in our sample of ADHD children with poor fine motor skills in ADHD children than normal children. ADHD children have illegible handwriting, not respecting lines, insufficient space between and within words, multiple spelling errors, and omissions of letters or words. Graphesthesia and stereognosis are affected more in ADHD children than in control children drawing and finger tapping speed affected in ADHD children.

Attention Deficit Hyperactivity Disorder and Scientific School Performances Among Moroccan Children

2017 ◽  
Vol 41 (S1) ◽  
pp. s248-s248
Author(s):  
F.Z. Rouim ◽  
F.Z. Azzaoui ◽  
A.O.T. Ahami
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
School Performance ◽  
Attention Deficit ◽  
Natural Science ◽  
Rating Scales ◽  
Rating Scale ◽  
Behavioral Difficulties ◽  
Scientific School ◽  
Children With Adhd ◽  
Hyperactivity Disorder

Background and aimAttention deficit hyperactivity disorder (ADHD) is classified as neurodevelopmental disorders. ADHD is one of the major problems in childhood encountered most often in schools. A study realized by Platt in 2011 show that children with ADHD often experience difficulties in mathematics. The aim of this study is to assess whether there is a relationship between school performance in scientific subjects (mathematics and natural science) and attention deficit hyperactivity disorder.MethodsThe study was realized among 239 children studying in a urban school in Kenitra city (North-West of Morocco), and aged from 6 to 16 years. To evaluate the relationship between ADHD and the average class results of mathematics and natural science, Conners rating scale (parent and teacher short version) and the academic transcripts are used.ResultsThe results show that there is a significant correlation (P < 0.05, P < 0.01) between the average class results in each natural science and mathematics and three components of Conners rating scales (parent's version), which are behavioral difficulties, learning difficulties and hyperactivity/impulsivity. Furthermore, the Conners rating scale (teacher's version) show, also, that there is a significant correlation (P < 0.05, P < 0.01) between behavioral difficulties, hyperactivity/impulsivity and Inattention passivity and the average class results in natural science and in mathematics.ConclusionAs known, children with ADHD are not less intelligent than other children, although our study show that children with ADHD represent low marks in natural science and in mathematics. In fact, deeper investigations are needed to study the possible factors that could affect ADHD children's school performance.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Serum Interleukin-6 Level in Children With Attention-Deficit Hyperactivity Disorder (ADHD)

2018 ◽  
Vol 34 (2) ◽  
pp. 61-67 ◽  
Author(s):  
Amira Hamed Darwish ◽  
Tarek Mohamed Elgohary ◽  
Nahla A. Nosair
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Interleukin 6 ◽  
Rating Scale ◽  
Enzyme Linked Immunosorbent Assay ◽  
Parent Rating ◽  
Hyperactivity Disorder ◽  
Diagnostic And Statistical Manual ◽  
Healthy Control ◽  
And Control

Introduction: Attention-deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder in children, but its specific etiology and pathophysiology are still incompletely understood. Objectives: This case-control study aimed to measure the level of serum interleukin-6 (IL-6) as a predictor of the immunologic status in children with ADHD, and to study its correlation with severity of symptoms. Subjects and Methods: 60 ADHD children who met the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, criteria for ADHD and 60 control children were subjected to complete history taking, clinical examination, and psychometric tests. Serum interleukin-6 of ADHD patients and control children was measured by enzyme-linked immunosorbent assay. Results: The mean serum level of IL-6 was 22.35 (95% confidence interval [CI], 17.68-26.99) in ADHD patients, and it was 5.44 (95% CI, 4.81-6.06) in controls. A significantly higher level of IL-6 was reported in ADHD patients compared with controls ( P = .001). No significant correlation was found between serum IL-6 level and either the Intelligence Quotient (IQ) or the Conners’ Parent Rating Scale score. Conclusion: Serum IL-6 values were significantly higher in ADHD patients compared to healthy control children. Increased production of IL-6 may play a role in the pathogenesis of ADHD.

scholarly journals Comparison of cognitive function, socioeconomic level, and the health-related quality of life between epileptic patients with attention deficit hyperactivity disorder and without

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Gellan K. Ahmed ◽  
Alaa M. Darwish ◽  
Hossam Khalifa ◽  
Mohamed A. Khashbah
Keyword(s):  
Quality Of Life ◽  
Attention Deficit Hyperactivity Disorder ◽  
Cognitive Function ◽  
Attention Deficit ◽  
Socioeconomic Level ◽  
Parent Rating ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Eeg Changes

Abstract Background Epilepsy is one of the most common neurological conditions. Attention deficit hyperactivity disorder (ADHD) in children with epilepsy proves to be very common. Both epilepsy and ADHD impair quality of life. We aimed to evaluate cognitive function, socioeconomic level, and quality of life (QOL) among children with ADHD and epilepsy. A total of 100 children were divided into 5 groups (20 children/group) as (I) epilepsy, (II) ADHD with epilepsy, (III) ADHD with EEG changes, (IV) ADHD without EEG changes, and (V) control. Children aged between 6 and 11 years were recruited for this study. Early Childhood Epilepsy Severity Scale (E-Chess), Conners’ Parent Rating Scale (CPRS), Wechsler Intelligence Scale for Children-3rd edition (WISC-III), socioeconomic scale for assessment of social burden and socioeconomic classes, and PedsQL (quality of life measure) assessed. Results Children with ADHD and epilepsy had the lowest PedsQL total scores and lower scores than other groups especially in performance IQ score. The highest percentage of low socioeconomic class (25%) was observed in the group of ADHD with epilepsy and the group of epilepsy. Conclusion ADHD with epilepsy is associated with low performance IQ, poor socioeconomic level, and quality of life. Pediatric Quality of Life Inventory scores show significant correlation with total IQ score in the group of ADHD with epilepsy.

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