The Effects of Exclusive Walking on Lipids and Lipoproteins in Women with Overweight and Obesity: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 089011712110481
Author(s):  
Anjulyn M. Ballard ◽  
Ashlee Davis ◽  
Brett Wong ◽  
Rodney Lyn ◽  
Walter R. Thompson
Keyword(s):  
Total Cholesterol ◽  
Data Extraction ◽  
Cochrane Review ◽  
Low Density Lipoproteins ◽  
Overweight And Obesity ◽  
Mean Difference ◽  
Lipid Lowering ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Lipids And Lipoproteins

Objective To evaluate the effects of walking, independent of diet and weight-loss, on lipids and lipoproteins in women with overweight and obesity. Data Source Academic Search Complete, Alternative Health Watch, Global Health, Health Source, CINAHL, MEDLINE, EMBASE, SportDiscus, and ProQuest. Study Inclusion and Exclusion Criteria (1) experiment-control design; (2) women with overweight or obesity; (3) walking as the experiment’s independent variable; (4) four or more weeks; and (5) pre- to post-assessment of lipids and/or lipoproteins. Excluded studies reported use of lipid-lowering medication, diet or other modes of physical activity, and alternative interventions as the control. Data Extraction Data extraction and study quality were completed by the first 2 authors using the Cochrane review protocol and risk of bias assessment. Data Synthesis Raw mean difference between the experiment and control groups using a random effects model. Results Meta-analyses of 21 interventions (N = 1129) demonstrated exclusive walking improves total cholesterol (raw mean difference = 6.67 mg/dL, P = .04) and low-density lipoproteins (raw mean difference = 7.38 mg/dL, P = .04). Greater improvement in total cholesterol, triglycerides, high-density lipoproteins, and low-density lipoproteins existed in women with obesity. Conclusions Exclusive walking aids in normalizing total cholesterol and LDLs in women with overweight and obesity. Exclusive walking can be used as a non-pharmacologic therapy, which may have positive clinical outcomes for individuals who especially struggle with diet and weight-reduction.

scholarly journals The Diabetes Prevention Program: A Worksite Experience

AAOHN Journal ◽  
2005 ◽  
Vol 53 (11) ◽  
pp. 499-505 ◽  
Author(s):  
Steven G. Aldana ◽  
Marilyn Barlow ◽  
Rebecca Smith ◽  
Frank G. Yanowitz ◽  
Ted Adams ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Total Cholesterol ◽  
Prevention Program ◽  
Diabetes Prevention ◽  
Diabetes Prevention Program ◽  
Low Density Lipoproteins ◽  
High Density Lipoproteins ◽  
Oral Glucose ◽  
Low Density ◽  
Very Low Density Lipoproteins

The purpose of this study was to determine if the U.S. National Institutes of Health Diabetes Prevention Program (DPP) could be successfully implemented in a worksite setting. Thirty-seven adult employees of BD Medical Systems of Sandy, Utah were enrolled in a single-group time-series study using the DPP. Two-hour oral glucose tolerance tests (OGTT) and other outcomes were measured at baseline, 6 months, and 12 months. Weight, body mass index, waist circumference, 2-hour OGTT, very low density lipoproteins, triglycerides, and aerobic fitness were significantly improved at 6 and 12 months and showed overall significant improvement across time. Fasting blood insulin, total cholesterol, low density lipoproteins, and total cholesterol/high density lipoproteins ratio were significantly improved at 6 months, but not at 12 months. Eighteen of the program participants (51%) were no longer in the pre-diabetes and diabetes categories after 1 year. Existing worksite health promotion and occupational health professionals can successfully offer the DPP and help employees improve glucose tolerance.

scholarly journals Changes in lipid metabolism in the pre- and postoperative periods in obese patients with laparoscopic cholecystectomy

2021 ◽  
Vol 17 (1) ◽  
pp. 55-58
Author(s):  
A.O. Maisuradze ◽  
I.V. Chubuk
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Low Density Lipoproteins ◽  
The Body ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Obese Patients ◽  
Obese People ◽  
Group 1

Background. Changes in lipid metabolism indicators in the pre- and postoperative periods are due to frequent metabolic disorders in obese people and particular difficulties with the selection of appropriate therapy. In turn, the cause for metabolic changes in the body is the influence of a certain extreme situation — surgical intervention. Objective: to study the changes in lipid metabolism in the pre- and postoperative periods in obese patients with laparoscopic cholecystectomy. Materials and methods. The study involved 50 individuals (mean age — 47.0 ± 1.5 years), who underwent surgery for acute cholecystitis by laparoscopic cholecystectomy. The patients were divided into 2 groups: 1 — obese, 2 — non-obese. The level of triglycerides, total cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL) was assessed in all patients and compared in the preoperative period and on days 1 and 5 after surgery. Results. The parameters of lipid metabolism in the pre- and postoperative periods in all groups had permissible fluctuations, given the fact that in obese patients lipids were initially increased compared to patients without obesity. In the postoperative period in group 1 on the first day, there was a decrease in triglycerides (1.1 ± 0.6 mmol/L) from the baseline, in total cholesterol (4.5 ± 0.3 mmol/L), an increase in HDL cholesterol (1.5 ± 0.2 mmol/L), a decrease in LDL (2.9 ± 0.2 mmol/L) and VLDL (1.0 ± 0.2 mmol/L). In group 2, indicators of triglyceri­des (0.6 ± 0.2 mmol/L), total cholesterol (3.4 ± 0.1 mmol/L), LDL (1.9 ± 0.3 mmol/L) and VLDL (0.8 ± 0.2 mmol/L) also tended to decrease and there was an increase in HDL (1.6 ± 0.1 mmol/L), but these values, regardless of their variation, were within the normal range. In group 1, three patients showed cognitive impairment, which was due to a significant increase in LDL over HDL and the possible development of atherosclerosis, which could lead to cerebrovascular accident. Conclusions. After conducting a study between two groups in which the lipids were studied, a variation in parame­ters was revealed in both groups, which is due to the characteristics of metabolism in such patients and the influence of surgical stress. Based on this, control and regulation of lipid values should be carried out in all patients with dyslipidemia, and in obese patients, additional consideration should be given to risk factors, concomitant diseases and possible complications.

scholarly journals EFFECTS OF GROSSHEMIN AND GROSSMISIN ON THE ACUTE HYPERLIPIDEMIA MODEL INDUCED BY ETHANOL

2014 ◽  
Vol 13 (1) ◽  
pp. 67-72 ◽  
Author(s):  
A. V. Ratkin ◽  
O. A. Kaidash ◽  
V. V. Ivanov ◽  
A. I. Vengerovsky ◽  
S. M. Adekenov ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Nicotinic Acid ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Total Cholesterol ◽  
Sesquiterpene Lactones ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density

Objective: study sesquiterpene lactones grosshemin and grossmisin lipid-lowering properties on the model of acute hyperlipidemia induced by ethanol in rats.Materials and methods. Rats during 7 days injected into the stomach grosshemin and grossmisin in a dose 10 mg/kg or reference drug nicotinic acid in a dose 25 mg/kg. Hyperlipidemia caused by single introduction of ethanol into the stomach in a dose 5 g/kg. In blood serum of tail vein measured the triacylglycerols, total cholesterol, high density and low density lipoproteins cholesterol, also the level of free fatty acids. Calculated the ratio of high density lipoproteins cholesterol to the amount of low density lipoproteins cholesterol and the index of atherogenicity.Results. A single dose of ethanol increased serum level of triacylglycerols in 1.9 times, free fatty acids – in 3.2 times, low density lipoproteins – on 44% in comparison with the intact animals indices. It shows the development of acute hyperlipidemia. Serum total cholesterol, high density lipoproteins cholesterol and the index of atherogenicity were not changed. Course sesquiterpene lactones grosshemin and grossmisin introduction against the background of acute hyperlipidemia was accompanied by a decrease in the serum of triacylglycerols levels respectively by 19.8% and 34.1%. Nicotinic acid lowered the content of triacylglycerols by 42.4%. Grosshemin and nicotinic acid reduced the increased level of free fatty acids in the blood serum by 60.7–67.9%. Grossmisin and nicotinic acid decreased by 14.6–17.2% of total cholesterol in the blood serum. In acute hyperlipidemia grosshemin and grossmisin reduced low density lipoproteins cholesterol by 17.6% and 20%, respectively, nicotinic acid – by 15.7%. Both of sesquiterpene lactone and nicotinic acid did not modify the content of high density lipoproteins cholesterol. When introduction grosshemin, grossmisin and nicotinic acid ratio of high density lipoproteins cholesterol to the amount of low density lipoproteins cholesterol significantly increased by 42.8%, 38,6% and 22.1% respectively.Conclusion. Sesquiterpene lactones grosshemin and grossmisin posses hypolipidemic effect in acute experimental hyperlipidemia caused by the ethanol introduction. Lactones normalize many indices of lipid metabolism, which can be caused by different biochemical targets of these molecules. Lactones, as nicotinic acid, in the model of acute hyperlipidemia decrease in blood serum triacylglycerols, total cholesterol, and low density lipoproteins cholesterol content. Grosshemin and nicotinic acid also reduce the free fatty acids level.

scholarly journals Haplotype Analysis of Genomic Prediction Using Structural and Functional Genomic Information for Seven Human Phenotypes

2020 ◽  
Vol 11 ◽  
Author(s):  
Zuoxiang Liang ◽  
Cheng Tan ◽  
Dzianis Prakapenka ◽  
Li Ma ◽  
Yang Da
Keyword(s):  
Body Mass Index ◽  
Total Cholesterol ◽  
Genomic Prediction ◽  
Prediction Accuracy ◽  
Haplotype Analysis ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Genomic Information

Genomic prediction using multi-allelic haplotype models improved the prediction accuracy for all seven human phenotypes, the normality transformed high density lipoproteins, low density lipoproteins, total cholesterol, triglycerides, weight, and the original height and body mass index without normality transformation. Eight SNP sets with 40,941-380,705 SNPs were evaluated. The increase in prediction accuracy due to haplotypes was 1.86-8.12%. Haplotypes using fixed chromosome distances had the best prediction accuracy for four phenotypes, fixed number of SNPs for two phenotypes, and gene-based haplotypes for high density lipoproteins and height (tied for best). Haplotypes of coding genes were more accurate than haplotypes of all autosome genes that included both coding and noncoding genes for triglycerides and weight, and nearly the same as haplotypes of all autosome genes for the other phenotypes. Haplotypes of noncoding genes (mostly lncRNAs) only improved the prediction accuracy over the SNP models for high density lipoproteins, total cholesterol, and height. ChIP-seq haplotypes had better prediction accuracy than gene-based haplotypes for total cholesterol, body mass index and low density lipoproteins. The accuracy of ChIP-seq haplotypes was most striking for low density lipoproteins, where all four haplotype models with ChIP-seq haplotypes had similarly high prediction accuracy over the best prediction model with gene-based haplotypes. Haplotype epistasis was shown to be the reason for the increased accuracy due to haplotypes. Low density lipoproteins had the largest haplotype epistasis heritability that explained 14.70% of the phenotypic variance and was 31.27% of the SNP additive heritability, and the largest increase in prediction accuracy relative to the best SNP model (8.12%). Relative to the SNP additive heritability of the same regions, noncoding genes had the highest haplotype epistasis heritability, followed by coding genes and ChIP-seq for the seven phenotypes. SNP and haplotype heritability profiles showed that the integration of SNP and haplotype additive values compensated the weakness of haplotypes in estimating SNP heritabilities for four phenotypes, whereas models with haplotype additive values fully accounted for SNP additive values for three phenotypes. These results showed that haplotype analysis can be a method to utilize functional and structural genomic information to improve the accuracy of genomic prediction.

scholarly journals Influence of Functional Sweet White Lupin Biscuits on Lipid Profile and Food Efficiency of Induced Hyperlipidemia Rats

2015 ◽  
Vol 4 (3) ◽  
pp. 14 ◽  
Author(s):  
Rasha Mousa Ahmed Mousa
Keyword(s):  
Weight Gain ◽  
Total Cholesterol ◽  
Low Density Lipoproteins ◽  
High Density ◽  
The Body ◽  
Atherogenic Index ◽  
White Lupin ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Food Efficiency

<p>In recent years, functional foods have attracted much interest to prevent nutrition-related diseases such as hyperlipidemia and weight gain. In this regard, this study was designed to examine the effect of use sweet white lupin (SWL) oil and flour with/without germination as a source of active healthy components to prepare functional biscuits for lowering blood lipids and growth. Functional biscuits were formulated by replacing wheat flour and butter in biscuit formulae by SWL extracted flour and SWL oil in the range of 20-30% (w/w) and 30-40% (v/w), respectively. Results indicated that the feed of hyperlipidemic rats on diets supplemented with different functional SWL biscuits for 6 weeks significantly (P &lt; 0.05) reduced serum total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins, ratio of total cholesterol/high density lipoproteins cholesterol, ratio of low density lipoproteins/high density lipoproteins cholesterol and atherogenic index. Furthermore, the feed of functional SWL biscuits significantly reduced the body weight gain of rats and their food efficiency compared to that of rats fed on hyperlipidemic diet. On the other hand, there was an increase in the value of high density lipoproteins cholesterol and its ratio with total cholesterol. All these findings supported that the addition of 25% germinated SWL flour and 35% or 40% germinated SWL oil in biscuits gave interested results compared to the common wheat biscuits. Therefore, the proposed functional SWL biscuits could be able to regulate the blood cholesterol and the body growth levels of individuals and patients.</p>

scholarly journals A Molecular and Biochemical Study for Cholesteryl Ester Transfer Protein (CETP) Taq1B in Iraqi Patients with Hyperlipidemia

2019 ◽  
Vol 16 (3(Suppl.)) ◽  
pp. 0747
Author(s):  
Alkhafajy Et al.
Keyword(s):  
Cholesteryl Ester ◽  
Total Cholesterol ◽  
Cholesteryl Ester Transfer Protein ◽  
Serum Lipid ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Transfer Protein

Cholesteryl ester transfer protein gene contains some single nucleotide polymorphisms, which have been associated with serum high-density lipoprotein concentration and other lipoproteins. This study is done for determining of cholesteryl ester transfer protein polymorphism and evaluate its effect on serum lipid profile concentrations in some hyperlipidemic patients compared with healthy subjects in Salah Al-din governorate-Iraq. Blood samples were taken from (90) patients suffering from hyperlipidemia, and (70) samples that were apparently healthy controls.  Serum lipid concentrations were measured by enzymatic assays. The polymorphism was genotyped using polymerase chain reaction restriction fragment length polymorphism analysis.  The results showed that there was a significant decrease (P<0.05) in the frequency B2 allele, and B1B2, B2B2 genotype, and a significant increase (P<0.05) in the frequency B1 allele, and B1B1 genotype between patients and controls groups. There was a non-significant decrease in the levels of high density lipoproteins, total cholesterol, low density lipoproteins, and very low density lipoproteins levels, and non-significant increase in levels of triglycerides in individuals with the B1B1 genotype than in the B1B2 and B2B2 genotype. However, high density lipoproteins showed a significant decrease (P<0.001) between individuals with the B1B1 genotype and B2B2 genotype. Also, there was a non-significant difference in the levels of high density lipoproteins, total cholesterol, low density lipoproteins, and very low density lipoproteins levels, in individuals with the B1B2 genotype when compared with that of the B2B2 genotype.

Changes in plasma lipids after a non-lethal dose of cycloheximide in rats

2003 ◽  
Vol 22 (5) ◽  
pp. 245-248
Author(s):  
A Lucić ◽  
V Bradamante ◽  
M Peraica ◽  
B Radić ◽  
A-M Domijan ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Lethal Dose ◽  
Hdl Cholesterol ◽  
Low Density Lipoproteins ◽  
Male Rats ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Apo B

This paper describes a study of the effect of a single intraperitoneal non-lethal dose of cycloheximide (CHM; 2.0 mg/kg body weight) on the concentration of plasma lipids and lipoproteins in male rats killed one, two, three, four and nine days after receiving the dose. The concentration of triglycerides, total cholesterol, high-density lipoproteins (HDL)-cholesterol and low-density lipoproteins (LDL)-cholesterol was measured in treated and control animals. The effect of CHM on the concentration of triglycerides, total cholesterol, HDL-cholesterol, and LDL-cholesterol was visible in rat plasma throughout the study. Total cholesterol and HDL-cholesterol concentrations showed the same pattern of changes, probably due to the reversible inhibition of apolipoprotein apo A-I synthesis by CHM. The concentration of triglycerides decreased after a lag period of three days when the reserves of apolipoprotein apo B, the main apolipoprotein of very low-density lipoproteins (VLDL)-cholesterols produced in the liver, were consumed.

EFFECT OF COLD EXPOSURE ON SERUM LIPIDS AND LIPOPROTEINS IN THE RAT

1966 ◽  
Vol 44 (5) ◽  
pp. 711-719 ◽  
Author(s):  
M. W. Radomski
Keyword(s):  
Cold Exposure ◽  
Serum Lipids ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Total Serum ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Triglyceride Fraction ◽  
Lipids And Lipoproteins

The effect of cold exposure for 1–52 days on the concentration and composition of the serum lipids and lipoproteins in male Wistar rats was studied. Serum lipoproteins were separated by preparative ultracentrifugation into three density classes, very low density (d < 1.006), low-density (d, 1.006–1.070), and high-density (d, 1.070–1.218). On the first day of cold exposure, total serum lipids were reduced by 20–25%, this decrease occurring mainly in the triglyceride fraction. Although the low-density and high-density lipoproteins were not affected by cold exposure, the concentration of the very low density lipoproteins fell markedly to 70–75% below normal levels. These alterations in the pattern of serum lipids and lipoproteins persisted throughout the cold-exposure period. Sex or prior feeding of a high-fat, high-carbohydrate, or high-protein diet did not modify these cold-induced changes. The response of the very low density lipoproteins to cold was immediate and rapid, the rate and degree of change being greatest in the first 4 hours of exposure. Conversely, the recovery of the very low density fraction to normal after removal of the rats from the cold was slow and depended upon the period of prior exposure. Animals exposed to 4 °C for 4 days required 3 days at 22 °C for the very low density lipoproteins to return to normal, and the recovery period was twice as long for cold-acclimatized (4 weeks) animals. The role of the triglyceride-rich very low density lipoproteins as a readily available energy source in the animals is discussed in the light of these results.

scholarly journals Comparison of lipid profile in thrombotic and hemorrhagic stroke patients

2016 ◽  
Vol 11 (4) ◽  
Author(s):  
Sohail Bashir Sulehria ◽  
Anser Asrar ◽  
Irshad Hussain Qureshi.
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Haemorrhagic Stroke ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Stroke Patients ◽  
Very Low Density Lipoproteins ◽  
The Difference

Objective: To compare lipid profile in thrombotic and haemorrhagic stroke patients. Place of Study: All general medical and neurology wards of Mayo Hospital Lahore. Patients and Methods: Study was conducted in 40 consecutive patients of stroke admitted in hospital. Serum lipid (total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins, high density lipoproteins and LDL/HDL ratio) were estimated in all selected patients within 7 days of onset of stroke and findings were entered on study proforma specifically designed for this purpose and analyzed statistically by student`s "t" test. Results: Out of 40 patients included in the study, 22(55%) were suffering from thrombotic stroke while 18(45%) suffered from haemorragic stroke. The difference in the values of total cholesterol, triglycerides, low-density lipoproteins, very low density lipoproteins, high density lipoproteins and LDL/HDL ratio was not statistically significant between the two groups of patients. Conclusion: It is concluded that serum lipids i.e., total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins, high density lipoproteins and LDL/HDL ratio does not have any differential effect in the causation of thrombotic or haemorrhagic strokes.

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