Case–control study of male cancer patients exposed to arsenic-contaminated drinking water and tobacco smoke with relation to non-exposed cancer patients

2011 ◽  
Vol 30 (12) ◽  
pp. 2013-2022 ◽  
Author(s):  
Sham Kumar Wadhwa ◽  
Tasneem Gul Kazi ◽  
Nida Fatima Kolachi ◽  
Hassan Imran Afridi ◽  
Sumaira Khan ◽  
...  
Keyword(s):  
Drinking Water ◽  
Cancer Patients ◽  
Biological Samples ◽  
Inorganic Arsenic ◽  
Different Types ◽  
Big City ◽  
Male Cancer Patient ◽  
Contaminated Drinking Water ◽  
Male Subjects ◽  
Control Study

The investigated data indicated that inorganic arsenic in drinking water is associated with increased mortality from different types of cancers. In the present study, biological samples (blood and scalp hair) of male subjects having lung and bladder cancers and non-cancerous subjects belonging to arsenic (As)-exposed area of southern parts of Pakistan were analysed for As contents. The As levels in drinking water of understudy area showed that sections of understudy population are exposed to arsenic concentrations, which was 3–15-fold higher than the permissible level (<10 μg/L). For comparative purposes the biological samples of matched male cancer patient, as referent patients belonging to big city (Hyderabad) who had used municipal treated water with low arsenic levels <10 μg/L, were also collected. The exposed cancer patients have 2–3-fold higher level of As in both biological samples compared to non-exposed case-matched cancerous male subjects. This study is compelling evidence in support of positive associations between arsenic-contaminated water, food and cigarette with different types of risks of cancer.

Quantitative toxicological study of dose-dependent arsenic-induced cells via synchrotron-based STXM and FTIR measurement

The Analyst ◽  
2020 ◽  
Vol 145 (13) ◽  
pp. 4560-4568
Author(s):  
Junshan Xiu ◽  
Yunyan Liu ◽  
Benyi Wang ◽  
Yanling Xue ◽  
Min Chen ◽  
...  
Keyword(s):  
Drinking Water ◽  
Inorganic Arsenic ◽  
Toxicological Study ◽  
Human Carcinogen ◽  
Naturally Occurring ◽  
Contaminated Drinking Water ◽  
Dose Dependent

Inorganic arsenic (iAs) is a well-known naturally occurring metalloid with abundant hazards to our environment, especially being a human carcinogen through arsenic-contaminated drinking water.

Arsenic concentrations and speciation in Australian and imported rice and commercial rice products

2018 ◽  
Vol 15 (7) ◽  
pp. 387 ◽  
Author(s):  
William Maher ◽  
Elliott Duncan ◽  
Hayden Martin ◽  
Peter Snell ◽  
Frank Krikowa ◽  
...  
Keyword(s):  
Drinking Water ◽  
Young Children ◽  
Potential Risk ◽  
Environmental Chemistry ◽  
Inorganic Arsenic ◽  
Dimethylarsinic Acid ◽  
Polished Rice ◽  
Inorganic As ◽  
Contaminated Drinking Water ◽  
Infants And Young Children

Environmental contextIn countries where inhabitants are not exposed to arsenic-contaminated drinking water, food is the major source of potentially toxic inorganic arsenic. To complement the existing worldwide dataset on arsenic in rice, data are presented on Australian- and overseas-grown rice, and assessed in terms of possible risk. Only a diet comprising multiple serves of some rice products per day poses a potential risk to young children. AbstractArsenic concentrations and speciation measurements were determined for six varieties of Australian-grown rice (n = 130), imported rice (n = 53) and rice products (n = 56) from supermarkets. Total As, inorganic As and dimethylarsinic acid (DMA) concentrations in Australian rice ranged from 16 to 630 µg As kg−1 (mean ± s.d.: 220 ± 122 µg kg−1), 16 to 250 µg As kg−1 (92 ± 52 µg As kg−1) and <5 to 432 µg As kg−1 (125 ± 109 µg As kg−1), respectively. Total As, inorganic As and DMA concentrations in imported rice ranged between 31 and 376 µg As kg−1 (130 ± 98 µg kg−1), 17 and 198 µg As kg−1 (73 ± 40 µg As kg−1) and <5 and 327 µg As kg−1 (84 ± 92 µg As kg−1) respectively. Few samples exceeded the guidelines for inorganic As in polished rice. In rice products, total As, inorganic As and DMA concentrations ranged between 21 and 480 µg As kg−1 (160 ± 110 µg As kg−1), 20 and 255 µg As kg−1 (92 ± 78 µg As kg−1) and <5 and 340 µg As kg−1 (65 ± 69 µg As kg−1) respectively. Sixteen samples exceeded the 100 µg kg−1 maximum for inorganic As concentration in rice foods for infants and young children. Ingestion of multiple serves of some rice products poses a potential risk. Environmental chemistry gaps, on processes influencing As occurrence in rice, are discussed.

Arsenic exposure and non-carcinogenic health effects

2021 ◽  
pp. 096032712110459
Author(s):  
Macario Martínez-Castillo ◽  
Eliud A García-Montalvo ◽  
Mónica G Arellano-Mendoza ◽  
Luz del C Sánchez-Peña ◽  
Luis E Soria Jasso ◽  
...  
Keyword(s):  
Drinking Water ◽  
Abdominal Pain ◽  
Urinary Tract ◽  
Health Effects ◽  
Health Problem ◽  
Molecular Mechanisms ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Severe Diarrhea ◽  
Contaminated Drinking Water

Inorganic arsenic (iAs) exposure is a serious health problem that affects more than 140 million individuals worldwide, mainly, through contaminated drinking water. Acute iAs poisoning produces several symptoms such as nausea, vomiting, abdominal pain, and severe diarrhea, whereas prolonged iAs exposure increased the risk of several malignant disorders such as lung, urinary tract, and skin tumors. Another sensitive endpoint less described of chronic iAs exposure are the non-malignant health effects in hepatic, endocrine, renal, neurological, hematological, immune, and cardiovascular systems. The present review outlines epidemiology evidence and possible molecular mechanisms associated with iAs-toxicity in several non-carcinogenic disorders.

scholarly journals Commonalities in Metabolism of Arsenicals

2005 ◽  
Vol 2 (3) ◽  
pp. 161 ◽  
Author(s):  
Blakely M. Adair ◽  
Stephen B. Waters ◽  
Vicenta Devesa ◽  
Zuzana Drobna ◽  
Miroslav Styblo ◽  
...  
Keyword(s):  
At Risk ◽  
Drinking Water ◽  
Health Effects ◽  
Inorganic Arsenic ◽  
Environmental Context ◽  
Arsenic Metabolism ◽  
Toxic Species ◽  
Increased Risk ◽  
Contaminated Drinking Water ◽  
Carcinogenic Effects

Environmental Context. Health effects associated with inorganic arsenic include various cancers and increased risk of diabetes. Millions of people in Bangladesh and India are at risk through use of contaminated drinking water. When humans ingest inorganic arsenic, it is rapidly converted to methylated metabolites. Although this methylation process is largely understood, the metabolism of other arsenicals (e.g. arsenosugars to dimethylarsenic) is very unclear. Connections among pathways for metabolism of various arsenicals are now being elucidated. Commonalities and differences in these pathways may be important determinants of the risk associated with exposure to these agents. Abstract. Elucidating the pathway of inorganic arsenic metabolism shows that some of methylated arsenicals formed as intermediates and products are reactive and toxic species. Hence, methylated arsenicals likely mediate at least some of the toxic and carcinogenic effects associated with exposure to arsenic. Trimethylarsonium compounds and arsenosugars are two other classes of arsenicals to which humans are routinely exposed and there is evidence that both classes are metabolized to produce methylated arsenicals. Here, we review evidence for production of methylated metabolism and consider the challenges posed in unraveling a complex web for metabolism of arsenicals in humans.

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