Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice

2015 ◽  
Vol 35 (2) ◽  
pp. 205-212 ◽  
Author(s):  
SS Nair ◽  
JJ Manalil ◽  
SK Ramavarma ◽  
IM Suseela ◽  
A Thekkepatt ◽  
...  
Keyword(s):  
Protective Efficacy ◽  
Cocos Nucifera ◽  
Experimental Studies ◽  
Coconut Oil ◽  
Thiobarbituric Acid ◽  
Similar Efficacy ◽  
Systemic Toxicity ◽  
Virgin Coconut Oil ◽  
Anti Inflammatory ◽  
Cocos Nucifera L

Virgin coconut oil (VCO) is an unrefined kernal oil, prepared from Cocos nucifera L., having substantial nutritional and medicinal value. Experimental studies have suggested its antioxidant, anti-inflammatory, immunostimulatory and hypolipidemic effects. The present study assesses its effect on formalin-induced chronic inflammation and cyclophosphamide (CTX)-induced systemic toxicity in murine models. Oral administration of VCO effectively reduced formalin-induced paw oedema in mice with more or less similar efficacy as that of diclofenac. The CTX-induced hike in blood urea, creatinine, thiobarbituric acid reactive substances (TBARS) and liver marker enzymes in mice was marginally decreased by VCO (8 g/kg body weight) ingestion orally. The liver and kidney catalase, superoxide dismutase and glutathione peroxidase activities, together with cellular glutathione and TBARS levels, were found to be improved in these animals. Overall the study reveals the protective efficacy of VCO against secondary toxicity induced by CTX possibly through its antioxidant and anti-inflammatory properties.

scholarly journals Physicochemical Properties of Virgin Coconut Oil Extracted from Different Coconut (Cocos nucifera L) Varieties

CORD ◽  
2021 ◽  
Vol 37 ◽  
pp. 1-10
Author(s):  
Dilani Hewa Pathirana ◽  
Chandi Yalegama ◽  
Darshana Jayawardhana Arachige ◽  
Malki Senarathne
Keyword(s):  
Fatty Acid ◽  
Sri Lanka ◽  
Antioxidant Capacity ◽  
Fatty Acid Profile ◽  
Cocos Nucifera ◽  
Coconut Oil ◽  
Total Phenolic ◽  
Virgin Coconut Oil ◽  
Phenolic Substances ◽  
Cocos Nucifera L

Virgin coconut oil (VCO) is a superior edible oil extracted from fresh coconut (Cocos nucifera L) kernel using mixed coconut varieties without considering the varietal effect. Therefore, this research focuses on the quality evaluation of VCO extracted from four types of coconut varieties, namely Sri lanka Tall×Tall (TT), a tall variety of Gon Thambili (GT), a tall variety of Ran Thambili (RT) and Philippines tall variety of San Ramon (SR). Mature coconuts from each variety were collected from the Bandirippuwa Estate of the Coconut Research Institute, Sri Lanka to extract VCO by cold press oil extraction method. The extractability of VCO from different varieties was investigated. Moisture, free fatty acid (FFA), fatty acid profile (gas chromatography), peroxide value (PV), color (Lovibond scale), total phenolic substances (Galic acid equivalent), antioxidant capacity (α,α-diphenyl-β-picrylhydrazyl, 0.1mM – DPPH method) and sun protection factor (SPF) of VCO extracted from each variety were analyzed. The experiment was conducted as a completely randomized design with three replicates. Data were analyzed using ANOVA using Tukey’s test by MINITAB 17. Oil extractability (58%-59%), FFA (0.04%-0.12%), color (0.43–0.93) and fatty acid profile of VCO did not show variation among varieties. A higher concentration of total phenolic substances was observed in GT (0.24±0.03mg GAE/100g) while antioxidant capacity (857.19±14.99mg/ml) and SPF (8.99±1.26) was rich in RT.

scholarly journals Pembuatan Virgin Coconut Oil (VCO) Menggunakan Enzim Bromelin di Kampung Kekupu, Depok

2020 ◽  
Vol 4 (1) ◽  
pp. 38
Author(s):  
Elfia Siska Yasa Putri
Keyword(s):  
Cocos Nucifera ◽  
Coconut Oil ◽  
Ananas Comosus ◽  
Virgin Coconut Oil ◽  
Cocos Nucifera L

Virgin Coconut Oil (VCO) merupakan produk olahan dari buah kelapa (Cocos nucifera L). Pada kegiatan pengabdian ini tim pengabdian mengajarkan pembuatan VCO melalui cara enzimatis dengan memanfaatkan buah nanas (Ananas comosus) yang banyak tumbuh di  Kampung Kekupu, Depok. Kegiatan ini dilakukan untuk (1) meningkakan pengetahuan mitra tentang VCO (2) mengajarkan cara pembuatan dan pengemasan VCO sehingga mitra bisa secara mandiri untuk memproduksi VCO. Dengan demikian, mitra dapat membantu penghasilan keluarga. Pada tahap pembuatan VCO ini, enzim bromelin dari buah nanas yang dicampur dengan krim kelapa. Setelah itu VCO yang terbentuk diambil menggunakan sendok sayur dan dikemas dalam wadah yang aman. Untuk menunjang kegiatan ini maka mitra diberikan buku saku panduan pembuatan VCO menggunakan enzim bromelin. Penyuluhan  tentang kandungan zat-zat kimia yang  yang terdapat pada buah kelapa , buah nenas, dan VCO serta  manfaat dan keunggulan VCO diberikan oleh narasumber. Setelah kegiatan ini, 86,7 % peserta berpendapat bahwa materi pelatihan mudah dipahami. Sebanyak 93,3 % peserta memperoleh banyak manfaat dari acara ini.

scholarly journals PEMBUATAN SEDIAAN MINYAK GOSOK DARI BAHAN KELAPA (Cocos nucifera L.), SERAI (Cymbopogon citratus DC.) dan DAUN DEWA (Gynura segetum L.) dengan METODE PENGENDAPAN TRADISIONAL

2017 ◽  
Vol 1 (1) ◽  
pp. 86-93
Author(s):  
Rickson Tanka ◽  
Susi Andriani ◽  
Yusi Helmiawati
Keyword(s):  
Cocos Nucifera ◽  
Coconut Oil ◽  
Cymbopogon Citratus ◽  
Virgin Coconut Oil ◽  
Cocos Nucifera L

Latar belakang: Tumbuhan merupakan keragaman hayati yang ada di sekitar kita, baik itu yang tumbuh secara liar maupun yang sengaja dibudidayakan. Sejak zaman dahulu, tumbuhan sudah digunakan sebagai tanaman obat, walaupun penggunaannya disebarkan secara turun-temurun maupun dari mulut ke mulut. Tujuan: Penelitian ini bertujuan untuk menyediakan sediaan jadi herbal yang dapat digunakan oleh masyarakat untuk pengobatan masuk angin. Metode: Penelitian ini merupakan penelitian deskriptif yang dikembangkan oleh masyarakat secara turun-temurun, dilakukan wawancara kepada masyarakat mengenai khasiat minyak kelapa murni ( virgin coconut oil ) dengan campuran serai (Cymbopogon citratus DC.) dan daun dewa (Gynura segetum L.) untuk kerik masuk angin. Dalam penelitian ini membuat sediaan minyak gosok dari kelapa (Cocos nucifera L.) yang menjadi minyak kelapa murni dengan tambahan serai dan daun dewa sebagai kerik masuk angin melalui proses pengendapan selama empat hari dengan menggunakan pelarut air. Minyak gosok dibuat dengan bahan kelapa dua kilogram yang diparut ditambahkan air sebanyak satu liter sebanyak dua kali perasan, didapat santan sebanyak 1800 mL lalu saring santan, hasil saringan endapkan selama tiga hari menghasilkan minyak kelapa murni sebanyak 200ml, setalah menjadi minyak kelapa murni (virgin coconut oil) tambahkan serai (Cymbopogon citratus DC.) sebanyak 20 gram dan daun dewa (Gynura segetum L.) 20 gram yang sudah dipotong-potong diendapkan selama satu hari kemudian disaring dan menghasilkan minyak gosok lima botol dengan masing-masing berat 20 mL. Hasil: Pengujian organoleptis sediaan dilakukan selama tiga minggu dengan hasil yang menunjukan bahwa tidak ada perubahan negatif yang terjadi dari bentuk, warna, bau, rasa maupun pertumbuhan jamur. Simpulan: Penelitian ini berhasil membuat sediaan dalam bentuk minyak gosok yang dapat bertahan selama tiga minggu.

scholarly journals Comparative Effectiveness of Corn Oil (Zea mays) with Pure Coconut Oil (Cocos nucifera L.) to Reduced Glucose Blood Levels of Alloxane Injected Wistar Rats

2017 ◽  
Vol 3 (3) ◽  
pp. 50
Author(s):  
Khadijah Nur Al Firdausi ◽  
Sugiyanta Sugiyanta ◽  
Pipiet Wulandari
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Wistar Rats ◽  
Corn Oil ◽  
Cocos Nucifera ◽  
Coconut Oil ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Cocos Nucifera L

Epidemiological studies show an increased incidence of diabetes mellitus. The initial therapy of diabetes mellitus is a diet treatment. The recommended intake of fat is a Saturated Fatty Acids (SFA) <7% and a Polyunsatturated Fatty Acid (PUFA) <10% of calories. The corn oil contains PUFA and the virgin coconut oil contains SFA as the main component. Aims of this study was to compare the effectivity of corn oil (Zea mays) and virgin coconut oil (Cocos nucifera L.) in decreasing blood glucose level in alloxane-ijnected wistar rats. This was a laboratory experiment research, used the posttest-only control design. The negative control group was wistar rats injected by aquabidest and standard feed diet (K-); the positive control group was alloxane-injected rats with standard feed diet (K+); alloxane-injected rats with standard food diet and 0.54 mL of corn oil/day for 28 days were P1 group; alloxane-injected rats with standard diet food and 0.54 mL of virgin coconut oil/day for 28 days were P2 group. Statistical analysis using the one way ANOVA test showed that the corn oil and virgin coconut oil decrease blood glucose level, but there was no significantly difference in decresing of blood glucose level between P1 and P2. This study concluded that the corn oil and the virgin coconut oil have the same effectiveness in decreasing blood glucose level in wistar rats injected with alloxane.Keywords: Corn oil, virgin coconut oil, blood glucose level, alloxane

scholarly journals Body scrub containing Virgin Coconut Oil, coffee grounds (Coffea arabica Linn) and carbon active coconut shell (Activated carbon Cocos nucifera L) as a moisturiser and a skin brightener

2021 ◽  
Vol 52 (1) ◽  
pp. 76-81
Author(s):  
Eka Desi ◽  
Ratna Djamil ◽  
Faizatun Faizatun
Keyword(s):  
Activated Carbon ◽  
Coffea Arabica ◽  
Cocos Nucifera ◽  
Skin Irritation ◽  
Coconut Oil ◽  
The Body ◽  
Virgin Coconut Oil ◽  
Coffee Grounds ◽  
Cocos Nucifera L

Introduction: Virgin Coconut Oil (VCO) contains a lot of medium chain fatty acids. VCO combined with coffee grounds (Coffea arabica Linn) and activated carbon (Activated carbon Cocos nucifera L) has the potential to form a preparation that can moisturise and brighten the skin. The purpose of this study was to make cosmetic cleansing preparations containing three natural ingredients. Methods: This study evaluated the organoleptic body scrub preparations, homogeneity, dispensability and pH for three different formulations. In vivo test for irritation (oedema and erythema) was carried out on albino rabbits (n = 3) for each treatment group. Clinical irritation testing was performed on the forearm of healthy volunteers, 17 - 45 years of age with no history of allergies (n = 30). Determination of skin moisture content and melanin index was carried out as a measure of effectiveness. Results: Organoleptic and homogeneity tests showed that preparations had dark black colour, the distinctive smell of coffee, it was homogeneous, spread ability was in the range of 4 cm with the pH at a safe pH for the skin. Irritation results also did not show any oedema and erythema in in vivo testing. In clinical testing no irritation occurred by testing the body scrub samples. Body scrubs routinely used by volunteers for 2 months increased moisture on the skin as well as brightness (p < 0.05). Conclusion: Body scrub creams containing VCO, coffee grounds and activated carbon are preparations that have the potential to be cosmetic cleansers.

scholarly journals Pengaruh Perbandingan Fase Minyak Virgin Coconout Oil (Cocos nucifera L.) dan Lemak Kakao (Theobrama Cacao L.) serta Suhu terhadap Karakteristik Sediaan Krim

2020 ◽  
Vol 8 (2) ◽  
pp. 223
Author(s):  
I Kadek Aditya Prasatya ◽  
Lutfi Suhendra ◽  
Ni Made Wartini
Keyword(s):  
Cocoa Butter ◽  
Heating Temperature ◽  
Cocos Nucifera ◽  
Coconut Oil ◽  
Temperature Characteristic ◽  
Temperature Treatment ◽  
Virgin Coconut Oil ◽  
Power Comparison ◽  
Factorial Trial ◽  
Cocos Nucifera L

Virgin coconut oil turn into liquid based in a room temperature  that has lot of vitamin E and coconut acid. Cocoa butter is solid in temperature that has lot of stearic acid. This research aims to know the temperature effects and comparation of oil phase , virgin coconut oil : cocoa butter in the characteristic of  cream based determine the temperature and comparation of oil phase (virgin coconut oil : cocoa butter) to produce cream based. The trial design in this research was the second factorial trial. This reasearch used factorial randomized  block. First factorial was the comparation oil phase of virgin coconut oil : cocoa butter consist of 3 levels, that is 1:3, 1:5 and 1:7. While in the second factorial the was heating temperatures, consist of 3 levels that is 60±2°C, 70±2°C and 80±2°C. The comparation treatments of oil phase virgin coconut oil : cocoa butter that really affected the viscosity, cohenren power, diameter of spread power and seperation ratio, heating temperature really affected with diameter of spread power and coherent power. Tempererature treatment and comporation of oil phase affected the diameter of spread power. The temperature treatment and oil phase ratio have a very significant effect on the dispersal power. Comparison of VCO and cocoa butter treatment (1:7) with a temperature of 80±2°C is the best treatment to produce cream preparations with characteristics of a homogeneous cream, viscosity (46.000 cp), cohenren power (9,77 seconds), diameter of spread power (7,075 cm), separator ratio (0,27 cm) and pH (6,65). Keywords: Virgin coconut oil, cocoa butter, temperature, characteristic, based cream.

scholarly journals UJI STABILITAS FISIK SECARA ORGANOLEPTIS PEMBUATAN SEDIAAN MINYAK GOSOK DARI BAHAN KELAPA (Cocos nucifera L.), SERAI (Cymbopogon citratus DC.) DAN DAUN JERUK NIPIS (Citrus aurantifolia)

2018 ◽  
Vol 1 (2) ◽  
pp. 119-124
Author(s):  
Susi Andriani ◽  
Ebih Sulisiyanti
Keyword(s):  
Cocos Nucifera ◽  
Coconut Oil ◽  
Cymbopogon Citratus ◽  
Virgin Coconut Oil ◽  
Citrus Aurantifolia ◽  
Cocos Nucifera L

Latar Belakang: Virgin Coconut Oil (VCO) dari minyak kelapa murni saat ini banyak dimanfaatkan masyarakat sebagai obat gosok, Pencampuran VCO sebagai minyak gosok dengan penambahan batang serai dan daun jeruk nipis dapat menambah khasiat dan kegunaannya. Tujuan: Penelitian ini bertujuan untuk melihat kestabilan minyak gosok setelah 4, 6 dan 8 minggu pada wadah tertutup serta menyediakan sediaan praktis dari bahan alam yang dapat digunakan oleh masyarakat dengan teknik pembuatan yang mudah, murah dan praktis. Metode: Penelitian ini merupakan penelitian deskriptif yang sebelumnya telah digunakan secara turun-temurun. Pembuatan dilakukan melalui proses pengendapan selama empat hari dengan menggunakan pelarut air. Minyak gosok dibuat dengan bahan kelapa satu kilogram yang diparut dan ditambahkan air sebanyak satu liter untuk dua kali perasan, didapat santan sebanyak 1000ml lalu santan disaring, hasil saringan endapkan selama tiga hari menghasilkan minyak kelapa murni sebanyak 400ml, setalah menjadi minyak kelapa murni (VCO) ditambahkan serai (Cymbopogon citratus DC.) sebanyak 25gram dan daun jeruk nipis (Citrus aurantifolia.) 25gram yang sudah dipotong-potong diendapkan selama satu hari kemudian disaring dan menghasilkan minyak gosok dibuat 3 botol dengan masing-masing berat 100ml. Hasil: Pengujian organoleptis sediaan dilakukan selama 4, 6 dan 8 minggu dengan hasil yang menunjukan bahwa tidak ada pertumbuhan jamur maupun perubahan negatif yang terjadi secara fisik dari warna, rasa, dan bentuk konsistensinya, sedangkan untuk bau pada minyak gosok  mengalami pengurangan bau serai dan jeruk nipis. Hal ini dapat dikatakan bahwa dalam waktu 8 minggu minyak gosok dapat digunakan secara aman. Simpulan: Sediaan minyak gosok sebagai perawatan pada kesehatan kulit dengan pengujian organoleptis selama 8 minggu dapat digunakan secara aman.

scholarly journals Cocos nucifera Oil Decreases Edema and Mechanical Hypernociception Induced by Bothrops jararacussu Venom in Mice

2017 ◽  
Vol 4 (01) ◽  
pp. e17-e23 ◽  
Author(s):  
Álvaro Lisboa-Neto ◽  
Anita Ribeiro ◽  
Eliane Feitosa ◽  
Carlos Wanderley ◽  
Ana de Oliveira ◽  
...  
Keyword(s):  
Unsaturated Fatty Acids ◽  
Cocos Nucifera ◽  
Folk Medicine ◽  
Coconut Oil ◽  
Resonance Spectroscopy ◽  
Virgin Coconut Oil ◽  
Bothrops Jararacussu ◽  
Analgesic Effects ◽  
Anti Inflammatory ◽  
Main Components

AbstractBothropic venoms cause intense local damage, pain, edema, and myonecrosis. Cocos nucifera is the naturally most widespread fruit plant on Earth, and both the fruit and the plant have been used in folk medicine for the treatment of several inflammatory disorders. We evaluated the anti-inflammatory and analgesic effects of virgin coconut oil that was obtained from C. nucifera on paw lesions that were induced by venom from the Bothrops jararacussu snake in mice. Nuclear magnetic resonance spectroscopy was used to determine the chemical profile of virgin coconut oil. The analysis of the main components showed that saturated and unsaturated fatty acids were prominent components of the oil. Virgin coconut oil at doses of 100, 200, and 400 mg reduced local edema that was induced by B. jararacussu venom. The 200-mg dose of virgin coconut oil prevented edema that was induced by histamine, serotonin, and bradykinin. However, virgin coconut oil did not prevent edema that was induced by substance P or prostaglandin E2. Virgin coconut oil also reduced peritoneal leukocyte infiltration that was induced by carrageenan and also decreased B. jararacussu venom-induced mechanical hypernociception of the paw. Virgin coconut oil exerted an anti-inflammatory effect on paw injury that was induced by B. jararacussu venom in mice, most likely by inhibiting leukocyte migration and reducing the action of the same inflammatory agents. The analgesic activity of virgin coconut oil appears to depend on opioid receptors.

Safety assessment of widely used fermented virgin coconut oil (Cocos nucifera) in Malaysia: Chronic toxicity studies and SAR analysis of the active components

2016 ◽  
Vol 81 ◽  
pp. 457-467 ◽  
Author(s):  
Ahmad H. Ibrahim ◽  
Md Shamsuddin Sultan Khan ◽  
Sawsan S. Al-Rawi ◽  
Mohamed B. Khadeer Ahamed ◽  
Aman Shah Bin Abdul Majid ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Chronic Toxicity ◽  
Cocos Nucifera ◽  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Active Components ◽  
Toxicity Studies ◽  
Sar Analysis

scholarly journals FORMULASI NANOEMULSI ASPIRIN MENGGUNAKAN ETANOL 96 % SEBAGAI KO-SURFAKTAN

WARTA FARMASI ◽  
2017 ◽  
Vol 6 (1) ◽  
pp. 1-11
Author(s):  
Nur Saadah Daud ◽  
Musdalipah Musdalipah ◽  
Asriyanti Lamadari
Keyword(s):  
Oral Administration ◽  
Pain Therapy ◽  
Coconut Oil ◽  
Tween 80 ◽  
Moderate Pain ◽  
Virgin Coconut Oil ◽  
Cycling Test ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
20 Nm

ABSTRAK Aspirin termasuk dalam golongan Non Steroidal Anti Inflammatory Drugs (NSAIDs) yang banyak digunakan pada pengobatan nyeri ringan sampai sedang, antipiretik, anti inflamasi, serta anti koagulan. Pada penggunaan secara oral dapat menurunkan efektifitas obat akibat metabolisme lintas pertama. Alternatif untuk mengatasi masalah tersebut yaitu membuat sediaan topikal nanoemulsi aspirin. Nanoemulsi yaitu sistem emulsi yang transparan, tembus cahaya dan merupakan d ispersi minyak air yang distabilkan oleh lapisan film dari surfaktan dan ko-surfaktan, yang memiliki ukuran droplet 20 nm-500 nm. Penelitian ini bertujuan untuk membuat nanoemulsi aspirin dengan variasi konsentrasi etanol 96 % sebagai ko-surfaktan. Nanoemulsi aspirin dibuat dengan Virgin Coconut Oil (VCO) sebagai fase minyak, tween 80 sebagai surfaktan,dan etanol 96 % sebagai ko-surfaktan. Hasil penelitian mendapatkan 5 formula nanoemulsi jernih beraroma khas dengan nilai pH berkisar pada range 4,0-4,5 yang telah memenuhi pH normal kulit. dengan konsentrasi etanol 96 % yaitu 10 %, 15 %, 20 %, 25 % dan 30 %, dan dibuat 3 replikasi. Hasil uji stabilitas fisik menunjukkan bahwa kelima formula menghasilkan nanoemulsi yang stabil dan tidak terjadi pemisahan fase sesudah uji sentrifugasi dan cycling test dilakukan. Kata Kunci     : Nanoemulsi, Aspirin, Etanol 96%, Ko-surfaktan   ABSTRACT Acetosal known to be a part of the group medications called Non Steroidal Anti Inflammatory Drugs (NSAIDs) that was used for mild to moderate pain therapy, antipyretic, anti inflamation and anti coagulan. Oral administration of acetosal may decrease its effectiveness because of the first past metabolism problem. The purpose of this study was to formulate acetosal into nanoemulsion form for topical preparation as an alternative to avoid those problem with ethanol 96% as co-surfactant.  Nanoemulsion was an emultion system which transparent, glasslike, and comes from dispertion of water and oil stabilized by film-coated that made from surfactant and co-surfactant combination, which has droplet size around 20 nm-500 nm. Acetosal nanoemulsions were prepared with Virgin Coconut Oil (VCO) as oil phase, tween 80 as surfactant and ethanol 96 % as co-surfactant. There were 5 formulas of transparent acetosal nanoemultion. Their yield of pH were about 4,0-4,5 were met the normal skin’s pH. They were acetosal nanoemulsions with ethanol 96 % of 10%, 15%, 20%, 25%, and 30%. These five were stable and did not show the separation of phase after both centrifugation and cycling test. Keyword          : Nanoemulsion, Acetosal, Ethanol 96%, Co-Surfactan

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