scholarly journals Cocos nucifera Oil Decreases Edema and Mechanical Hypernociception Induced by Bothrops jararacussu Venom in Mice

2017 ◽  
Vol 4 (01) ◽  
pp. e17-e23 ◽  
Author(s):  
Álvaro Lisboa-Neto ◽  
Anita Ribeiro ◽  
Eliane Feitosa ◽  
Carlos Wanderley ◽  
Ana de Oliveira ◽  
...  
Keyword(s):  
Unsaturated Fatty Acids ◽  
Cocos Nucifera ◽  
Folk Medicine ◽  
Coconut Oil ◽  
Resonance Spectroscopy ◽  
Virgin Coconut Oil ◽  
Bothrops Jararacussu ◽  
Analgesic Effects ◽  
Anti Inflammatory ◽  
Main Components

AbstractBothropic venoms cause intense local damage, pain, edema, and myonecrosis. Cocos nucifera is the naturally most widespread fruit plant on Earth, and both the fruit and the plant have been used in folk medicine for the treatment of several inflammatory disorders. We evaluated the anti-inflammatory and analgesic effects of virgin coconut oil that was obtained from C. nucifera on paw lesions that were induced by venom from the Bothrops jararacussu snake in mice. Nuclear magnetic resonance spectroscopy was used to determine the chemical profile of virgin coconut oil. The analysis of the main components showed that saturated and unsaturated fatty acids were prominent components of the oil. Virgin coconut oil at doses of 100, 200, and 400 mg reduced local edema that was induced by B. jararacussu venom. The 200-mg dose of virgin coconut oil prevented edema that was induced by histamine, serotonin, and bradykinin. However, virgin coconut oil did not prevent edema that was induced by substance P or prostaglandin E2. Virgin coconut oil also reduced peritoneal leukocyte infiltration that was induced by carrageenan and also decreased B. jararacussu venom-induced mechanical hypernociception of the paw. Virgin coconut oil exerted an anti-inflammatory effect on paw injury that was induced by B. jararacussu venom in mice, most likely by inhibiting leukocyte migration and reducing the action of the same inflammatory agents. The analgesic activity of virgin coconut oil appears to depend on opioid receptors.

Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice

2015 ◽  
Vol 35 (2) ◽  
pp. 205-212 ◽  
Author(s):  
SS Nair ◽  
JJ Manalil ◽  
SK Ramavarma ◽  
IM Suseela ◽  
A Thekkepatt ◽  
...  
Keyword(s):  
Protective Efficacy ◽  
Cocos Nucifera ◽  
Experimental Studies ◽  
Coconut Oil ◽  
Thiobarbituric Acid ◽  
Similar Efficacy ◽  
Systemic Toxicity ◽  
Virgin Coconut Oil ◽  
Anti Inflammatory ◽  
Cocos Nucifera L

Virgin coconut oil (VCO) is an unrefined kernal oil, prepared from Cocos nucifera L., having substantial nutritional and medicinal value. Experimental studies have suggested its antioxidant, anti-inflammatory, immunostimulatory and hypolipidemic effects. The present study assesses its effect on formalin-induced chronic inflammation and cyclophosphamide (CTX)-induced systemic toxicity in murine models. Oral administration of VCO effectively reduced formalin-induced paw oedema in mice with more or less similar efficacy as that of diclofenac. The CTX-induced hike in blood urea, creatinine, thiobarbituric acid reactive substances (TBARS) and liver marker enzymes in mice was marginally decreased by VCO (8 g/kg body weight) ingestion orally. The liver and kidney catalase, superoxide dismutase and glutathione peroxidase activities, together with cellular glutathione and TBARS levels, were found to be improved in these animals. Overall the study reveals the protective efficacy of VCO against secondary toxicity induced by CTX possibly through its antioxidant and anti-inflammatory properties.

Safety assessment of widely used fermented virgin coconut oil (Cocos nucifera) in Malaysia: Chronic toxicity studies and SAR analysis of the active components

2016 ◽  
Vol 81 ◽  
pp. 457-467 ◽  
Author(s):  
Ahmad H. Ibrahim ◽  
Md Shamsuddin Sultan Khan ◽  
Sawsan S. Al-Rawi ◽  
Mohamed B. Khadeer Ahamed ◽  
Aman Shah Bin Abdul Majid ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Chronic Toxicity ◽  
Cocos Nucifera ◽  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Active Components ◽  
Toxicity Studies ◽  
Sar Analysis

scholarly journals FORMULASI NANOEMULSI ASPIRIN MENGGUNAKAN ETANOL 96 % SEBAGAI KO-SURFAKTAN

WARTA FARMASI ◽  
2017 ◽  
Vol 6 (1) ◽  
pp. 1-11
Author(s):  
Nur Saadah Daud ◽  
Musdalipah Musdalipah ◽  
Asriyanti Lamadari
Keyword(s):  
Oral Administration ◽  
Pain Therapy ◽  
Coconut Oil ◽  
Tween 80 ◽  
Moderate Pain ◽  
Virgin Coconut Oil ◽  
Cycling Test ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
20 Nm

ABSTRAK Aspirin termasuk dalam golongan Non Steroidal Anti Inflammatory Drugs (NSAIDs) yang banyak digunakan pada pengobatan nyeri ringan sampai sedang, antipiretik, anti inflamasi, serta anti koagulan. Pada penggunaan secara oral dapat menurunkan efektifitas obat akibat metabolisme lintas pertama. Alternatif untuk mengatasi masalah tersebut yaitu membuat sediaan topikal nanoemulsi aspirin. Nanoemulsi yaitu sistem emulsi yang transparan, tembus cahaya dan merupakan d ispersi minyak air yang distabilkan oleh lapisan film dari surfaktan dan ko-surfaktan, yang memiliki ukuran droplet 20 nm-500 nm. Penelitian ini bertujuan untuk membuat nanoemulsi aspirin dengan variasi konsentrasi etanol 96 % sebagai ko-surfaktan. Nanoemulsi aspirin dibuat dengan Virgin Coconut Oil (VCO) sebagai fase minyak, tween 80 sebagai surfaktan,dan etanol 96 % sebagai ko-surfaktan. Hasil penelitian mendapatkan 5 formula nanoemulsi jernih beraroma khas dengan nilai pH berkisar pada range 4,0-4,5 yang telah memenuhi pH normal kulit. dengan konsentrasi etanol 96 % yaitu 10 %, 15 %, 20 %, 25 % dan 30 %, dan dibuat 3 replikasi. Hasil uji stabilitas fisik menunjukkan bahwa kelima formula menghasilkan nanoemulsi yang stabil dan tidak terjadi pemisahan fase sesudah uji sentrifugasi dan cycling test dilakukan. Kata Kunci     : Nanoemulsi, Aspirin, Etanol 96%, Ko-surfaktan   ABSTRACT Acetosal known to be a part of the group medications called Non Steroidal Anti Inflammatory Drugs (NSAIDs) that was used for mild to moderate pain therapy, antipyretic, anti inflamation and anti coagulan. Oral administration of acetosal may decrease its effectiveness because of the first past metabolism problem. The purpose of this study was to formulate acetosal into nanoemulsion form for topical preparation as an alternative to avoid those problem with ethanol 96% as co-surfactant.  Nanoemulsion was an emultion system which transparent, glasslike, and comes from dispertion of water and oil stabilized by film-coated that made from surfactant and co-surfactant combination, which has droplet size around 20 nm-500 nm. Acetosal nanoemulsions were prepared with Virgin Coconut Oil (VCO) as oil phase, tween 80 as surfactant and ethanol 96 % as co-surfactant. There were 5 formulas of transparent acetosal nanoemultion. Their yield of pH were about 4,0-4,5 were met the normal skin’s pH. They were acetosal nanoemulsions with ethanol 96 % of 10%, 15%, 20%, 25%, and 30%. These five were stable and did not show the separation of phase after both centrifugation and cycling test. Keyword          : Nanoemulsion, Acetosal, Ethanol 96%, Co-Surfactan

scholarly journals Pembuatan Virgin Coconut Oil dari Kelapa Hibrida Menggunakan Metode Penggaraman dengan NaCl dan Garam Dapur

2018 ◽  
Vol 1 (2) ◽  
pp. 7
Author(s):  
Marlina Marlina ◽  
Dwi Wijayanti ◽  
Ivo Pangesti Yudiastari ◽  
Lilis Safitri
Keyword(s):  
Cocos Nucifera ◽  
Coconut Oil ◽  
Virgin Coconut Oil

Kelapa (Cocos nucifera) adalah tanaman yang sangat banyak ditemukan di daerah tropis. VCO merupakanminyak kelapa murni yang terbuat dari daging kelapa segar yang diolah dalam suhu rendah atau tanpa pemanasan, sehingga kandungan yang penting seperti Asam Laurat dalam minyak tetap dapat dipertahankan. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan garam dapur dan NaCl terhadap rendemen VCO. Krim santan 400 gram ditambahkan garam dapur dan NaCl masing-masing sebanyak 0 gram, 2 gram, 4 gram dan 6 gram lalu didiamkan selama 3 hari dan 6 hari. VCO yang dihasilkan kemudian dianalisa dengan metode titrasi menggunakan KOH 0,1N untuk mendapatkan bilangan asam yang digunakan untuk mengetahui kualitas VCO yang dihasilkan.Dari penelitian yang telah dilakukan menunjukkan bahwa konsentrasi NaCl dan Garam Dapur yang dapat menghasilkan rendemen optimum yaitu sebanyak 6 gram dengan hasil 49%. Semakin tinggi konsentrasi garam dan semakin lama waktu pendiaman, maka semakin banyak rendemen VCO yang dihasilkan akan tetapi, semakin tinggi juga bilangan asamnya yang menyebabakan rendahnya kualitas dari VCO yang dihasilkan.Kata Kunci: Garam Dapur, NaCl, Penggaraman, VCO.

scholarly journals Extraction of Virgin Coconut (Cocos nucifera) Oil Using Supercritical Fluid Carbon Dioxide

2014 ◽  
Vol 67 (2) ◽  
Author(s):  
Mohd Azizi Che Yunus ◽  
Muhammad Naim Rozak ◽  
Lee Nian-Yian ◽  
Muhammad Syafiq Hazwan Ruslan ◽  
Siti Hamidah Mohd-Setapar ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Fluid ◽  
Cocos Nucifera ◽  
Coconut Oil ◽  
Bioactive Compound ◽  
Extraction Process ◽  
Total Phenolic ◽  
Virgin Coconut Oil ◽  
Solvent Residue ◽  
Supercritical Fluid Carbon Dioxide

Bioactive compound is an important component in health care to a majority of the world’s population.  Virgin Coconut (Cocos nucifera) oil is used in Southeast Asia for treating various diseases and is well-known of its rich nutrients.  In this study, supercritical fluid extraction (SFE), an environmental friendly technique was used to extract the interest compounds from crude virgin coconut. The extracted virgin coconut oil is free from organic solvent and safe to be consumed. This is because the solvent used in the extraction process is carbon dioxide which is inert and no solvent residue inside the extracted oil. The layout of the experiment was developed via Statistica 8.0 using the Box-Behnken experimental design model. The oil yield, antioxidant activity and total phenolic content were calculated while the comparison of the experimental results and the statistical data was done using response surface methodology (RSM). Therefore, the optimum conditions of temperature and pressure for the extraction of virgin coconut oil was obtained through the statistical study which is 47°C and 20MPa respectively.

Virgin coconut oil enhances neuroprotective and anti‐inflammatory factors in the thymus and mesenteric lymph nodes of rats

2019 ◽  
Vol 11 (1) ◽  
pp. 65-72
Author(s):  
Sunil Karrunanithi ◽  
Kishore A. Ravichandran ◽  
Lalgi Hima ◽  
Uday P. Pratap ◽  
Ramasamy Vasantharekha ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Coconut Oil ◽  
Inflammatory Factors ◽  
Virgin Coconut Oil ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Anti Inflammatory

scholarly journals In vitro anti-inflammatory and skin protective properties of Virgin coconut oil

2019 ◽  
Vol 9 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Sandeep R. Varma ◽  
Thiyagarajan O. Sivaprakasam ◽  
Ilavarasu Arumugam ◽  
N. Dilip ◽  
M. Raghuraman ◽  
...  
Keyword(s):  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Protective Properties ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory and Analgesic Properties of Pulegone, a Major Component in Calamintha Nepeta

2021 ◽  
Author(s):  
Alexandre Charlet ◽  
Hugues Petitjean ◽  
Louis Hilfiger ◽  
Zélie Triaux ◽  
Christophe Marcic ◽  
...  
Keyword(s):  
Biological Activities ◽  
Chronic Inflammatory Disease ◽  
Mentha Piperita ◽  
Mechanical Stimuli ◽  
Cytotoxic Effects ◽  
Analgesic Effects ◽  
Pain Pathways ◽  
Anti Inflammatory ◽  
Pass Through ◽  
Main Components

Abstract Monoterpenes are small molecules, composed of two isoprene units, able to pass through the blood brain barrier, allowing to target both peripheral and central pain pathways. They are the main components of essential oils, responsible for their diverse well-known biological activities. Menthol, the main monoterpene found in Mentha piperita (L.) is known to modulate nociceptive threshold and is present in different curative preparations that reduces sensory hypersensitivities in pain conditions. While pulegone is a menthol-like monoterpene, only a limited number of studies focuses on its putative analgesic effects. Pulegone is the most abundant monoterpene presents in Calamintha nepeta (L.), a Laminaceae plant used in traditional medicine to alleviate rheumatic disorders, a chronic inflammatory disease. Here, we compared the impacts of menthol and pulegone on pain and inflammation. First, we described that both monoterpenes are anti-inflammatory compounds. Secondly, we found that while menthol is highly cytotoxic at anti-inflammatory concentrations, the cytotoxic effects of pulegone are limited, if not absent. Finally, in a model of peripheral inflammatory-induced pain a pulegone treatment exerts a significantly higher anti-hyperalgesic effect than menthol in response to mechanical stimuli, heat and cold thermal stimulations than a menthol treatment. In conclusion we demonstrated that pulegone is an anti-inflammatory compound and it is acting a potent pain-killer in acute inflammatory pain condition.

scholarly journals Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil

2009 ◽  
Vol 48 (2) ◽  
pp. 151-157 ◽  
Author(s):  
S. Intahphuak ◽  
P. Khonsung ◽  
A. Panthong
Keyword(s):  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Anti Inflammatory
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