Precise medication for tumor patients in the context of mental stress

Cancer is the leading cause of disease-related death worldwide due to its late diagnosis and poor outcomes. Precision medicine plays an important role in the treatment of tumors. As found for many types of tumors, mental stress plays a vital role in the promotion and progression of tumors. In this paper, we briefly introduce the manifestation and effects of mental symptoms in tumor patients. We next specifically discuss the multiple roles of precision medicine in the tumor therapy. Finally, we also highlight the precision medicine strategy for psychiatric symptoms in tumor patients, which promises to enhance the efficacy of tumor therapy.

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Acute psychological impact of coronavirus disease 2019 outbreak among psychiatric professionals in China: a multicentre, cross-sectional, web-based study

BMJ Open ◽

10.1136/bmjopen-2020-047828 ◽

2021 ◽

Vol 11 (5) ◽

pp. e047828

Author(s):

Xin Guo ◽

Robert McCutcheon ◽

Toby Pillinger ◽

Atheeshaan Arumuham ◽

Jianhua Chen ◽

...

Keyword(s):

Mental Health ◽

Health Outcomes ◽

Mental Stress ◽

Structural Equation ◽

Psychiatric Symptoms ◽

Mental Health Outcomes ◽

Considerable Proportion ◽

Cross Sectional ◽

Event Scale ◽

Symptoms Of Depression

ObjectivesTo assess the magnitude of mental health outcomes and associated factors among psychiatric professionals in mental health services during COVID-19 in China.Design, setting and participantsThis cross-sectional, survey-based, region-stratified study collected demographic data and mental health measurements from psychiatric professionals in 34 hospitals between 29 January and 7 February 2020, in China. Hospitals equipped with fever clinics or deployed on wards for patients with COVID-19 were eligible.Primary outcome and measuresThe severity of symptoms of depression, anxiety, insomnia and distress were assessed by the Chinese versions of 9-item Patient Health Questionnaire, 7-item Generalised Anxiety Disorder, 7-item Insomnia Severity Index and 22-item Impact of Event Scale-Revised, respectively. Multivariable logistic regression and structural equation modelling was performed to identify factors associated with mental health outcomes.ResultsA total of 610 psychiatric professionals were included. 29.8% were employed in Wuhan, and 22.5% were frontline workers. A considerable proportion of participants reported symptoms of depression (461 (75.6%)), anxiety (282 (46.2%)), insomnia (336 (55.1%)) and mental stress (481 (78.9%)). Psychiatric symptoms were associated with worrying about infection (eg, OR 2.36 (95% CI 1.27 to 4.39) for anxiety), risks of exposure to COVID-19 (eg, having inadequate personal protection equipment, OR 2.43 (1.32 to 4.47) for depression) and self-perceived physical health (eg, OR 3.22 (2.24 to 4.64) for mental stress). Information sources of COVID-19 were also found to be both positively (eg, information from relatives, OR 2.16 (1.46 to 3.21) for mental stress) and negatively (eg, information from TV, OR 0.52 (0.35 to 0.77) for mental stress) associated with mental stress. There is preliminary evidence that mental health might benefit from greater availability of mental healthcare services. The structural equation model analysis indicated that worrying about infection may be the primary mediator via which risk of exposure to COVID-19 pandemic affects the mental health of psychiatric professionals.ConclusionsThe current findings demonstrate several pathways via which the COVID-19 pandemic may have negatively affected the mental health of psychiatric professionals in China.

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Gender Role Stereotyping Of Women As Housewives In Conventional Pakistani Society

Pakistan Journal of Gender Studies ◽

10.46568/pjgs.v15i1.125 ◽

2017 ◽

Vol 15 (1) ◽

pp. 1-16

Author(s):

Amna Saeed ◽

Noreen Zainab

Keyword(s):

Middle Class ◽

Gender Role ◽

Physical Abuse ◽

Short Story ◽

Vital Role ◽

Multiple Roles ◽

Close Reading ◽

Social Expectations ◽

Gender Role Stereotyping ◽

Status Of Women

This study aims to analyze the short story, The Spell and the Ever Changing Moon (2014) by Rukhsana Ahmad, from the feminist perspective. A close reading of the text reveals that facing everyday challenges and juggling between multiple roles is a common practice for middleclass house wives in Pakistani society. The economic instabilities added with emotional, psychological as well as physical abuse plays a vital role in their oppression and humiliation on regular basis. These roles as assigned to them define their social standing and suffering becomes their destiny. Multiple roles of such women and social expectations outside and inside the house define their way of living. Each and every movement and thought becomes codependent on their social familial roles. Being selfless becomes an obligation and ‘sacrifice’ becomes convention for middle class women who spend their whole lives living under the thumb of their men folk. Moreover, the movement and status of women inside and outside the home is also a major concern addressed in this paper including the concept of home, and its significance in lives of Pakistani women.

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Schizophrenia patients with a metabolically abnormal obese phenotype have milder negative symptoms

10.21203/rs.3.rs-15825/v1 ◽

2020 ◽

Author(s):

Juan Wang ◽

Yulong Zhang ◽

Zhiwei Liu ◽

Yating Yang ◽

Yi Zhong ◽

...

Keyword(s):

Metabolic Syndrome ◽

Negative Symptoms ◽

Psychiatric Symptoms ◽

Normal Weight ◽

Control Group ◽

Strongly Correlated ◽

Clinical Trial Registration ◽

Negative Factor ◽

Syndrome Scale ◽

Mental Symptoms

Abstract Background: Schizophrenia patients with a metabolically abnormal obese (MAO) phenotype have been shown poor cardiovascular outcomes, but the characteristics of their current mental symptoms have not been characterized. This study mainly explored the psychiatric symptoms of schizophrenia patients with the MAO phenotype.Methods: A total of 329 patients with schizophrenia and 175 sex- and age-matched people without schizophrenia from Anhui Province in China were enrolled. The Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms of the schizophrenia patients. The MAO phenotype was defined as meeting 1-4 metabolic syndrome criteria (excluding waist circumference) and having a body mass index (BMI) ≥ 28 kg/m 2 . And, metabolically healthy normal-weight (MHNW) phenotype was defined as meeting 0 criteria for metabolic syndrome and 18.5 ≤ BMI < 24 kg/m 2.Results: Overall, 15.8% of the schizophrenia patients and 9.1% of the control group were consistent with the MAO phenotype, and the prevalence of MAO in the schizophrenia group was higher than that in the control group. Among the patients with schizophrenia, the MAO group had lower negative factor, cognitive factor and total PANSS scores than the MHNW group. However, when confounding factors were controlled, only the negative factor remained lower. The correlation analysis showed that the MAO phenotype was strongly correlated with C-peptide and insulin levels.Conclusion: we found that schizophrenia patients with the MAO phenotype had reduced negative symptoms, which may indicate an internal mechanism linking metabolic disorders and negative symptoms.Trial registration: This study was registered in the China Clinical Trial Registration Center (No. chiCTR 1800017044)

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Schizophrenia patients with a metabolically abnormal obese phenotype have milder negative symptoms

10.21203/rs.3.rs-15825/v2 ◽

2020 ◽

Author(s):

Juan Wang ◽

Yulong Zhang ◽

Zhiwei Liu ◽

Yating Yang ◽

Yi Zhong ◽

...

Keyword(s):

Metabolic Syndrome ◽

Negative Symptoms ◽

Psychiatric Symptoms ◽

Normal Weight ◽

Trial Registration ◽

Control Group ◽

Clinical Trial Registration ◽

Negative Factor ◽

Syndrome Scale ◽

Mental Symptoms

Abstract Background: Schizophrenia patients with a metabolically abnormal obese (MAO) phenotype have been shown poor cardiovascular outcomes, but the characteristics of their current psychiatric symptoms have not been characterized. This study mainly explored the psychiatric symptoms of schizophrenia patients with the MAO phenotype. Methods: A total of 329 patients with schizophrenia and 175 sex- and age-matched people without schizophrenia from Anhui Province in China were enrolled. The Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms of the schizophrenia patients. The MAO phenotype was defined as meeting 1-4 metabolic syndrome criteria (excluding waist circumference) and having a body mass index (BMI) ≥ 28 kg/m2. And, metabolically healthy normal-weight (MHNW) phenotype was defined as meeting 0 criteria for metabolic syndrome and 18.5 ≤ BMI < 24 kg/m2. Results: Overall, 15.8% of the schizophrenia patients and 9.1% of the control group were consistent with the MAO phenotype, and the prevalence of MAO in the schizophrenia group was higher than that in the control group. Among the patients with schizophrenia, the MAO group had lower negative factor, cognitive factor and total PANSS scores than the MHNW group. However, when confounding factors were controlled, only the negative factor remained lower. The correlation analysis showed that the MAO phenotype was strongly correlated with C-peptide and insulin levels.Conclusion: we found that schizophrenia patients with the MAO phenotype had reduced negative symptoms, which may indicate an internal mechanism linking metabolic disorders and negative symptoms.Trial registration: This study was registered in the China Clinical Trial Registration Center (No. chiCTR 1800017044)

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Novel Approaches in Ovarian Cancer Research against Heterogeneity, Late Diagnosis, Drug Resistance, and Transcoelomic Metastases

International Journal of Molecular Sciences ◽

10.3390/ijms20112649 ◽

2019 ◽

Vol 20 (11) ◽

pp. 2649 ◽

Cited By ~ 1

Author(s):

Anna Erol ◽

Magdalena Niemira ◽

Adam Jacek Krętowski

Keyword(s):

Ovarian Cancer ◽

Cancer Research ◽

Drug Resistance ◽

Precision Medicine ◽

Late Diagnosis ◽

Huge Impact ◽

Gynaecologic Malignancy ◽

Novel Approaches ◽

Treatment And Diagnosis ◽

Modern Technologies

The development of modern technologies has revolutionised science and has had a huge impact on biomedical studies. This review focuses on possible tools that scientists can use to face the challenges of fighting ovarian cancer. Ovarian cancer is the deadliest gynaecologic malignancy and, even after years of study, the mortality has not decreased significantly. In the era of sequencing and personalised and precision medicine, we are now closer than ever to helping patients and physicians in regard to treatment and diagnosis of this disease. This work summarises the newest findings in the development of ovarian cancer research.

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4448 Mental Stress Induced Myocardial Ischemia as a Marker for Adverse Cardiovascular Events After MI

Journal of Clinical and Translational Science ◽

10.1017/cts.2020.134 ◽

2020 ◽

Vol 4 (s1) ◽

pp. 32-33

Author(s):

Zakaria Almuwaqqat ◽

Bruno Lima ◽

An Young ◽

Samaah Sullivan ◽

Amit Shah ◽

...

Keyword(s):

Risk Factors ◽

Myocardial Ischemia ◽

Psychological Stress ◽

Stress Reduction ◽

Mental Stress ◽

Composite Endpoint ◽

Risk Indicators ◽

Risk Indicator ◽

Middle Aged ◽

Poor Outcomes

OBJECTIVES/GOALS: Young and middle-aged adults with a myocardial infarction (MI) represent an understudied group potentially with unique risk indicators such as emotional stress. We sought to investigate if mental stress-induced myocardial ischemia (MSIMI), a marker of cardiovascular vulnerability to psychological stress, is associated with poor outcomes among this population. METHODS/STUDY POPULATION: We studied 306 patients (150 women and 156 men) ≤61 years of age who were hospitalized for MI in the previous 8 months. Clinical, behavioral and psychosocial factors were assessed with standardized measures. Patients underwent myocardial perfusion imaging with mental stress (public speaking) and conventional stress (exercise or pharmacological testing). MSIMI and conventional stress-induced ischemia were defined as a new or worsening perfusion defect. Patients were followed for 3 years for adverse events, which were independently adjudicated. Cox proportional hazard models were used to estimate the association of MSIMI and CSIMI with a composite endpoint of recurrent MI or cardiovascular (CV) death with adjustment for demographic, clinical and psychosocial risk factors. RESULTS/ANTICIPATED RESULTS: The mean age of the sample was 50 years (range, 22-61). MSIMI occurred in 16% of the patients, and conventional ischemia in 35%. Over a 3-year follow-up, 28 individuals had a recurrent MI and 2 died due to cardiovascular causes. The incidence of the composite endpoint of MI or CV death was more than doubled in patients with MSIMI (20%) than those without MSIMI (8%), HR 2.6, 95%CI, 1.2-5.6. Further adjustment for demographic and clinical risk factors and depressive symptoms did not substantially change the relationship. In contrast, conventional stress ischemia was not significantly related to the outcome (HR 1.4, 95%CI, 0.6-3.0). DISCUSSION/SIGNIFICANCE OF IMPACT: Young and middle-aged individuals with MSIMI after MI have a >2-fold higher likelihood of recurrent MI and CV mortality compared with those without MSIMI. In this patient group, MSIMI is a better risk indicator than ischemia with a conventional stress. These findings point to psychological stress as an important determinant of risk in this patient population. Ischemia induced by mental stress is a potent risk indicator in young post-MI patients. Stress-reduction interventions may be especially beneficial in patients who show this abnormal response.

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Heterogeneous multi-compartmental DNA hydrogel particles through microfluidic assembly for lymphocyte inspired precision medicine

Nanoscale ◽

10.1039/d1nr06594g ◽

2021 ◽

Author(s):

Sophie Wan Mei Lian ◽

Song Guo ◽

Kewei Ren ◽

Ying XU ◽

John S. Ho ◽

...

Keyword(s):

Precision Medicine ◽

Drug Loading ◽

Vital Role ◽

Hydrogel Particles ◽

Microfluidic Assembly ◽

Dna Hydrogel

Lymphocytes play a vital role in immunosurveillance by sensing biomolecules and eliminating targeted invaders. Compared with conventional therapies depending on timing drug loading, lymphocytes are advantageous as they ensure automatic...

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Psychosis in hypoparathyroidism

Journal of Mental Science ◽

10.1192/bjp.108.457.811 ◽

1962 ◽

Vol 108 (457) ◽

pp. 811-815 ◽

Cited By ~ 8

Author(s):

John A. Clark ◽

L. J. Davidson ◽

H. C. Ferguson

Keyword(s):

Psychiatric Symptoms ◽

Plasma Calcium ◽

Mental Symptoms ◽

The Subject

Recently there has been a resurgence of interest in the subject of hypoparathyroidism and it has become increasingly clear that psychiatric symptoms may frequently be found in patients with hypoparathyroidism, even where no evidence of tetany is present. It is significant that in a survey, in the Cardiff area, of 82 patients who had had a thyroidectomy, Davis et al. (1961) found that mental symptoms (defined as a feeling of uneasiness, tension and anxiety, sometimes with attacks of panic, often with depression) occurred in 66 per cent. of 26 patients whose plasma calcium was below 9·3 mgms/cent, in 51 per cent. of 31 patients whose plasma calcium lay between 9·3 and 9·8 mgms./cent. and in 35 per cent. of 23 patients whose plasma calcium was above 9 · 8 mgms./cent. They estimated that at least 24 per cent. of the patients showed partial parathyroid insufficiency, and that this apparently accounted for many minor but disabling symptoms, particularly depression and lassitude. They found that often these symptoms could be cured by the administration of calcium.

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EPT-20CLINICAL TARGETED EXOME-BASED SEQUENCING IN COMBINATION WITH GENOME WIDE COPY NUMBER PROFILING: A CLIA CERTIFIED APPROACH FOR PRECISION MEDICINE IN 203 PEDIATRIC BRAIN TUMOR PATIENTS

Neuro-Oncology ◽

10.1093/neuonc/now069.19 ◽

2016 ◽

Vol 18 (suppl 3) ◽

pp. iii28.2-iii28 ◽

Cited By ~ 1

Author(s):

Pratiti Bandopadhayay ◽

Shakti Ramkissoon ◽

Jaeho Hwang ◽

Lori Ramkissoon ◽

Adrian Dubuc ◽

...

Keyword(s):

Brain Tumor ◽

Precision Medicine ◽

Copy Number ◽

Pediatric Brain Tumor ◽

Tumor Patients ◽

Genome Wide ◽

Pediatric Brain

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Controlled Delivery of Nitric Oxide for Cancer Therapy

Pharmaceutical Nanotechnology ◽

10.2174/2211738507666190429111306 ◽

2019 ◽

Vol 7 (4) ◽

pp. 279-303 ◽

Cited By ~ 4

Author(s):

Houman Alimoradi ◽

Khaled Greish ◽

Allan B. Gamble ◽

Gregory I. Giles

Keyword(s):

Nitric Oxide ◽

Cancer Biology ◽

Tumor Targeting ◽

Chemical Reactivity ◽

Tumor Therapy ◽

Multiple Roles ◽

Controlled Delivery ◽

Low Molecular Weight ◽

No Donors ◽

Potential Therapeutics

Nitric oxide (NO) is a short-lived, endogenously produced, signaling molecule which plays multiple roles in mammalian physiology. Underproduction of NO is associated with several pathological processes; hence a broad range of NO donors have emerged as potential therapeutics for cardiovascular and respiratory disorders, wound healing, the immune response to infection, and cancer. However, short half-lives, chemical reactivity, rapid systemic clearance, and cytotoxicity have hindered the clinical development of most low molecular weight NO donors. Hence, for controlled NO delivery, there has been extensive effort to design novel NO-releasing biomaterials for tumor targeting. This review covers the effects of NO in cancer biology, NO releasing moieties which can be used for NO delivery, and current advances in the design of NO releasing biomaterials focusing on their applications for tumor therapy.

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