Psychosocial Issues of AIDS Long-Term Survivors

1994 ◽  
Vol 75 (6) ◽  
pp. 324-332 ◽  
Author(s):  
Sally Jue
Keyword(s):  
Therapeutic Relationship ◽  
Extended Period ◽  
Therapeutic Interventions ◽  
Psychosocial Issues ◽  
Definition Of ◽  
Aids Diagnosis ◽  
The Impact ◽  
Long Term Survivors ◽  
Term Survivor

The Centers for Disease Control and Prevention's definition of an AIDS long-term survivor is someone who has lived at least three years after an AIDS diagnosis. Data from the late 1980s indicate a three-year survival rate of 15% to 20%, a rate that doubled in less than a decade. Despite the growing number of long-term survivors, little research has focused on how these persons cope with AIDS or on the impact of AIDS over an extended period. The author describes and gives examples of key nonmedical characteristics of AIDS long-term survivors and the special issues they bring to the therapeutic relationship. Suggestions for therapeutic interventions based on a client-empowerment approach are offered.

The impact of cancer and quality of life for long-term survivors

2008 ◽  
Vol 17 (9) ◽  
pp. 891-900 ◽  
Author(s):  
Brad J. Zebrack ◽  
Jaehee Yi ◽  
Laura Petersen ◽  
Patricia A. Ganz
Keyword(s):  
Quality Of Life ◽  
The Impact ◽  
Long Term Survivors

scholarly journals Studies of the Logistics Services Market: Information and Analytical Support and a System of Statistical Indicators

2020 ◽  
pp. 5-11
Author(s):  
N. HRYNCHAK
Keyword(s):  
Medium Term ◽  
Secondary Sources ◽  
The Core ◽  
Logistics Services ◽  
Rational Management ◽  
Definition Of ◽  
Definition Of Information ◽  
The Impact ◽  
Statistical Indicators

Information and analytical database for the market support is required to prevent communications of contradictory information to higher levels of management, with adverse effects for the process of taking rational management decisions. The article’s objective is to substantiate the information and analytical support for studies of the logistics services market, with constructing a system of statistical indicators for this market assessment, to be laid as the solid basis for elaborating medium-term and long-term strategies and policies of the logistics services market in Ukraine.  A definition of information and analytical support for studies of the logistics services market is given; a review of secondary sources of data for this market studies is made. A conceptual model for information and analytical studies of the logistics services market is proposed. The key statistical indicators for studies of this market are identified, with substantiating the feasibility of their use in computing multivariate indicators for the assessment of performance and capacities of the logistics services market in Ukraine. The core criteria to be met by the abovementioned system of statistical indicators are highlighted. A system of statistical indicators for the assessment of the logistics services market is proposed, containing four modules. It allows for diagnosis of this market performance and tendencies, with accounting for the impact of other related markets and activities, and for forecasting. This system, constructed with consideration to the global practice, is designed for comprehensive studies of the logistics services market.

scholarly journals NEUROPHYSIOLOGICAL AND NEUROPSYCHOLOGICAL FEATURES AT PATIENTS FROM OCCUPATIONAL NOISE-INDUCED HEARING LOSS

2019 ◽  
Vol 98 (10) ◽  
pp. 1068-1073
Author(s):  
Oksana I. Shevchenko ◽  
D. V. Rusanova ◽  
O. L. Lakhman
Keyword(s):  
Latent Period ◽  
Cognitive Activity ◽  
Functional Condition ◽  
Long Term Memory ◽  
Term Memory ◽  
Diagnostic Signs ◽  
Constant Potential ◽  
Definition Of ◽  
The Impact

Introduction. Issues of studying the central origins and development of оccupational pathology in the faces of flight personnel define a need for the application of neurophysiological and neuropsychological methods of research. Material and methods. The levels of constant potential (LCP), characteristics the somatosensory caused potentials (SSVP), neuropsychological features in 95 patients with оccupational neurosensory deafness (ONSD) and 35 cases in a group of comparison are studied. Methods of the statistical analysis with a definition of W-of criterion of Shapiro-Uilka, Mann-Whitney›s U-criterion, coefficient of correlation of Spirmen, the discriminant analysis are applied. Results. in ONSD at patients the quantity of cases with the increased values of average LCP were established to prevail significantly in comparison with those in patients of a group of comparison (39% and 13% respectively, р = 0.03), strengthening of neuropower exchange in right and left frontal, central, left central, left parietal, right temporal assignments, increase in duration of the latent period of N18, N30 components are registered (р < 0.05). The condition of the cognitive sphere was characterized by the easily expressed violations of functions of analytical and synthetic thinking, оral-aural memory, visual, long-term memory, reciprocal coordination, impressive speech. Correlation connection between the index of N13-N20 and indices characterizing a condition of long-term memory, reciprocal coordination, the expressional speech is established (rs=0.45; 0.28; 0.28 at р =0.008; 0.04; 0.03 respectively), an index the between hemispheres of the relations Fd-Fs and latency of P25 and N30 (rs = 0.53 and 0.29 at р =0.009; 0.02 respectively). Diagnostic signs of brain deficiency at patients with ONSD were indices of visual gnosis, reciprocal coordination, LCP in right central, central parietal assignments of a brain, duration of the latent period of N30, N18-N20 (F=9.14; 5.43; 6.08; 4.41 4.77; 4.34 respectively). Conclusions. Violations of power metabolism in the frontal and central and parietal and temporal assignments of a brain, a functional condition of the central carrying-out structures, disorganization of cognitive activity were established to be a consequence of the impact of aviation noise and the reason of brain deficiency.

Assessment of Package Performance During Long-Term Storage of Intermediate-Level Radioactive Waste

2003 ◽  
Author(s):  
A. V. Chambers ◽  
W. R. Rodwell ◽  
M. Kelly ◽  
A. R. Hoch ◽  
A. J. Baker
Keyword(s):  
Extended Period ◽  
Intermediate Level ◽  
Passive Safety ◽  
Long Term Storage ◽  
Waste Storage ◽  
Disposal Option ◽  
Intermediate Level Radioactive Waste ◽  
The Uk ◽  
The Impact

In the UK, the need for the long-term management of intermediate-level radioactive wastes arises from the absence of an established deep disposal option. As a consequence there is a requirement to demonstrate the ‘passive safety’ of waste packages in stores over a necessarily lengthy period (perhaps 150 years or more). ‘Passive safety’ is taken here to imply that the waste packages themselves would remain safe without intervention; it is assumed however, that the store building and associated infrastructure would need to be actively maintained and that the store may need to be ventilated. Importantly, methods for waste storage also need to ensure that possible future options for disposal are not foreclosed. An extended period of storage suggests that emphasis will need to be placed by waste producers on understanding a number of issues such as: • the impact of corrosion on container integrity; • the assessment of container vents and other features as a pathway for the release of radioactivity; • the extent to which wastes are conditioned for storage and the selection of appropriate methods; • the generation and behaviour of toxic or flammable gases in the storage facility; and the mitigating steps that might be needed to address adverse impacts (e.g. the type of ventilation that the store requires). In this paper, we review the requirements and current state of knowledge relevant to the assessment of operational releases of radioactive, flammable and toxic gases from wastes in long-term interim storage.

scholarly journals A study of serious case reviews between 2016 and 2018: what are the key barriers for social workers in identifying and responding to child neglect?

2020 ◽  
Vol 15 (1) ◽  
pp. 1-14
Author(s):  
Linda Solem ◽  
Clive Diaz ◽  
Lauren Hill
Keyword(s):  
Social Workers ◽  
Child Neglect ◽  
Negative Impact ◽  
Content Type ◽  
Effective Interventions ◽  
Effective Manner ◽  
Definition Of ◽  
The Impact ◽  
The Voice

Purpose Child neglect is the most common form of maltreatment but is also one of the most complex. Neglect has a long-term negative impact on children and young people’s development and wellbeing. This study examined 20 recent serious case reviews that had taken place in England where neglect was a feature. The purpose of this study is sought to explore the barriers, which exist for social workers in England in identifying and responding to neglect in a timely, appropriate and effective manner. Design/methodology/approach Thematic analysis identified four main themes that were likely to impact upon effective interventions. Findings Challenges in terms of the definition of neglect and how to identify it; the use of neglect toolkits; the impact of organisational cultures on practice and the voice of the child. Originality/value In spite of its prevalence there is a dearth of literature relating specifically to the issue of neglect. There is a need for further research to be undertaken because of the acknowledged, seriousness and potential longstanding negative impact on children even into adulthood (Horwath, 2013). It is hoped that this study provides a useful insight into some of the barriers that exist for social workers in working effectively with children and families for whom neglect is an issue.

Allogeneic Hematopoietic Stem Cell Transplantation Cures CLL: A Retrospective Analysis from the SFGM-TC Registry.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 2991-2991
Author(s):  
Mauricette Michallet ◽  
Quoc-Hung Lê ◽  
Jean-Paul Vernant ◽  
Franck E. Nicolini ◽  
Jean-Luc Harousseau ◽  
...  
Keyword(s):  
Autologous Transplantation ◽  
Disease Status ◽  
Allogeneic Transplantation ◽  
Cell Transplant ◽  
Hematopoietic Stem ◽  
Cord Blood Cell ◽  
The Status ◽  
The Impact ◽  
Long Term Survivors

Abstract This retrospective study concerned 471 B-CLL patients registered in the SFGM-TC registry from Apr 1,984 to Feb 2,005, who underwent either autologous transplantation (n=313, 138 F and 175 M, median age = 54, 236 PBSC and 77 BM) or allogeneic transplantation (n=158, 78 F and 80 M, median age = 49, 76 PBSC, 81 BM and 1 cord blood cell transplant from 17 related and 141 unrelated donors). Among alloT patients, 50 were ABO incompatible and 70 sex-mismatched. The median interval diagnosis-transplantation was 32 months for autoT and 51 months for alloT. Just before conditioning 302 autoT and 143 alloT were evaluated for the disease status: 100 and 26 patients were in CR, 170 and 55 were in PR, 4 and 13 in stable disease (SD), 28 and 49 in progressive disease (PD) for autoT and alloT respectively. Among alloT patients, 73 received reduced intensity conditioning (RIC) and 85 standard conditioning (72 Cyt+TBI, 33 Fluda+TBI, 23 Fluda+Bu+ATG, 8 Cyt+Bu and 21 other). Before autoT the conditioning consisted of 224 Cyt+TBI, 45 BEAM and 44 other. After alloT, 71 patients developed an aGVHD ≥ grade II and 60 developed a cGVHD (25 limited and 35 extensive). The non-relapse mortality at 1 year was 29%. With a mean follow-up of 28 months for autoT and 40 months for alloT, the probabilities of 3-year, 5-year and 8-year overall survival were 80%, 66%, 45.5% after autoT and 52%, 48% and 35% after alloT respectively. An analysis aimed to determine the percentage of long-term survivors, or patients censored on the final plateau of survival curves was performed on alloT and autoT groups. A mixture model, gfcure with Splus statistical package determined the percentages of long-term survivors and its adequacy was verified graphically. The percentage of long-term survivors for the autoT group was 1.2%, with a mean survival length for uncured population of 160 months. Fig A shows that both curves were close and consequently shows good adequacy and the absence of a final plateau. The percentage of long-term survivors for alloT was 34.03% (figure1). Fig B shows rather good adequacy. The study of the impact of usual prognosis factors (age, time diagnosis-transplant, sex match, HLA match, CMV status, type of conditioning, BM or PBSC, ABO compatibility and disease status before transplantation) on the percentage of long-term survivors showed that only the status of disease at transplant had a significant impact: (CR vs SD or PD, HR: 0.11 [0.02–0.5] p=0.01 and PR vs SD or PD, HR: 0.30 [0.09–0.96] p=0.04). This study pointed out the possibility of curing B-CLL patients who responded to conventional chemotherapy with allogeneic transplantation rather than with autologous transplantation. Figure Figure Figure Figure

Parenthood in Long-Term Survivors After CHOEP Treatment for Aggressive Lymphoma Is Not Significantly Impaired in Comparison to the General Population. Results From the Mabthera International Trial (MInT) and the DSHNHL NHLB1 Study

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 3649-3649
Author(s):  
Julia Meissner ◽  
Sascha Dietrich ◽  
Marita Ziepert ◽  
Evelyn Kuhnt ◽  
Tanja Rixecker ◽  
...  
Keyword(s):  
General Population ◽  
Hodgkin Lymphoma ◽  
Aggressive Lymphoma ◽  
Gnrh Analogue ◽  
International Trial ◽  
Female Patients ◽  
Male Patients ◽  
The Impact ◽  
Long Term Survivors

Abstract Abstract 3649 Background: A growing number of patients with aggressive lymphoma experience long term survival after front-line treatment and survivorship issues have been increasingly addressed in recent years. Within treatment-induced sequelae, gonadal failure represents a major late-effect of chemotherapy. With respect to hematologic malignancies the majority of data on fertility effects pertains to Hodgkin Lymphoma treatment regimens whereas information on gonadal toxicity of non-Hodgkin Lymphoma treatments is limited. While CHOP as the standard treatment for aggressive lymphoma is supposed to be associated with only temporary side-effects on fertility in both sexes, nothing is known about the fertility effect of a moderate intensification of CHOP by adding etoposide in frequently used regimens such as CHOEP or dose-adjusted EPOCH. Methods: Our study assessed fertility aspects in young patients with aggressive lymphoma who enjoy ongoing first remission after treatment in the Mabthera International Trial or the German DSHNHL NHLB1 study between 1995 and 2003. Long term survivors of both prospective studies were contacted and invited to answer a questionnaire. Patients who received radiotherapy to the gonadal area as part of their primary treatment as well as those who received chemotherapy for secondary neoplasia were excluded from the analysis. Data on parenthood obtained in the subgroup of patients who received 6 complete cycles (R)-CHOEP (total cyclophosphamide and etoposide dose 4,500 mg/m2 and 1,800 mg/m2, respectively) is reported here. Results: Altogether 66 (31 female, 35 male) patients agreed to participate in the survey. Median age at treatment was 32.5 years (range: 18 – 40) and at time of data collection 44 years (range: 28 – 55), respectively, with a median follow-up after treatment completion of 11 years (range: 7 – 17). While 31 (46.9%) patients already had children before treatment (18 female – 58.1%, 13 male – 37.1%), 35 (53.0%) expressed a clear desire for children after treatment (14 female – 45.2%, 21 male – 60.0%). Ten of these 35 patients did not try to achieve pregnancy, with lack of partner being the main reason. Of the remaining 25 patients (12 female, 13 male) who tried to achieve pregnancy, 18 (9 female – 75%, 9 male – 69%) were finally successful. Apart from 2 deliberate abortions all pregnancies were uncomplicated and resulted in 25 live births. No major health problems were reported in the children. The interval between completion of treatment and birth of first child after treatment ranged from 21 to 146 months (median 58 months) in female patients and from 25 months to 106 months (median 60.5 months) in male patients. Patients not achieving pregnancy tended to be older then patients who successfully achieved pregnancy (median age 30 versus 25 in female patients and 34.5 versus 28 years in male patients). Not achieving parenthood after treatment was associated with emotional stress in 3 of 3 female patients but only in 1 of 4 male patients. Fourteen patients chose cryopreservation of sperm before treatment but none of them utilized preserved sperm for reproductive purposes. Cryopreservation techniques were not used in female patients. Only one female patient received a GnRH analogue in parallel to chemotherapy and gave birth to two children after treatment. Comparison of the presented patient data with the German general population (The German Socio-Economic Panel, 2011) revealed only non-significant differences in the overall percentage of childless women (16.1% in the study population versus 26.0% in the general population, p=0.15) and men (45.7% versus 33.8%, p=0.07). Total fertility rate in female study patients (1.45) paralleled that in the general population (around 1.4 between 1980 and 2010). Conclusions: Parenthood after treatment with CHOP plus etoposide seems not to be significantly impaired in comparison to the general population. Most patients who had attempted post-treatment parenthood were successful. The small percentage of patients not achieving pregnancy despite a clear desire for parenthood after treatment is in line with previous reports on the fertility effects of CHOP. However, all patients of reproductive age should be offered counselling with regard to the impact of planned therapy on their fertility. Disclosures: No relevant conflicts of interest to declare.

The impact of treatment for osteosarcoma on long term survivors with therapy of increasing dosage and dose intensity

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 8571-8571 ◽  
Author(s):  
I. J. Cohen ◽  
S. Ash ◽  
Y. Goshen ◽  
E. Boneda ◽  
M. Berant ◽  
...  
Keyword(s):  
Dose Intensity ◽  
The Impact ◽  
Long Term Survivors

scholarly journals Quality of Life Among Long-Term Survivors of Non-Hodgkin Lymphoma: A Follow-Up Study

2013 ◽  
Vol 31 (2) ◽  
pp. 272-279 ◽  
Author(s):  
Sophia K. Smith ◽  
Deborah K. Mayer ◽  
Sheryl Zimmerman ◽  
Christianna S. Williams ◽  
Habtamu Benecha ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Hodgkin Lymphoma ◽  
Symptom Burden ◽  
Non Hodgkin Lymphoma ◽  
The Impact ◽  
Long Term Survivors ◽  
Over Time

Purpose Little is known about change in quality of life (QOL) among long-term cancer survivors. We examined change over time in QOL among long-term survivors of non-Hodgkin lymphoma and identified demographic, clinical, and psychosocial risk factors for poor outcomes. Methods Surveys were mailed to 682 lymphoma survivors who participated in a study 5 years earlier, when on average they were 10.4 years postdiagnosis. Standardized measures of QOL, perceptions of the impact of cancer, symptoms, medical history, and demographic variables were reported at both time points and examined using linear regression modeling to identify predictors of QOL over time. Results A total of 566 individuals participated (83% response rate) who were a mean of 15.3 years postdiagnosis; 52% were women, and 87% were white. One third of participants (32%) reported persistently high or improved QOL, yet a notable proportion (42%) reported persistently low or worsening QOL since the earlier survey. Participants who received only biologic systemic therapy reported improvement in physical health despite the passage of time. Older age, more comorbidity, and more or increasing negative and decreasing positive perceptions of cancer's impact were independent predictors of poor QOL. Lymphoma symptom burden, less social support, and having received a transplantation were related to negative perceptions of cancer's impact. Conclusion Moderate to severe symptom burden, limited social support, or having received a transplantation should alert the clinician to potential need for supportive services. Perceptions of cancer's impact are associated with QOL cross-sectionally and longitudinally; modifying these perceptions may thus provide a strategy for improving QOL.

scholarly journals The impact of disinformation on dangerous goods operation

2018 ◽  
Vol 27 (2018) ◽  
pp. 137-140
Author(s):  
Razvan Bazaitu ◽  
Adrian Nicolae Antohi
Keyword(s):  
Business Strategy ◽  
Moral Values ◽  
Global Business ◽  
New Era ◽  
Dangerous Goods ◽  
Definition Of Success ◽  
Definition Of ◽  
The Impact ◽  
Informational Networks

It becomes increasingly obvious that the current social stage comes with unique challenges, so the definition of success as gaining advantages only to one party to the detriment of the other must be overcome. In the new era, highly interconnected and transparent, we must find solutions to raise ourselves together, or together we will collapse. Our goal is to build a global community, energized by the vast informational networks (which have canceled all distances), based on responsibility, creativity, common benefits and values. Using new approaches and solving problems not solitary but synergistically, effectively, principally, the new strong currency in the global business strategy will become the trust. This cannot be achieved either by fear or legal over-regulation, but only by higher moral values, assumed and followed as the only long-term sustainable solution.

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