scholarly journals The Incidence and Severity of Drug Interactions Before and After Antiretroviral Therapy Simplification in Treatment-Experienced Patients With HIV Infection

2019 ◽  
Vol 54 (1) ◽  
pp. 36-42
Author(s):  
Nicholas V. Hastain ◽  
Aleena Santana ◽  
Jason J. Schafer
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Drug Interactions ◽  
Patient Adherence ◽  
Potential Interaction ◽  
Rank Test ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test

Background: Current guidelines advocate for antiretroviral therapy (ART) simplification in patients on complicated regimens. Simplifying ART improves patient adherence and quality of life, but changes in drug interactions (DIs) are uncertain. Objective: This study assessed changes in DIs following ART simplification in patients with HIV. Methods: This was an observational, retrospective cohort study of patients attending an urban HIV clinic. Patients were included if they had ART simplification (a decreased number of daily tablets) and ≥1 concomitant medication (CM). Total DI scores were generated for each patient pre–ART simplification and post–ART simplification using an online DI database. Each ART-CM pair labeled as “do not co-administer” was given a score of 2, “potential interaction” a score of 1, or “no interaction” a score of 0. Differences in total DI scores following simplification were analyzed with a Wilcoxon Signed-Rank test. Predictors of DI score reductions were examined with linear regression. Results: A total of 99 patients were included. Their median age was 54 years, and 79% were male. The median durations of HIV infection and ART were 16 and 10 years, respectively. Patients were receiving an average of 4.5 CMs. Median interaction scores presimplification and postsimplification were 3 (interquartile range [IQR], 1-6) and 1 (IQR, 0-2) respectively ( P < 0.001). Predictors of score reductions were the patient’s number of CMs, discontinuing a protease inhibitor, and switching to a dolutegravir-based regimen. Conclusion and Relevance: ART simplification decreased the incidence of DIs in this analysis of patients with advanced age who had ART experience and polypharmacy.

scholarly journals Pengaruh Program Empathic Caring Consultation terhadap Professional Quality of Life Pada Psikolog

2020 ◽  
Vol 12 (2) ◽  
pp. 97-106
Author(s):  
Anya Asbar ◽  
Maya Khairani ◽  
Marty Mawarpury
Keyword(s):  
Quality Of Life ◽  
Sampling Method ◽  
Rank Test ◽  
Professional Quality Of Life ◽  
Professional Quality ◽  
Signed Rank ◽  
Before And After ◽  
Post Test ◽  
Signed Rank Test

This study aims to determine the effect of the Empathic Caring Consultation (ECC) program on Professional Quality of Life (ProQOL) in psychologists. This study involved seven psychologists. The research sample was taken using purposive sampling method. The research method used was one group pretest-post test design. ProQOL is measured using the Professional Quality of Life Version V scale, while the implementation of ECC training refers to the concept of Prawitasari. Analysis using Wilcoxon signed-rank test with a significant value (p) = 0.340 (BO); 0.932 (STS); 0.496 (CS) (p> 0.05). The results of the study showed that there was no effect of the ECC program on ProQOL on psychologists. This is because there are several variations of the three ProQOL components before and after treatment.

scholarly journals Evaluasi Edukasi Personal Dalam Pemahaman, HBA1c dan Kualitas Hidup Pasien DM Tipe 2 di Sidoarjo

2021 ◽  
Vol 8 (1) ◽  
pp. 132
Author(s):  
Khurin In Wahyuni ◽  
Martina Kurnia Rohmah ◽  
Herni Setyawati
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Rank Test ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
Sugar Levels

Diabetes Mellitus (DM) merupakan salah satu penyakit degeneratif tertinggi ke-enam di dunia, dimana prevalensi diabetes semakin meningkat sejalan dengan perubahan gaya hidup masyarakat yang cenderung konsumtif dan minim aktifitas fisik. Diabetes Mellitus ditandai dengan kenaikan gula darah karena kelainan insulin, resistensi insulin atau bisa juga keduanya. Salah satu upaya untuk penanganan dan pencegahan timbulnya peningkatan DM tipe 2 adalah dengan pemberian edukasi menggunakan media booklet. Edukasi merupakan penyampaian pesan kesehatan kepada kelompok atau individu dengan tujuan memperoleh pemahaman dan peningkatan kualitas hidup yang ditandai dengan penurunan HBA1c yang lebih baik. Penelitian ini bertujuan untuk mengevaluasi pemahaman, kualitas hidup dan perbedaan kadar gula darah sebelum dan sesudah pemberian edukasi dengan media booklet terhadap pasien DM tipe 2 di Sidoarjo. Rancangan penelitian yang digunakan adalah Random Control Trial Design. Penelitian ini dilakukan dari bulan Juni sampai Oktober 2020 dengan sampel 60 pasien. Pengukuran pemahaman menggunakan kuesioner DKQ Quessioner, perubahan perilaku menggunakan kuesioner DQOL sedangkan penetapan kadar HBA1c dengan alat tes gula darah. Hasil analisis kuantitatif dilakukan dengan menggunakan uji Wilcoxon Signed Rank Test dan uji Mann Whitney dimana terdapat perbedaan yang signifikan antara, pemahaman, kualitas hidup serta kadar gula darah HBA1c sebelum dan sesudah edukasi.  Pada hasil uji Spearman’Rank’s kelompok intervensi diperoleh nilai koefisien korelasi sebesar 0,586 dengan signifikansi 0,001 untuk pemahaman dengan HBA1c, hasil pemahaman dengan kualitas hidup diperoleh korelasi dengan nilai 0,552 dan p= 0,002. Pada uji korelasi antara HBA1c dengan kualitas hidup diperoleh nilai -0,434, sedangkan signifikansi diperoleh p=0,017, Hal ini menunjukan hubungan antara variable didapat korelasi sedang. Berdasarkan penelitian ini maka dapat disimpulan bahwa terdapat efektivitas edukasi terhadap pemahaman, A1c dan kualitas hidup. Kata Kunci: Diabetes Mellitus, Edukasi, Pemahaman, Kualitas Hidup, Kadar HBA1C, Kualitas Hidup  Diabetes Mellitus (DM) is one of the sixth highest degenerative diseases in the world, the prevalence of diabetes is increasing in line with changes in people's lifestyles that tend to be consuming and minimal physical activity. DM is characterized by an increase in blood sugar due to insulin disorders, insulin resistance or both. One of the efforts to handle and prevent an increase in type 2 diabetes is trough education using booklet media. Education is the delivery of health messages to groups or individuals to gain understanding and improve the quality of life, marked by a better decrease in HBA1c. This study used a Random Control Trial Design. This study aims to determine the understanding, quality of life and differences in blood sugar levels before and after giving education with booklet media to type 2 DM patients in Sidoarjo. This study was conducted from June-October 2020 with a sample of 60 patients. Measurement of understanding using the DKQ Quessioner questionnaire, behavior change using the DQOL questionnaire while HBA1c levels using a blood sugar test kit. The results of quantitative analysis were carried out using the Wilcoxon Signed Rank Test and the Mann Whitney test, from these results there were significant differences between, understanding, quality of life and blood sugar levels of HBA1c before and after education. While the results of the Spearman 'Ranks test for the intervention group obtained a correlation coefficient of -0.586 with a significance of 0.001 for understanding with HBA1c, the results of understanding with quality of life obtained a correlation with a value of 0.552 and p = 0.002. In the correlation test between HBA1c and quality of life, the value -0.434, while the significance was p = 0.017, and this shows the relationship between variables obtained moderate correlation. From this research, there is educational effectiveness on understanding, A1c and quality of life.

The Degree of Subjective Complaints of Students Practice in Mechanical Technology Laboratories

2018 ◽  
Vol 4 (1) ◽  
pp. 22
Author(s):  
I Ketut Widana
Keyword(s):  
Engineering Students ◽  
Standing Position ◽  
Statistical Test ◽  
Rank Test ◽  
Cross Sectional ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
The Difference ◽  
Paired T Test

The working practice of the engineering students is part of the learning process that is irreducible and indispensable. The composition of  lecturing between theoretical and practical one is 40% to 60%. With this condition, the students spend more time at the laboratory. Generally, the students perform in the laboratory work by standing position. The design of research is observational cross-sectional. The method applied is observation, interview and measuring. The subjects of research are practicing students amounting to 21 students. Referring to the analysis of statistical test or Wilcoxon signed ranks test, the difference of effect of work position is significant, namely p < 0.05 towards musculoskeletal disorders (MSDs) before and after working. The quantity of the average complaint after working is score 44.62 ± 9.47. The result of Wilcoxon signed rank test shows that there is significant different effects of standing work position, namely p < 0.05 towards fatigue generally before and after working. The degree of the working pulse is on the average of 110.78  ± 17.80 bpm (beats per minutes) which can be categorized into the medium workload. Using paired t-test, the result is p < 0.05.

PERBANDINGAN KADAR ENZIM KREATININ FOSFOKINASE DAN NYERI OTOT SEBELUM DAN SESUDAH LATIHAN BERENANG SELAMA EMPAT MINGGU PADA PERENANG UNIT KEGIATAN MAHASISWA KLUB RENANG

2020 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
Nur Akmal Binti A'ffan ◽  
Reni Farenia ◽  
Delita Prihatni
Keyword(s):  
Muscle Soreness ◽  
Creatine Phosphokinase ◽  
Rank Test ◽  
Healthy Male ◽  
Blood Draw ◽  
Normality Test ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
Enzyme Elevation

A research has been done to compare the differences on the enzyme creatine phosphokinase (CPK) level and muscle soreness before and after 4-weeks swim practices on swimmers of College swimming club. Eighteen healthy male swimmers (mean ± SD; age: 19,94 ± 1,86 years; weight: 65,28 ± 6,14 kg; height: 1,72 ± 0,43 m) participated in this study. All subjects performed their 4-weeks swim practices which consist of 2x120 hours per week with 500 meters average daily swim distance and weight training. Blood was collected before and after the practices and CPK were analyzed. Questionnaires concerning muscle soreness were filled put before each blood draw. Results were analyzed using normality test and Wilcoxon signed rank test (p<0.05). There was significant increase in CPK level during 4-weeks swim practices by 59.41% (p=0.044). Whereas for muscle soreness (overall and specifically in arms and thighs), there was no significant differences between before and after the 4-weeks swim practices. As a conclusion, participation in 4-weeks swim practices resulted in significant serum CPK enzyme elevation, but there was lack of significance in muscle soreness differences on swimmers of College swimming club.

Frenotomy in Infants with Tongue-Tie and Breastfeeding Problems

2018 ◽  
Vol 35 (4) ◽  
pp. 706-712 ◽  
Author(s):  
Anjana Srinivasan ◽  
Alex Al Khoury ◽  
Svetlana Puzhko ◽  
Carole Dobrich ◽  
Meira Stern ◽  
...  
Keyword(s):  
Medical Community ◽  
Rank Test ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test ◽  
Breastfeeding Counseling ◽  
The Right ◽  
Breastfeeding Problems ◽  
Numeric Rating

Background: Infant tongue-tie can cause breastfeeding problems, which may be improved by frenotomy. However, controversy exists among the medical community. Research aim: To examine the influence of frenotomy on infants with posterior ankyloglossia, by quantifying the changes in breastfeeding and maternal nipple pain using standardized tools. Methods: Newborns ( N = 30) below 12 weeks of age were recruited from the Herzl–Goldfarb Breastfeeding Clinic between April 2014 and April 2015. Diagnosis of posterior ankyloglossia was made clinically. Frenotomy was performed. Mothers received breastfeeding counseling before and after the procedure. Pain and breastfeeding were assessed before the procedure, immediately after the procedure, and after 2 days, 7 days and 14 days. Breastfeeding was assessed using the LATCH Tool and by subjective questioning. Maternal nipple pain was assessed using the Numeric Rating System. Results: No complications were reported with frenotomy. There was a significant improvement in LATCH score immediately post-frenotomy, with an increase in median scores from 7.5 to 8.5 ( p < .0001, Wilcoxon signed rank test). There was a significant decrease in median pain score immediately post-frenotomy, from 3.0 on the left nipple and 3.25 on the right nipple, to 0 bilaterally ( p < .0001, Wilcoxon signed rank test). Subjective improvement in breastfeeding was reported by 90% of mothers immediately after frenotomy and 83% of mothers at Day 14. Conclusion: Frenotomy for posterior ankyloglossia may improve breastfeeding and nipple pain.

scholarly journals Improving indicators of tuberculosis program cascades by leveraging HIV program strategies

2019 ◽  
Vol 9 (4) ◽  
pp. 191-195
Author(s):  
S. C. Meribe ◽  
E. Harausz ◽  
I. Lawal ◽  
A. Ogundeji ◽  
C. Mbanefo ◽  
...  
Keyword(s):  
Standard Of Care ◽  
Rank Test ◽  
Military Hospitals ◽  
Us Army ◽  
Signed Rank ◽  
Before And After ◽  
Army Medical Research ◽  
Signed Rank Test ◽  
The Impact ◽  
Number Of Individuals

Background: To improve rates of human immunodeficiency virus (HIV) case detection and treatment, the Nigerian Ministry of Defense Health Implementation Program and the US Army Medical Research Directorate-Africa/Nigeria introduced a HIV standard of care (SOC) package. Given the integration of tuberculosis (TB) and HIV programs and evolving policies, we evaluated the impact of this strategy on TB program indicators.Methods: Routine, de-identified program data from 27 Nigerian military hospitals were analyzed. Using Wilcoxon signed-rank test, bivariate analyses were performed to compare data from 12 months before and after implementation of the SOC package.Results: Our data showed improvements post-implementation as follows: the number of individuals receiving antiretroviral therapy (ART) screened for TB increased from 14 530 to 29 467 (P < 0.001); the number of individuals with presumptive TB identified increased from 803 to 1800 (P < 0.001); the number of ART clients bacteriologically tested for TB increased from 746 to 1717 (P < 0.001); and the number of ART clients treated for TB increased from 152 to 282 (P < 0.001). Newly registered or relapsed TB cases increased from 436 to 906 (P < 0.001), the number of TB cases with known HIV status increased from 437 to 837 (P < 0.001), the number of TB-HIV co-infected cases increased from 182 to 301 (P = 0.006), and the number of TB-HIV co-infected clients who started ART increased from 101 to 176 (P = 0.003).Conclusion: The implementation of the updated HIV SOC package led to the improvement in key TB diagnosis and treatment indicators. When emulated, this could help improve the performance of other TB programs in countries other than Nigeria.

scholarly journals MARKET REACTION ON THE ANNOUNCEMENT OF SRI KEHATI INDEX IN INDONESIAN STOCK EXCHANGE

2019 ◽  
Author(s):  
Anggita Langgeng Wijaya ◽  
Mia Noviyanti ◽  
Probo Mahayu
Keyword(s):  
Trading Volume ◽  
Market Reaction ◽  
Stock Exchange ◽  
Abnormal Returns ◽  
Rank Test ◽  
Stock Trading ◽  
Population Sampling ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test

The purpose of this study was to test the market reaction to the announcement of the Sri Kehati Index on the Indonesia Stock Exchange. The population in this study is all companies included in the Sri Kehati Index from 2013 to 2016. The selection of samples was taken by the population sampling method. Hypothesis testing is done by paired t test and Wilcoxon Signed Rank Test. The findings of this research are: 1) there is no difference in abnormal returns before and after the announcement of the Sri Kehati Index on the Indonesia Stock Exchange. 2) There is a difference in the activity of stock trading volume before and after the announcement of the Sri Kehati index in the 5th and 6th periods, but there is no difference in the activity of stock trading volume in other periods. The Indonesia Stock Exchange did not react consistently to the announcement of the Sri Kehati Index.

scholarly journals Effectiveness of Picture Story Books Reading to Increase Kindness in Children Aged 5-6 Years

2018 ◽  
Vol 12 (1) ◽  
pp. 89 ◽  
Author(s):  
Giyati Retnowati ◽  
Rose Mini Agoes Salim ◽  
Airin Y Saleh
Keyword(s):  
Test Score ◽  
Measurement Instrument ◽  
Rank Test ◽  
Average Score ◽  
Storybook Reading ◽  
Signed Rank ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
Signed Rank Test

This research aimed to determine the effectiveness of picture in storybook reading to increase kindness in children. This research involved 31 children aged 5-6 years; they were taken from the kindergarten in Bandung as the participants. The intervention was done by reading eight picture books in eight days. The kindness was measured using a measurement instrument created by the researcher, in the form of nine coloured cards that described the behaviour of kindness. The measurement was also done by seeing through the kindness tree and observation sheets that filled out by the teacher. The data analysis using the Wilcoxon Signed-rank test shows a significant difference in the average score of kindness (p<0,05) before and after picture storybook reading. Two weeks after the intervention, the improvement on all kindness behaviours with the post-test score is greater than pre-test score that still can be found. Observation through kindness tree and observational sheets shows the same result.

scholarly journals Analisis Kinerja Keuangan Bank Umum Syariah Sebelum dan Sesudah Pengalihan Dana Haji pada Bank Syariah

2021 ◽  
Vol 1 (2) ◽  
pp. 309-331
Author(s):  
Lisa Erliana Marwan ◽  
Iwan Setiawan ◽  
Ine Mayasari
Keyword(s):  
Financial Performance ◽  
Rank Test ◽  
Positive Contribution ◽  
Islamic Banks ◽  
Fund Management ◽  
Financial Report ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
Conventional Banks

Government policy through UU No 34 Thn 2014 about Hajj Fund Management said that the Hajj Fund Management should with the principle of sharia. Then in 2014, there was a transfer Hajj Fund from Conventional banks to Islamic banks. Hajj Fund that transferred to Islamic banks have a large value so it can give positive contribution to the  financial performance such as DPK.The aim of this study was to find out the financial performance of 6 BPS BPIH before and after the transfer of Hajj Fund from conventional banks to Islamic banks. Taking case studies at PT. Bank Syariah Mandiri, PT. Bank BRI Syariah, PT. Bank BNI Syariah, PT. Bank Mega Syariah, PT. Bank Panin Dubai Syariah, and PT. Bank Muamalat.  The Data that used in this study is Return On Assets (ROA) and Financing to Deposit Ratio (FDR) in Quarterly Financial Report of 6 BPS BPIH,4 years before the transfer of hajj fund that started 2010 until 2013, and 4 years after the transfer of hajj fund that started from 2015 until 2018. The method of data analysis in this study uses a different samples in non parametrik, which is Wilcoxon Signed Rank Test. The result of this  study  shows us that there was a difference in ROA and FDR of BPS BPIH before and after the transfer of  hajj  fund  from  conventional  banks  to Islamic banks.

scholarly journals Amprenavir and Efavirenz Pharmacokinetics before and after the Addition of Nelfinavir, Indinavir, Ritonavir, or Saquinavir in Seronegative Individuals

2005 ◽  
Vol 49 (8) ◽  
pp. 3373-3381 ◽  
Author(s):  
Gene D. Morse ◽  
Susan Rosenkranz ◽  
Michael F. Para ◽  
Yoninah Segal ◽  
Robin DiFrancesco ◽  
...  
Keyword(s):  
Confidence Intervals ◽  
Geometric Mean ◽  
Rank Test ◽  
Control Group ◽  
Median Percentage ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test ◽  
Aids Clinical Trials

ABSTRACT Adult AIDS Clinical Trials Group 5043 examined pharmacokinetic (PK) interactions between amprenavir (APV) and efavirenz (EFV) both by themselves and when nelfinavir (NFV), indinavir (IDV), ritonavir (RTV), or saquinavir (SQV) is added. A PK study was conducted after the administration of single doses of APV (day 0). Subjects (n = 56) received 600 mg of EFV every 24 h (q24h) for 10 days and restarted APV with EFV for days 11 to 13 with a PK study on day 14. A second protease inhibitor (PI) (NFV, 1,250 mg, q12h; IDV, 1,200 mg, q12h; RTV, 100 mg, q12h; or SQV, 1,600 mg, q12h) was added to APV and EFV on day 15, and a PK study was conducted on day 21. Controls continued APV and EFV without a second PI. Among subjects, the APV areas under the curve (AUCs) on days 0, 14, and 21 were compared using the Wilcoxon signed-rank test. Ninety-percent confidence intervals around the geometric mean ratios (GMR) were calculated. APV AUCs were 46% to 61% lower (median percentage of AUC) with EFV (day 14 versus day 0; P values of <0.05). In the NFV, IDV, and RTV groups, day 21 APV AUCs with EFV were higher than AUCs for EFV alone. Ninety-percent confidence intervals around the GMR were 3.5 to 5.3 for NFV (P < 0.001), 2.8 to 4.5 for IDV (P < 0.001), and 7.8 to 11.5 for RTV (P = 0.004). Saquinavir modestly increased the APV AUCs (GMR, 1.0 to 1.4; P = 0.106). Control group AUCs were lower on day 21 compared to those on day 14 (GMR, 0.7 to 1.0; P = 0.042). African-American non-Hispanics had higher day 14 efavirenz AUCs than white non-Hispanics. We conclude that EFV lowered APV AUCs, but nelfinavir, indinavir, or ritonavir compensated for EFV induction.

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