Progress in oncology biosimilars till 2020: Scrutinizing comparative studies of biosimilar monoclonal antibodies

2021 ◽  
pp. 107815522110160
Author(s):  
Aqsa Safdar ◽  
Muhammad Hammad Butt ◽  
Abrar Ahmad ◽  
Muhammad Zaman
Keyword(s):  
Monoclonal Antibodies ◽  
Comparative Studies ◽  
Healthcare Professionals ◽  
Reference Product ◽  
Point Of View ◽  
Biological Drugs ◽  
Regulatory Aspects ◽  
The World ◽  
Clinical Point ◽  
Different Parts

Stupendous elevation in the healthcare costs has followed with the inception of the current unconventional options of treatment available for cancer patients. There is a dire need of innovative financing approaches to lessen the financial load on healthcare system. Biosimilars are biological drugs consisting of an active ingredient from a reference biological drug that has a great potential of relieving financial load. Strict requirements from regulatory point of view are required as biosimilars are exceedingly similar to but not identical to the reference product. This provides with a certainty that no consequential differences from clinical point of view as compared to the respective biologics exists with regards to efficacy, safety and purity. Safety and effectiveness of biosimilars have been disclosed since more than 10 years of affirmations. However, there is a need to educate the healthcare professionals to abolish potential misconceptions and coalesce biosimilars into regular clinical practice. The present review focuses on providing an overview of regulatory aspects and requirements for biosimilars, the main challenges in the selection and development of biosimilars and the economic impact and financial savings observed in recent studies carried out in different parts of the world. In addition, we have discussed the different successful comparative studies which have been done in different parts of the world to depict the biosimilarity for monoclonal antibodies such as bevacizumab, trastuzumab and rituximab.

DETERMINANTS OF TERROR ACTS ACCOMPLISHES-SUICIDE BOMBERS BEHAVIOR

2018 ◽  
Vol 1 (82) ◽  
pp. 29
Author(s):  
Gediminas Buciunas
Keyword(s):  
National Security ◽  
Country Of Origin ◽  
Point Of View ◽  
Direct Connection ◽  
Moon Phases ◽  
Suicide Bombers ◽  
The World ◽  
Criminal Background ◽  
Psychological Point ◽  
Different Parts

The aim of this paper is to analyze determinants which impact on behaviour of terror acts accomplishes-suicide bombers from psychological point of view, for example, whether there is a direct connection between Moon phases and suicide terrorists who conducted terror acts from 2015 to 2016 in the different parts of the world. The author also analyzes randomly selected terror acts carried out between 2016 and 2017 in the continent of Europe. Several factors have been taken into account, such as: terror acts location, suicide terrorist’s citizenship, country of origin, age, education, criminal background, country’s unemployment rate.The novelty of this paper is the fact that this type of research was not been carried out yet. This will allow us to see a more precise direction which should be taken in order to effectively prevent terror acts and what kind of changes can be carried out in certain programs for identification of individuals who may be posed real threat to country’s national security, can be easier involved into terror organizations activities than others.

scholarly journals Missing Maps Project and Its Use in Education

2020 ◽  
Vol 2 ◽  
pp. 1-1
Author(s):  
Jan Brodský
Keyword(s):  
Remote Sensing ◽  
Open Source ◽  
Crisis Management ◽  
Satellite Imagery ◽  
Geographic Information ◽  
Point Of View ◽  
Non Profit ◽  
Real Model ◽  
The World ◽  
Different Parts

Abstract. The article is about OpenStreetMap and Missing Maps Project and their introducing in the remote sensing classes at universities to show potential of geographic information to improve education of people about how to help to solve the disaster and crisis situations in the World. This approach also serves as a real model for learning to interpret satellite imagery in such situations.At the beginning of the article different kinds of disasters are briefly mentioned including their causes and effect on the life of people. Then crisis management is briefly introduced from the point of view selected voluntary projects which are analysed to make process more targeted and efficient. After that Missing Maps project is introduced together with OpenStreetMap and their outputs on the example of non-profit organization Doctors Without Borders (MSF) operating in different parts of the World. In the next part the ways how to contribute and improve their activities and how the whole cooperation works are arranged. Next part of the article focuses on Missing Maps mapathons (meetings of volunteers who create open-source maps for MSF) and the way how they are organized in Brno, Czechia. Editing of the OpenStreetMap for the Missing Maps project has been recently introduced to usual remote sensing classes for students of Masaryk University in Brno. Information about this activity is also described.

scholarly journals Biosimilars: New guns for the treatment of rheumatologic patients?

2019 ◽  
Vol 1 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Daniela Marotto ◽  
Angela Ceribelli ◽  
Piercarlo Sarzi Puttini
Keyword(s):  
Healthcare Professionals ◽  
Medical Information ◽  
Reference Product ◽  
Point Of View ◽  
Biological Therapies ◽  
Great Opportunity ◽  
Economic Point ◽  
The Right ◽  
Current Guidelines ◽  
Rheumatic Patients

The advent of biological therapies in 2000s has represented a real revolution in the treatment of patients affected by rheumatic diseases, but biosimilars represent nowadays a further revolution both from an economic point of view and for the accessibility to treatment for rheumatic patients. The main scientific rheumatologic societies have clearly expressed themselves on the biosimilars topic, by highlighting how they represent a great opportunity to contain costs and treat more patients, and these advantages should be accepted by rheumatologists. The use of biosimilars in different European countries varies widely; in fact, in some of them their use is mandatory (at least in naïve patients), while in other countries it is only recommended. The knowledge and consequently the acceptance of biosimilars are different among patients, and this also depends on the correct medical information on this topic. As more and more biosimilars receive regulatory approval and reach the market, it is essential for healthcare professionals to have the right knowledge about them, so that they are properly transferred to their patients. Biosimilars are not identical to the reference product, and clinicians are particularly interested in the safety and effectiveness of switching from the biooriginator to the bio-similar in experienced patients. We will develop these aspects on biosimilars in the present manuscript, for an update on current guidelines in their use in rheumatic patients.

scholarly journals Trading Partners: New Views on Theatre Translation in Canada

2003 ◽  
Vol 15 (1) ◽  
pp. 117-135 ◽  
Author(s):  
Glen Nichols
Keyword(s):  
Detailed Analysis ◽  
Fairy Tales ◽  
Point Of View ◽  
Reference Source ◽  
Canadian Theatre ◽  
The World ◽  
Trading Partners ◽  
Linguistic Groups ◽  
Different Parts

Abstract What kinds of modern Canadian plays are most often translated or adapted for production elsewhere in Canada or overseas? How many modern Canadian plays are translations or adaptations of non-theatrical originals (novels, poetry, fairy tales)? Where can one find out if a translation of a Canadian play is available? These are among the questions addressed by the catalogue From Around the World and at Home: Translations and Adaptations in Canadian Theatre, the first comprehensive database of Canadian theatre translations. This paper examines the two basic questions of translation in Canadian theatre as revealed by the database, not from the usual point of view of one or several individual works looked at closely, but from the broader perspective of a large statistical overview: 1. What is the state of theatre translation within the borders of Canada? That is, what transfers are happening between linguistic groups within Canada? And what role do inter-generic translations play here? 2. Are there regional variations in terms of overseas influence? In other words, do different parts of Canada look to different parts of the world for theatrical sources? Published by Playwrights Union of Canada in 2001, the Catalogue contains over 3000 separate entries, including source and target references to Canadian plays translated for production or publication either inside or outside Canada, and Canadian plays which are themselves translations of other domestic or overseas pieces. With the term “translation” including generic as well as linguistic transfers, the Catalogue is designed to serve as both a reference source and the basis for more detailed analysis of the ongoing role of translation in Canadian theatre.

The Patient

2018 ◽  
pp. 19-37
Keyword(s):  
Point Of View ◽  
The Self ◽  
The World ◽  
Clinical Point ◽  
The Mind ◽  
The Brain

This chapter addresses the issue of a stroke's impact on consciousness and the self, from a clinical point of view. We look at how the mind is seen by three experts—a neuroscientist, a brain surgeon, and a neuro-philosopher—and find that, instead of solving the mystery of the mind, they in fact add to it. Indeed, they all agree on the lingering mystery of consciousness, underneath and beyond the brain, as well as on the surprising rapport the self seems to establish to the world and its environment – in ways that are not constitutive to the brain itself. This suggests we might need to call on psychologists and sociologists next, to help us solve the conundrum of the self.

General discussion: climatic analysis

1977 ◽  
Vol 280 (972) ◽  
pp. 341-350 ◽  
Keyword(s):  
Climatic Change ◽  
Large Scale ◽  
Point Of View ◽  
Last Glaciation ◽  
Field Evidence ◽  
The World ◽  
Scientific Papers ◽  
The Many ◽  
Different Parts

In opening the proceedings of this meeting Mr J. S. Sawyer of the U.K. Meteorological Office uttered the view that it is really premature as yet to ask a meteorologist to interpret the events of the last glaciation. Nevertheless, that is just what I have been asked to do and, though one must tread warily, I believe it must be attempted. Indeed, it has been attempted in a number of scientific papers in recent years and these two days’ proceedings have surely helped us to see a number of things more clearly. I have no time to do justice to all the points that appear interesting. A meteorologist looks first for the large-scale patterns, which are probably the least difficult to discern and which provide the framework into which all else must fit. Most meteorologists, oceanographers and perhaps all who are neither geologists nor palaeobotanists, will also probably echo Professor W. A. Watts’s reservations about the many names adopted for the various cold and warm stages. One must acknowledge the need which has called the multiplicity of naming systems into being, but the outsider can only accept them reluctantly as marking a provisional stage until the dating is firm and the correspondence of the events known by different names in different parts of the world has been established. This huge, and growing, vocabulary is formidable to those outside the debates about the field evidence and tends to deter other scientists who might contribute to interpreting the processes of climatic change in the Quaternary. From this point of view, and to such audiences, dates and numbered stages, or one single series of names, are much to be preferred.

Medical Diagnosis from a Clinician’s Point of View

1978 ◽  
Vol 17 (01) ◽  
pp. 28-35
Author(s):  
F. T. De Dombal
Keyword(s):  
Decision Making ◽  
Data Analysis ◽  
Computer Science ◽  
Medical Diagnosis ◽  
Information Science ◽  
Point Of View ◽  
Joint Research ◽  
The World

This paper discusses medical diagnosis from the clinicians point of view. The aim of the paper is to identify areas where computer science and information science may be of help to the practising clinician. Collection of data, analysis, and decision-making are discussed in turn. Finally, some specific recommendations are made for further joint research on the basis of experience around the world to date.

Russia and China: The Vector of Development of Economic Cooperation

2004 ◽  
pp. 113-122
Author(s):  
L. Kabir
Keyword(s):  
World Economy ◽  
Economic Cooperation ◽  
Point Of View ◽  
Basic Commodity ◽  
The World ◽  
Economic Ties

This article considers the basic tendencies of development of trade and economic cooperation of the two countries with accent on increasing volumes and consolidating trade and economic ties in Russian-Chinese relations. The author compares Russian and Chinese participation in the world economy and analyzes the counter trade from the point of view of basic commodity groups.

THE GENESIS OF CONSERVATIVE IDEOLOGY, DEVELOPMENT TRENDS AND PROSPECTS IN THE POLITICAL REFORM OF MODERN COUNTRIES (ON THE EXAMPLE OF RUSSIA AND FRANCE)

2020 ◽  
Vol 10 (4) ◽  
pp. 38-43
Author(s):  
MARIETA EPREMYAN ◽  
Keyword(s):  
Political Reform ◽  
Point Of View ◽  
The Political ◽  
Development Trends ◽  
Conservative Ideology ◽  
The World ◽  
Christian Conservatism ◽  
The Future ◽  
Conservative Policy ◽  
Depth Interviews

The article examines the epistemological roots of conservative ideology, development trends and further prospects in political reform not only in modern Russia, but also in other countries. The author focuses on the “world” and Russian conservatism. In the course of the study, the author illustrates what opportunities and limitations a conservative ideology can have in political reform not only in modern Russia, but also in the world. In conclusion, it is concluded that the prospect of a conservative trend in the world is wide enough. To avoid immigration and to control the development of technology in society, it is necessary to adhere to a conservative policy. Conservatism is a consolidating ideology. It is no coincidence that the author cites as an example the understanding of conservative ideology by the French due to the fact that Russia has its own vision of the ideology of conservatism. If we say that conservatism seeks to preserve something and respects tradition, we must bear in mind that traditions in different societies, which form some kind of moral imperatives, cannot be a single phenomenon due to different historical destinies and differing religious views. Considered from the point of view of religion, Muslim and Christian conservatism will be somewhat confrontational on some issues. The purpose of the work was to consider issues related to the role, evolution and prospects of conservative ideology in the political reform of modern countries. The author focuses on Russia and France. To achieve this goal, the method of in-depth interviews with experts on how they understand conservatism was chosen. Already today, conservatism is quite diverse. It is quite possible that in the future it will transform even more and acquire new reflections.

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