Treatment of Skin Injury due to Vinorelbine Extravasation Using bFGF and rhGM-CSF: An Experimental Study in a Murine Model

Background and objective: A murine model of skin injury from vinorelbine extravasation was established to evaluate the treatment efficacy of basic fibroblast growth factor (bFGF) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF). Materials and method: Experimental models were divided into bFGF, rhGM-CSF, and control (saline) groups, with 40 mice in each group. Edema and ulceration were measured on Days 1, 3, 5, 7, 10, 14, and 18 after the onset of extravasation; injuries were examined pathomorphologically in three mice/group/time point. Results: Edema reached maximum size on Day 3 in the bFGF and rhGM-CSF groups and Day 5 in the control group. The difference between the two experimental groups was not significant; differences between the control group and the experimental groups were statistically significant at all time points. Edema and ulceration began to improve on Day 10 in the bFGF and rhGM-CSF groups and Day 18 in the control group. Healing duration was 14—18 days in the experimental groups, with a (not significantly) shorter duration in the bFGF group. Healing was completed by Day 27.5 in the control group. Pathomorphological evaluation showed regular reepithelization and newly formed granulation tissue in the bFGF and rhGM-CSF groups on Day 13. In the control group, wounds were partially healed, edema and shallow ulcers existed, and epithelization was fragile and disorganized on Day 18. Conclusions: bFGF and rhGM-CSF are useful for the treatment of skin injury due to vinorelbine extravasation, but bFGF may be slightly more effective in decreasing time and improving quality of healing.

Download Full-text

Smile esthetic evaluation of mucogingival reconstructive surgery

Odontology ◽

10.1007/s10266-020-00544-6 ◽

2020 ◽

Vol 109 (1) ◽

pp. 295-302

Author(s):

Roberto Rotundo ◽

Luigi Genzano ◽

Michele Nieri ◽

Ugo Covani ◽

David Peñarrocha-Oltra ◽

...

Keyword(s):

Treatment Group ◽

Test Group ◽

Collagen Matrix ◽

Gingival Recession ◽

Control Group ◽

Root Coverage ◽

Coronally Advanced Flap ◽

The Difference ◽

And Control

AbstractTo assess the difference in smile esthetic impact of Coronally Advanced Flap (CAF) with or without the adjunct of a collagen matrix (CMX) used as root coverage procedures. Subjects with esthetic demands showing multiple upper gingival recessions of at least 2 mm, without interproximal attachment loss and cervical abrasion no more than 1 mm were recruited and randomized to CAF plus CMX or CAF alone. The Smile Esthetic Index (SEI) was adopted to quantify the quality of the smile recorded at baseline and 12 months after treatment for each treatment group. In addition, between group difference in the SEI was calculated. 24 Patients were treated and analysed. At baseline, mean gingival recession depths were 2.3 ± 0.7 mm for Test group and 2.6 ± 1.0 mm for Control group. After 1 year, the residual recession depth was 0.3 ± 0.4 mm in the CAF + CMX group and 0.6 ± 0.3 mm in the control group. The SEI at baseline was 8.1 ± 1.0 and 7.9 ± 0.7 for Test and Control group, respectively. The between groups difference at 12 months in SEI was 0.4 (95% C.I. − 0.0 to 0.8, P = 0.0697). Twelve months after treatment, CAF + CMX provided a similar SEI compared to CAF alone and the adjunct of a collagen matrix did not show a different impact on the smile esthetic appearance.

Download Full-text

Efecto de una intervención estructurada de enfermería en disminución del hábito tabáquico en mujeres fumadoras

Enfermería Global ◽

10.6018/eglobal.18.1.315761 ◽

2018 ◽

Vol 18 (1) ◽

pp. 281-303

Author(s):

Patricia Cid Henriquez ◽

Olivia Sanhueza Alvarado ◽

José Manuel Merino ◽

Katia Sáez Carrillo

Keyword(s):

Quality Of Life ◽

Intervention Group ◽

Control Group ◽

Calidad De Vida ◽

Structured Intervention ◽

The Difference ◽

Las Mujeres ◽

And Control ◽

Los Grupos

Introducción: El consumo del tabaco está asociado al incremento de la morbilidad y la mortalidad femenina. Este hábito implica además un deterioro en la calidad de vida relacionada con salud. El propósito de esta investigación fue determinar el efecto de una intervención estructurada que motivara a las mujeres a disminuir el consumo diario de cigarrillos y mejorar su calidad de vida. Método: Diseño experimental con preprueba-postprueba y grupo de control con asignación de los grupos al azar. De 120 personas se homologaron los dos grupos con cinco caracteristicas, se homologó nuevamente la muestra porque respondieron la entrevista en domicilio sólo 64 personas. El grupo intervención estuvo constituido por 10 mujeres entre 18 y 65 años de la región del Bio- Bío, y el grupo control por 20 mujeres. Se aplicó un cuestionario semiestructurado de características sociodemográficas, de test, cuestionarios y escalas que midieron las variables asociadas al consumo, y las orientaciones subjetivas y conductuales, previo consentimiento informado. La intervención estructurada estuvo conformada por: métodos activos de aprendizaje, consejería con énfasis en el fortalecimiento de la percepción de autoeficacia. Resultados: La diferencia de medias en el tiempo y la diferencia de medias entre los grupos (grupo tratamiento y grupo control) es de casi 5 cigarrillos (4,8), esta interacción (tiempo-grupo) resulta a un nivel de significación menor al uno por diez mil.Conclusiones: Esta intervención requiere de reforzamiento periódico hasta lograr la deshabituación tabáquica e incidir en la calidad de vida relacionada con salud de las mujeres con hábito tabáquico. Introduction: Tobacco consumption is associated with an increase in female morbidity and mortality. This habit also implies deterioration in the quality of life related to health. The purpose of this research was to determine the effect of a structured intervention that motivated women to reduce their daily consumption of cigarettes and improve their quality of life.Method: Experimental design with pre-test-post-test and control group with allocation of the groups at random. Out of 120 people, the two groups were approved with five characteristics. The sample was homologated again because the home interview was answered by only 64 people. The intervention group consisted of 10 women between 18 and 65 years old from the Bio-Bio region, and the control group by 20 women. A semi-structured questionnaire with sociodemographic characteristics, test, questionnaires and scales that measured the variables associated with consumption, and subjective and behavioral guidelines, with prior informed consent, was applied. The structured intervention consisted of: active learning methods, counseling with emphasis on strengthening the perception of self-efficacy. Results: The difference of means in time and the difference of means between the groups (treatment group and control group) is of almost 5 cigarettes (4,8). This interaction (time-group) results has a level of significance less than one in ten thousand. Conclusions: This intervention requires periodic reinforcement to achieve smoking cessation and affect the quality of life related to health of women with smoking.

Download Full-text

The clinical application of an innovative tracheotomy fixation belt in critically ill patients

Technology and Health Care ◽

10.3233/thc-213537 ◽

2021 ◽

pp. 1-5

Author(s):

Gui-Li Zhang ◽

Ping Hao ◽

Zhi-Jing Shi ◽

Lei Xu ◽

Yun-Mei Shi ◽

...

Keyword(s):

Critically Ill ◽

Critically Ill Patients ◽

Fixation Method ◽

Control Group ◽

Observation Group ◽

Skin Damage ◽

Tracheotomy Tube ◽

Skin Injury ◽

The Difference ◽

And Control

BACKGROUND: Tracheotomy is one of the first-aid measures for rescuing critically ill patients. OBJECTIVE: This study was designed to observe the clinical effect of using an innovative tracheotomy fixation belt in critically ill patients and to explore the feasibility of using this fixation method. METHODS: Eighty critically ill patients requiring a tracheotomy in Putuo District Central Hospital of Shanghai were enrolled in this study and divided into the observation group and control group (n= 40, each). In the control group, fixation was performed with conventional cotton twill tape, while in the observation group the fixation was carried out using a tracheotomy fixation belt. The differences in neck skin injury, the occurrence of eczema, and the rate of detachment of the tracheotomy tube in the two groups were compared. RESULTS: The rate of neck skin injury was 7.5% lower in the observation group than in the control group (30%), and the difference was statistically significant (p< 0.05). The incidence of skin eczema was 5% lower in the observation group than in the control group (22.5%), and the difference was statistically significant (p< 0.05). The detachment rate of the tracheotomy tube was 5% lower in the observation group than in the control group (20%), and the difference was statistically significant (p< 0.05). CONCLUSION: The use of an innovative tracheotomy fixation belt can effectively reduce skin damage to the patient’s neck, the incidence of eczema, and the incidence of detachment of the tracheotomy tube.

Download Full-text

Multiplication of the Enterocyte Mass by Serosal Patch Technique / Umnožavanje Enterocitne Mase Tehnikom Seroznog Patch-A

Acta veterinaria ◽

10.1515/acve-2015-0014 ◽

2015 ◽

Vol 65 (2) ◽

pp. 162-174

Author(s):

P. Slobodan Grebeldinger ◽

S. Branka Radojčić ◽

N. Jelena Ćulafić ◽

M. Bojana Andrejić Višnjić

Keyword(s):

Small Intestine ◽

Control Group ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Hematopoietic Stem ◽

Macrophage Colony Stimulating Factor ◽

Macrophage Colony ◽

Patch Technique ◽

Stimulating Factor

Abstract Damage to the small intestine and impairment of the intestinal epithelium occur in various diseases, resulting in a need for new epithelium. Therefore, bioengineering of the small intestine is becoming an attractive field of research where all contributions are highly appreciated. The purpose of this study was to determine the possibility of the multiplication of the enterocyte mass using the technique of serosal patch with the application of hematopoietic stem cells, as well as the assessment of the quality of newly formed mucosa. Sixty Mill Hill hooded rats were divided in 4 groups, 15 animals each. In the control group animals, the patch was not created. In the other three groups, the animals were operated on and in each group 8 parietal and 7 visceral patches have been created. One of the groups with operated animals (Group NS) was not postoperatively treated. The second group of operated animals (Group G) was stimulated with granulocyte colony-stimulating factor (G-CSF). The third group of operated animals (Group GM) was stimulated with recombined humane granulocyte-macrophage colony-stimulating factor (rHuGM-CSF). In the group of animals that were not stimulated, epithelium proliferated slowly. In the group of animals stimulated with G-CSF stimulants, the epithelium initially proliferated rapidly, but appeared atrophic after eight weeks. Stimulation by rHuGM-CSF led to faster epithelization, and epithelium showed signs of advancing proliferation after eight weeks. We confirmed the possibility of enterocyte mass multiplication by using the serosal patch technique, as well as that stimulation with rHuGM-CSF is more effective than stimulation with G-CSF.

Download Full-text

Effects of Aromatherapy with Lavender and Peppermint Essential Oils on the Sleep Quality of Cancer Patients: A Randomized Controlled Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/7480204 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Sahar Hamzeh ◽

Roya Safari-Faramani ◽

Alireza Khatony

Keyword(s):

Sleep Quality ◽

Essential Oils ◽

Cancer Patients ◽

Controlled Trial ◽

Control Group ◽

Significant Difference ◽

The Mean ◽

The Difference ◽

And Control

One of the problems of cancer patients is sleep disorder. Given the absence of studies on comparing the effect of inhalation aromatherapy with lavender and peppermint on the sleep quality of the cancer patients, this study was performed to compare the effect of inhalation aromatherapy with lavender and peppermint essential oils on the sleep quality of cancer patients. For this purpose, 120 patients were randomly allocated to three groups of lavender, peppermint, and control. The intervention groups received three drops of the essential oil for 7 days. In the control group, aromatic distilled water was used instead. Pittsburgh Sleep Quality Inventory (PSQI) was used. Before the intervention, no significant difference was observed between the mean PSQI scores of three groups, while the difference was statistically significant after the intervention. The mean PSQI scores were lower in lavender and peppermint groups than in the control group. Aromatherapy can improve the sleep quality of cancer patients. To confirm the findings, more studies should be done.

Download Full-text

The effectiveness of acceptance and commitment therapy on perceived stress, resilience, and the quality of life in thalassemia major patients

Journal of Shahrekord University of Medical Sciences ◽

10.34172/jsums.2019.16 ◽

2019 ◽

Vol 21 (2) ◽

pp. 91-97

Author(s):

Fariborz Jabbarifard ◽

Tayebeh Sharifi ◽

Kamal Solati ◽

Ahmad Ghazanfari

Keyword(s):

Quality Of Life ◽

Perceived Stress ◽

Thalassemia Major ◽

Control Group ◽

Stress Resilience ◽

Acceptance And Commitment ◽

Significant Difference ◽

The Difference ◽

And Control

Background and aims: The present study aimed to determine the effect of acceptance and commitment therapy on perceived stress, resilience, and the quality of life in thalassemia major patients in Lordegan during 2015-2016. Methods: This semi-experimental study used the pre-test and post-test designs with a control group and period. The samples included 40 patients with thalassemia major who referred to Lordegan Shohada hospital, were selected by the purposeful sampling technique based on the inclusion and exclusion criteria, and were randomly assigned to experimental and control groups. The experimental group received eight-week sessions of the acceptance and commitment-based therapy, while the control group received no intervention until the end of the study. The data were collected by the perceived stress questionnaire (Cohen et al), Researcher Conner and Davison Resilience Scale, and the World Health Organization Quality of Life (SF-26). Finally, the obtained data were analyzed using the SPSS software, repeated measure, and covariance tests Results: The results showed that there was a significant difference between the experimental and control groups in terms of the perceived stress, resilience, and the quality of life (P<0.001). In addition, based on the results, 66% of the changes in the perceived stress scores, 81% of the difference in the resiliency scores, and 75% of the difference in the quality of life scores were related to the impact of therapy based on the acceptance and group commitment. Further, the results of the analysis variance of the internal group revealed that the effect of therapy based on the acceptance and commitment on the perceived stress, resilience, and the quality of life had a significant difference in pretest, posttest, and follow-up stages. Conclusion: In general, the therapy based on the acceptance and commitment is found to be a useful practice in reducing the perceived stress while increasing the resilience and improving the quality of life in patients with thalassemia major.

Download Full-text

PATHOGENETIC ROLE OF MACROPHAGE COLONY-STIMULATING FACTOR (CSF-1) IN PREDICTING ENDOMETRIOID DISEASE

Wiadomości Lekarskie ◽

10.36740/wlek202108128 ◽

2021 ◽

Vol 74 (8) ◽

pp. 1939-1944

Author(s):

Yuliia A. Orlova ◽

Antonina M. Hromova ◽

Igor P. Kaidashev ◽

Oksana A. Shlykova ◽

Olha V. Izmailova ◽

...

Keyword(s):

Peritoneal Fluid ◽

Menstrual Blood ◽

Control Group ◽

Study Group ◽

Child Bearing ◽

Macrophage Colony Stimulating Factor ◽

Macrophage Colony ◽

Severity Of The Disease ◽

And Control

The aim: To assess the CSF – 1 level in peritoneal fluid and menstrual blood of women with endometrioid disease and to investigate its diagnostic and prognostic specificity. Materials and methods: The study included 80 women of child-bearing age (mean age 30.95 ± 6.49 years) with benign gynaecological pathology of the ovaries and / or fallopian tubes. The women included in the study were divided into two groups: study group (n = 50, mean age 31.04 ± 6.3 years), consisting of patients with confirmed endometrioid disease, and control group (n = 30, mean age 30.8 ± 6.8 years), involving individuals without signs of endometriosis (p> 0.05). Results: We have found significantly higher level of CSF-1 content in the peritoneal fluid in the subjects of the study group (2027.05 ± 732.64 pg / ml) compared with those in the control group (1725.62 ± 466.06 pg / ml) (p = 0.029). There is a tendency towards an increase in CSF-1 level in women with endometriosis in its more severe stages and more severe and extended adhesions. The investigation of CSF-1 content in menstrual blood has demonstrated significant increase in its values in the women of the study group (9431.6 ± 2866.22 pg / ml) compared with the values in the control group (6637.12 ± 954.05 pg / ml), (p = 0.00004). Thus, there is a tendency towards the growth in CSF-1 level in peritoneal fluid and menstrual blood in women with endometriosis and concurrent increase in severity of the disease. Conclusions: There has been found significant increase in CSF-1 content in women with endometrioid disease in both peritoneal fluid and menstrual blood (1.2 and 1.4 times, respectively). Thus, macrophage growth factor (CSF-1) can be used as a diagnostic and prognostic criterion in evaluating the progression of endomertioid disease.

Download Full-text

Exploration and Analysis of the Application of Nursing Risks Management in the Nursing Management of Department of Respiration

Journal of Nursing ◽

10.18686/jn.v1i1.5 ◽

2012 ◽

Vol 1 ◽

pp. 16

Author(s):

Yi Luo

Keyword(s):

Risk Management ◽

Environmental Indicators ◽

Control Group ◽

Observation Group ◽

Nursing Management ◽

Care Satisfaction ◽

The Difference ◽

Safety Accident ◽

And Control

Objective: To analyze the application of nursing risk management in nursing management in Department of Respiration. Method: Select the medical records of 64 cases of hospitalized patients as the research object, then randomly divide them into observation group and control group with 32 cases in each. The observation group is given nursing risk management, and the control group is given basic nursing management. Two groups are compared quality of life and care satisfaction. Results: The environmental indicators, physiological indices and psychological indices, emotional state, degree of independence and social function sub-index score of the patients in the observation group are significantly higher than that of patients in the control group, and the difference is statistically significant (p < 0.05). Patient care satisfaction rate and medical staff satisfaction of the patients in the observation group are significantly better than that of control group, and the difference is significant (p < 0.05). In addition, nursing safety accident rate in the observation group is significantly lower than that of control group, and the difference is significant (p < 0.05). Conclusion: Application of nursing risk management has a high value in nursing management in Department of Respiration, and is worthy of promotion in clinical.

Download Full-text

The Effect of Dongeui Qigong for Prehypertension and Mild Essential Hypertension

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2017/4274538 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Ji-Eun Park ◽

Jung-Eun Kim ◽

Soyoung Jung ◽

Aeran Kim ◽

Hyoju Park ◽

...

Keyword(s):

Blood Pressure ◽

Mild Hypertension ◽

Information Service ◽

Pressure Control ◽

Control Group ◽

Research Information ◽

Control Groups ◽

The Difference ◽

And Control

Although several previous studies have reported the effect of qigong on lowering blood pressure, rigorous trials are lacking. Studies evaluating the effect of qigong on prehypertension are also scarce. This study aimed to assess the effect of qigong on prehypertension and mild hypertension. Participants with prehypertension or mild hypertension were randomized to the Dongeui qigong group or a nontreated control group. In the qigong group, Dongeui qigong was administered 5 times/week for 12 weeks. The control group did not receive any intervention for blood pressure control. Fifty-two participants were included in this study. Even though diastolic blood pressure was significantly reduced in the qigong group after 8 weeks (p=0.04) compared to baseline, the difference in change in blood pressure between the qigong and control groups was not significant. There were no significant differences in quality of life between the qigong and control groups. Dongeui qigong is not significantly effective in pre/mild hypertension compared with controls. This result could be due to a lack of effect of qigong or caused by other factors, such as the type of qigong, target symptoms, inappropriate sample size, and compliance of participants. Trial Registration. This trial is registered with KCT0001397 (Clinical Research Information Service).

Download Full-text

The Implementation of Learning Materials Based on Local Wisdom of Agricultural in Binjai to Improve the Students Problem Solving Abilities

10.31237/osf.io/5xmuh ◽

2019 ◽

Author(s):

Nur Tsalits Fahman Mughni

Keyword(s):

Problem Solving ◽

Control Group ◽

School Grade ◽

Teaching Materials ◽

Quasi Experimental ◽

Equivalent Control ◽

The Subject ◽

And Control ◽

Experimental Group

Teaching materials by integrating local culture makes easier for students to understand the subject matter in the learning process. The aims of the study is to measure the effectiveness of teaching materials based on local wisdom of agriculture in Binjai in improving the students problem solving abilities. The research method was a quasi experimental which use non equivalent control group in the pretest posttest design. The sample of study were students of Senior High School grade X in Binjai that consisted of experiment group which used teaching materials based on local wisdom of agriculture in Binjai and control group that used student handbooks. Teaching materials are tested by material experts and technology experts to ensure the quality of teaching materials. Data collection was conducted through test. The results showed that the teaching materials based on local wisdom of agriculture in Binjai effective in improving students problem solving abilities in the experimental group students based on the results of N gain value was 0.67 which has medium criteria. It means teaching materials based on agricultural local wisdom of agriculture in Binjai can be used as one of the teaching materials in learning activities.

Download Full-text