Vitrectomy with fovea-sparing ILM peeling versus total ILM peeling for myopic traction maculopathy: A meta-analysis

Purpose: To evaluate the effect and safety of fovea-sparing internal limiting membrane (ILM) peeling (FSIP) for myopic traction maculopathy comparing with that of total ILM peeling (TP). Methods: PubMed, Web of science, Embase, Cochrane, EBSCO and CNKI, published until January 2020, were searched. Postoperative best-corrected visual acuity (BCVA), postoperative central foveal thickness (CFT), the rate of visual improvement and anatomic success were the main outcome parameters, and the secondary outcome parameters were postoperative complications. Random-effects models were chosen in regard with multi-studies. Standard mean difference (SMD) with 95% confidence interval (CI) and odds ratio (OR) were applied as effect sizes of continuous and binomial data, respectively. Results: Six comparative studies involving 193 eyes were included. Better postoperative BCVA was detected in the FSIP group (SMD = −0.39, 95%CI: −0.69 to −0.09, p = 0.01). The FSIP group had a higher rate of vision improvement with statistical significance (OR = 3.86, 95%CI: 1.36 to 10.97, p = 0.01). Both surgical methods had similar outcomes for postoperative CFT (SMD = 0.07, 95%CI: −0.27 to 0.40, p = 0.70). The FSIP group had a higher rate of anatomic success, though there was no obvious significance (OR = 2.54, 95%CI: 0.96 to 6.74, p = 0.06). For the development of postoperative full-thickness macular hole (FTMH), the rate was lower in the FSIP group (OR = 0.18, 95%CI: 0.05 to 0.64, p = 0.008). Conclusion: Vitrectomy with fovea-sparing ILM peeling for myopic traction maculopathy could gain better visual outcomes and decrease incidence of FTMH development, though there was no obvious difference in postoperative CFT and the rate of anatomic success between two groups.

Download Full-text

Fertility outcomes of deep infiltrating endometriosis with fertility desire——a meta analysis

10.21203/rs.2.21329/v2 ◽

2020 ◽

Author(s):

yue shen ◽

Ziyi Feng ◽

Lili Jiang ◽

Yue Li ◽

Kuiran Liu

Keyword(s):

Subgroup Analysis ◽

Meta Analysis ◽

Statistical Significance ◽

Random Effect ◽

Random Effect Model ◽

Cochrane Library ◽

Deep Infiltrating Endometriosis ◽

Fertility Desire ◽

Surgical Methods ◽

Infiltrating Endometriosis

Abstract Background: And the incidence of endometriosis has been increased in recent years. Deep infiltrating endometriosis is the most advanced type of endometriosis. The treatments for patients with DIE and fertility desire are controversial. Materials and Methods: We had search Pubmed, OVID Medline, Cochrane Library published before 2019-10-31, According to the inclusion criteria and exclusion criteria, a total of 17 articles were selected. A 95% confidence interval (CI) was used for clinical pregnancy data, and a random-effect model was used for meta-analysis. Subgroup analysis and sensitivity analysis were performed using Review manager 5.3. Results: Among patients with fertility desire, 370/1142 (32.40%) conceived spontaneously after surgery, compared with 306/1108(27.62%) got pregnant after surgery and assisted reproductive technology（P=0.36,I2=82%）.There is no significant statistical significance in this comparison and the heterogeneity is high. Then，we performed subgroup analysis and found that the heterogeneity was not caused by fertility status ,surgical methods or study characteristics. Conclusion: Through this meta-analysis, we think that surgery combined ART or not doesn’t affect the pregnancy rate in patients with DIE. But further investigations are required to determine fertility outcomes according to age, endometrioma, adenomyosis, ASRM scores and so on.

Download Full-text

Fertility outcomes of deep infiltrating endometriosis with fertility desire—a meta analysis

10.21203/rs.2.21329/v1 ◽

2020 ◽

Author(s):

yue shen ◽

Ziyi Feng ◽

Lili Jiang ◽

Yue Li ◽

Kuiran Liu

Keyword(s):

Subgroup Analysis ◽

Meta Analysis ◽

Statistical Significance ◽

Random Effect ◽

Random Effect Model ◽

Cochrane Library ◽

Deep Infiltrating Endometriosis ◽

Fertility Desire ◽

Surgical Methods ◽

Infiltrating Endometriosis

Abstract Background: The morbidity of endometriosis has been ascending in recent years. Deep infiltrating endometriosis is the most advanced type of endometriosis. The treatments for patients with DIE and fertility desire are controversial. Materials and Methods: We had search Pubmed, OVID Medline, Cochrane Library published before 2019-10-31, According to the inclusion criteria and exclusion criteria, a total of 17 articles were selected. A 95% confidence interval (CI) was used for clinical pregnancy data, and a random-effect model was used for meta-analysis. Subgroup analysis and sensitivity analysis were performed using Review manager 5.3. Results: Among patients with fertility desire, 370/1142 (32.40%) conceived spontaneously after surgery, compared with 306/1108(27.62%) got pregnant after surgery and assisted reproductive technology（P=0.36,I2=82%）.There is no significant statistical significance in this comparison and the heterogeneity is high. Then，we performed subgroup analysis and found that the heterogeneity was not caused by fertility status ,surgical methods or study characteristics. Conclusion: Through this meta-analysis, we think that surgery combined ART or not doesn’t effect on pregnancy rate in patients with DIE. But further investigations are required to determine fertility outcomes according to age, endometrioma, adenomyosis, ASRM scores and so on.

Download Full-text

Effect of Yoga on Blood Pressure in Prehypertension: A Systematic Review and Meta-Analysis

The Scientific World JOURNAL ◽

10.1155/2021/4039364 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Janhavi Sandeep Khandekar ◽

Vanamala Lakshmi Vasavi ◽

Vijay Pratap Singh ◽

Stephen Rajan Samuel ◽

S. G. Sudhan ◽

...

Keyword(s):

Systematic Review ◽

Cardiovascular Diseases ◽

Lipid Profile ◽

Diastolic Pressure ◽

Meta Analysis ◽

Mean Difference ◽

Secondary Outcome ◽

Yoga Therapy ◽

Standard Mean Difference ◽

Blood Pressures

Introduction. Prehypertension is a precursor for developing hypertension and is a risk factor for cardiovascular diseases. Yoga therapy may have a role in lowering the blood pressures in prehypertension and hypertension. This systematic review aims to synthesize the available literature for the same. Methodology. Databases such as PubMed, Embase, Scopus, and Web of Science were searched for randomised control trials only in the time duration of 2010–2021. The main outcome of interest was systolic and diastolic blood pressures. Articles were screened based on the inclusion criteria, and 8 articles were recruited for the review. Meta-analysis was done for suitable articles. RevMan 5.4 by Cochrane was used for meta-analysis and forest plot construction. Risk of bias was determined using the Downs and Black checklist by three independent authors. Results. The meta-analysis of the articles favoured yoga intervention over the control intervention. Yoga therapy had significantly reduced the systolic pressure (−0.62 standard mean difference, at IV fixed 95% CI: −0.83, −0.41) and diastolic pressure (−0.81 standard mean difference, at IV random 95% CI: −1.39, −0.22). Secondary outcome measures studied were heart rate, weight, BMI, waist circumference, and lipid profile. The main protocol of yoga therapy included postures, breathing exercises, and different meditation techniques. A significant reduction in secondary outcomes was observed, except for HDL values in lipid profile which showed a gradual increase in yoga group in comparison with alternative therapy. Conclusion. Yoga therapy has shown to be significant in the reduction of systolic and diastolic pressure in prehypertensive population. Supporting evidence lacks in providing a proper structured dosage of yoga asanas and breathing techniques. Considering the existing literature and evidence, Yoga therapy can be used and recommended in prehypertensive population and can be beneficial in reducing the chances of developing hypertension or cardiovascular diseases.

Download Full-text

A Review of Surgical Outcomes and Advances for Macular Holes

Journal of Ophthalmology ◽

10.1155/2018/7389412 ◽

2018 ◽

Vol 2018 ◽

pp. 1-10 ◽

Cited By ~ 4

Author(s):

Peng-peng Zhao ◽

Shuang Wang ◽

Nan Liu ◽

Zhi-min Shu ◽

Jin-song Zhao

Keyword(s):

Indocyanine Green ◽

Surgical Outcomes ◽

Visual Outcome ◽

Internal Limiting Membrane ◽

Ilm Peeling ◽

Closure Rate ◽

Macular Holes ◽

Surgical Methods ◽

Highly Correlated ◽

Anatomic Success

The surgical outcomes of macular holes (MHs) have improved greatly in recent years. The closure rate is as high as 90–100%, but the outcomes of some special types of MHs remain unsatisfactory. Internal limiting membrane (ILM) peeling dramatically improves the anatomic success rate, but recent studies have found that it could also cause mechanical and subclinical traumatic changes to the retina. Dyes are widely used, and apart from indocyanine green (ICG), the toxicities of other dyes require further research. Face-down posturing is necessary for MHs larger than 400 μm, and the duration of this posture is determined by the type of tamponade and the case. The ellipsoid zone has been shown to be highly correlated with visual outcome and recovery. New surgical methods include the inverted ILM flap technique and the ILM abrasion technique. However, they require further research to determine their effectiveness.

Download Full-text

Comparison of surgical strategies in patients with spontaneous intracerebral haemorrhage: a protocol for a network meta-analysis

BMJ Open ◽

10.1136/bmjopen-2018-027658 ◽

2019 ◽

Vol 9 (7) ◽

pp. e027658 ◽

Cited By ~ 1

Author(s):

Zhiyuan Yu ◽

Jun Zheng ◽

Lu Ma ◽

Rui Guo ◽

Chao You ◽

...

Keyword(s):

Surgical Treatment ◽

Intracerebral Haemorrhage ◽

Meta Analysis ◽

Cochrane Library ◽

Secondary Outcome ◽

China National Knowledge Infrastructure ◽

Stroke Subtype ◽

Surgical Strategies ◽

Surgical Methods ◽

Spontaneous Intracerebral Haemorrhage

IntroductionSpontaneous intracerebral haemorrhage (sICH) is a severe stroke subtype. The effective therapies for patients with sICH are still unclear, and the role of surgical treatment in sICH management is still controversial. Although some large trials did not show that surgery could benefit patients with sICH, some other studies suggested that some specific surgical strategies can have potential benefits to these patients. For a better understanding of the surgical treatment in patients with sICH, it is necessary to conduct a network meta-analysis to compare the effects of medical treatment and different surgical methods comprehensively.Methods and analysisThis protocol has been reported following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. Related studies until August 2018 will be searched in the following databases: PubMed, Embase, Scopus, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP and Wanfang. Randomised controlled trials and non-randomised prospective studies comparing at least two different interventions in patients with sICH will be included. Quality assessment will be conducted using Cochrane Collaboration’s tool or Newcastle-Ottawa Scale based on their study designs. The primary outcome will be functional outcome and the secondary outcome will be mortality. Pairwise and network meta-analysis will be conducted using STATA V.14 (StataCorp, College Station, Texas, USA). Mean ranks and the surface under the cumulative ranking curve will be used to evaluate every intervention. Statistical inconsistency assessment, subgroup analysis, sensitivity analysis and publication bias assessment will be performed.Ethics and disseminationEthics approval is not necessary because this study will be based on publications. The results of this study will be published in a peer-reviewed journal.PROSPERO registration numberCRD42018112239

Download Full-text

Systematic review with meta-analysis: effectiveness of hyperbaric oxygenation therapy for ulcerative colitis

Therapeutic Advances in Gastroenterology ◽

10.1177/17562848211023394 ◽

2021 ◽

Vol 14 ◽

pp. 175628482110233

Author(s):

Pingrun Chen ◽

Yina Li ◽

Xian Zhang ◽

Yan Zhang

Keyword(s):

Ulcerative Colitis ◽

Combination Therapy ◽

Hyperbaric Oxygen ◽

Hyperbaric Oxygenation ◽

Meta Analysis ◽

Serum Levels ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Complementary Method ◽

Standard Mean Difference

Background and aims: Hyperbaric oxygenation therapy has been used in the treatment of ulcerative colitis in the past few years. However, its efficacy still remains unclear. The aim of the study was to investigate the efficacy of hyperbaric oxygen combination therapy in patients with ulcerative colitis. Methods: We conducted a comprehensive study search up to September 2020, from the online databases Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure, WanFang and VIP. Results: Thirteen studies comprising 780 patients were included. We found that compared with conventional therapy, hyperbaric oxygen combination therapy was superior in reaching clinical remission [risk ratio (RR)=1.62; 95% confidence interval (CI) 1.42 to 1.84; p < 0.001] and clinical response (RR=1.29; 95% CI 1.21 to 1.38; p < 0.001), with lower disease activity scores [standard mean difference (SMD)= −1.19; 95%CI −1.74 to −0.65; p < 0.001]. An obvious reduction of serum levels of tumor necrosis factor-α (SMD= −1.96; 95%CI −2.50 to −1.41; p < 0.001) and interleukin (IL)-6 (SMD= −2.49; 95% CI −2.84 to −2.15; p < 0.001), and elevation of IL-10 level (SMD=2.40; 95% CI 0.68 to 4.12; p = 0.006) were also observed. Conclusion: Hyperbaric oxygen combination therapy was effective in patients with ulcerative colitis, and has potential as a complementary method for its treatment.

Download Full-text

Clinical Evaluation of Microendoscopy-Assisted Oblique Lateral Interbody Fusion

Medicina ◽

10.3390/medicina57020135 ◽

2021 ◽

Vol 57 (2) ◽

pp. 135

Author(s):

Tomohide Segawa ◽

Hisashi Koga ◽

Masahito Oshina ◽

Katsuhiko Ishibashi ◽

Yuichi Takano ◽

...

Keyword(s):

Interbody Fusion ◽

Outcome Measure ◽

Operation Time ◽

Secondary Outcome ◽

Invasive Technique ◽

Lateral Interbody Fusion ◽

Surgical Methods ◽

Significant Difference ◽

Oblique Lateral Interbody Fusion ◽

Lateral Interbody

Background and objectives: Oblique Lateral Interbody Fusion (OLIF) is a widely performed, minimally invasive technique to achieve lumbar lateral interbody fusion. However, some complications can arise due to constraints posed by the limited surgical space and visual field. The purpose of this study was to assess the short-term postoperative clinical outcomes of microendoscopy-assisted OLIF (ME-OLIF) compared to conventional OLIF. Materials and Methods: We retrospectively investigated 75 consecutive patients who underwent OLIF or ME-OLIF. The age, sex, diagnosis, and number of fused levels were obtained from medical records. Operation time, estimated blood loss (EBL), and intraoperative complications were also collected. Operation time and EBL were only measured per level required for the lateral procedure, excluding the posterior fixation surgery. The primary outcome measure was assessed using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOABPEQ). The secondary outcome measure was assessed using the Oswestry Disability Index (ODI) and the European Quality of Life–5 Dimensions (EQ-5D), measured preoperatively and 1-year postoperatively. Results: This case series consisted of 14 patients in the OLIF group and 61 patients in the ME-OLIF group. There was no significant difference between the two groups in terms of the mean operative time and EBL (p = 0.90 and p = 0.50, respectively). The perioperative complication rate was 21.4% in the OLIF group and 21.3% in the ME-OLIF group (p = 0.99). In both groups, the postoperative JOABPEQ, EQ-5D, and ODI scores improved significantly (p < 0.001). Conclusions: Although there was no significant difference in clinical results between the two surgical methods, the results suggest that both are safe surgical methods and that microendoscopy-assisted OLIF could serve as a potential alternative to the conventional OLIF procedure.

Download Full-text

Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity

Scientific Reports ◽

10.1038/s41598-021-85676-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

María Isabel Iñiguez-Luna ◽

Jorge Cadena-Iñiguez ◽

Ramón Marcos Soto-Hernández ◽

Francisco Javier Morales-Flores ◽

Moisés Cortes-Cruz ◽

...

Keyword(s):

Cell Lines ◽

Proliferative Activity ◽

Meta Analysis ◽

Pearson Correlation ◽

Statistical Significance ◽

Economic Value ◽

Principal Component ◽

Malignant Cell ◽

Length Polymorphisms ◽

Relevant Variables

AbstractBioprospecting identifies new sources of compounds with actual or potential economic value that come from biodiversity. An analysis was performed regarding bioprospecting purposes in ten genotypes of Sechium spp., through a meta-analysis of 20 information sources considering different variables: five morphological, 19 biochemical, anti-proliferative activity of extracts on five malignant cell lines, and 188 polymorphic bands of amplified fragment length polymorphisms, were used in order to identify the most relevant variables for the design of genetic interbreeding. Significant relationships between morphological and biochemical characters and anti-proliferative activity in cell lines were obtained, with five principal components for principal component analysis (SAS/ETS); variables were identified with a statistical significance (< 0.7 and Pearson values ≥ 0.7), with 80.81% of the accumulation of genetic variation and 110 genetic bands. Thirty-nine (39) variables were recovered using NTSYSpc software where 30 showed a Pearson correlation (> 0.5) and nine variables (< 0.05), Finally, using a cladistics analysis approach highlighted 65 genetic bands, in addition to color of the fruit, presence of thorns, bitter flavor, piriform and oblong shape, and also content of chlorophylls a and b, presence of cucurbitacins, and the IC50 effect of chayote extracts on the four cell lines.

Download Full-text

Relative Efficacy of Weight Management, Exercise, and Combined Treatment for Muscle Mass and Physical Sarcopenia Indices in Adults with Overweight or Obesity and Osteoarthritis: A Network Meta-Analysis of Randomized Controlled Trials

Nutrients ◽

10.3390/nu13061992 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1992

Author(s):

Shu-Fen Chu ◽

Tsan-Hon Liou ◽

Hung-Chou Chen ◽

Shih-Wei Huang ◽

Chun-De Liao

Keyword(s):

Randomized Controlled Trials ◽

Weight Management ◽

Muscle Mass ◽

Lower Limb ◽

Meta Analysis ◽

Combined Treatment ◽

Controlled Trials ◽

Randomized Controlled ◽

Standard Mean Difference ◽

Evidence Database

Aging and osteoarthritis are associated with high risk of muscle mass loss, which leads to physical disability; this loss can be effectively alleviated by diet (DI) and exercise (ET) interventions. This study investigated the relative effects of different types of diet, exercise, and combined treatment (DI+ET) on muscle mass and functional outcomes in individuals with obesity and lower-limb osteoarthritis. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) examining the efficacy of DI, ET, and DI+ET in patients with obesity and lower-extremity osteoarthritis. The included RCTs were analyzed through network meta-analysis and risk-of-bias assessment. We finally included 34 RCTs with a median (range/total) Physiotherapy Evidence Database score of 6.5 (4–8/10). DI plus resistance ET, resistance ET alone, and aerobic ET alone were ranked as the most effective treatments for increasing muscle mass (standard mean difference (SMD) = 1.40), muscle strength (SMD = 1.93), and walking speed (SMD = 0.46). Our findings suggest that DI+ET is beneficial overall for muscle mass in overweight or obese adults with lower-limb osteoarthritis, especially those who are undergoing weight management.

Download Full-text

A systematic review and meta-analysis on endovascular treatment as an attractive alternative for acute superior mesenteric venous thrombosis

Vascular ◽

10.1177/1708538121991270 ◽

2021 ◽

pp. 170853812199127

Author(s):

Lixin Wang ◽

Enci Wang ◽

Fei Liu ◽

Wei Zhang ◽

Xiaolong Shu ◽

...

Keyword(s):

Systematic Review ◽

Treatment Group ◽

Conservative Treatment ◽

Venous Thrombosis ◽

Endovascular Treatment ◽

Meta Analysis ◽

Statistical Significance ◽

Published Data ◽

Mesenteric Venous Thrombosis ◽

Surgery Group

Objective This systematic review and meta-analysis evaluated the published data on the efficacy and safety of therapies for superior mesenteric venous thrombosis (SMVT), aiming to provide a reference and set of recommendations for clinical treatment. Methods Relevant databases were searched for studies published from 2000 to June 2020 on SMVT treated with conservative treatment, surgical treatment, or endovascular approach. Different treatment types were grouped for analysis and comparison, and odds ratios with corresponding 95% confidence intervals were calculated. The outcomes were pooled using meta-analytic methods and presented by forest plots. Results Eighteen articles, including eight on SMVT patients treated with endovascular therapies, were enrolled. The treatment effectiveness was compared between different groups according to the change of symptoms, the occurrence of complications, and mortality as well. The conservative treatment group had better efficacy compared to the surgery group (89.0% vs. 78.6%, P <0.05), and the one-year survival rate was also higher (94.4% vs. 80.0%, P >0.05), but without statistical significance. As for endovascular treatment, the effectiveness was significantly higher than the surgery group (94.8% vs. 75.2%, P <0.05), and the conservative treatment group as well (93.3% vs. 86.3%, P >0.05), which still requires further research for the lack of statistical significance. Conclusions Present findings indicate that anticoagulation, as conservative treatment should be the preferred clinical option in the clinic for SMVT, due to its better curative effect compared to other treatment options, including lower mortality, fewer complications, and better prognosis. Moreover, endovascular treatment is a feasible and promising approach that is worth in-depth research, for it is less invasive than surgery and has relatively better effectiveness, thus can provide an alternative option for SMVT treatment and may be considered as a reliable method in clinical.

Download Full-text