scholarly journals Sex Hormone/Cortisol Ratios Differentially Modulate Risk-Taking in Men and Women

2017 ◽  
Vol 15 (1) ◽  
pp. 147470491769733 ◽  
Author(s):  
Efrat Barel ◽  
Shosh Shahrabani ◽  
Orna Tzischinsky
Keyword(s):  
Sex Differences ◽  
Sex Hormones ◽  
Risk Taking ◽  
Sex Steroids ◽  
Sex Hormone ◽  
Opposite Pattern ◽  
Men And Women ◽  
Joint Influence ◽  
Self Reports ◽  
Neuroendocrine Mechanisms

The present study aimed to extend the original focus of the dual-hormone hypothesis on testosterone and cortisol involvement in risk-taking to other sex hormones: estrogen and progesterone. The study also examined two alternative models for the proposed relationship between cortisol and sex steroids and for their joint influence on risk-taking: interaction and ratio terms. In all, 40 women and 37 men were tested for circulating sex hormones and provided self-reports on risk-taking. The findings suggest that sex hormone–cortisol ratios differentially modulate risk-taking in men and women: In men, high ratios were associated with risk-taking, whereas in women the opposite pattern was found. The findings are discussed in light of evolutionary assumptions regarding sex differences in neuroendocrine mechanisms, suggesting sex differences in neural sensitivity to sex hormones in risk-taking.

scholarly journals Regulatory Role of Sex Hormones in Cardiovascular Calcification

2021 ◽  
Vol 22 (9) ◽  
pp. 4620
Author(s):  
Holly J. Woodward ◽  
Dongxing Zhu ◽  
Patrick W. F. Hadoke ◽  
Victoria E. MacRae
Keyword(s):  
Cardiovascular Disease ◽  
Sex Differences ◽  
Sexual Dimorphism ◽  
Aortic Stenosis ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Increased Risk ◽  
Male Sex ◽  
Primary Male

Sex differences in cardiovascular disease (CVD), including aortic stenosis, atherosclerosis and cardiovascular calcification, are well documented. High levels of testosterone, the primary male sex hormone, are associated with increased risk of cardiovascular calcification, whilst estrogen, the primary female sex hormone, is considered cardioprotective. Current understanding of sexual dimorphism in cardiovascular calcification is still very limited. This review assesses the evidence that the actions of sex hormones influence the development of cardiovascular calcification. We address the current question of whether sex hormones could play a role in the sexual dimorphism seen in cardiovascular calcification, by discussing potential mechanisms of actions of sex hormones and evidence in pre-clinical research. More advanced investigations and understanding of sex hormones in calcification could provide a better translational outcome for those suffering with cardiovascular calcification.

Sex Differences in Communication with Close Friends: Testing Tannen's Claims

2002 ◽  
Vol 91 (2) ◽  
pp. 537-544 ◽  
Author(s):  
Nicole L. Oxley ◽  
Mary T. Dzindolet ◽  
Jessica L. Miller
Keyword(s):  
Sex Differences ◽  
Interpersonal Communication ◽  
Men And Women ◽  
Self Reports

In 1990 Tannen reported that men have fewer close friends than women, men discuss less intimate topics with their friends than women, and men and women respond differently to close friends' problems. 168 students completed a three-page survey designed to examine Tannen's claims. Consistent with Tannen's observations, men discussed less intimate topics (politics and school or work) with their five closest friends and reportedly were less likely to comfort or listen to their friends' problems than women were. Inconsistent with Tannen's statements, these women and men did not differ in the number of close friends they reported having or in the likelihood of offering advice when presented with a friend's problem. Present self-reports corroborate other researchers who questioned Tannen's findings and concluded that sex differences in interpersonal communication are small.

scholarly journals Handedness and gender influence blood pressure in young healthy men and women: A pilot study

2016 ◽  
Vol 50 (1) ◽  
pp. 10-15 ◽  
Author(s):  
I Rueda ◽  
I Banegas ◽  
I Prieto ◽  
R Wangensteen ◽  
AB Segarra ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sex Hormones ◽  
Sex Steroids ◽  
Menstrual Phase ◽  
Men And Women ◽  
Left Handed ◽  
Gender Influence ◽  
Left And Right ◽  
And Gender ◽  
The Right

AbstractObjective. The type and level of sex steroids influence blood pressure (BP). It has been suggested that functional brain asymmetries may be influenced by sex hormones. In addition, there are inter-arm differences in BP not yet related with handedness. In this study, we hypothesize a possible association between sex hormones, handedness, and inter-arm differences in blood pressure.Methods. To analyze this hypothesis, we measured BP in the left and right arm of the left and right handed adult young men and women in menstrual and ovulatory phase and calculated their mean arterial pressure (MAP).Results. Significant differences depending on sex, arm, handedness or phase of the cycle were observed. MAP was mostly higher in men than in women. Remarkably, in women, the highest levels were observed in the left handed in menstrual phase. Interestingly, the level of handedness correlated negatively with MAP measured in the left arm of right-handed women in the ovulatory phase but positively with the MAP measured in the right arm of right-handed women in the menstrual phase.Conclusions. These results may reflect an asymmetrical modulatory influence of sex hormones in BP control.

scholarly journals Sex Differences in Lipid and Lipoprotein Metabolism: It's Not Just about Sex Hormones

Endocrinology ◽  
2011 ◽  
Vol 152 (3) ◽  
pp. 1192-1192
Author(s):  
Xuewen Wang ◽  
Faidon Magkos ◽  
Bettina Mittendorfer
Keyword(s):  
Sex Differences ◽  
Sex Hormones ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Lipoprotein Metabolism ◽  
Men And Women ◽  
Beneficial Effects ◽  
Physiological Alterations ◽  
First Pass ◽  
Hormonal Milieu

Abstract It is commonly thought that sex hormones are important regulators of plasma lipid kinetics and are responsible for sexual dimorphism in the plasma lipid profile. Here we discuss the findings from studies evaluating lipid and lipoprotein kinetics in men and women in the context of what we know about the effects of exogenous sex hormone administration, and we conclude that it is more complicated than that. It has become clear that normal physiological alterations in the hormonal milieu (i.e. due to menopause or throughout the menstrual cycle) do not significantly affect plasma lipid homeostasis. Furthermore, parenterally administered estrogens have either no effect or only very small beneficial effects, whereas orally administered estrogens raise plasma triglyceride concentrations—a phenomenon that is not consistent with the observed sex differences and likely results from the hepatic “first-pass effect.” The effects of progestogens and androgens mimic only in part the differences in plasma lipids between men and women. Thus, the underlying physiological modulators of plasma lipid metabolism responsible for the differences between men and women remain to be elucidated.

scholarly journals A Tutorial of the Effects of Sex Hormones on Laryngeal Senescence and Neuromuscular Response to Exercise

2019 ◽  
Vol 62 (3) ◽  
pp. 602-610 ◽  
Author(s):  
Charles Lenell ◽  
Mary J. Sandage ◽  
Aaron M. Johnson
Keyword(s):  
Sex Differences ◽  
Sexual Dimorphism ◽  
Sex Hormones ◽  
Voice Therapy ◽  
Sexually Dimorphic ◽  
Men And Women ◽  
Women's Voices ◽  
Age Related ◽  
Neuromuscular Response ◽  
Response To Exercise

Purpose The purpose of this tutorial is to summarize how sex hormones affect both laryngeal senescence and neuromuscular response to exercise, highlighting the importance of considering sex differences in developing treatment for the senescent voice. Conclusion Men and women's voices are sexually dimorphic throughout the life span, including during the laryngeal adaptations observed during senescence. Therefore, presbyphonia (age-related dysphonia) likely clinically manifests differently for men and women due to differences in how the male and the female larynx change in response to aging. Because sexual dimorphism is evident in both laryngeal aging and response to exercise, voice therapy programs aimed at treating the typical and disordered aged voice should consider sex differences in their design.

Abstract P054: Endogenous Sex Hormone Levels and Endothelial Function Among Men and Post-Menopausal Women in the Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Lena Mathews ◽  
Vinita Subramanya ◽  
Di Zhao ◽  
Pamela Ouyang ◽  
Dhanajay Vaidya ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Cvd Risk ◽  
Men And Women ◽  
Hormone Levels ◽  
Menopausal Women ◽  
Post Menopausal

Background: Sex is a major determinant of cardiovascular disease (CVD). Endogenous sex hormones exert a variety of effects on the vascular endothelium, and changes in sex hormone levels after menopause may play a role in CVD risk in women. We hypothesized that a more androgenic sex hormone profile among post-menopausal women, but not among men, would be associated with reduced blood flow-mediated vasodilation (FMD) of the brachial artery, a marker of worse endothelial function. Methods: We examined 1396 post-menopausal women and 1707 men participating in MESA, who were free of clinical CVD at baseline. Sex hormone levels [total testosterone (T), sex hormone binding globulin (SHBG), estradiol (E2)] were measured at Exam 1 (2000-02); free T and T/E2 ratio were calculated. FMD was measured by high-resolution ultrasound. Using multivariable adjusted Poisson and linear regression methods, we tested the cross-sectional associations of sex hormones (log transformed) with FMD. Results: The mean age of men and women was 61 and 64 years, respectively. Of women, 34% were using hormone therapy (HT). Among women, after adjusting for demographics, CVD risk factors, and HT use, higher SHBG was associated with higher FMD, whereas higher free T was associated with lower FMD (Table, Model 2). In women, when examining the “best FMD response” (top decile vs. bottom 9 deciles), higher E2 was positively associated with a prevalent best response, whereas higher free T was inversely associated. Among men, a higher T/E2 ratio was marginally associated with lower FMD. Conclusion: The association between sex hormones and FMD differs in men and women. Higher E2 and SHBG and lower free T levels were associated with better FMD in post-menopausal women but not in men. Higher T/E2 ratio was associated with lower FMD in men. Further studies are needed to assess longitudinal changes in sex hormone levels and their association with vascular aging. Sex hormone levels may help identify individuals at increased CVD risk who may benefit from other risk reduction strategies.

scholarly journals Sex Differences in Lipid and Lipoprotein Metabolism: It's Not Just about Sex Hormones

2011 ◽  
Vol 96 (4) ◽  
pp. 885-893 ◽  
Author(s):  
Xuewen Wang ◽  
Faidon Magkos ◽  
Bettina Mittendorfer
Keyword(s):  
Sex Differences ◽  
Sex Hormones ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Lipoprotein Metabolism ◽  
Men And Women ◽  
Beneficial Effects ◽  
Physiological Alterations ◽  
First Pass ◽  
Hormonal Milieu

Abstract It is commonly thought that sex hormones are important regulators of plasma lipid kinetics and are responsible for sexual dimorphism in the plasma lipid profile. Here we discuss the findings from studies evaluating lipid and lipoprotein kinetics in men and women in the context of what we know about the effects of exogenous sex hormone administration, and we conclude that it is more complicated than that. It has become clear that normal physiological alterations in the hormonal milieu (i.e. due to menopause or throughout the menstrual cycle) do not significantly affect plasma lipid homeostasis. Furthermore, parenterally administered estrogens have either no effect or only very small beneficial effects, whereas orally administered estrogens raise plasma triglyceride concentrations—a phenomenon that is not consistent with the observed sex differences and likely results from the hepatic “first-pass effect.” The effects of progestogens and androgens mimic only in part the differences in plasma lipids between men and women. Thus, the underlying physiological modulators of plasma lipid metabolism responsible for the differences between men and women remain to be elucidated.

scholarly journals Do women fare worse? A metaanalysis of gender differences in outcome after traumatic brain injury

2000 ◽  
Vol 8 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Elana Farace ◽  
Wayne M. Alves
Keyword(s):  
Gender Differences ◽  
Traumatic Brain Injury ◽  
Sex Differences ◽  
Brain Injury ◽  
Prospective Study ◽  
Case Fatality ◽  
Average Effect ◽  
Opposite Pattern ◽  
Quantitative Review ◽  
Men And Women

The purpose of this metaanalysis was to investigate possible gender differences in TBI sequelae. The case fatality rates in patients after TBI have previously been shown to be significantly higher in women as compared with men. A quantitative review of published studies of TBI outcome revealed eight studies (20 outcome variables) of TBI in which outcome was reported separately for men and women. Outcome was worse in women than in men for 85% of the measured variables, with an average effect size of −0.15. Although clinical opinion is often that women tend to experience better outcomes than do men after TBI, the opposite pattern was suggested in the results of this metaanalysis. However, this conclusion is limited by the fact that in only a small percentage of the total published reports on TBI outcome was outcome described separately for each sex. A careful, prospective study of sex differences in TBI outcome is clearly needed.

scholarly journals Associations of sex hormones with components of insulin-glucose homeostasis

2018 ◽  
Vol 15 (2) ◽  
pp. 3-10
Author(s):  
Oksana V Tsygankova ◽  
Artur R Badin ◽  
Zoya G Bondareva ◽  
Natalya G Lozhkina ◽  
Dmitrii Y Platonov
Keyword(s):  
Insulin Resistance ◽  
Literature Review ◽  
Sex Hormones ◽  
Glucose Homeostasis ◽  
Sex Steroids ◽  
Glucose Transporters ◽  
Sex Hormone ◽  
Complex Approach ◽  
Sodium Dependent ◽  
Males And Females

In this literature review, an attempt is made to analyze the interrelationships of the main sex hormones with the processes of development and progression of insulin resistance as a fundamental pathogenetic component of insulin-glucose homeostasis. In the evaluation of sex steroids, a complex approach was used - the associations of both androgens and estrogens in males and females are described in detail, a great deal of attention is paid to the violation of the secretion and effectiveness of the main adipocytokines - leptin and adiponectin in the sex hormone-insulin-glucose interaction chain. At the end of the review, new data on the expression of sodium-dependent glucose cotransporter (SGLT) and glucose transporters (GLUT) in animals, depending on sex, are presented.

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