scholarly journals A Tutorial of the Effects of Sex Hormones on Laryngeal Senescence and Neuromuscular Response to Exercise

2019 ◽  
Vol 62 (3) ◽  
pp. 602-610 ◽  
Author(s):  
Charles Lenell ◽  
Mary J. Sandage ◽  
Aaron M. Johnson
Keyword(s):  
Sex Differences ◽  
Sexual Dimorphism ◽  
Sex Hormones ◽  
Voice Therapy ◽  
Sexually Dimorphic ◽  
Men And Women ◽  
Women's Voices ◽  
Age Related ◽  
Neuromuscular Response ◽  
Response To Exercise

Purpose The purpose of this tutorial is to summarize how sex hormones affect both laryngeal senescence and neuromuscular response to exercise, highlighting the importance of considering sex differences in developing treatment for the senescent voice. Conclusion Men and women's voices are sexually dimorphic throughout the life span, including during the laryngeal adaptations observed during senescence. Therefore, presbyphonia (age-related dysphonia) likely clinically manifests differently for men and women due to differences in how the male and the female larynx change in response to aging. Because sexual dimorphism is evident in both laryngeal aging and response to exercise, voice therapy programs aimed at treating the typical and disordered aged voice should consider sex differences in their design.

scholarly journals Regulatory Role of Sex Hormones in Cardiovascular Calcification

2021 ◽  
Vol 22 (9) ◽  
pp. 4620
Author(s):  
Holly J. Woodward ◽  
Dongxing Zhu ◽  
Patrick W. F. Hadoke ◽  
Victoria E. MacRae
Keyword(s):  
Cardiovascular Disease ◽  
Sex Differences ◽  
Sexual Dimorphism ◽  
Aortic Stenosis ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Increased Risk ◽  
Male Sex ◽  
Primary Male

Sex differences in cardiovascular disease (CVD), including aortic stenosis, atherosclerosis and cardiovascular calcification, are well documented. High levels of testosterone, the primary male sex hormone, are associated with increased risk of cardiovascular calcification, whilst estrogen, the primary female sex hormone, is considered cardioprotective. Current understanding of sexual dimorphism in cardiovascular calcification is still very limited. This review assesses the evidence that the actions of sex hormones influence the development of cardiovascular calcification. We address the current question of whether sex hormones could play a role in the sexual dimorphism seen in cardiovascular calcification, by discussing potential mechanisms of actions of sex hormones and evidence in pre-clinical research. More advanced investigations and understanding of sex hormones in calcification could provide a better translational outcome for those suffering with cardiovascular calcification.

scholarly journals Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

2021 ◽  
Vol 22 (15) ◽  
pp. 8111
Author(s):  
Kuang-Hsu Lien ◽  
Chao-Hui Yang
Keyword(s):  
Hearing Loss ◽  
Sex Differences ◽  
Sexual Dimorphism ◽  
Sensorineural Hearing Loss ◽  
Hormone Replacement ◽  
Modern Society ◽  
Sensorineural Hearing ◽  
Drug Induced ◽  
Age Related ◽  
Age Related Hearing Loss

The triad of noise-generated, drug-induced, and age-related hearing loss is the major cause of acquired sensorineural hearing loss (ASNHL) in modern society. Although these three forms of hearing loss display similar underlying mechanisms, detailed studies have revealed the presence of sex differences in the auditory system both in human and animal models of ASNHL. However, the sexual dimorphism of hearing varies among noise-induced hearing loss (NIHL), ototoxicity, and age-related hearing loss (ARHL). Importantly, estrogen may play an essential role in modulating the pathophysiological mechanisms in the cochlea and several reports have shown that the effects of hormone replacement therapy on hearing loss are complex. This review will summarize the clinical features of sex differences in ASNHL, compare the animal investigations of cochlear sexual dimorphism in response to the three insults, and address how estrogen affects the auditory organ at molecular levels.

scholarly journals ET-1 as a Sex-Specific Mechanism Impacting Age-Related Changes in Vascular Function

2021 ◽  
Vol 2 ◽  
Author(s):  
Andrew V. Kuczmarski ◽  
Laura M. Welti ◽  
Kerrie L. Moreau ◽  
Megan M. Wenner
Keyword(s):  
Sex Differences ◽  
Vascular Function ◽  
Cardiovascular Health ◽  
Vascular Dysfunction ◽  
Developed Countries ◽  
Therapeutic Interventions ◽  
Vascular Aging ◽  
Cvd Risk ◽  
Men And Women ◽  
Age Related

Aging is a primary risk factor for cardiovascular disease (CVD), which is the leading cause of death in developed countries. Globally, the population of adults over the age of 60 is expected to double by the year 2050. CVD prevalence and mortality rates differ between men and women as they age in part due to sex-specific mechanisms impacting the biological processes of aging. Measures of vascular function offer key insights into cardiovascular health. Changes in vascular function precede changes in CVD prevalence rates in men and women and with aging. A key mechanism underlying these changes in vascular function is the endothelin (ET) system. Studies have demonstrated sex and sex hormone effects on endothelin-1 (ET-1), and its receptors ETA and ETB. However, with aging there is a dysregulation of this system resulting in an imbalance between vasodilation and vasoconstriction. Thus, ET-1 may play a role in the sex differences observed with vascular aging. While most research has been conducted in pre-clinical animal models, we describe more recent translational data in humans showing that the ET system is an important regulator of vascular dysfunction with aging and acts through sex-specific ET receptor mechanisms. In this review, we present translational evidence (cell, tissue, animal, and human) that the ET system is a key mechanism regulating sex-specific changes in vascular function with aging, along with therapeutic interventions to reduce ET-mediated vascular dysfunction associated with aging. More knowledge on the factors responsible for the sex differences with vascular aging allow for optimized therapeutic strategies to attenuate CVD risk in the expanding aging population.

scholarly journals Sexual dimorphism of the mandibular conformational changes in aging human adults: A multislice computed tomographic study by geometric morphometrics

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253564
Author(s):  
Leonor Costa Mendes ◽  
Julien Delrieu ◽  
Claudia Gillet ◽  
Norbert Telmon ◽  
Delphine Maret ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Conformational Changes ◽  
Sexually Dimorphic ◽  
Shape Variation ◽  
Geometric Morphometric ◽  
Computed Tomographic ◽  
Age Related ◽  
Human Adults ◽  
Geometric Morphometric Analysis ◽  
Shape Changes

The aging process has an impact on mandibular bone morphology and can therefore affect shape sexual dimorphism. Understanding the effect of senescence on mandibular shape changes is particularly important to correctly estimate the sex of an individual and predict age-related conformational modifications. The purpose of this study was to assess age-related changes in mandibular shape and sexual dimorphism. The study sample comprised 160 Multi Slice Computed Tomography examinations of individuals aged 40 to 79 years. Geometric morphometric analysis of fourteen osteometric landmarks was used to examine sexual dimorphism and patterns of mandibular shape variation with age. Results showed that mandibular sexual dimorphism of shape remained significant with aging. Conformational changes occurred between 50 and 70 years and were different for male and female individuals. Females presented earlier and more marked age-related shape changes than males. These observations suggest that mandibular senescence is a sexually dimorphic process since its onset, rate, and the areas subjected to conformational changes differ from male to female individuals. Senescence-related changes present substantial variability, and further investigation is required to determine precisely the age that marks their onset.

scholarly journals Sex Differences in Lipid and Lipoprotein Metabolism: It's Not Just about Sex Hormones

Endocrinology ◽  
2011 ◽  
Vol 152 (3) ◽  
pp. 1192-1192
Author(s):  
Xuewen Wang ◽  
Faidon Magkos ◽  
Bettina Mittendorfer
Keyword(s):  
Sex Differences ◽  
Sex Hormones ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Lipoprotein Metabolism ◽  
Men And Women ◽  
Beneficial Effects ◽  
Physiological Alterations ◽  
First Pass ◽  
Hormonal Milieu

Abstract It is commonly thought that sex hormones are important regulators of plasma lipid kinetics and are responsible for sexual dimorphism in the plasma lipid profile. Here we discuss the findings from studies evaluating lipid and lipoprotein kinetics in men and women in the context of what we know about the effects of exogenous sex hormone administration, and we conclude that it is more complicated than that. It has become clear that normal physiological alterations in the hormonal milieu (i.e. due to menopause or throughout the menstrual cycle) do not significantly affect plasma lipid homeostasis. Furthermore, parenterally administered estrogens have either no effect or only very small beneficial effects, whereas orally administered estrogens raise plasma triglyceride concentrations—a phenomenon that is not consistent with the observed sex differences and likely results from the hepatic “first-pass effect.” The effects of progestogens and androgens mimic only in part the differences in plasma lipids between men and women. Thus, the underlying physiological modulators of plasma lipid metabolism responsible for the differences between men and women remain to be elucidated.

scholarly journals Sex Differences in Lipid and Lipoprotein Metabolism: It's Not Just about Sex Hormones

2011 ◽  
Vol 96 (4) ◽  
pp. 885-893 ◽  
Author(s):  
Xuewen Wang ◽  
Faidon Magkos ◽  
Bettina Mittendorfer
Keyword(s):  
Sex Differences ◽  
Sex Hormones ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Lipoprotein Metabolism ◽  
Men And Women ◽  
Beneficial Effects ◽  
Physiological Alterations ◽  
First Pass ◽  
Hormonal Milieu

Abstract It is commonly thought that sex hormones are important regulators of plasma lipid kinetics and are responsible for sexual dimorphism in the plasma lipid profile. Here we discuss the findings from studies evaluating lipid and lipoprotein kinetics in men and women in the context of what we know about the effects of exogenous sex hormone administration, and we conclude that it is more complicated than that. It has become clear that normal physiological alterations in the hormonal milieu (i.e. due to menopause or throughout the menstrual cycle) do not significantly affect plasma lipid homeostasis. Furthermore, parenterally administered estrogens have either no effect or only very small beneficial effects, whereas orally administered estrogens raise plasma triglyceride concentrations—a phenomenon that is not consistent with the observed sex differences and likely results from the hepatic “first-pass effect.” The effects of progestogens and androgens mimic only in part the differences in plasma lipids between men and women. Thus, the underlying physiological modulators of plasma lipid metabolism responsible for the differences between men and women remain to be elucidated.

Sensory neurons, neuroimmunity, and pain modulation by sex hormones

Endocrinology ◽  
2021 ◽  
Author(s):  
Melissa E Lenert ◽  
Amanda Avona ◽  
Katherine M Garner ◽  
Luz R Barron ◽  
Michael D Burton
Keyword(s):  
Sex Differences ◽  
Sex Hormones ◽  
Cell Types ◽  
Pain Modulation ◽  
National Institutes Of Health ◽  
Neuron Activity ◽  
Sexually Dimorphic ◽  
Dependent Manner ◽  
Biological Variable ◽  
Different Cell Types

Abstract The inclusion of females in preclinical pain studies has become more commonplace in the last decade, as the National Institutes of Health (NIH) “Sex as a Biological Variable” (SABV) mandate was released. Presumably, basic researchers have not had a comprehensive understanding about neuroimmune interactions in half of the population and how hormones play a role in this. To date, we have learned that sex hormones contribute to sexual differentiation of the nervous system and sex differences in behavior throughout the lifespan; however, the cycling of sex hormones does not always explain these differences. Here, we highlight recent advances in our understanding of sex differences and how hormones and immune interactions influence sensory neuron activity to contribute to physiology and pain. Neuroimmune mechanisms may be mediated by different cell types in each sex, as the actions of immune cells are sexually dimorphic. Unfortunately, the majority of studies assessing neuronal contributions to immune function have been limited to males, so it is unclear if the mechanisms are similar in females. Finally, pathways that control cellular metabolism, like nuclear receptors have been shown to play a regulatory role in both pain and inflammation. Overall, communication between the neuroimmune and endocrine systems modulate pain signaling in a sex-dependent manner, but more research is needed to reveal nuances of these mechanisms.

Rat liver carbonic anhydrase I is not sexually dimorphic but is estrogen repressible

1985 ◽  
Vol 5 (9) ◽  
pp. 735-738 ◽  
Author(s):  
S. Jeffery ◽  
N. D. Carter ◽  
C. A. Wilson
Keyword(s):  
Sexual Dimorphism ◽  
Carbonic Anhydrase ◽  
Sex Hormones ◽  
Rat Liver ◽  
Female Rats ◽  
Sexually Dimorphic ◽  
Male And Female ◽  
Carbonic Anhydrase I ◽  
Male And Female Rats ◽  
Low Levels

Carbonic anhydrase (CA) isozymes CAII and CAIII are known to exhibit sexual dimorphism in rat liver, and the levels of these isozymes are affected by sex hormones. In this paper we show that the isozyme CAI is present at low levels in rat liver, with no difference in concentration between male and female rats. Estrogen and diethylstilbestrol reduce CAI levels in both sexes.

Age and Sex Differences in Blood Lactate Response to Sprint Running in Elite Master Athletes

2005 ◽  
Vol 30 (6) ◽  
pp. 647-665 ◽  
Author(s):  
Marko T. Korhonen ◽  
Harri Suominen ◽  
Antti Mero
Keyword(s):  
Sex Differences ◽  
Blood Lactate ◽  
Lactate Concentration ◽  
Key Words Aging ◽  
Master Athletes ◽  
Cross Sectional ◽  
Men And Women ◽  
Sprint Running ◽  
Age Related ◽  
Age And Sex

The effect of age and sex on anaerobic glycolytic capacity in master athletes is currently unclear. To study this issue, we determined blood lactate concentrations after competitive sprint running in male and female master athletes of different age. Eighty-one men (40-88 yrs) and 75 women (35-87 yrs) participating in the sprint events (100-m, 200-m, 400-m) in the European Veterans Athletics Championships were studied. Blood samples were taken from the fingertip and analysed for peak lactate concentration ([La]bpeak). The [La]bpeak following 100-m to 400-m races showed a curvilinear decline (p <  0.001-0.05) with age in both men and women. However, the age related differences in the [La]bpeak were not significant before 70 years of age. No significant sex related differences were found in [La]bpeak for any sprint event. The [La]bpeak correlated significantly (p <  0.001-0.05) with running times in all sprint distances except for the age-controlled correlation in men for the 100-m and 200-m. In conclusion, the present study showed age but not sex differences in blood lactate response to competitive sprint running in master athletes. Although the [La]bpeak level of the athletes was considerably higher than that reported for untrained men and women, these cross-sectional findings suggest that anaerobic energy production from glycolysis declines in later years and may be a factor in the deterioration in sprint performance. Key words: aging, anaerobic metabolism, exercise performance

scholarly journals Mechanisms for sex differences in energy homeostasis

2019 ◽  
Vol 62 (2) ◽  
pp. R129-R143 ◽  
Author(s):  
Chunmei Wang ◽  
Yong Xu
Keyword(s):  
Sex Differences ◽  
Energy Balance ◽  
Sex Hormones ◽  
Sex Chromosomes ◽  
Energy Homeostasis ◽  
Liver Fat ◽  
Sexually Dimorphic ◽  
Multiple Organs ◽  
Specific Regulation ◽  
Underlying Mechanisms

Sex differences exist in the regulation of energy homeostasis. Better understanding of the underlying mechanisms for sexual dimorphism in energy balance may facilitate development of gender-specific therapies for human diseases, e.g. obesity. Multiple organs, including the brain, liver, fat and muscle, play important roles in the regulations of feeding behavior, energy expenditure and physical activity, which therefore contribute to the maintenance of energy balance. It has been increasingly appreciated that this multi-organ system is under different regulations in male vs female animals. Much of effort has been focused on roles of sex hormones (including androgens, estrogens and progesterone) and sex chromosomes in this sex-specific regulation of energy balance. Emerging evidence also indicates that other factors (not sex hormones/receptors and not encoded by the sex chromosomes) exist to regulate energy homeostasis differentially in males vs females. In this review, we summarize factors and signals that have been shown to regulate energy homeostasis in a sexually dimorphic fashion and propose a framework where these factors and signals may be integrated to mediate sex differences in energy homeostasis.

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