A comparison between solvent casting and electrospinning methods for the fabrication of neem extract-containing buccal films

2021 ◽  
pp. 152808372110277
Author(s):  
Anahita Rohani Shirvan ◽  
Nahid Hemmatinejad ◽  
S Hajir Bahrami ◽  
Azadeh Bashari
Keyword(s):  
Drug Loading ◽  
Antibacterial Properties ◽  
Weibull Model ◽  
Solvent Casting ◽  
Neem Extract ◽  
Therapeutic Applications ◽  
Cast Film ◽  
Solvent Cast ◽  
Experimental Values ◽  
Oral Films

In the present study a double layer mucoadhesive buccal film containing nanocarriers encapsulated with neem extract was fabricated through electrospinning and solvent casting techniques for dental therapeutic applications. The morphological, physical and mucoadhesive properties of the resulting electrospun and solvent cast oral films were mutually compared, and their drug release behavior and antibacterial activity were further investigated. Chitosan/poly(vinylalcohol) (PVA) as a mucoadhesive component and phenylalanine amino acid nanotubes (PhNTs)-containing neem extract as a drug nanocarrier were used to fabricate oral films. A poly(caprolactone) (PCL) layer was used as an impermeable backing layer to protect the mucoadhesive component from tongue movement and drug loss. The results indicated an interconnected porous and fully filled solid structures for electrospun and solvent cast films, respectively. The physicomechanical parameters of the samples such as pH, weight, thickness, folding endurance and tensile strength were also evaluated. The crosslinked electrospun buccal film indicated better swelling and mucoadhesive properties compared to the solvent cast film. In addition, the drug loading capacity and encapsulation efficiency of the solvent cast film showed lower experimental values than those of electrospun oral film. On the other hand, the electrospun oral film had a well-controlled release of neem extract up to 82% at oral pH, which is best fitted to the Weibull model, and demonstrated the highest antibacterial properties against S. mutans bacteria with high biocompatibility on L929 fibroblast cells. Generally, the synthesized electrospun mucoadhesive film has a better potential for oral therapeutic applications than the solvent cast film.

scholarly journals Improving Drug Loading of Mucosal Solvent Cast Films Using a Combination of Hydrophilic Polymers with Amoxicillin and Paracetamol as Model Drugs

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Joshua Boateng ◽  
Justine Mani ◽  
Farnoosh Kianfar
Keyword(s):  
Drug Loading ◽  
Film Surface ◽  
Work Of Adhesion ◽  
Drug Dissolution ◽  
X Ray ◽  
Drug Diffusion ◽  
Molecular Dispersion ◽  
Swelling Capacity ◽  
Solvent Cast ◽  
Polymer Erosion

Solvent cast mucosal films with improved drug loading have been developed by combining carboxymethyl cellulose (CMC), sodium alginate (SA), and carrageenan (CAR) using paracetamol and amoxicillin as model drugs and glycerol (GLY) as plasticizer. Films were characterized using X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), folding resilience, swelling capacity, mucoadhesivity, and drug dissolution studies. SA, CMC, and GLY (5 : 3 : 6) films showed maximum amoxicillin loading of 26.3% whilst CAR, CMC, and GLY (1 : 2 : 3) films had a maximum paracetamol loading of 40%. XRPD analysis showed different physical forms of the drugs depending on the amount loaded. Films containing 29.4% paracetamol and 26.3% amoxicillin showed molecular dispersion of the drugs while excess paracetamol was observed on the film surface when the maximum 40% was loaded. Work of adhesion was similar for blank films with slightly higher cohesiveness for CAR and CMC based films, but the differences were significant between paracetamol and amoxicillin containing films. The stickiness and cohesiveness for drug loaded films were generally similar with no significant differences. The maximum percentage cumulative drug release was 84.65% and 70.59% for paracetamol and amoxicillin, respectively, with anomalous case two transport mechanism involving both drug diffusion and polymer erosion.

Study on the Antibacterial Performance of the Antibacterial Shutter Blades

2013 ◽  
Vol 815 ◽  
pp. 333-338
Author(s):  
Ming Li Liu ◽  
Chun Feng Li ◽  
Yun Long Wang ◽  
Kai Lu ◽  
Jiu Yin Pang ◽  
...  
Keyword(s):  
Antibacterial Agent ◽  
Antibacterial Agents ◽  
Drug Loading ◽  
Antibacterial Properties ◽  
Water Soluble ◽  
Single Factor ◽  
Antibacterial Performance ◽  
Loading Amount ◽  
Single Factor Experiment ◽  
Impregnation Solution

This study used Ag-embedded nanoTiO2, xylan and water-soluble Chitosan as antibacterial agents, respectively prepared shutter blades through the treating solution of the different concentration and the different drug loading amount of the poplar veneer. Through a single factor experiment, this paper analyzes that the different antibacterial agent, concentration of antibacterial agent and the drug loading amount have an effect on the antibacterial properties of the shutter blades. The results show that the order of antibacterial performance of the shutter blades impregnated antibacterial agents is the Ag-embedded nanoTiO2, Chitosan, Xylan. Comprehensiv-ely thought the antibacterial properties and economic index, the optimal concentration of the Ag-embedded nanoTiO2 impregnation solution is 1%.

Ceftizoxime Loaded ZnO/L-Cysteine Based an Advanced Nanocarrier Drug for Growth Inhibition of Salmonella Typhimurium

2021 ◽  
Author(s):  
Md. Sadek Bacchu ◽  
Md. Romzan Ali ◽  
Md. Ali Ahasan Setu ◽  
Selina Akter ◽  
Md. Zaved Hossain Khan
Keyword(s):  
Drug Loading ◽  
Hollow Spheres ◽  
Antibacterial Properties ◽  
Trisodium Citrate ◽  
Release Profile ◽  
Attenuated Total Reflection ◽  
Diffusion Method ◽  
Dilution Method ◽  
Agar Disc ◽  
Serovar Typhimurium

Abstract L-Cysteine coated zinc oxide (ZnO) nano hollow spheres were prepared as a potent drug delivery agent to eradicate Salmonella enterica serovar Typhimurium (S. typhimurium). The ZnO nano hollow spheres were synthesized by following the environmentally-friendly trisodium citrate assisted method and L-Cysteine (L-Cys) conjugate with its surface. ZnO/L-Cys@CFX nanocarrier drug has been fabricated by incorporating ceftizoxime with L-Cys coated ZnO nano hollow spheres and characterized using different techniques such as scanning electron microscope (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR), and X-ray diffraction (XRD) etc. Furthermore, the drug-loading and encapsulation efficiency at different pH levels was measured using UV-vis spectrometer and optimized. A control and gradual manner of pH-sensitive release profile was found after investigating the release profile of CFX from the carrier drug. The antibacterial activity of ZnO/L-Cys@CFX and CFX were evaluated through the agar disc diffusion method and the broth dilution method, which indicate the antibacterial properties of antibiotics enhance after conjugating. Surprisingly, the ZnO/L-Cys@CFX exhibits a minimum inhibitory concentration (MIC) of 5µg/ml against S. typhimurium is lower than CFX (20µg/ml) itself. These results indicate the nanocarrier can reduce the amount of CFX dosed to eradicate S. typhimurium.

scholarly journals Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4717 ◽  
Author(s):  
Jelena Pajnik ◽  
Ivana Lukić ◽  
Jelena Dikić ◽  
Jelena Asanin ◽  
Milan Gordic ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Antibacterial Properties ◽  
Water Vapor Permeability ◽  
Weibull Model ◽  
Vapor Permeability ◽  
E Coli ◽  
Supercritical Solvent ◽  
Composite Polymers ◽  
Before And After ◽  
Impregnation Time

In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material. Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent. Experiments were performed at 35 °C, pressures of 15.5 and 30 MPa, and an impregnation time in the range of 4–24 h. The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively. The addition of natural zeolite (15–60%) significantly increased the loading capacity of films enabling thymol incorporation in a quantity of 16.7–27.3%. FTIR and SEM analyses were applied for the characterization of the films. Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well. Thymol release kinetics in deionized water was followed and modeled by the Korsmeyer-Peppas and Weibull model. SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).

scholarly journals Antibacterial Activity and Drug Loading of Moxifloxacin-Loaded Poly(Vinyl Alcohol)/Chitosan Electrospun Nanofibers

2021 ◽  
Vol 8 ◽  
Author(s):  
Qi Liu ◽  
Wen-Chong Ouyang ◽  
Xiu-Hong Zhou ◽  
Tao Jin ◽  
Zheng-Wei Wu
Keyword(s):  
Antibacterial Activity ◽  
Vinyl Alcohol ◽  
Composite Nanofibers ◽  
Drug Loading ◽  
Antibacterial Properties ◽  
Electrospun Nanofibers ◽  
Poly Vinyl Alcohol ◽  
X Ray Diffraction ◽  
Blank Group

In this study, nanofibers with different ratios of poly(vinyl alcohol) and chitosan incorporated with moxifloxacin hydrochloride (MH/PVA/CS) were fabricated through the blending electrospinning, and the morphological features were tested using scanning electron microscopy (SEM). Further characterization of the new nanofiber was accomplished by Thermogravimetric analysis (TG), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). Antibacterial activity of the MH-loaded nanofibers at different drug loading were tested and compared with the blank group. Experimental results show that the MH/PVA/CS nanofibers exhibited the good antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa due to the MH incorporation. Compared with blank nanofibers, MH/PVA/CS nanofibers have significantly better antibacterial properties, and different proportions of PVA and CS have a certain effect on the antibacterial activity of nanofibers. The conclusions in this paper show that MH/PVA/CS composite nanofibers may have great potential in antibacterial materials.

scholarly journals Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics

2019 ◽  
Vol 69 (12) ◽  
pp. 3400-3405
Author(s):  
Mariana Mateescu ◽  
Sanda Maria Doncea ◽  
Iuliana Raut ◽  
Cristina Lavinia Nistor ◽  
Ioneta Codrina Bujanca
Keyword(s):  
Controlled Release ◽  
Biomedical Application ◽  
Drug Loading ◽  
Antibacterial Properties ◽  
Drug Carriers ◽  
Chemical Precipitation ◽  
Controlled Delivery ◽  
Wet Chemical ◽  
Uv Visible ◽  
Wet Chemical Precipitation

The hydroxyapatite (HA) nano and microparticles were synthesized by wet-chemical precipitation in order to use them as drug carriers for biomedical applications. Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS) and Fourier Transform Infrared Spectroscopy (FTIR) were performed to assess their size, external morphology and chemical composition. The properties of HA particles as drug carriers for antibiotics delivery were evaluated with doxycycline and chloramphenicol. The amount of drug loading and release was determined by UV-Visible spectrophotometry. The antibacterial properties of loaded HA particles were evaluated using gram-positive Bacillus subtilis bacteria and gram-negative Pseudomonas aeruginosa bacteria. The synthesized particles of HA exhibit a high adsorption capacity (around 99%) and good controlled release properties for doxycycline. The adsorption of chloramphenicol on HA was extremely low (about 2%). According to the results, the compatibility between the drug and substrate is an important factor in the absorption process, and the hydroxyapatite is a very promising carrier for controlled release of antibiotics.

scholarly journals Development and Optimization of Fast Dissolving Oral Film Containing Aripiprazole

2017 ◽  
Vol 9 (06) ◽  
Author(s):  
S. Jyothi Sri ◽  
D.V. R.N Bhikshapathi
Keyword(s):  
Good Alternative ◽  
In Vitro Dissolution ◽  
Content Uniformity ◽  
Solvent Casting ◽  
Casting Method ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Folding Endurance ◽  
Oral Films

The present investigation was aimed with the objective of developing fast dissolving oral films of Aripiprazole to attain quick onset of action for the better management of Schizophrenia. Fourteen formulations (F1-F14) of Aripiprazole mouth dissolving films by solvent-casting method using HPMC E5, HPMC E15, Maltodextrin, PG and PVA. Formulations were evaluated for their physical characteristics, thickness, folding endurance, tensile strength, disintegration time, drug content uniformity and drug release characteristics and found to be within the limits. Among the prepared formulations F13 showed minimum disintegration time 10 sec, maximum drug was released i.e. 99.49 ± 0.36% of drug within 8 min when compared to the other formulations and finalized as optimized formulation. FTIR data revealed that no interactions take place between the drug and polymers used in the optimized formulation. The in vitro dissolution profiles of marketed product and optimized formulation was compared and found to be the drug released was 20.73 ± 0.25 after 8 min. Therefore, it can be a good alternative to conventional Aripiprazole for immediate action. In vitro evaluation of the Aripiprazole fast dissolving oral films confirmed their potential as an innovative dosage form to improve delivery and quick onset of action of Aripiprazole. The mouth dissolving film is potentially useful for the treatment of Schizophrenia where the quick onset of action is desired.

scholarly journals Preparation and stability of microcapsule wood preservative from neem extract

BioResources ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. 3352-3363
Author(s):  
Luchen Liu ◽  
Guoqi Xu
Keyword(s):  
Urea Formaldehyde ◽  
Antibacterial Properties ◽  
Wood Preservative ◽  
Environmental Stability ◽  
Wall Material ◽  
Melia Azedarach ◽  
Water Spray ◽  
Neem Extract ◽  
Decay Test ◽  
Different Temperatures

Neem (Melia azedarach) extract has good antibacterial properties, but its bioactivities are easily decomposed. In order to protect the bioactivities of neem extract, melamine urea formaldehyde (MUF) was used as wall material to prepare a wood microcapsule preservative. The size and distribution of microcapsules after treatments at different temperatures were determined by microscopy. These observations showed that increases in temperature caused the microcapsule particles to become smaller and more evenly distributed. The stability of this preservative was studied by use of an environmental factors experiment (ultraviolet light, condensation, and water spray) and a decay test. The results indicated that the microcapsule preservative from neem extract was more stable than the neem extract preservative. The results indicated that the microcapsule preservative from neem extract showed acceptable environmental stability. The water spray resistance of microcapsule preservative from neem extract was the best.

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