scholarly journals Multiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge

2021 ◽  
Vol 15 (5) ◽  
pp. 155798832110448
Author(s):  
Sorin Dema ◽  
Andreea Bota ◽  
Sorina Maria Tăban ◽  
Adelina Gheju ◽  
Alis Liliana Carmen Dema ◽  
...  
Keyword(s):  
Medical Records ◽  
Malignant Tumors ◽  
Synchronous Tumors ◽  
Primary Tumors ◽  
Oncologic Patients ◽  
Multiple Primary ◽  
Reference Hospital ◽  
The Mean ◽  
Personalized Approach ◽  
Metachronous Tumors

Considering that the incidence of colorectal (CRC) and prostatic cancer (PC) increases with age, metachronous and synchronous tumors can often affect the same patient. Despite the importance of this subject for the diagnosis and management of oncologic patients, in medical literature the data are scarce. The aim of the study was to evaluate the incidence and the characteristics of double/multiple primary malignant tumors (D/MPMTs) with colorectal and prostatic origin, in patients admitted to a reference hospital in West Romania. A 4-year retrospective observational study (2016–2019) was conducted by analyzing the medical records of all patients admitted in the hospital. Demographic and clinical data, as well as tumor-related parameters, were extracted. We identified 413 consecutive hospitalized patients with PC, and 21 (5%) of them also had a primary CRC. At the time of diagnosis, the mean age of the patients with PC was 71.2 ± 6 years, and 71.8 ± 10 years for patients with CRC. Synchronous PC and CRC tumors were identified in 3/21 cases and metachronous tumors in 18/21 cases. Prostate cancer was the first tumor to be diagnosed in 13/18 cases and CRC in 5/18 cases. The most frequent subtype of PC was acinar adenocarcinoma (90%) and for CRC cases, conventional adenocarcinoma (90%). Prostate and colorectal cancers tend to co-occur in a single patient. The diagnosis of one of these two types of tumors should imply the screening for the other one, because these patients require a multidisciplinary and personalized approach.

scholarly journals Characteristics of the patients with cutaneous melanoma and multiple primary malignant tumors: clinical observations

2017 ◽  
Vol 16 (3) ◽  
pp. 43-51
Author(s):  
D. A. Ponkratova ◽  
I. V. Tsyganova ◽  
A. S. Vikhrova ◽  
A. A. Lushnikova
Keyword(s):  
Cutaneous Melanoma ◽  
Malignant Tumors ◽  
Excess Body Weight ◽  
Surgical Removal ◽  
Primary Tumors ◽  
Genetic Characteristics ◽  
Female Patients ◽  
Mutational Status ◽  
Multiple Primary ◽  
Male Patients

Background. Multiple primary malignant tumors (MPMT) - 2 or more tumors, arising during patient life - are an important risk factor of cutaneous melanoma (CM). The frequency of MPMT in Russia ranges from 2 to 20 % with the incidence increasing. This tendency is linked mainly with the increasing life expectancy of the patients, with use of a potentially carcinogenic treatment methods, with the influence of adverse environmental factors and genetic predisposition In 15 patients with MPMT, including CM, has revealed a trend towards more frequent family history in male patients. In female patients MPMT included breast, ovarian and renal malignant tumors. CM relapses were observed shortly after surgical removal of the primary tumors. Objective. Clinical and genetic characteristics of patients with MK in MPMT structure. Materials and methods. Disease histories, MPMT structure and CM mutational status (PCR followed by direct sequencing of amplions) were analyzed in 8 male and 7 female patients with MPMT included metastatic CM. Results. A preliminary analysis of 15 patients with metastatic CM in MPMT structure has revealed some gender features. In female patients MPMT more often included breast, ovaries or kidney tumors. Excess body weight or obesity was detected in female patients (5/7) more often than in male patients (4/8). There is a tendency to more frequent family cancer histories in male patients compared to female ones - 3/8 vs. 1/7 in 3/8 male patients somatic mutations in BRAF gene (2) and PDGF gene (1) were identified in CM. The frequency of mutations of BRAF and NRAS genes in CM of female patients was 2 times higher than that of male patients. The combination of CM with bowel cancer was prevalent in male patients. In 2/7 male patients CM was the last tumor in MPMT structure, in 5/7 - the first, with the exception of the patient with primary multiple melanomas, while CM as the first tumor was revealed in 4/7 female patients and last CM - in 1/7 ones. Conclusions. Various combinations of tumors in MPMT structure were characterized in male and female patients. In female patients MPMT included breast, ovarian and renal malignant tumors/were the most frequent, while the combination CM with bowel tumors were prevalent in male ones. In male patients CM was diagnosed as the first tumor more frequently than the last one. The frequency of mutations in BRAF and NRAS genes in MK tumors in female patients with MPMT was 2 times higher than that in male patients. In 15 patients with MPMT, including CM, a trend towards more frequent family cancer history in male patients was revealed. CM relases were observed shortly after surgical removal of the primary tumor.

scholarly journals Experience in the treatment of primary malignant tumors (retinoblastoma and osteosarcoma): analysis of the clinical case

2021 ◽  
Vol 13 (2) ◽  
pp. 36-43
Author(s):  
A. A. Zagidullina ◽  
V. Kh. Kharbediya ◽  
A. Z. Dzampaev ◽  
D. V. Nisichenko ◽  
S. N. Mikhailova
Keyword(s):  
Risk Factors ◽  
Malignant Tumors ◽  
Treatment Protocol ◽  
Patient Treatment ◽  
Special Treatment ◽  
Primary Tumors ◽  
Secondary Tumor ◽  
Multiple Primary Tumors ◽  
Multiple Primary ◽  
The Impact

Background. Retinoblastoma is a malignant intraocular tumor developing from the retinal neuroectoderm and diagnosed primarily in young children. This type of cancer is associated with a high risk of multiple primary tumors emerging after treatment completion. Multiple primary tumors are two or more independent tumors developing in one patient. Treatment of this disease is challenging.Objective – to evaluate the impact of risk factors on the efficacy of therapy for multiple primary tumors and to analyze treatment outcomes.Materials and methods. A 2-year-old boy was diagnosed with bilateral retinoblastoma (OD – stage T3bN0M0 and OS – stage T3cN0M0). He received special treatment from September 2005 to November 2006. In 2012, the patient underwent cataract surgery: the lens was removed, then an intraocular lens was installed, and laser dissection of the posterior capsule of the lens was performed. Six years later, in August 2018, the patient was diagnosed with osteosarcoma. The boy received combination organ-sparing therapy according to the EURAMOS-1 treatment protocol for osteosarcoma. During therapy, he developed a secondary tumor, namely osteoblastic osteosarcoma. Both the boy and his father were found to have a mutation in the RB1 gene.Results. Currently, patient’s condition is satisfactory; he has no complains. The boy is in remission for 2 years.Conclusion. The development of secondary tumors depends on the genetic factors, type of treatment for primary tumor, and environmental factors. Therefore, it is extremely important to assess risk factors for multiple primary tumors at the moment of primary retinoblastoma detection. The results of such assessment will help to choose an optimal treatment strategy.

Multiple primary tumors, especially malignant

1927 ◽  
Vol 23 (12) ◽  
pp. 1288-1288
Keyword(s):  
Malignant Tumors ◽  
Primary Tumors ◽  
Multiple Primary Tumors ◽  
Multiple Cancers ◽  
Multiple Primary ◽  
Primary Origin

The author reports that 9,371 autopsies performed between 1920 and 1926 at the Pathologoanat. The author reports that from the total number of cases of malignant tumors of 1.123 (11.98%) in the Institute of Pathology and Anatomy of Prof. Kiml in Prague 14 multiple cancers were found. Besides 4 cases in which the primary origin of the tumor was questionable, 10 cases (0,107% of all autopsies and 0.89% of malignant tumors) remain, where the primary plurality may be considered as reliable or at least very probable.

scholarly journals Frequency and type of eyelid neoplasia in Tuzla region, Bosnia and Herzegovina

2018 ◽  
Vol 8 (1) ◽  
pp. 20-23
Author(s):  
Mufid Burgic ◽  
Ermina Iljazovic ◽  
Amra Nadarevic Vodencarevic ◽  
Musfaha Burgic ◽  
Meliha Halilbasic ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bosnia And Herzegovina ◽  
Basal Cell ◽  
Medical Records ◽  
Malignant Tumors ◽  
Seborrheic Keratosis ◽  
Eyelid Tumors ◽  
Clinical Center ◽  
The Mean

Introduction: Benign and malignant tumors can arise from each of the eyelid layers. Our aim was to investigate the frequency and distribution of the eyelid tumors in tertiary health institution in Tuzla Region in Bosnia and Herzegovina.             Methods: We analyzed medical records for all the patients treated for eyelid malignancies in University Clinical Center Tuzla, from January 2012 to December 2016. Demographic, clinical and pathological data were collected and analyzed.           Results: A total of 89 patients were treated during the 5 year period. Forty seven of the patients were male (52 %) and 42 (48 %) were female. Patient age ranged from 11 to 92 years, with the mean age of 66.6 years. The most common eyelid malignancy was basal cell carcinoma (80.95%), followed by squamous cell carcinoma (14.29%), merkel cell carcinoma (3.17%) and melanoma (1.59%). Conclusion: The annual incidence of eyelid tumors in Tuzla region is about 3.73/100 000 population. Majority of the malignant tumors were basal cell carcinoma, while melanoma was the least frequent. Most frequent benign lesions were seborrheic keratosis and benign nevi.

Multiple primary neoplasms involving the breast

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10786-10786
Author(s):  
L. S. Maddali ◽  
S. Maddali
Keyword(s):  
Breast Cancer ◽  
Primary Group ◽  
Second Primary ◽  
Synchronous Tumors ◽  
Multiple Primary Neoplasms ◽  
Cancer Group ◽  
Multiple Primary ◽  
Breast Cancer Group ◽  
Primary Neoplasms ◽  
Metachronous Tumors

10786 Background: Multiple Primary Neoplasms (MPN) are being identified with increasing frequency in Breast cancer patients. We studied MPN involving Breast cancer as at least one primary for (1) incidence and (2) identifying. subsets with special features. Methods: 83 patients with MPN were identified among 3378 patients seen between January 1st 1999 and 31st December 2005. (2.15%). 40 of these had Breast primary (48.19%). which form the basis of the present report. One or both primaries were identified during this period. But in some cases with primaries in remote past, available documentation was accepted. Results: Breast cancer was the Index cancer 31/40 (77.50%)and second primary in 9/40 (22.50%). Among the index cancers, 4/31 cases (12.90%) were synchronous and 27/31 (87.10%) were metachronous. 100% of the second primary in breast group were metachronous. Breast-Breast MPN 15/40 (37.50%) and Breast-Non breast MPN 25/40 (62.50%). Mean ages for Breast-Breast MPN 47.33 years, Synchronous tumors 38.66 yrs, metachronous tumors 58.20 yrs, Breast-Non Breast MPN 55.44 yrs. Mortality for Breast-Breast MPN as a group was 73.33%, synchronous tumors (2/3) 66.67%, metachronous tumors (10/12) 83.33%, Breast-Non Breast MPN, metachronous tumors (13/24) 54.17%. When the interval between index and second primary was studied, the Breast-Breast MPN mortality was (7/9) 77.78% for 2 yrs or less duration, (3/3) 100% for more than 2yrs. For Breast-NonBreast MPN, mortality was (6/9) 66.67% for duration of 2 yrs or less and (7/15) 46.67% for more than 2 yrs. The common malignancies associated in the index Breast cancer group were from Ovary (6),Thyroid (2),pancreas (2), Hematologic neoplasms (3) Upper Aero Digestive Tract (2). The second primary Breast cancer group had primaries in ovary (2), colon (2), hematologic (3) neoplasms. Conclusions: Breast-Breast MPN are seen in younger patients with higher mortality than Breast-Non Breast MPN. In the Breast-Non Breast MPN group, longer interval between the primaries is associated with lower mortality. There were no major differences between the Index Breast cancer group and Breast Second Primary group. Mortality appeared to be determined by the nature of the Non Breast Primary. No significant financial relationships to disclose.

SPORADIC AND HEREDITARY FORMS OF MULTIPLE PRIMARY MALIGNANT TUMORS IN CHILDREN

2019 ◽  
Vol 65 (4) ◽  
pp. 565-574
Author(s):  
Alina Malakhova ◽  
Tatyana Kazubskaya ◽  
V. Kozlova ◽  
Tatyana Kondrateva ◽  
Yevgeniy Trofimov ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Malignant Tumors ◽  
Later Life ◽  
Primary Tumors ◽  
Multiple Primary Tumors ◽  
National Medical ◽  
Multiple Primaries ◽  
Increased Risk ◽  
Multiple Primary ◽  
Second Tumors

The article presents the features of the clinical manifestation of multiple primary sporadic and heritable malignant tumors in 104 children who observed at Pediatric Oncology and Hematology Research Institute of «NN Blokhin's National Medical Research Center of Oncology» from 1998 to 2012. The age of patients at the time of occurrence of the second malignant tumor ranged from 2.8 to 28 years and averaged 15.6 years. The second neoplasia occurred significantly more frequently in the group of primary hemoblastosis, compared with the group of solid tumors - 8.7% versus 3.4%, respectively (p <0.0001). In children with multiple primaries, were found tumors that occur in common the most frequency. Retinoblastoma patients have an increased risk of developing sarcoma. Patients with Hodgkin's lymphoma have an increased risk of developing leukemia. In surviving children after treatment of the first neoplasia the thyroid, bone tissue and breast have a specific risk for the development of metachronous cancer and are target organs for control. Children with new hematopoietic tumors may be candidates for metachronous development of leukemia and bone tissue tumors. The using methods Next Generation Sequencing (NGS) and Multiplex Ligation-dependent Probe Amplification (MLPA) revealed germinal mutations in 12 children with of multiple primary tumors. The mutations in the TP53, RB1, CHEK2, FANCN/PALB2, MLH1, PMS2 genes identified in patients were associated with hereditary syndromes and an increased risk of developing second tumors, among which: sarcomas, brain tumors, hematopoietic tumors were the most frequent. It was shown that the second tumors can appear at the any age. Children who survived the treatment of the first tumor in later life should be monitored annually. Clinical management of children with multiple primary tumors requires a multidisciplinary approach.

scholarly journals metastasis of two malignant tumors of different genesis in axillary lymph node (a case report)

2016 ◽  
Vol 38 (3) ◽  
pp. 198-201
Author(s):  
A Rusin ◽  
O V Petrosov ◽  
A I Chumak ◽  
V M Kushnir
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Lymph Node ◽  
Axillary Lymph Node ◽  
Immunohistochemical Study ◽  
Malignant Tumors ◽  
Axillary Lymph ◽  
Skin Melanoma ◽  
Primary Tumors ◽  
Multiple Primary

This case report describes a rare clinical condition: metastasis of synchronous multiple primary tumors — skin melanoma and breast cancer in one axillary lymph node, confirmed with the results of clinical, morphological and immunohistochemical study of surgical material from 40 year-old woman.

Multiple primary colorectal cancer: Clinical aspects

2016 ◽  
Vol 88 (8) ◽  
pp. 53-58
Author(s):  
N V Soldatkina ◽  
O I Kit ◽  
Yu A Gevorkyan ◽  
A G Milakin
Keyword(s):  
Colorectal Cancer ◽  
Malignant Tumors ◽  
Morphological Characteristics ◽  
Primary Diagnosis ◽  
Clinical Aspects ◽  
Colorectal Tumors ◽  
Primary Tumors ◽  
Multiple Primary ◽  
Colon And Rectum ◽  
Metachronous Colorectal Cancer

Aim. To define some clinical characteristics of synchronous and metachronous colorectal cancer (CRC). Materials and methods. The investigation was concerned with the data of 150 patients with T1—4N0—2M0—1 multiple primary CRC. The clinical, biological, and morphological characteristics of synchronous and metachronous tumors were analyzed. Results. Multiple primary tumors were 6.01% of all the cases of CRC. There was a preponderance of synchronous CRC (63.75%) with the tumor localized in the sigmoid colon and rectum. In women, synchronous colorectal tumors were more often concurrent with breast tumors; metachronous ones were detected after treatment for genital tumors. In men, synchronous colorectal tumors were more frequently concurrent with kidney cancer; metachronous ones were identified after treatment for gastric cancer. Conclusion. The found characteristics of multiple primary colorectal tumors may be taken in account in programs for both primary diagnosis and follow-up after treatment for malignant tumors, which will be able to improve the early detection of cancer patients and their treatment results.

scholarly journals Multiple Warthin Tumors With Epithelial–Myoepithelial Carcinoma of the Ipsilateral Parotid Gland: A Case Report

2021 ◽  
pp. 014556132110280
Author(s):  
Tong Sha ◽  
Yang Yu ◽  
Kang Liu ◽  
Bin Sun ◽  
Wei Zhang
Keyword(s):  
Case Report ◽  
Parotid Gland ◽  
Rare Case ◽  
Malignant Tumors ◽  
Postoperative Recurrence ◽  
Myoepithelial Carcinoma ◽  
Primary Tumors ◽  
Multiple Primary Tumors ◽  
Multiple Primary ◽  
Epithelial Myoepithelial Carcinoma

Multiple primary tumors of the parotid gland refer to the occurrence of 2 or more primary tumors in the ipsilateral or bilateral parotid gland metachronously or synchronously, which do not originate from postoperative recurrence or metastasis. Multiple primary tumors of the parotid gland, especially synchronous benign and malignant tumors, are extremely uncommon. A rare case of multiple Warthin tumors with epithelial–myoepithelial carcinoma of the ipsilateral parotid gland is reported as follows.

Evaluation of Low-Dose Gentamicin Once Daily Dosing Regimen at A General Hospital in Malaysia

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
Ab Rahman A F ◽  
Md Sahak N. ◽  
Ali A. M.
Keyword(s):  
Medical Records ◽  
Public Hospital ◽  
Low Dose ◽  
Dosing Regimen ◽  
Once Daily ◽  
Neutropenic Sepsis ◽  
Wide Acceptance ◽  
The Mean ◽  
Initiation Of Therapy ◽  
Almost All

Objective: Once daily dosing (ODD) aminoglycoside is gaining wide acceptance as an alternative way of dosing. In our setting it is the regimen of choice whenever gentamicin is indicated. The objective of this study was to evaluate the practice of gentamicin ODD in a public hospital in Malaysia. Methods: We conducted a retrospective review of medical records of patients on gentamicin ODD who were admitted to Hospital Melaka during January 2002 until March 2010. All adult patients who were on ODD gentamicin with various level of renal function were included in the study. Patients on gentamicin less than 72 hours and pregnant women were excluded. Results: From 110 patients, 75 (68.2%) were male and 35 (31.8%) were female. Indications for ODD gentamicin included pneumonia, 34 (31.0%) neutropenic sepsis, 27 (24.5%) and sepsis, 11 (10.0%). The mean dose and duration of gentamicin was 3.2 mg/kg/day and 7 days, respectively. Almost all patients were on gentamicin combined with other antibiotics. Clinical cure based on fever resolution was found in 89.1% of patients treated with ODD. Resolution of fever took an average of 48 hours after initiation of therapy. The evaluation for bacteriologic cure could not be performed because of insufficient data on culture and sensitivity. Out of 38 patients with analyzable serum creatinine data, four patients might have developed nephrotoxicity. Conclusion: In our setting, lower dosages of ODD gentamicin when used in combination with other antibiotics seemed to be effective and safe in treating most gram negative infections.

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