Multiple primary colorectal cancer: Clinical aspects

2016 ◽  
Vol 88 (8) ◽  
pp. 53-58
Author(s):  
N V Soldatkina ◽  
O I Kit ◽  
Yu A Gevorkyan ◽  
A G Milakin
Keyword(s):  
Colorectal Cancer ◽  
Malignant Tumors ◽  
Morphological Characteristics ◽  
Primary Diagnosis ◽  
Clinical Aspects ◽  
Colorectal Tumors ◽  
Primary Tumors ◽  
Multiple Primary ◽  
Colon And Rectum ◽  
Metachronous Colorectal Cancer

Aim. To define some clinical characteristics of synchronous and metachronous colorectal cancer (CRC). Materials and methods. The investigation was concerned with the data of 150 patients with T1—4N0—2M0—1 multiple primary CRC. The clinical, biological, and morphological characteristics of synchronous and metachronous tumors were analyzed. Results. Multiple primary tumors were 6.01% of all the cases of CRC. There was a preponderance of synchronous CRC (63.75%) with the tumor localized in the sigmoid colon and rectum. In women, synchronous colorectal tumors were more often concurrent with breast tumors; metachronous ones were detected after treatment for genital tumors. In men, synchronous colorectal tumors were more frequently concurrent with kidney cancer; metachronous ones were identified after treatment for gastric cancer. Conclusion. The found characteristics of multiple primary colorectal tumors may be taken in account in programs for both primary diagnosis and follow-up after treatment for malignant tumors, which will be able to improve the early detection of cancer patients and their treatment results.

scholarly journals MULTIPLE PRIMARY COLORECTAL CANCER: THE POSSIBILITIES OF MINIMALLY INVASIVE SURGICAL INTERVENTIONS

2017 ◽  
pp. 38-42 ◽  
Author(s):  
O. I. Kit ◽  
Yu. A. Gevorkyan ◽  
N. V. Soldatkina ◽  
D. A. Kharagezov ◽  
V. E. Kolesnikov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Minimally Invasive ◽  
Morphological Characteristics ◽  
Colorectal Tumors ◽  
Primary Colorectal Cancer ◽  
Invasive Approach ◽  
Surgical Interventions ◽  
Minimally Invasive Surgical ◽  
Multiple Primary ◽  
Colon And Rectum

BACKGROUND. Study of oncobiological aspects of such a phenomenon as multiplicity of primary colorectal tumors, as well as improvement of methods of their treatment is relevant nowadays. The aim of the study was to reveal the potential of minimally invasive surgery for multiple primary colorectal cancer. MATERIAL AND METHODS. Data on 51 patients with synchronous multiple primary colorectal cancer were studied. Clinical, biological and morphological characteristics ofsynchronous colorectal tumors were analyzed. 12 of 51 patients underwent minimally invasive surgeries of the colon and rectum - laparoscopy and transanal endoscopic resection of the rectum. RESULTS showed that synchronous colorectal cancer prevailed in patients with multiple primary colorectal cancer (63,8 %), with tumors localized mainly in the sigmoid (62,75 %) and the rectum (56,86%). Minimally invasive approach allowed reduction of the number of postoperative complications by 2,5 times and improvement of rehabilitation of patients. CONCLUSION. Application of modern technologies in treatment for synchronous multiple primary colorectal cancer contributes to improvement of the treatment outcomes.

scholarly journals Intratumor Heterogeneity and Evolution of Colorectal Cancer

2020 ◽  
Author(s):  
Santasree Banerjee ◽  
Xianxiang Zhang ◽  
Shan Kuang ◽  
Jigang Wang ◽  
Lei Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Driver Mutations ◽  
Intratumor Heterogeneity ◽  
Primary Tumors ◽  
Node Metastasis ◽  
Evolution Pattern ◽  
Whole Exome ◽  
Colon And Rectum ◽  
High Depth

AbstractIntratumor heterogeneity (ITH) enable us to understand the evolution of cancer. ITH and evolution of colorectal cancer (CRC) has not been well studied. In this prospective study, we recruited different stages of 68 CRC patients with primary tumor at right-sided colon, left-sided colon and rectum. We performed high-depth whole exome sequencing of 206 multi-region tumor samples including primary tumors, lymph node metastasis (LN) and extranodal tumor deposits (ENTD). Our result showed extreme ITH with Darwinian pattern of CRC evolution, evolution pattern of left-sided CRC was more complex and divergent than right-sided CRC and both LN and ENTD were of polyclonal in origin. Extensive ITH was found in driver mutations in KRAS and PIK3CA genes, suggesting major limitations of single biopsies in clinical diagnosis for the CRC patients. In conclusion, our study showed the Darwinian pattern of CRC evolution with differences in evolution pattern between right-sided and left-sided CRC patients.

scholarly journals Pks+ Escherichia Coli More Prevalent in Benign than Malignant Colorectal Tumors

2021 ◽  
Author(s):  
Carmina Villariba Tolentino ◽  
Ana Maria Cariño ◽  
Kin Israel Notarte ◽  
Imee Macaranas ◽  
Allan Fellizar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Escherichia Coli ◽  
Malignant Tumors ◽  
Colorectal Tumors ◽  
Tissue Samples ◽  
E Coli ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Formalin Fixed

Abstract Background: Some E. coli strains that synthesize the toxin colibactin within the 54-kb pks island are being implicated in colorectal cancer (CRC) development. Here, the prevalence of pks+ E. coli in malignant and benign colorectal tumors obtained from selected Filipino patients was compared to determine the association of pks+ E. coli with CRC in this population. Methods and Results: A realtime qPCR protocol was developed to quantify uidA, clbB, clbN, and clbA genes in formalin fixed paraffin embedded colorectal tissues. The number of malignant tumors (44/62; 71%) positive for the uidA gene was not significantly different (p=0.3428) from benign (38/62; 61%) tumors. Significantly higher number of benign samples (p<0.05) were positive for all three colibactin genes (clbB, clbN, and clbA) compared with malignant samples. There was also higher prevalence of pks+ E. coli among older females and in tissue samples taken from the rectum. Conclusion: Hence, pks+ E. coli may not be associated with CRC development among Filipinos.

Early Diagnosis of Occult Blood of Colorectal Cancer Based on Nano-Colloidal Gold Sandwich Immunochromatography

2021 ◽  
Vol 17 (8) ◽  
pp. 1525-1534
Author(s):  
Yongying Wu ◽  
Jiaoyan Zhang ◽  
Xiaolin Yang ◽  
Zou Yin ◽  
Hui Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colloidal Gold ◽  
Ph Value ◽  
Malignant Tumors ◽  
Raw Materials ◽  
Morphological Characteristics ◽  
Occult Blood ◽  
Screening Methods ◽  
Early Screening ◽  
Crc Screening

The development of science and technology has deepened people’s understanding of cancer, changing the management of malignant tumors in the medical field. Given the common precancerous characteristics of colorectal cancer (CRC), researchers studied early CRC screening. The complexity of traditional diagnostics forced medical staff to speed up CRC innovation early screening methods. Here, we prepared nano-colloidal gold raw materials with different particle sizes (15 and 30 nm) and observed the morphological characteristics and properties of the materials. Simultaneously, the nanocolloidal gold double antibody sandwich kit was designed through the optimum pH value and protein content screening experiment. The results of clinical enteroscopy confirmed the important guiding significance of the equipment in early CRC screening.

scholarly journals A clinical study on multiple primary malignant tumors associated with colorectal cancer.

1990 ◽  
Vol 23 (10) ◽  
pp. 2370-2375 ◽  
Author(s):  
Norihiro Yuasa ◽  
Yuji Nimura ◽  
Naokazu Hayakawa ◽  
Junichi Kamiya ◽  
Shoji Maeda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Study ◽  
Malignant Tumors ◽  
Multiple Primary

scholarly journals Characteristics of the patients with cutaneous melanoma and multiple primary malignant tumors: clinical observations

2017 ◽  
Vol 16 (3) ◽  
pp. 43-51
Author(s):  
D. A. Ponkratova ◽  
I. V. Tsyganova ◽  
A. S. Vikhrova ◽  
A. A. Lushnikova
Keyword(s):  
Cutaneous Melanoma ◽  
Malignant Tumors ◽  
Excess Body Weight ◽  
Surgical Removal ◽  
Primary Tumors ◽  
Genetic Characteristics ◽  
Female Patients ◽  
Mutational Status ◽  
Multiple Primary ◽  
Male Patients

Background. Multiple primary malignant tumors (MPMT) - 2 or more tumors, arising during patient life - are an important risk factor of cutaneous melanoma (CM). The frequency of MPMT in Russia ranges from 2 to 20 % with the incidence increasing. This tendency is linked mainly with the increasing life expectancy of the patients, with use of a potentially carcinogenic treatment methods, with the influence of adverse environmental factors and genetic predisposition In 15 patients with MPMT, including CM, has revealed a trend towards more frequent family history in male patients. In female patients MPMT included breast, ovarian and renal malignant tumors. CM relapses were observed shortly after surgical removal of the primary tumors. Objective. Clinical and genetic characteristics of patients with MK in MPMT structure. Materials and methods. Disease histories, MPMT structure and CM mutational status (PCR followed by direct sequencing of amplions) were analyzed in 8 male and 7 female patients with MPMT included metastatic CM. Results. A preliminary analysis of 15 patients with metastatic CM in MPMT structure has revealed some gender features. In female patients MPMT more often included breast, ovaries or kidney tumors. Excess body weight or obesity was detected in female patients (5/7) more often than in male patients (4/8). There is a tendency to more frequent family cancer histories in male patients compared to female ones - 3/8 vs. 1/7 in 3/8 male patients somatic mutations in BRAF gene (2) and PDGF gene (1) were identified in CM. The frequency of mutations of BRAF and NRAS genes in CM of female patients was 2 times higher than that of male patients. The combination of CM with bowel cancer was prevalent in male patients. In 2/7 male patients CM was the last tumor in MPMT structure, in 5/7 - the first, with the exception of the patient with primary multiple melanomas, while CM as the first tumor was revealed in 4/7 female patients and last CM - in 1/7 ones. Conclusions. Various combinations of tumors in MPMT structure were characterized in male and female patients. In female patients MPMT included breast, ovarian and renal malignant tumors/were the most frequent, while the combination CM with bowel tumors were prevalent in male ones. In male patients CM was diagnosed as the first tumor more frequently than the last one. The frequency of mutations in BRAF and NRAS genes in MK tumors in female patients with MPMT was 2 times higher than that in male patients. In 15 patients with MPMT, including CM, a trend towards more frequent family cancer history in male patients was revealed. CM relases were observed shortly after surgical removal of the primary tumor.

scholarly journals Experience in the treatment of primary malignant tumors (retinoblastoma and osteosarcoma): analysis of the clinical case

2021 ◽  
Vol 13 (2) ◽  
pp. 36-43
Author(s):  
A. A. Zagidullina ◽  
V. Kh. Kharbediya ◽  
A. Z. Dzampaev ◽  
D. V. Nisichenko ◽  
S. N. Mikhailova
Keyword(s):  
Risk Factors ◽  
Malignant Tumors ◽  
Treatment Protocol ◽  
Patient Treatment ◽  
Special Treatment ◽  
Primary Tumors ◽  
Secondary Tumor ◽  
Multiple Primary Tumors ◽  
Multiple Primary ◽  
The Impact

Background. Retinoblastoma is a malignant intraocular tumor developing from the retinal neuroectoderm and diagnosed primarily in young children. This type of cancer is associated with a high risk of multiple primary tumors emerging after treatment completion. Multiple primary tumors are two or more independent tumors developing in one patient. Treatment of this disease is challenging.Objective – to evaluate the impact of risk factors on the efficacy of therapy for multiple primary tumors and to analyze treatment outcomes.Materials and methods. A 2-year-old boy was diagnosed with bilateral retinoblastoma (OD – stage T3bN0M0 and OS – stage T3cN0M0). He received special treatment from September 2005 to November 2006. In 2012, the patient underwent cataract surgery: the lens was removed, then an intraocular lens was installed, and laser dissection of the posterior capsule of the lens was performed. Six years later, in August 2018, the patient was diagnosed with osteosarcoma. The boy received combination organ-sparing therapy according to the EURAMOS-1 treatment protocol for osteosarcoma. During therapy, he developed a secondary tumor, namely osteoblastic osteosarcoma. Both the boy and his father were found to have a mutation in the RB1 gene.Results. Currently, patient’s condition is satisfactory; he has no complains. The boy is in remission for 2 years.Conclusion. The development of secondary tumors depends on the genetic factors, type of treatment for primary tumor, and environmental factors. Therefore, it is extremely important to assess risk factors for multiple primary tumors at the moment of primary retinoblastoma detection. The results of such assessment will help to choose an optimal treatment strategy.

Multiple primary tumors, especially malignant

1927 ◽  
Vol 23 (12) ◽  
pp. 1288-1288
Keyword(s):  
Malignant Tumors ◽  
Primary Tumors ◽  
Multiple Primary Tumors ◽  
Multiple Cancers ◽  
Multiple Primary ◽  
Primary Origin

The author reports that 9,371 autopsies performed between 1920 and 1926 at the Pathologoanat. The author reports that from the total number of cases of malignant tumors of 1.123 (11.98%) in the Institute of Pathology and Anatomy of Prof. Kiml in Prague 14 multiple cancers were found. Besides 4 cases in which the primary origin of the tumor was questionable, 10 cases (0,107% of all autopsies and 0.89% of malignant tumors) remain, where the primary plurality may be considered as reliable or at least very probable.

Multiple primary malignant tumors involving the colon and rectum

1952 ◽  
Vol 83 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Harry E. Bacon ◽  
Michael C. Tavenner
Keyword(s):  
Malignant Tumors ◽  
Multiple Primary ◽  
Colon And Rectum

Clinicopathologic and Pedigree Differences in Amsterdam I–Positive Hereditary Nonpolyposis Colorectal Cancer Families According to Tumor Microsatellite Instability Status

2007 ◽  
Vol 25 (7) ◽  
pp. 781-786 ◽  
Author(s):  
Laura Valle ◽  
Jose Perea ◽  
Pablo Carbonell ◽  
Victoria Fernandez ◽  
Ana M. Dotor ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Protein Expression ◽  
Microsatellite Instability ◽  
Mismatch Repair ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Repair System ◽  
Primary Tumors ◽  
Multiple Primary Tumors ◽  
Hereditary Nonpolyposis ◽  
Multiple Primary

Purpose To establish the clinicopathologic and familial differences within Amsterdam I–positive families, showing either tumor microsatellite instability (MSI) or microsatellite stability (MSS) in order to confirm or deny the existence of hereditary nonpolyposis colorectal cancer (HNPCC) without defects in the mismatch repair system. Patients and Methods Sixty-four Amsterdam I–positive families were included in the study for which full, three-generation, family medical histories and colorectal paraffin-embedded tumors were obtained. Both personal and clinicopathologic information of patients were collected. In all cases, both the MSI status and the mismatch repair (MMR) protein expression were analyzed. MMR genetic testing was performed on the MSI families. Results Of the Amsterdam I–positive families, 59.4% were tumor MSI, and 40.6% were tumor MSS. When comparing both groups, the statistical differences were observed in the age of onset (MSI, 41 years; MSS, 53 years); in the colorectal tumor location, more frequently proximal in MSI cases; in fewer mucinous tumors in MSS; and loss of MMR protein expression in the MSI tumors. Regarding the individual and familial cancer history, we observed a predominance of individuals with multiple primary tumors in MSI pedigrees, as well as differences in the type of tumors developed within the family. Conclusion Our findings support the suspicion of another hereditary colorectal syndrome different from HNPCC and characterized by MSS, the normal MMR immunohistochemical expression, the presence of only colorectal tumors, and the absence of individuals with multiple primary tumors. All these circumstances suggest the existence of a non-MMR gene being responsible for this new syndrome.

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